期刊
JOURNAL OF BIOCHEMISTRY
卷 151, 期 5, 页码 477-481出版社
OXFORD UNIV PRESS
DOI: 10.1093/jb/mvs035
关键词
COX2; chemokines; invasion; metastasis; Notch signalling
资金
- MEXT (Ministry of Education, Culture, Sports, Science and Technology), Japan
Although our understanding of epithelial cancer cells has advanced significantly, our understanding of the cancer microenvironment is still fragmentary. In contrast to our intuitive impression that our body always suppresses cancer growth, recent pieces of evidence show that cancer often exploits our body reactions to expand, invade local tissues and metastasize to distant organs. Accordingly, investigations of such body reactions in the tumour microenvironment should help us to design novel therapeutic strategies that can be combined with the traditional therapeutics targeted at the cancer cells themselves. In this article, I am going to review our recent efforts in search of novel therapeutic strategies against colon cancer using mouse models.
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