期刊
JOURNAL OF BIOCHEMISTRY
卷 150, 期 3, 页码 223-232出版社
OXFORD UNIV PRESS
DOI: 10.1093/jb/mvr087
关键词
Edg family LPA receptors; G protein-coupled receptor; lysophosphatidic acid; non-Edg family LPA receptors; orphan receptor
资金
- Ministry of Education, Science, Culture, Sports, and Technology of Japan
- Ministry of Health, Labor, and Welfare of Japan
- Takeda Science Foundation
- Naito Foundation
- Mochida Memorial Foundation
- Uehara Memorial Foundation
- Grants-in-Aid for Scientific Research [23390061, 22890034] Funding Source: KAKEN
Lysophosphatidic acid (LPA) is a bioactive lipid mediator with diverse physiological and pathological actions on many types of cells. Originally, LPA was thought to elicit its biological functions through three subtypes of endothelial differentiation gene (Edg) family G protein-coupled receptors (LPA1, LPA2 and LPA3) until our group identified a fourth subtype, LPA4. The discovery of this receptor, which is structurally distinct from the Edg family LPA receptors, led to the identification of two additional LPA receptors, LPA5 and LPA6, homologous to LPA4. These 'non-Edg family' LPA receptors now provide a new framework for understanding the diverse functions of LPA, including vascular development, platelet activation and hair growth. In this review, we summarize the identification, intracellular signalling and biological functions of this novel cluster of LPA receptors.
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