期刊
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
卷 40, 期 5, 页码 541-549出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10863-008-9182-6
关键词
Proton pumping; Heme-copper oxidases; Chemiosmotic principles
资金
- NIGMS NIH HHS [R37 GM026916, R37 GM026916-30, R01 GM026916] Funding Source: Medline
A mechanism for proton pumping is described that is based on chemiosmotic principles and the detailed molecular structures now available for cytochrome oxidases. The importance of conserved water positions and a step-wise gated process of proton translocation is emphasized, where discrete electron transfer events are coupled to proton uptake and expulsion. The trajectory of each pumped proton is the same for all four substrate electrons. An essential role for the His-Tyr cross-linked species is discussed, in gating of the D- and K-channels and as an acceptor/donor of electrons and protons at the binuclear center.
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