Review
Cell Biology
Shareen Singh, Thakur Gurjeet Singh
Summary: Neuroinflammation and mitochondrial dysfunction are closely linked in epilepsy, where elevated levels of inflammatory mediators and pro-apoptotic proteins may contribute to hyperexcitability. Understanding the correlation between inflammation and mitochondrial damage can potentially lead to new drug treatments targeting mitochondrial dysfunction in epilepsy.
INFLAMMATION RESEARCH
(2021)
Article
Environmental Sciences
Fuping Ye, Lu Wu, Han Li, Xiaoshan Peng, Yuan Xu, Wenqi Li, Yongyue Wei, Feng Chen, Jingshu Zhang, Qizhan Liu
Summary: Exposure to arsenic leads to male reproductive damage by causing oxidative stress, inhibiting the SIRT1/PGC-1 alpha pathway, and impairing mitochondrial function. However, zinc supplementation can block these processes and reverse the damage to testes, sperm quality, and fertility. This study provides insights into the mechanisms of arsenic-induced male reproductive damage and highlights the therapeutic significance of zinc.
ENVIRONMENTAL POLLUTION
(2023)
Review
Cell Biology
Shareen Singh, Thakur Gurjeet Singh, Ashish Kumar Rehni, Vivek Sharma, Manjinder Singh, Rupinder Kaur
Summary: Epileptogenesis is closely linked to neurodegeneration and bioenergetic defects, primarily due to mitochondrial dysfunction leading to neuronal death. Mitochondria play a crucial role in neuronal cells, and dysfunction can disrupt calcium homeostasis, leading to abnormal neuronal excitation and death in epilepsy.
Article
Biochemistry & Molecular Biology
Fan Li, Xiaojing Wu, Hongli Liu, Mengqi Liu, Zhengkai Yue, Zhenyu Wu, Lei Liu, Fuchang Li
Summary: This study reveals that copper depletion enhances ferroptosis by causing mitochondrial perturbation and reducing antioxidative mechanisms.
Review
Biochemistry & Molecular Biology
Hammad Ullah, Alessandro Di Minno, Cristina Santarcangelo, Haroon Khan, Maria Daglia
Summary: Mitochondrial dysfunction leads to cellular defects and neuronal damage, contributing to neurodegenerative disorders. Antioxidants and beta-caryophyllene show potential in stabilizing mitochondria and reducing oxidative stress.
Review
Biochemistry & Molecular Biology
Dan Xu, Ya-Hui Hu, Xue Gou, Feng-Yang Li, Xi-Yu-Chen Yang, Yun-Man Li, Feng Chen
Summary: Pulmonary arterial hypertension (PAH) is a clinical condition characterized by progressive increase in pulmonary artery pressure, leading to right ventricular hypertrophy and right heart failure. Oxidative stress plays a critical role in the pathogenesis of PAH, affecting cell proliferation and vascular remodeling. Antioxidant treatment has become a key research area for PAH therapy.
Article
Biochemistry & Molecular Biology
Wenfei Yu, Zhuxun Li, Wenjing Wu, Dandan Zhao, Chuanzhu Yan, Pengfei Lin
Summary: This study investigated the mechanisms underlying telbivudine-induced myopathy and found that it is associated with mitochondrial toxicity and impaired energy metabolism. This provides evidence supporting the common mechanism of NAs causing neuromyopathy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Fisheries
Huifan Liu, Yuke Fang, Cuiyun Zou
Summary: This study found that crude polysaccharide YZW-A extracted from pomelo fruitlets has protective effects on oxidative stress, inflammation, and mitochondrial dysfunction-mediated apoptosis. YZW-A increased activities of mitochondrial respiratory complexes and antioxidative enzymes, decreased expression of proinflammatory cytokines, and alleviated cell apoptosis through mitigating oxidative stress. These results suggest the therapeutic potential of YZW-A on aquatic animals.
Article
Biotechnology & Applied Microbiology
Youyu Wang, Bo Jiang, Wang Luo
Summary: Memantine can alleviate oxidative stress and mitochondrial damage caused by oxaliplatin in neuronal cells, thus protecting neurons from cytotoxic effects.
Article
Immunology
Qian Wang, Zhenzhen Sun, Shihan Cao, Xiuli Lin, Mengying Wu, Yuanyuan Li, Jie Yin, Wei Zhou, Songming Huang, Aihua Zhang, Yue Zhang, Weiwei Xia, Zhanjun Jia
Summary: The study reveals the involvement of MAVS in cardiac dysfunction, showing reduced MAVS expression in non-hypertrophic cardiac dysfunction and enhanced MAVS expression in hypertrophic heart. MAVS deficiency leads to cardiac dysfunction, mitochondrial impairment, and disturbed energy metabolism. These findings suggest a crucial role of MAVS in the pathogenesis of non-hypertrophic cardiac dysfunction.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Jay Kumar, Ghulam Mohammad, Kumari Alka, Renu A. Kowluru
Summary: Mitochondrial dysfunction plays a critical role in the development of diabetic retinopathy. Hyperglycemia downregulates the mtDNA-encoded LncRNA cytochrome B (LncCytB) in retinal endothelial cells, leading to impaired mtDNA packaging and increased vulnerability to damage.
Article
Nutrition & Dietetics
Elena Gonzalez-Burgos, Isabel Urena-Vacas, Marta Sanchez, M. Pilar Gomez-Serranillos
Summary: Moringa oleifera leaf powder methanol extracts possess high phenolic content and antioxidant activity, providing neuroprotective effects against H2O2-induced oxidative stress and safeguarding mitochondrial function.
Review
Biochemistry & Molecular Biology
Nerea Mendez-Barbero, Jorge Oller, Ana B. Sanz, Adrian M. Ramos, Alberto Ortiz, Marta Ruiz-Ortega, Sandra Rayego-Mateos
Summary: Cardiovascular disease (CVD) often accompanies chronic kidney disease (CKD), and patients with both conditions have an increased risk of all-cause mortality ranging from 20% to 500%. Maintaining mitochondrial homeostasis appears to be a promising therapeutic strategy for the cardio-renal syndrome (CRS). This review explores the role of mitochondrial dysfunction in cardiovascular and renal diseases and how it may guide the development of novel therapeutic strategies for CRS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Sudha Sharma, Papori Sharma, Tara Bailey, Susmita Bhattarai, Utsab Subedi, Chloe Miller, Hosne Ara, Srivatsan Kidambi, Hong Sun, Manikandan Panchatcharam, Sumitra Miriyala
Summary: Reactive oxygen species (ROS) are highly reactive molecules generated as a by-product of aerobic life, which can lead to oxidative stress and the formation of bioactive compounds like 4-hydroxynonenal (4-HNE). 4-HNE forms covalent adducts with proteins, nucleic acids, and lipids, affecting mitochondrial functions and promoting apoptosis.
Article
Environmental Sciences
Weiqi Sun, Zhijing Ni, Rui Li, Xiuli Chang, Weihua Li, Mingjun Yang, Zhijun Zhou
Summary: The study showed that flurochloridone induces apoptosis in TM4 cells through the mitochondrial apoptotic pathway, accompanied by accumulation of ROS, depolarization of the mitochondrial membrane potential, etc. Pretreatment with the ROS scavenger NAC significantly alleviated flurochloridone-induced cell apoptosis and MMP depolarization.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)