Article
Multidisciplinary Sciences
Sylvain Delaunay, Gloria Pascual, Bohai Feng, Kevin Klann, Mikaela Behm, Agnes Hotz-Wagenblatt, Karsten Richter, Karim Zaoui, Esther Herpel, Christian Munch, Sabine Dietmann, Jochen Hess, Salvador Aznar Benitah, Michaela Frye
Summary: The study reveals that the NSUN3-dependent RNA modifications of mitochondrial mRNA can impact metabolic plasticity, thus affecting the metastatic potential of cancer cells, providing new therapeutic targets for combating cancer metastasis.
Review
Immunology
Monika Groth, Elzbieta Skrzydlewska, Marta Dobrzynska, Slawomir Pancewicz, Anna Moniuszko-Malinowska
Summary: Vector-borne diseases, including tick-borne diseases, are a growing global health problem. Oxidative stress, inflammation, and metabolic effects play key roles in the pathogenesis of these diseases, impacting the structure and function of phospholipids and proteins. Finding diagnostic biomarkers related to redox imbalance and phospholipid metabolites can help in monitoring disease progression and treatment efficacy.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Geriatrics & Gerontology
Xiaoxin Wu, Xiwei Fan, Ross Crawford, Yin Xiao, Indira Prasadam
Summary: The function of articular cartilage relies on the coordinated metabolic regulation in chondrocytes. Dysregulation of cellular metabolism can lead to degenerative diseases like osteoarthritis. Chondrocytes in cartilage have limited access to nutrients and oxygen, as well as pathways for metabolite removal. Central carbon metabolism pathways are crucial for maintaining cartilage homeostasis. Increased understanding of cellular metabolism and its dysregulation in osteoarthritis can provide insights into potential therapeutic opportunities.
Article
Biochemistry & Molecular Biology
Pablo Balino, Ricard Romero-Cano, Maria Muriach
Summary: Ethanol abuse and metabolic syndrome both have negative impacts on the central nervous system, but their combined effects have not been fully elucidated. This study aims to determine the effects of ethanol intake on a mouse model of metabolic syndrome at the behavioral and biochemical levels. Ethanol intake modulated the insulin response and impaired the oxidative status in the ob mouse brain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Cassandra M. Moshfegh, Adam J. Case
Summary: T lymphocytes play a crucial role in the adaptive immune system and their adaptability in extreme cellular microenvironments depends on their response to cues from reactive oxygen and nitrogen species, as well as metabolic flux. Recent studies have shown the strong link and regulatory consequences of the redox and metabolic environments in T lymphocytes. Disruptions in this duo may lead to inflammatory consequences such as hypertension.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Nutrition & Dietetics
Adela Kabelova, Hana Malinska, Irena Markova, Olena Oliyarnyk, Blanka Chylikova, Ondrej Seda
Summary: Ellagic acid, a natural substance found in fruits and nuts, has beneficial effects on metabolic syndrome by lowering oxidative stress levels and improving characteristics of brown adipose tissue.
Article
Biology
Jonathan Sulc, Anthony Sonrel, Ninon Mounier, Chiara Auwerx, Eirini Marouli, Liza Darrous, Bogdan Draganski, Tuomas O. Kilpelainen, Peter Joshi, Ruth J. F. Loos, Zoltan Kutalik
Summary: Jonathan Sulc et al. conducted a comprehensive analysis of 14 body morphology metrics using data from the UK Biobank, utilizing principal component analysis and Mendelian randomization. Their findings suggest distinct impacts of body size and adiposity on obesity-related outcomes, as well as highlighting a BMI-neutral component influencing body fat distribution.
COMMUNICATIONS BIOLOGY
(2021)
Review
Cell Biology
Chao Wan, Fengjie Zhang, Hanyu Yao, Haitao Li, Rocky S. Tuan
Summary: Histone modifications play a significant role in cartilage development, pathology, and regeneration. Targeting histone modifying proteins with candidate molecules or drugs shows promising therapeutic potential in treating cartilage lesions associated with joint degeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Sihao Zheng, Qibin Song, Pingfeng Zhang
Summary: In recent years, there has been increasing research on metabolic modifications in cancer immunotherapy, focusing on the roles of glycosylation and palmitoylation in the tumor microenvironment. Targeting these metabolic modifications in immune checkpoints and inflammation presents an attractive therapeutic strategy to improve individualized therapy responses.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Asen Georgiev, Cesare Granata, Michael Roden
Summary: Common metabolic diseases such as obesity, type 2 diabetes mellitus, and nonalcoholic fatty liver disease are associated with insulin resistance and mitochondrial dysfunction. Changes in mitochondrial features may reflect adaptation to a certain metabolic condition rather than abnormalities. Lifestyle modifications and drug treatments can help improve these metabolic diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Natalya P. Degtyareva, Victoria C. Placentra, Scott A. Gabel, Leszek J. Klimczak, Dmitry A. Gordenin, Brett A. Wagner, Garry R. Buettner, Geoffrey A. Mueller, Tatyana Smirnova, Paul W. Doetsch
Summary: Mutational signatures have been found in cancer genomes, aging tissues, and cells exposed to toxic agents, reflecting the complex processes of cell transformation. A new mutational signature of the oxidizing agent potassium bromate was discovered in yeast DNA, revealing unexpected heterogeneity in oxidizing agents' mutational profiles. Redox stress induced different metabolic changes in cells exposed to hydrogen peroxide and potassium bromate, and the predominance of G to T substitutions in the mutational spectra distinguished potassium bromate. These findings provide insights into the multidimensional processes triggered by oxidants and suggest that detecting increased mutational loads associated with potassium bromate-related motifs may be clinically relevant.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yuki Kitamura, Shinji Oikawa, Jie Chang, Yurie Mori, Gaku Ichihara, Sahoko Ichihara
Summary: This study used 2D-Oxyblot and 2D-DIGE techniques to analyze carbonylated proteins induced by oxidative stress in a metabolic syndrome animal model, as well as changes in protein expression levels in adipose tissue at different stages of the syndrome. The results showed that up-regulated proteins at the pre-symptomatic stage were mainly involved in ATP production and redox reactions, while down-regulated proteins at the symptomatic stage were associated with antioxidant activity and the TCA cycle. Increased levels of carbonylated proteins, including gelsolin, may contribute to the oxidative stress state and progression of metabolic syndrome.
Article
Biochemistry & Molecular Biology
Chun-Ting Liu, Jiashing Yu, Min-Hsuan Lin, Kai-Hsiang Chang, Che-Yu Lin, Nai-Chen Cheng, Po- Wu, Chun-Wei Huang, Pin-Yu Zhang, Min-Tzu Hung, Yu-Sheng Hsiao
Summary: The investigation of electrical and mechanical stimulations on chondrogenesis in tissue engineering is crucial for successful cartilage repair and regeneration. Electrical stimulation promotes MSC chondrogenesis, while mechanical stimulation enhances the chondrogenic differentiation capacity of MSCs. Understanding the impact of these stimuli is essential for developing effective tissue engineering strategies.
Review
Cell Biology
Wen-Jin Fan, Di Liu, Lin-Yuan Pan, Wei-Yang Wang, Yi-Lan Ding, Yue-Yao Zhang, Rui-Xi Ye, Yang Zhou, Sen-Bo An, Wen-Feng Xiao
Summary: Osteoarthritis (OA) is a prevalent public health problem worldwide, with no effective disease-modifying drugs available. Exosomes, which contain various important components, play a role in the pathophysiological processes of OA and can potentially serve as diagnostic biomarkers for the disease. Additionally, exosomes derived from different cells have therapeutic potential in restoring OA cartilage and attenuating inflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Hamidreza Tolabi, Niyousha Davari, Mehran Khajehmohammadi, Haniyeh Malektaj, Katayoun Nazemi, Samaneh Vahedi, Behafarid Ghalandari, Rui L. Reis, Farnaz Ghorbani, Joaquim Miguel Oliveira
Summary: Cartilage degeneration is a major cause of disability and pain worldwide, but current treatments have limited success in the long term. The convergence of tissue engineering and microfabrication principles offers advanced microfluidic technologies as alternatives. This review summarizes the developments in microfluidic hydrogel-based scaffolds for cartilage regeneration and discusses the advantages over traditional hydrogels. It also presents the technologies for fabricating microfluidic scaffolds and chips, and highlights the preclinical and clinical applications and challenges in developing microfluidic systems for cartilage repair.
ADVANCED MATERIALS
(2023)