Impaired mitochondrial homeostasis and neurodegeneration: towards new therapeutic targets?

Neurodegenerative lysosomal disorders: A continuum from development to late age

(2014) Ralph A. Nixon et al.   Autophagy

PPARγ activation rescues mitochondrial function from inhibition of complex I and loss of PINK1

(2014) Juan Carlos Corona et al.   EXPERIMENTAL NEUROLOGY

An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore

(2014) K. N. Alavian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Establishing a novel C. elegans model to investigate the role of autophagy in amyotrophic lateral sclerosis

(2013) Jia Li et al.   ACTA PHARMACOLOGICA SINICA

After the banquet

(2013) Jianhui Zhu et al.   Autophagy

Mitochondrial quality control and communications with the nucleus are important in maintaining mitochondrial function and cell health

(2013) Vassilios N. Kotiadis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Inhibition of LRRK2 kinase activity stimulates macroautophagy

(2013) Claudia Manzoni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Food restriction-induced autophagy modulates degradation of mutant SOD1 in an amyotrophic lateral sclerosis mouse model

(2013) Kunxi Zhang et al.   BRAIN RESEARCH

Mitochondria and Quality Control Defects in a Mouse Model of Gaucher Disease—Links to Parkinson’s Disease

(2013) Laura D. Osellame et al.   Cell Metabolism

Mitochondrial permeability transition pore induces mitochondria injury in Huntington disease

(2013) Rodrigo A Quintanilla et al.   Molecular Neurodegeneration

The Parkinson's disease–linked proteins Fbxo7 and Parkin interact to mediate mitophagy

(2013) Victoria S Burchell et al.   NATURE NEUROSCIENCE

Dimers of mitochondrial ATP synthase form the permeability transition pore

(2013) V. Giorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy

(2012) Jia-Hong Lu et al.   Autophagy

Cellular and molecular mechanisms of mitochondrial function

(2012) Laura D. Osellame et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

The permeability transition pore as a Ca2+ release channel: New answers to an old question

(2012) Paolo Bernardi et al.   CELL CALCIUM

Elevated PGC-1α Activity Sustains Mitochondrial Biogenesis and Muscle Function without Extending Survival in a Mouse Model of Inherited ALS

(2012) Sandrine Da Cruz et al.   Cell Metabolism

Sustained expression of PGC-1  in the rat nigrostriatal system selectively impairs dopaminergic function

(2012) C. Ciron et al.   HUMAN MOLECULAR GENETICS

Effect of mitochondrial transcription factor a overexpression on motor neurons in amyotrophic lateral sclerosis model mice

(2012) Nobutoshi Morimoto et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Regulation of mitochondrial permeability transition pore by PINK1

(2012) Clement A Gautier et al.   Molecular Neurodegeneration

Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: Neuroprotection by SIRT3 and PGC-1α

(2012) Wenjun Song et al.   NEUROBIOLOGY OF DISEASE

Dopamine Induced Neurodegeneration in a PINK1 Model of Parkinson's Disease

(2012) Sonia Gandhi et al.   PLoS One

Loss of DJ-1 Does Not Affect Mitochondrial Respiration but Increases ROS Production and Mitochondrial Permeability Transition Pore Opening

(2012) Emilie Giaime et al.   PLoS One

Pgc-1α Overexpression Downregulates Pitx3 and Increases Susceptibility to MPTP Toxicity Associated with Decreased Bdnf

(2012) Joanne Clark et al.   PLoS One

Rapamycin treatment augments motor neuron degeneration in SOD1G93Amouse model of amyotrophic lateral sclerosis

(2011) Xiaojie Zhang et al.   Autophagy

A mitochondrial-targeted cyclosporin A with high binding affinity for cyclophilin D yields improved cytoprotection of cardiomyocytes

(2011) Henry Dube et al.   BIOCHEMICAL JOURNAL

Overexpression of TFAM, NRF-1 and myr-AKT protects the MPP+-induced mitochondrial dysfunctions in neuronal cells

(2011) Ying Piao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

β-amyloid activates PARP causing astrocytic metabolic failure and neuronal death

(2011) Rosella Abeti et al.   BRAIN

Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

(2011) Joseph R. Mazzulli et al.   CELL

In Vivo Correction of COX Deficiency by Activation of the AMPK/PGC-1α Axis

(2011) Carlo Viscomi et al.   Cell Metabolism

Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease

(2011) Ashu Johri et al.   HUMAN MOLECULAR GENETICS

Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer’s disease

(2011) Baiyang Sheng et al.   JOURNAL OF NEUROCHEMISTRY

Reduction of mutant huntingtin accumulation and toxicity by lysosomal cathepsins D and B in neurons

(2011) Qiuli Liang et al.   Molecular Neurodegeneration

PPARgamma rescue of the mitochondrial dysfunction in Huntington's disease

(2011) Ming-Chang Chiang et al.   NEUROBIOLOGY OF DISEASE

Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease

(2011) Yuncheng Wu et al.   NEUROSIGNALS

Autosomal recessive parkinsonism

(2011) Vincenzo Bonifati   PARKINSONISM & RELATED DISORDERS

Is mPTP the gatekeeper for necrosis, apoptosis, or both?

(2010) Kathleen W. Kinnally et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Role of mitochondrial ion channels in cell death

(2010) Shin-Young Ryu et al.   BIOFACTORS

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease

(2010) Giuseppe Filomeni et al.   NEUROBIOLOGY OF AGING

Mutant superoxide dismutase 1 overexpression in NSC-34 cells: Effect of trehalose on aggregation, TDP-43 localization and levels of co-expressed glycoproteins

(2010) Catarina Gomes et al.   NEUROSCIENCE LETTERS

PGC-1 , A Potential Therapeutic Target for Early Intervention in Parkinson's Disease

(2010) B. Zheng et al.   Science Translational Medicine

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Mitophagy

(2009) Aviva M. Tolkovsky   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The mitochondrial permeability transition pore in motor neurons: Involvement in the pathobiology of ALS mice

(2009) Lee J. Martin et al.   EXPERIMENTAL NEUROLOGY

Overexpression of Tfam protects mitochondria against β-amyloid-induced oxidative damage in SH-SY5Y cells

(2009) Shangcheng Xu et al.   FEBS Journal

PGC-1α/β induced expression partially compensates for respiratory chain defects in cells from patients with mitochondrial disorders

(2009) Sarika Srivastava et al.   HUMAN MOLECULAR GENETICS

SUMOylation Attenuates the Function of PGC-1α

(2009) Miia M. Rytinki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

What is the mitochondrial permeability transition pore?

(2009) Andrew P. Halestrap   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Developmental Shift of Cyclophilin D Contribution to Hypoxic-Ischemic Brain Injury

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in  -Synuclein Models of Parkinson's and Lewy Body Diseases

(2009) B. Spencer et al.   JOURNAL OF NEUROSCIENCE

PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death

(2009) Sonia Gandhi et al.   MOLECULAR CELL

PPARγ stimulation promotes mitochondrial biogenesis and prevents glucose deprivation-induced neuronal cell loss

(2009) Gianluca Miglio et al.   NEUROCHEMISTRY INTERNATIONAL

Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

(2009) E. Sidransky et al.   NEW ENGLAND JOURNAL OF MEDICINE

IF1: setting the pace of the F1Fo-ATP synthase

(2009) Michelangelo Campanella et al.   TRENDS IN BIOCHEMICAL SCIENCES

Molecular mechanism of PPAR in the regulation of age-related inflammation

(2008) Jae Heun Chung et al.   AGEING RESEARCH REVIEWS

Autophagy: Basic Principles and Relevance to Disease

(2008) Mondira Kundu et al.   Annual Review of Pathology-Mechanisms of Disease

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Synergistic activation of the human MnSOD promoter by DJ-1 and PGC-1α: regulation by SUMOylation and oxidation

(2008) Nan Zhong et al.   HUMAN MOLECULAR GENETICS

Rosiglitazone Treatment Prevents Mitochondrial Dysfunction in Mutant Huntingtin-expressing Cells

(2008) Rodrigo A. Quintanilla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

Effect of Cyclosporine on Reperfusion Injury in Acute Myocardial Infarction

(2008) Christophe Piot et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transcriptional Paradigms in Mammalian Mitochondrial Biogenesis and Function

(2008) Richard C. Scarpulla   PHYSIOLOGICAL REVIEWS

Lithium delays progression of amyotrophic lateral sclerosis

(2008) F. Fornai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA