Article
Cell Biology
Sai Krupa Das, Rachel E. Silver, Alistair Senior, Cheryl H. Gilhooly, Manjushri Bhapkar, David Le Couteur
Summary: This study used the Geometric Framework for Nutrition to examine the impact of macronutrient composition on adherence to calorie restriction (CR) and its effect on cardiometabolic markers of healthspan. The study found that a higher percentage of reported energy intake from protein and carbohydrate, and lower fat intake, were associated with greater adherence to CR. However, there was no significant correlation between macronutrient composition and cardiometabolic risk factors in the CR group. This study suggests that individual macronutrients have an interactive role in CR adherence, but further research is needed to understand the effect of different macronutrient compositions on adherence to CR and cardiometabolic risk factors.
Article
Multidisciplinary Sciences
Libia Alejandra Garcia-Flores, Cara L. Green, Sharon E. Mitchell, Daniel E. L. Promislow, David Lusseau, Alex Douglas, John R. Speakman
Summary: Caloric restriction affects the metabolome in a tissue-specific manner, with only a small number of common metabolic features responding in the same way across all tissues. The top modulated pathways were related to biosynthesis and degradation processes, suggesting each tissue has its own unique way of coping with reduced energy intake, supporting the clean cupboards hypothesis over the disposable soma interpretation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Geriatrics & Gerontology
Satchidananda Panda, Geraldine Maier, Dennis T. Villareal
Summary: With the rise in obesity across age groups, engaging in physical activity and mobility in older adults has become difficult. Calorie restriction (CR) up to 25% has been used for obesity management, but its safety in older adults is not fully understood. There are challenges in adopting and complying with CR, and concerns about the negative effects on sarcopenia, osteopenia, and frailty. Time-Restricted Feeding/Eating (TRF/TRE), which optimizes circadian rhythm and combines with CR, may reduce weight and improve health.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Nutrition & Dietetics
Emiliana Giacomello, Luana Toniolo
Summary: Aging is a biological process influenced by multiple cellular mechanisms leading to functional decline. The growth of the elderly population and their susceptibility to diseases drive the search for anti-aging interventions, with calorie restriction identified as an effective approach.
Article
Cell Biology
Kavitha Kurup, Stephanie Matyi, Cory B. Giles, Jonathan D. Wren, Kenneth Jones, Aaron Ericsson, Daniel Raftery, Lu Wang, Daniel Promislow, Arlan Richardson, Archana Unnikrishnan
Summary: The study shows that calorie restriction has significant effects on the microbiome, fecal metabolome, and colon transcriptome of mice, maintaining a more youthful state of the gastrointestinal system, which may lead to a more diverse and youthful microbiome.
Article
Nutrition & Dietetics
Margalida Torrens-Mas, Cayetano Navas-Enamorado, Devin Wahl, Andres Sanchez-Polo, Anna Picca, Jordi Oliver, Pilar Roca, Marta Gonzalez-Freire
Summary: “Calorie restriction (CR) is the only nutritional strategy proven to extend lifespan, prevent age-related diseases, and delay functional decline. The effects of CR when started early in life are not well understood. This study found that young female rats treated with CR showed similar expression patterns of key genes/pathways associated with healthy aging compared to old animals treated with CR, while in male rats these effects were reduced.”
Review
Cell Biology
Begun Erbaba, Ayca Arslan-Ergul, Michelle M. Adams
Summary: Caloric restriction is a non-genetic intervention that extends lifespan and healthspan by promoting cell survival, reducing cell proliferation, inducing stem cell quiescence, and preserving stem cell reserve for extreme needs. This protective mechanism induced by diet may involve downregulation of crucial cell cycle-related transcription activators and could offer new targets for treatments against neurodegenerative diseases.
AGEING RESEARCH REVIEWS
(2021)
Article
Nutrition & Dietetics
Zofia Strojny, Rafal Rutkowski, Alina Kanikowska, Agnieszka Zawada, Aldona Juchacz, Marian Grzymislawski, Maki Sato, Monika Litwinowicz, Katarzyna Korybalska, Andrzej Breborowicz, Janusz Witowski, Dominika Kanikowska
Summary: A study on individuals with obesity undergoing a 3-week moderate calorie restriction found that chronotype did not have a significant effect on the magnitude of weight loss, but there was a tendency for owls to reduce body fat content.
Article
Nutrition & Dietetics
Ana Teofilovic, Milos Vrataric, Natasa Velickovic, Danijela Vojnovic Milutinovic, Aleksandra Mladenovic, Milica Prvulovic, Ana Djordjevic
Summary: Late-onset calorie restriction has a positive impact on lipid metabolism but a negative impact on inflammation in the liver of old rats. It can restore age-related imbalance in lipid metabolism but does not improve expression of antioxidant enzymes and leads to progression of age-related inflammation in the liver.
FRONTIERS IN NUTRITION
(2022)
Article
Cell Biology
Dennis Mangan
Summary: Iron is essential for living organisms, but excessive accumulation can lead to health issues, age-related diseases, and shortened lifespan. Blocking iron absorption can extend lifespan, while controlling body iron stores may be an important intervention for health and longevity.
Review
Biochemistry & Molecular Biology
Patrick C. Bradshaw
Summary: Acetyl-CoA plays important roles in regulating gene expression and promoting longevity, with decreased cytoplasmic levels potentially contributing to longevity and increased nuclear levels aiding in histone acetylation and lifespan extension. Future research should focus on the role of nuclear acetyl-CoA and histone acetylation in controlling hypothalamic inflammation, a key driver of organismal aging.
Article
Neurosciences
Qian Wang, Ying Kong, Song Lin, Ding-Yu Wu, Jian Hu, Lang Huang, Wen-Si Zang, Xiao-Wen Li, Jian-Ming Yang, Tian-Ming Gao
Summary: Food deprivation can improve mood disorders caused by obesity, and studies have shown a connection between calorie restriction and antidepressant-like effects. The role of astrocytic ATP in calorie restriction-induced antidepressant effects is highlighted in this research.
NEUROSCIENCE BULLETIN
(2021)
Article
Nutrition & Dietetics
Shanlin Ke, Sarah J. Mitchell, Michael R. MacArthur, Alice E. Kane, David A. Sinclair, Emily M. Venable, Katia S. Chadaideh, Rachel N. Carmody, Francine Grodstein, James R. Mitchell, Yangyu Liu
Summary: The study found that calorie restriction can significantly reduce the rate of increase in the frailty index (FI), showing that CR can slow down the aging process. Significant alterations in diversity and compositional patterns of the mouse gut microbiota were also observed during the aging process. The gut microbial features of 21-month-old mice can predict the healthy aging of 30-month-old mice with reasonable accuracy.
Editorial Material
Multidisciplinary Sciences
Shaunak Deota, Satchidananda Panda
Summary: By combining calorie restriction, fasting, and regulating circadian rhythms, mice can achieve a long and healthy life.
Article
Biochemistry & Molecular Biology
Nadezda V. Andrianova, Ljubava D. Zorova, Irina B. Pevzner, Nataliya G. Kolosova, Egor Y. Plotnikov, Dmitry B. Zorov
Summary: Kidney diseases are common among elderly people due to age-related changes in renal tissue. The lack of targeted pharmacotherapies for acute kidney injury (AKI) results in high mortality rates. This study investigated the protective effects of calorie restriction (CR) on ischemic AKI in OXYS rats and found that CR provided significant nephroprotection. Improvements in mitochondrial functioning may be one of the mechanisms for the beneficial effects of CR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Mario H. Barros, Gavin P. McStay
Article
Geriatrics & Gerontology
Vittoria de Lima Camandona, Rafaela Maria Rios-Anjos, Thiago Geronimo Pires Alegria, Fabio Pereira, Renata Naporano Bicev, Fernanda Marques da Cunha, Luciano Antonio Digiampietri, Mario Henrique de Barros, Luis Eduardo Soares Netto, Jose Ribamar Ferreira-Junior
Article
Biochemistry & Molecular Biology
Michelle C. Bradley, Krista Yang, Lucia Fernandez-del-Rio, Jennifer Ngo, Anita Ayer, Hui S. Tsui, Noelle Alexa Novales, Roland Stocker, Orian S. Shirihai, Mario H. Barros, Catherine F. Clarke
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Suhas R. Seshadri, Chitra Banarjee, Mario H. Barros, Flavia Fontanesi
NUCLEIC ACIDS RESEARCH
(2020)
Article
Neurosciences
Fernando Carlos Sousa, Christiano Rodrigues Schamber, Eneri Vieira de Souza Leite Mello, Fernanda Andrade Martins, Miguel Machinski Junior, Cleverson Busso, Mario Henrique de Barros, Maria Raquel Marcal Natali
Summary: This study found that diets containing fumonisins had no significant effects on food consumption or body weight in rats, but it did decrease the metabolic activity of myenteric neurons and nitrergic neurons. This decrease in metabolic activity had a negative impact on neuroplasticity of the enteric nervous system.
NUTRITIONAL NEUROSCIENCE
(2022)
Review
Biology
Leticia V. R. Franco, Luca Bremner, Mario H. Barros
Article
Biotechnology & Applied Microbiology
Maria Dolores Pendon, Jose V. Madeira, David E. Romanin, Martin Rumbo, Andreas K. Gombert, Graciela L. Garrote
Summary: The study demonstrates that K. marxianus CIDCA 9121 efficiently ferments lactose in whey permeate to ethanol, while the remaining yeast biomass has probiotic properties, enabling an integrated process for obtaining whey protein, fuel ethanol, and probiotics from cheese whey.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Carla Ines Soares Rodrigues, Aljoscha Wahl, Andreas K. Gombert
Summary: The study shows that sucrose metabolism in S. cerevisiae is a strain-specific trait, with each strain displaying distinct characteristics in extracellular hexose concentrations and invertase activity profiles. The results also suggest potential mixed mechanisms of sucrose utilization by the industrial strain JP1 and the remarkable ability of the wild isolate UFMG-CM-259 to grow faster on sucrose than on glucose. This work provides insights into metabolic traits that can be exploited to enhance sucrose catabolic rates and bioprocess efficiency.
FEMS YEAST RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hanna Viktoria Racz, Fezan Mukhtar, Alexandra Imre, Zoltan Radai, Andreas Karoly Gombert, Tamas Ratonyi, Janos Nagy, Istvan Pocsi, Walter P. Pfliegler
Summary: The study found significant differences among subclone lineages of industrial yeasts, with isolation of single-cell bottleneck having a considerable influence on the observable phenotype.
Review
Biochemistry & Molecular Biology
Ana Paula Jacobus, Jeferson Gross, John H. Evans, Sandra Regina Ceccato-Antonini, Andreas Karoly Gombert
Summary: Fuel ethanol production in the United States and Brazil differs in the use of genetically engineered strains (GE) and non-GE strains, respectively. Despite research on lignocellulosic ethanol, it still represents less than 1% of global ethanol production.
MICROBIAL CELL FACTORIES-BOOK
(2021)
Article
Biotechnology & Applied Microbiology
Kevy Pontes Eliodorio, Gabriel Caetano de Gois E. Cunha, Brianna A. White, Demisha H. M. Patel, Fangyi Zhang, Ewald H. Hettema, Thiago Olitta Basso, Andreas Karoly Gombert, Vijayendran Raghavendran
Summary: Blocking mitophagy by deleting the mitophagy receptor gene ATG32 in S. cerevisiae did not lead to a significant improvement in cell viability or ethanol levels during fermentation in commercial bioethanol strains, highlighting the need for further research to determine the role of autophagic processes in fermentation.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Janaina A. Paulela, Fernando Gomes, Vittoria de Lima Camandona, Thiago G. P. Alegria, Luis E. S. Netto, Lucas Bleicher, Mario H. Barros, Jose Ribamar Ferreira-Junior
Summary: Coenzyme Q (CoQ) is a crucial molecule involved in aerobic growth and its synthesis in yeast depends on multiple proteins. Through molecular modeling and mutagenesis, functional residues of the Coq3p protein can be identified, which play essential roles in CoQ biosynthesis.
FEMS YEAST RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Barbara Santos, Rui Zeng, Sasa F. Jorge, Jose Ribamar Ferreira-Junior, Antoni Barrientos, Mario H. Barros
Summary: Mitoribosomes in Saccharomyces cerevisiae consist of a 54S large subunit and a 37S small subunit, containing a total of 73 mitoribosome proteins and two ribosomal RNAs. These proteins have adapted by acquiring new proteins, extensions, and RNA segments, to synthesize highly hydrophobic membrane proteins. The study investigates the functional relevance of mitochondria-specific protein extensions in the mtLSU, revealing their importance in mitochondrial protein synthesis capacities and rRNAs interactions.
Review
Biophysics
Fernando Gomes, Helena Turano, Angelica Ramos, Mario Henrique de Barros, Luciana A. Haddad, Luis E. S. Netto
Summary: Peroxiredoxins (Prxs) are cysteine-based peroxidases that regulate H2O2 levels in cells. Different isoforms of Prxs in eukaryotic cells have varying subcellular locations and substrate specificities. Mitochondrial Prxs were initially thought to be localized in the matrix, but recent studies have shown they can also be targeted to the intermembrane space by unknown mechanisms.
BIOPHYSICAL REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Jhulia Almeida Clarck Chagas, Maria Antonia Kfouri Martins Soares, Leticia Veloso Ribeiro Franco, Mario H. Barros
Summary: Mitochondrial translation is a highly regulated process, and in this study, a new factor called Mrx9p is identified to control the expression of COX1 and COB. Excess Mrx9p leads to lower levels of mature COX1 and COB mRNAs and an accumulation of unprocessed transcripts. The findings suggest a regulatory role of Mrx9p in COX1 RNA processing.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)