Article
Plant Sciences
Yongchao Cai, Xinyu Liu, Lingbo Shen, Nian Wang, Yangjie He, Haifeng Zhang, Ping Wang, Zhengguang Zhang
Summary: This study identified two protein phosphatases MoPtc1 and MoPtc2 as negative regulators of the cell wall integrity (CWI) pathway in the rice blast fungus Magnaporthe oryzae, crucial for maintaining the stability of the CWI signaling pathway and plant pathogenicity.
MOLECULAR PLANT PATHOLOGY
(2022)
Article
Medicine, Research & Experimental
Laura Planas-Serra, Nathalie Launay, Leire Goicoechea, Benedicte Heron, Cristina Jou, Natalia Julia-Palacios, Montserrat Ruiz, Stephane Fourcade, Carlos Casasnovas, Carolina De La Torre, Antoinette Gelot, Maria Marsal, Pablo Loza-Alvarez, Angels Garcia-Cazorla, Ali Fatemi, Isidre Ferrer, Manel Portero-Otin, Estela Area-Gomez, Aurora Pujol
Summary: Sphingolipids play important roles as membrane constituents and signaling molecules, and are crucial in human diseases, such as neurodevelopmental disorders and cancer. The deficiency in the DEGS1 enzyme, which functions in the sphingolipid pathway, is associated with hypomyelinating leukodystrophy-18 (HLD18). This study reveals that DEGS1 is a mitochondria-associated endoplasmic reticulum membrane-resident enzyme, and its deficiency disrupts core functions of the mitochondria-associated endoplasmic reticulum membrane, resulting in various dysfunctions related to mitochondrial dynamics, cholesterol metabolism, phospholipid metabolism, and lipid droplet biogenesis.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Multidisciplinary Sciences
Jianfeng Wu, Kang Yang, Shaowei Cai, Xiaohan Zhang, Lichen Hu, Fanjia Lin, Su-qin Wu, Changchun Xiao, Wen-Hsien Liu, Jiahuai Han
Summary: This study highlights the important role of p38 alpha kinase in B cell differentiation, affecting plasma cell differentiation through regulating the transcriptional program by BLIMP1. This finding is crucial for understanding the mechanism of plasma cell differentiation.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Sarmistha Deb, Daniel A. Felix, Philipp Koch, Maharshi Krishna Deb, Karol Szafranski, Katrin Buder, Mara Sannai, Marco Groth, Joanna Kirkpatrick, Stefan Pietsch, Andre Gollowitzer, Alexander Gross, Philip Riemenschneider, Andreas Koeberle, Cristina Gonzalez-Estevez, Karl Lenhard Rudolph
Summary: The study identifies Tnfaip2 and Smed-exoc3 as key regulators of lipid metabolism, essential for ESC differentiation and planarian organ maintenance. Tnfaip2 knockout impairs ESC differentiation, while depletion of Smed-exoc3 affects tissue homeostasis and regeneration in planarians.
Article
Microbiology
Angela Sellers-Moya, Marcos Nuevalos, Maria Molina, Humberto Martin
Summary: Azoles, particularly clotrimazole, have a significant impact on the MAPK signaling in fungi, triggering deep changes in phosphorylation. Clotrimazole-induced ROS production and Slt2 phosphorylation are linked to PKA activity, while resistance depends on stress responses and novel signaling rewiring through the CWI pathway. The strong influence of azole treatment on MAPK signaling is conserved in other yeast species.
Article
Biology
Gilberto Garcia, Hanlin Zhang, Sophia Moreno, C. Kimberly Tsui, Brant Michael Webster, Ryo Higuchi-Sanabria, Andrew Dillin, Randy Y. Hampton
Summary: Changes in lipid metabolism are associated with aging and age-related diseases, including proteopathies. This study identified let-767 as an essential gene for both lipid and ER protein homeostasis in Caenorhabditis elegans. Knockdown of let-767 affects lipid stores, ER morphology, and the induction of the UPRER. A reduction in lipogenic pathways restores UPRER induction in animals with reduced let-767 by blocking the metabolite 3-oxoacyl.
Article
Biochemistry & Molecular Biology
Chen Zhang, Haifeng Zhang, Xiaobo Zheng, Yuanchao Wang, Wenwu Ye
Summary: A polyethylene glycol-mediated protoplast transformation system was developed for studying the pathogenic mechanisms of the fungus Phomopsis longicolla. Knockout mutants of two genes involved in cell wall integrity showed deficiencies in growth, development, and virulence.
MOLECULAR PLANT-MICROBE INTERACTIONS
(2022)
Article
Microbiology
Jose Cansado, Teresa Soto, Alejandro Franco, Jero Vicente-Soler, Marisa Madrid
Summary: This review provides an overview of the organization and underlying regulatory mechanisms of the Cell Integrity Pathway (CIP) in Schizosaccharomyces pombe, a simple eukaryote. It discusses the diverse functions of this pathway in mRNA stability, calcium homeostasis, cell wall integrity, and cytokinesis. Additionally, it explores the intricate interplay between the CIP and other environmentally regulated pathways. The evolutionary conservation of CIP signaling in the dimorphic fission yeast S. japonicus is also addressed.
Article
Microbiology
Joao Henrique Tadini Marilhano Fabri, Marina Campos Rocha, Caroline Mota Fernandes, Gabriela Felix Persinoti, Laure Nicolas Annick Ries, Anderson Ferreira da Cunha, Gustavo Henrique Goldman, Maurizio Del Poeta, Iran Malavazi
Summary: Research has shown the importance of new diseases, including fungal infections, as a consequence of global warming. The connection between fungal thermotolerance and cell wall integrity has been revealed, with the transcription factor HsfA playing a crucial role in cross-pathway regulation.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Jie Cong, Kunqin Xiao, Wenli Jiao, Cheng Zhang, Xianghui Zhang, Jinliang Liu, Yanhua Zhang, Hongyu Pan
Summary: The FKH protein in the plant pathogenic fungus Sclerotinia sclerotiorum plays an important role in hyphal development, virulence, and sclerotia formation. It is involved in maintaining cell wall integrity and the MAPK signaling pathway. SsFkh1 interacts with SsMkk1 and may function as its downstream substrate.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Agronomy
Yangyang Yang, Pengdong Xie, Jing Yuan, Yongxiang Liu, Miao Zhang, Yongcai Li, Yang Bi, Dov B. Prusky
Summary: This study identifies the crucial role of AaCrz1 in the development, infection structure formation, calcium homeostasis, cell wall integrity, and virulence of the phytopathogenic fungus A. alternata.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2022)
Article
Microbiology
Muyun Du, Yongbo Xie, Meng Wang, Huan Yang, Banghui Hu, Irum Mukhtar, Yuanyuan Liu, Yongxin Tao, Fang Liu, Baogui Xie
Summary: The Gαi gene in Flammulina filiformis plays a crucial role in regulating mycelium growth and stress response, and is essential for maintaining cell wall integrity and protection against biotic and abiotic stresses.
Article
Cell Biology
Zijie Huang, Zhong Tian, Yulian Zhao, Fen Zhu, Wen Liu, Xiaoping Wang
Summary: This study investigated the role of the MAPK signaling pathway in ovarian growth and oviposition in the cabbage beetle and found that ERK and P38 pathways are important for female survival and reproduction. Additionally, ERK pathway possibly regulates ecdysone biosynthesis and P38 pathway may be involved in germline stem cell development and differentiation.
Article
Chemistry, Multidisciplinary
Ainy Zehra, Hassan Alshemmari, Yasar N. Kavil, Abdul Majid Khan, Muhammad Zaffar Hashmi
Summary: The study focused on assessing the toxic effects of PCB70 and PCB75 on HeLa cells, showing PCB70 promotes cell proliferation at low doses and inhibits at high doses, while PCB75 causes membrane integrity deformities in a dose and time-dependent manner. The exposure to PCB congeners also induced the expression of ERK1/2 and JNK in a dose- and time-dependent manner in HeLa cells.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Fisheries
Yuehong Zhao, Xiaoli Zhang, Xiaona Zhang, Guoqing Shen, Weiwei Li, Qun Wang
Summary: This study found that integrin01 regulates the survival of Chinese mitten crab hemocytes by activating the FAK/ERK signaling cascade, and reducing the phosphorylation of ERK can enhance apoptosis.
FISH & SHELLFISH IMMUNOLOGY
(2023)