Signalling mechanisms of RhoGTPase regulation by the heterotrimeric G proteins G12 and G13

Identification of Critical Residues in Gα13for Stimulation of p115RhoGEF Activity and the Structure of the Gα13-p115RhoGEF Regulator of G Protein Signaling Homology (RH) Domain Complex

(2011) Nicole Hajicek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein kinase C-α signals P115RhoGEF phosphorylation and RhoA activation in TNF-α-induced mouse brain microvascular endothelial cell barrier dysfunction

(2011) Jing Peng et al.   Journal of Neuroinflammation

The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins

(2011) Christophe Guilluy et al.   NATURE CELL BIOLOGY

The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement

(2011) Jesse A Green et al.   NATURE IMMUNOLOGY

Sphingosine 1-Phosphate Receptor 2 Signals Through Leukemia-Associated RhoGEF (LARG), to Promote Smooth Muscle Cell Differentiation

(2010) Matt D. Medlin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Loss of Lsc/p115 Protein Leads to Neuronal Hypoplasia in the Esophagus and an Achalasia-Like Phenotype in Mice

(2010) Eugen Zizer et al.   GASTROENTEROLOGY

The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure

(2010) Christophe Guilluy et al.   NATURE MEDICINE

G protein-coupled receptors: novel targets for drug discovery in cancer

(2010) Rosamaria Lappano et al.   NATURE REVIEWS DRUG DISCOVERY

Modulation of a GEF switch: Autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF

(2010) Zhe Chen et al.   PROTEIN SCIENCE

PYK2/PDZ-RhoGEF Links Ca 2+ Signaling to RhoA

(2009) Zhekang Ying et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells

(2009) Mohamed Aittaleb et al.   CELLULAR SIGNALLING

Structure and Function of Heterotrimeric G Protein-Regulated Rho Guanine Nucleotide Exchange Factors

(2009) M. Aittaleb et al.   MOLECULAR PHARMACOLOGY

LARG at chromosome 11q23 has functional characteristics of a tumor suppressor in human breast and colorectal cancer

(2009) D C T Ong et al.   ONCOGENE

The solution structure and dynamics of the DH-PH module of PDZRhoGEF in isolation and in complex with nucleotide-free RhoA

(2009) Tomasz Cierpicki et al.   PROTEIN SCIENCE

On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF

(2009) Meiying Zheng et al.   BMC STRUCTURAL BIOLOGY

Activation of Leukemia-associated RhoGEF by Gα13with Significant Conformational Rearrangements in the Interface

(2008) Nobuchika Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A quantitative atlas of mitotic phosphorylation

(2008) N. Dephoure et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recognition of the Activated States of Gα13 by the rgRGS Domain of PDZRhoGEF

(2008) Zhe Chen et al.   STRUCTURE