The metabolic response to excitotoxicity – lessons from single-cell imaging

Involvement of autophagy in hypoxic-excitotoxic neuronal death

(2014) Vanessa Ginet et al.   Autophagy

Study on ATP concentration changes in cytosol of individual cultured neurons during glutamate-induced deregulation of calcium homeostasis

(2014) A. M. Surin et al.   BIOCHEMISTRY-MOSCOW

Neurons Have an Active Glycogen Metabolism that Contributes to Tolerance to Hypoxia

(2014) Isabel Saez et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Single-Cell Imaging of Bioenergetic Responses to Neuronal Excitotoxicity and Oxygen and Glucose Deprivation

(2014) N. M. C. Connolly et al.   JOURNAL OF NEUROSCIENCE

Calcium-Regulation of Mitochondrial Respiration Maintains ATP Homeostasis and Requires ARALAR/AGC1-Malate Aspartate Shuttle in Intact Cortical Neurons

(2013) I. Llorente-Folch et al.   JOURNAL OF NEUROSCIENCE

Understanding Metabolic Regulation and Its Influence on Cell Physiology

(2013) Christian M. Metallo et al.   MOLECULAR CELL

Brain energy metabolism in glutamate-receptor activation and excitotoxicity: Role for APC/C-Cdh1 in the balance glycolysis/pentose phosphate pathway

(2013) Patricia Rodriguez-Rodriguez et al.   NEUROCHEMISTRY INTERNATIONAL

A Genetically Encoded FRET Lactate Sensor and Its Use To Detect the Warburg Effect in Single Cancer Cells

(2013) Alejandro San Martín et al.   PLoS One

Small is fast: astrocytic glucose and lactate metabolism at cellular resolution

(2013) L. F. Barros et al.   Frontiers in Cellular Neuroscience

‘Mild mitochondrial uncoupling’ induced protection against neuronal excitotoxicity requires AMPK activity

(2012) Petronela Weisová et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Two-step activation of FOXO3 by AMPK generates a coherent feed-forward loop determining excitotoxic cell fate

(2012) D Davila et al.   CELL DEATH AND DIFFERENTIATION

Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegeneration

(2012) P Rodriguez-Rodriguez et al.   CELL DEATH AND DIFFERENTIATION

Deleterious effects of neuronal accumulation of glycogen in flies and mice

(2012) Jordi Duran et al.   EMBO Molecular Medicine

Quantitative Importance of the Pentose Phosphate Pathway Determined by Incorporation of 13C from [2-13C]- and [3-13C]Glucose into TCA Cycle Intermediates and Neurotransmitter Amino Acids in Functionally Intact Neurons

(2012) Eva M F Brekke et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

AMP-activated protein kinase (AMPK)-induced preconditioning in primary cortical neurons involves activation of MCL-1

(2012) Ujval Anilkumar et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial biogenesis contributes to ischemic neuroprotection afforded by LPS pre-conditioning

(2012) R. Anne Stetler et al.   JOURNAL OF NEUROCHEMISTRY

Calpains Are Downstream Effectors of bax-Dependent Excitotoxic Apoptosis

(2012) B. D'Orsi et al.   JOURNAL OF NEUROSCIENCE

Activation of Neuronal NMDA Receptors Induces Superoxide-Mediated Oxidative Stress in Neighboring Neurons and Astrocytes

(2012) R. C. Reyes et al.   JOURNAL OF NEUROSCIENCE

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Imaging Calcium in Neurons

(2012) Christine Grienberger et al.   NEURON

The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR

(2011) Dan Egan et al.   Autophagy

Mitochondrial membrane potential probes and the proton gradient: a practical usage guide

(2011) Seth W. Perry et al.   BIOTECHNIQUES

Astrocyte - neuron lactate shuttle may boost more ATP supply to the neuron under hypoxic conditions - in silico study supported by in vitro expression data

(2011) Seda Genc et al.   BMC Systems Biology

A Fluorescent Reporter of AMPK Activity and Cellular Energy Stress

(2011) Peiling Tsou et al.   Cell Metabolism

We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells

(2011) Alexander Loewer et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Dynamic Regulation of the Mitochondrial Proton Gradient during Cytosolic Calcium Elevations

(2011) Damon Poburko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear translocation of AMPK-α1 potentiates striatal neurodegeneration in Huntington’s disease

(2011) Tz-Chuen Ju et al.   JOURNAL OF CELL BIOLOGY

Response to ‘Comment on Recent Modeling Studies of Astrocyte—Neuron Metabolic Interactions’: Much ado about Nothing

(2011) Silvia Mangia et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Sweet Sixteen for ANLS

(2011) Luc Pellerin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuroprotection by NMDA Preconditioning Against Glutamate Cytotoxicity is Mediated Through Activation of ERK 1/2, Inactivation of JNK, and by Prevention of Glutamate-Induced CREB Inactivation

(2011) Hila Navon et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Activity-Dependent Regulation of Surface Glucose Transporter-3

(2011) J. M. Ferreira et al.   JOURNAL OF NEUROSCIENCE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Oxidative Stress and Energy Crises in Neuronal Dysfunction

(2010) David G. Nicholls   Annals of the New York Academy of Sciences

Molecular and cellular mechanisms of excitotoxic neuronal death

(2010) Yan Wang et al.   APOPTOSIS

Hydroethidine- and MitoSOX-derived red fluorescence is not a reliable indicator of intracellular superoxide formation: Another inconvenient truth

(2010) Jacek Zielonka et al.   FREE RADICAL BIOLOGY AND MEDICINE

AMP kinase–mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis

(2010) Caoimhín G. Concannon et al.   JOURNAL OF CELL BIOLOGY

Effects of AMP-Activated Protein Kinase in Cerebral Ischemia

(2010) Jun Li et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inhibition of hexokinase leads to neuroprotection against excitotoxicity in organotypic hippocampal slice culture

(2010) Kyung Hee Lee et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Fluorescence Applications in Molecular Neurobiology

(2010) Justin W. Taraska et al.   NEURON

Amyloid-β Triggers the Release of Neuronal Hexokinase 1 from Mitochondria

(2010) Leonardo M. Saraiva et al.   PLoS One

Impaired mitochondrial bioenergetics determines glutamate-induced delayed calcium deregulation in neurons

(2009) Andrey Y. Abramov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Expanding roles for AMP-activated protein kinase in neuronal survival and autophagy

(2009) Jeroen Poels et al.   BIOESSAYS

Neuronal glucose but not lactate utilization is positively correlated with NMDA-induced neurotransmission and fluctuations in cytosolic Ca2+levels

(2009) Lasse K. Bak et al.   JOURNAL OF NEUROCHEMISTRY

Simultaneous single neuron recording of O2consumption, [Ca2+]iand mitochondrial membrane potential in glutamate toxicity

(2009) Marc Gleichmann et al.   JOURNAL OF NEUROCHEMISTRY

AMPK in the brain: its roles in energy balance and neuroprotection

(2009) Gabriele V. Ronnett et al.   JOURNAL OF NEUROCHEMISTRY

Regulation of Glucose Transporter 3 Surface Expression by the AMP-Activated Protein Kinase Mediates Tolerance to Glutamate Excitation in Neurons

(2009) P. Weisova et al.   JOURNAL OF NEUROSCIENCE

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

(2009) Angel Herrero-Mendez et al.   NATURE CELL BIOLOGY

NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation

(2009) Angela M Brennan et al.   NATURE NEUROSCIENCE

Use of NAD(P)H and flavoprotein autofluorescence transients to probe neuron and astrocyte responses to synaptic activation

(2009) C. William Shuttleworth   NEUROCHEMISTRY INTERNATIONAL

Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators

(2009) H. Imamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycolysis: a bioenergetic or a survival pathway?

(2009) Juan P. Bolaños et al.   TRENDS IN BIOCHEMICAL SCIENCES

The facilitative glucose transporter GLUT3: 20 years of distinction

(2008) Ian A. Simpson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glucose and NADPH oxidase drive neuronal superoxide formation in stroke

(2008) Sang Won Suh et al.   ANNALS OF NEUROLOGY

GLUT1 and GLUT9 as major contributors to glucose influx in HepG2 cells identified by a high sensitivity intramolecular FRET glucose sensor

(2008) Hitomi Takanaga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Single live-cell imaging for systems biology 9

(2008) Dhanya Mullassery et al.   Essays in Biochemistry

Mitochondrial Hexokinase II Promotes Neuronal Survival and Acts Downstream of Glycogen Synthase Kinase-3

(2008) Alfredo Gimenez-Cassina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

The biochemistry, metabolism and inherited defects of the pentose phosphate pathway: A review

(2008) M. M. C. Wamelink et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Bioenergetics of cerebral ischemia: A cellular perspective

(2008) Leif Hertz   NEUROPHARMACOLOGY

Molecular Physiology of Preconditioning-Induced Brain Tolerance to Ischemia

(2008) Tihomir Paul Obrenovitch   PHYSIOLOGICAL REVIEWS

Glucose neurotoxicity

(2007) David R. Tomlinson et al.   NATURE REVIEWS NEUROSCIENCE