期刊
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
卷 27, 期 6, 页码 585-603出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0883911512458050
关键词
Remineralization; biocompatibility; enamel-like crystals; amelogenin; oral bacterial biofilm
资金
- NIH/NCRR CoBRE pilot grant [5P20RR020160-05]
- NIH/NIDCR grant [1R01DE19452, 1R01DE019203]
Recently, the use of recombinant full-length amelogenin protein in combination with fluoride has shown promising results in the formation of densely packed enamel-like structures. In this study, amelogenin (rP172)-releasing hydrogels containing calcium, phosphate, and fluoride were investigated for remineralization efficacy using in vitro early enamel caries models. The hydrogels were applied to artificial caries lesions on extracted human third molars, and the remineralization efficacy was tested in different models: static gel remineralization in the presence of artificial saliva, pH cyclic treatment at pH 5.4 acetic buffer and pH 7.3 gel remineralization, and treatment with multispecies oral biofilms grown in a continuous flowing constant-depth film fermenter. The surface microhardness of remineralized enamel increased significantly when amelogenin was released from hydrogel. No cytotoxicity was observed when periodontal ligament cells were cultured with the mineralized hydrogels.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据