Linear ubiquitination-mediated NF- B regulation and its related disorders

The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system

(2013) Sam Strickson et al.   BIOCHEMICAL JOURNAL

OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked Polyubiquitin

(2013) Kirstin Keusekotten et al.   CELL

Regulation of NF-κB by ubiquitination

(2013) Jueqi Chen et al.   CURRENT OPINION IN IMMUNOLOGY

The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO

(2013) Anne Kathrin Müller-Rischart et al.   MOLECULAR CELL

OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling

(2013) Berthe Katrine Fiil et al.   MOLECULAR CELL

The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis

(2013) Elena Rivkin et al.   NATURE

Ubiquitin-Like Proteins

(2012) Annemarthe G. van der Veen et al.   Annual Review of Biochemistry

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Regulation of Parkin E3 ubiquitin ligase activity

(2012) Helen Walden et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7

(2012) Kelly Verhelst et al.   EMBO JOURNAL

Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation

(2012) Fuminori Tokunaga et al.   EMBO JOURNAL

The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension

(2012) Judith J Smit et al.   EMBO JOURNAL

A non-canonical UBA–UBL interaction forms the linear-ubiquitin-chain assembly complex

(2012) Hirokazu Yagi et al.   EMBO REPORTS

LUBAC synthesizes linear ubiquitin chains via a thioester intermediate

(2012) Benjamin Stieglitz et al.   EMBO REPORTS

Linear ubiquitination: A novel NF-^|^kappa;B regulatory mechanism for inflammatory and immune responses by the LUBAC ubiquitin ligase complex [Review]

(2012) Fuminori Tokunaga et al.   ENDOCRINE JOURNAL

NF- B, the first quarter-century: remarkable progress and outstanding questions

(2012) M. S. Hayden et al.   GENES & DEVELOPMENT

Structural Analysis of SHARPIN, a Subunit of a Large Multi-protein E3 Ubiquitin Ligase, Reveals a Novel Dimerization Function for the Pleckstrin Homology Superfold

(2012) Benjamin Stieglitz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of Nuclear Factor-κB (NF-κB) Essential Modulator (NEMO) Binding to Linear and Lysine-linked Ubiquitin Chains and Its Role in the Activation of NF-κB

(2012) Tobias Kensche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LUBAC, a novel ubiquitin ligase for linear ubiquitination, is crucial for inflammation and immune responses

(2012) Fuminori Tokunaga et al.   MICROBES AND INFECTION

The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

(2012) Rune Busk Damgaard et al.   MOLECULAR CELL

Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency

(2012) Bertrand Boisson et al.   NATURE IMMUNOLOGY

Cellular Inhibitors of Apoptosis Are Global Regulators of NF- B and MAPK Activation by Members of the TNF Family of Receptors

(2012) E. Varfolomeev et al.   Science Signaling

Diverse ubiquitin signaling in NF-κB activation

(2012) Kazuhiro Iwai   TRENDS IN CELL BIOLOGY

New mechanism of X-linked anhidrotic ectodermal dysplasia with immunodeficiency: impairment of ubiquitin binding despite normal folding of NEMO protein

(2011) M. Hubeau et al.   BLOOD

LUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO

(2011) Jixiao Niu et al.   EMBO JOURNAL

Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction

(2011) Kyung-Soo Inn et al.   MOLECULAR CELL

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

(2011) Fuminori Tokunaga et al.   NATURE

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

(2011) Fumiyo Ikeda et al.   NATURE

Linear ubiquitination prevents inflammation and regulates immune signalling

(2011) Björn Gerlach et al.   NATURE

HOIL-1L Interacting Protein (HOIP) Is Essential for CD40 Signaling

(2011) Bruce S. Hostager et al.   PLoS One

Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses

(2011) D. E. Zak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex

(2011) Y. Sato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functions of nuclear factor κB in bone

(2010) Brendan F. Boyce et al.   Annals of the New York Academy of Sciences

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Deubiquitinases in the regulation of NF-κB signaling

(2010) Edward W Harhaj et al.   CELL RESEARCH

Nuclear initiated NF-κB signaling: NEMO and ATM take center stage

(2010) Shigeki Miyamoto   CELL RESEARCH

c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling

(2010) Jasmin N Dynek et al.   EMBO JOURNAL

Newly identified tumor-associated role of human Sharpin

(2010) Jinyoung Jung et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Sipl1 and Rbck1 Are Novel Eya1-Binding Proteins with a Role in Craniofacial Development

(2010) K. Landgraf et al.   MOLECULAR AND CELLULAR BIOLOGY

A Cytoplasmic ATM-TRAF6-cIAP1 Module Links Nuclear DNA Damage Signaling to Ubiquitin-Mediated NF-κB Activation

(2010) Michael Hinz et al.   MOLECULAR CELL

HOIL-1L Interacting Protein (HOIP) as an NF-κB Regulating Component of the CD40 Signaling Complex

(2010) Bruce S. Hostager et al.   PLoS One

Regulation and Function of NF-κB Transcription Factors in the Immune System

(2009) Sivakumar Vallabhapurapu et al.   Annual Review of Immunology

cIAP1, cIAP2, and XIAP Act Cooperatively via Nonredundant Pathways to Regulate Genotoxic Stress-Induced Nuclear Factor- B Activation

(2009) H.-S. Jin et al.   CANCER RESEARCH

Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-κB Activation

(2009) Simin Rahighi et al.   CELL

Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by NZF domains of TAB2 and TAB3

(2009) Yusuke Sato et al.   EMBO JOURNAL

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

(2009) David Komander et al.   EMBO REPORTS

Structural Basis for Recognition of Diubiquitins by NEMO

(2009) Yu-Chih Lo et al.   MOLECULAR CELL

Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction

(2009) Tobias L. Haas et al.   MOLECULAR CELL

Frequent inactivation of A20 in B-cell lymphomas

(2009) Motohiro Kato et al.   NATURE

Involvement of linear polyubiquitylation of NEMO in NF-κB activation

(2009) Fuminori Tokunaga et al.   NATURE CELL BIOLOGY

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3

(2008) Min Zhang et al.   CELL RESEARCH