期刊
JOURNAL OF BIOCHEMISTRY
卷 156, 期 5, 页码 239-248出版社
OXFORD UNIV PRESS
DOI: 10.1093/jb/mvu053
关键词
actin; cell migration; focal adhesion; retrograde flow; single-molecule speckle microscopy
资金
- Cabinet Office, Government of Japan [LS013]
- Takeda Science Foundation
- Ministry of Education, Science, Sports and Culture of Japan [00624347]
- Grants-in-Aid for Scientific Research [26112702] Funding Source: KAKEN
The retrograde actin flow, continuous centripetal movement of the cell peripheral actin networks, is widely observed in adherent cells. The retrograde flow is believed to facilitate cell migration when linked to cell adhesion molecules. In this review, we summarize our current knowledge regarding the functional relationship between the retrograde actin flow and focal adhesions (FAs). We also introduce our recent study in which single-molecule speckle (SiMS) microscopy dissected the complex interactions between FAs and the local actin flow. FAs do not simply impede the actin flow, but actively attract and remodel the local actin network. Our findings provide a new insight into the mechanisms for protrusion and traction force generation at the cell leading edge. Furthermore, we discuss possible roles of the actin flow-FA interaction based on the accumulated knowledge and our SiMS study.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据