Article
Pediatrics
Weifeng Zhang, Yanru Chen, Chunmei Lin, Weilin Peng, Qingliu Fu, Yiming Lin
Summary: The incidence of CPT1A deficiency in the Chinese population was estimated to be 1:102,388. Among 12 patients identified in the study, 5 were diagnosed via newborn screening and 7 presented with clinical symptoms. A total of 18 distinct CPT1A variants were identified, with 3 novel variants potentially pathogenic.
FRONTIERS IN PEDIATRICS
(2021)
Article
Medicine, Research & Experimental
Wenyan Su, Zuoyu Hu, Xiaohong Zhong, Ansheng Cong, Ying Zhang, Zhanmei Zhou, Jianyi Li, Cailing Su, Yujie Huang, Wei Cao
Summary: This study found that the fibrosis in peritoneal dialysis patients is associated with decreased fatty acid oxidation and carnitine palmitoyltransferase 1A expression. Overexpression of carnitine palmitoyltransferase 1A can reverse the fibrosis process.
Article
Reproductive Biology
Na Li, Rufei Gao, Xuemei Chen, Xueqing Liu, Yubin Ding, Junlin He, Fangfang Li, Xianqing Cao, Chengshun Yang, Yingxiong Wang
Summary: CPT1A plays a crucial role in decidualization during early pregnancy by regulating stromal cell proliferation. The study revealed a significant increase in CPT1A expression on days 5-7 of pregnancy, showing a positive impact on artificially induced decidualization.
Article
Medicine, Research & Experimental
Lifang Li, Yaqian Zhang, Jiannan Gong, Guang Yang, Shuyin Zhi, Dongping Ren, Hui Zhao
Summary: The study aimed to determine the expression of Cpt1a in the lung tissue of COPD patients and its correlation with lung function. Increased Cpt1a expression improved lung function in patients with COPD by inhibiting apoptosis and inflammation in lung endothelial cells. In vivo and in vitro experiments confirmed that Cpt1a attenuated lung dysfunction in COPD by inhibiting endothelial cell apoptosis and inflammatory responses.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Oncology
Seo Jin Kim, Soo Jeong Park, Junseong Park, Hye Joung Cho, Jin-Kyoung Shim, Jieun Seon, Ran Joo Choi, Seon-Jin Yoon, Ju Hyung Moon, Eui Hyun Kim, Eui Kyo Seo, Sun Ho Kim, Hyun Sil Kim, Wan-Yee Teo, Jong Hee Chang, Jong In Yook, Seok-Gu Kang
Summary: The study evaluated the therapeutic effects and underlying mechanisms of dual inhibition of CPT1A and G6PD in GBM, and found that this treatment approach effectively suppressed tumor growth and invasion, and extended survival in GBM mice models.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Peng Wang, Ruikai Li, Yuqi Li, Siwei Tan, Jie Jiang, Huiling Liu, Xiuqing Wei
Summary: Berberine effectively alleviates non-alcoholic fatty liver disease (NAFLD) by promoting the deacetylation of CPT1A through SIRT1, thereby reducing its degradation and improving lipid metabolism.
GASTROENTEROLOGY REPORT
(2023)
Article
Genetics & Heredity
Qingwen Ren, Mengzhu Guo, Feifei Yang, Tianbi Han, Wenqiong Du, Feng Zhao, Jinbo Li, Wangjun Li, Yongliang Feng, Suping Wang, Yawei Zhang, Weiwei Wu
Summary: The study found that certain single-nucleotide polymorphisms (SNPs) in the CPT1A gene were associated with both increased and decreased risk of gestational diabetes mellitus (GDM). Additionally, a specific haplotype in the CPT1A gene was linked to a reduced risk of GDM.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Immunology
Yan Xue, Hui Liu, Xin-Xiang Yang, Li Pang, Jiang Liu, Kevin T. P. Ng, Oscar W. H. Yeung, Yin-Fan Lam, Wei-Yi Zhang, Chung-Mau Lo, Kwan Man
Summary: The study indicates that reduced expression of CPT1A in fatty liver transplantation is significantly associated with liver dysfunction. While inhibition of CPT1A may trigger MPT and worsen cell damage, activation of CPT1A could potentially attenuate hepatic IRI in fatty liver grafts.
Article
Biochemistry & Molecular Biology
Yuling Zhao, Haixia Feng, Ying Wang, Lu Jiang, Junkai Yan, Wei Cai
Summary: This study discovered that villus atrophy is a major cause of intestinal failure in children with short bowel syndrome (SBS) who receive parenteral nutrition (PN), but the mechanism is unclear. The study demonstrated the crucial role of farnesoid X receptor (FXR) signaling and fatty acid oxidation (FAO) in PN-induced villus atrophy. Impaired FXR/CPT1a axis and disturbed FAO may play a pivotal role in PN-induced villus atrophy, contributing to intestinal failure in SBS patients.
Article
Gastroenterology & Hepatology
Robert N. Helsley, Se-Hyung Park, Hemendra J. Vekaria, Patrick G. Sullivan, Lindsey R. Conroy, Ramon C. Sun, Maria del Mar Romero, Laura Herrero, Joanna Bons, Christina D. King, Jacob Rose, Jesse G. Meyer, Birgit Schilling, C. Ronald Kahn, Samir Softic
Summary: The consumption of sugar and a high-fat diet promotes the development of obesity and metabolic dysfunction. The study found that glucose or fructose supplementation increases the enzyme KHK-C, which leads to abnormal lipogenesis. The researchers also discovered that KHK-C increases lipogenesis and decreases fatty acid oxidation by acetylating CPT1a protein. This finding reveals the mechanism by which dietary fructose exacerbates metabolic complications caused by a high-fat diet.
JOURNAL OF HEPATOLOGY
(2023)
Article
Pediatrics
Sorcha A. Collins, Sharon Edmunds, Gwen Healey Akearok, J. Robert Thompson, Anders C. Erickson, Elske Hildes-Ripstein, Amber Miners, Martin Somerville, David M. Goldfarb, Cheryl Rockman-Greenberg, Laura Arbour
Summary: Through retrospective clinical chart review of Inuit children, the study found that the p.P479L variant is associated with increased risk of infectious illness, with homozygosity being more likely to result in hospitalization for respiratory tract infections. Further research is needed to explore the role of the variant in immune response.
FRONTIERS IN PEDIATRICS
(2021)
Article
Materials Science, Biomaterials
West Kristian D. Paraiso, Jesus Garcia-Chica, Xavier Ariza, Sebastian Zagmutt, Shigeto Fukushima, Jordi Garcia, Yuki Mochida, Dolors Serra, Laura Herrero, Hiroaki Kinoh, Nuria Casals, Kazunori Kataoka, Rosalia Rodriguez-Rodriguez, Sabina Quader
Summary: The study demonstrates the use of PIC micelles as a promising delivery platform for specific CPT1A inhibitors in glioma cells and neurons, resulting in a significant reduction in ATP synthesis and subsequent inhibition of fatty acid oxidation, with a lowered IC50 after long-term incubation.
BIOMATERIALS SCIENCE
(2021)
Article
Oncology
Mei Wang, Wanjun Yu, Xiaoli Cao, Hongbing Gu, Jiaying Huang, Chen Wu, Lin Wang, Xin Sha, Bo Shen, Ting Wang, Yongliang Yao, Wei Zhu, Feng Huang
Summary: Exosomal CD44 transmits lymph node metastasis (LNM) capacity between gastric cancer (GC) cells via the RhoA/YAP/Prox1/CPT1A signaling axis. Abnormal expression of CD44/YAP/CPT1A is associated with LNM status, stages, invasion, and poor survival in GC patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Dongqing Huang, Shrabanti Chowdhury, Hong Wang, Sara R. Savage, Richard G. Ivey, Jacob J. Kennedy, Jeffrey R. Whiteaker, Chenwei Lin, Xiaonan Hou, Ann L. Oberg, Melissa C. Larson, Najmeh Eskandari, Davide A. Delisi, Saverio Gentile, Catherine J. Huntoon, Uliana J. Voytovich, Zahra J. Shire, Qing Yu, Steven P. Gygi, Andrew N. Hoofnagle, Zachary T. Herbert, Travis D. Lorentzen, Anna Calinawan, Larry M. Karnitz, S. John Weroha, Scott H. Kaufmann, Bing Zhang, Pei Wang, Michael J. Birrer, Amanda G. Paulovich
Summary: Resistance to platinum compounds is a major factor affecting patient survival in high-grade serous ovarian cancer. By analyzing multiomic data from HGSOC cells, this study identified that increased fatty acid oxidation pathway expression and inhibition of the key enzyme CPT1A can sensitize ovarian cancer cells to platinum. The results were further validated in patient-derived xenograft models, indicating CPT1A as a potential therapeutic target to overcome platinum resistance.
CELL REPORTS MEDICINE
(2021)
Article
Hematology
Anna Sandstroem Gerdtsson, Joana de Matos Rodrigues, Christian Winther Eskelund, Simon Husby, Kirsten Gronbaek, Riikka Raety, Arne Kolstad, Christian Geisler, Anna Porwit, Mats Jerkeman, Sara Ek
Summary: The variable response to standard immunochemotherapy in patients with mantle cell lymphoma (MCL) remains a clinical challenge. Established risk factors only partially identify patients requiring alternative treatment. Gene expression analyses revealed alterations in thermogenesis, fatty acid degradation, and oxidative phosphorylation in patients with poor survival, and high expression of CPT1A can specifically identify high-risk MCL patients. Complementary investigations of metabolism and immunohistochemistry-based assessment of CPT1A may improve patient stratification.