Article
Endocrinology & Metabolism
Olga Bondareva, Jesus Rafael Rodriguez-Aguilera, Fabiana Oliveira, Longsheng Liao, Alina Rose, Anubhuti Gupta, Kunal Singh, Florian Geier, Jenny Schuster, Jes-Niels Boeckel, Joerg M. Buescher, Shrey Kohli, Nora Kloeting, Berend Isermann, Matthias Blueher, Bilal N. Sheikh
Summary: Obesity has organ- and endothelial cell subtype-specific effects on gene expression networks, including lipid handling, metabolic pathways, and inflammatory signaling. These transcriptomic aberrations worsen with sustained obesity and are only partially mitigated by dietary intervention and weight loss. The study provides insights into the impact of obesity on the endothelium and identifies potential therapeutic targets.
Review
Engineering, Mechanical
Fangfang Sun, Tianze Wang, Yong Yang
Summary: This review paper provides a comprehensive study of various types of HAp composite scaffold fabricated with RP technologies, introducing their potential applications in bone tissue engineering and discussing future research directions.
RAPID PROTOTYPING JOURNAL
(2022)
Article
Medicine, General & Internal
Tsuyoshi Takamura, Hiroshi Nagashima, Hitomi Matsunari, Shuichiro Yamanaka, Yatsumu Saito, Yoshitaka Kinoshita, Toshinari Fujimoto, Kei Matsumoto, Kazuaki Nakano, Hirotaka James Okano, Eiji Kobayashi, Takashi Yokoo
Summary: This study proposes a novel method of xenogeneic regenerative medicine for chronic kidney disease treatment by grafting porcine fetal kidneys injected with human renal progenitor cells. A cryopreserve system for fetal kidneys and renal progenitor cells was developed, and it was confirmed that cryopreserved fetal kidneys can grow and regenerate nephrons.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Analytical
Roberto Paoli, Davide Di Giuseppe, Maider Badiola-Mateos, Eugenio Martinelli, Maria Jose Lopez-Martinez, Josep Samitier
Summary: This paper discusses the application of digital manufacturing and rapid prototyping technologies in Organ-on-a-Chip applications, as well as the main thermoplastic material choices and manufacturing methods, and investigates the limitations of the PDMS soft lithography strategy.
Article
Biotechnology & Applied Microbiology
Darius Leon Zibulski, Niels Schlichting, Johannes Kabisch
Summary: The rapid prototyping of biological functions aims to generate, screen, and select variant libraries as quickly as possible. This study introduces a new workflow called HyperXpress, which combines ligase cycling reaction, multiply-primed rolling circle amplification, and cell-free protein synthesis into a single vessel reaction. By expanding, reducing, and replacing beta-strands of three different green fluorescent proteins, the authors demonstrate the high flexibility of HyperXpress for semi-rational protein engineering, resulting in six functional, new-to-nature GFP prototypes in single-day experiments.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Endocrinology & Metabolism
Irem Altun, Xiaocheng Yan, Siegfried Ussar
Summary: Adipose tissue is important for energy storage and regulating metabolism. Obesity can lead to dysfunction in adipose tissue, affecting the composition and function of stromal cells. Immune cells in adipose tissue play essential roles in regulating adipocyte function. Macrophages, mast cells, innate lymphoid cells, and T cells all have a significant impact on adipocyte progenitor proliferation, differentiation, and lineage commitment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Materials Science, Biomaterials
Marisa Assuncao, Chi Him Kendrick Yiu, Ho-Ying Wan, Dan Wang, Dai Fei Elmer Ker, Rocky S. Tuan, Anna Blocki
Summary: Hyaluronic acid plays a significant role in promoting fibronectin fibril formation during wound healing and tissue regeneration, indicating its potential for applications in biomaterial design.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Materials Science, Biomaterials
Sachi Moriwaki, Yuta Yoshizaki, Tomohiro Konno
Summary: A reversible and spontaneously forming phospholipid polymer hydrogel was developed as a cell immobilization matrix, causing no harm to the cells. By designing stimuli-responsive dissociation rate, the recovery ratio of the immobilized cells was improved.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Engineering, Biomedical
Qingxi Hu, Haihu Tang, Yuan Yao, Suihong Liu, Haiguang Zhang, Murugan Ramalingam
Summary: The study introduced a promising approach to prepare hydrogel scaffold with prevascularized channels through liquid bath printing, addressing the complexity and precision issues of engineered scaffold prevascularized channels.
BIOMEDICAL MATERIALS
(2021)
Article
Engineering, Biomedical
Pascal Morissette Martin, John T. Walker, Kellie J. Kim, Courtney R. Brooks, Fiona E. Serack, Anna Kornmuller, Laura Juignet, Amanda M. Hamilton, P. Joy Dunmore-Buyze, Maria Drangova, John A. Ronald, Lauren E. Flynn
Summary: A novel cell-assembled bioscaffold format was developed to deliver high densities of human adipose-derived stromal cells for soft tissue regeneration. Both in vitro and in vivo studies demonstrated the potential of the new scaffold format in enhancing stability and vascular formation.
Article
Multidisciplinary Sciences
Ariel C. Vonk, Xiaofan Zhao, Zheyu Pan, Megan L. Hudnall, Conrad G. Oakes, Gabriela A. Lopez, Sarah C. Hasel-Kolossa, Alexander W. C. Kuncz, Sasha B. Sengelmann, Darian J. Gamble, Thomas P. Lozito
Summary: Single-cell analysis of regenerating lizard tails reveals a fibroblast and phagocyte population linked to cartilage formation. The study shows that lizard blastema cells express sulf1 and form cartilage under Hedgehog signaling regulation, distinguishing them from homeostatic and injury-stimulated fibroblasts. This research provides potential actionable targets for inducing regeneration in other species, including humans.
NATURE COMMUNICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Rokas Garmasukis, Claudia Hackl, Christian Dusny, Christian Elsner, Ales Charvat, Andreas Schmid, Bernd Abel
Summary: This paper presents an innovative and low-cost method for rapid prototyping of microfluidic chips. The technique involves controlled deposition of aqueous microdroplets on a cooled surface to create printed ice microstructures, which are then coated with a UV-curable acrylic cover layer. The technology is applied to create a microfluidic chip for cell-customized optical-cell analysis, and the chip design is optimized for different cell types. The authors demonstrate the feasibility of using this chip for physiological analysis of different cell types.
MICROFLUIDICS AND NANOFLUIDICS
(2023)
Article
Chemistry, Analytical
Henrik Persson, Siwan Park, Michael Mohan, Ka Kit Cheung, Craig A. Simmons, Edmond W. K. Young
Summary: This study presents a method to bond poly(methylmethacrylate) layers to a polyethylene terephthalate porous membrane for creating membrane-based microfluidic devices. The bonding method allows for rapid fabrication of devices without adverse effects on the membrane structure. The bonded devices support long term cell culture and experiments related to barrier and endothelial function.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Review
Cardiac & Cardiovascular Systems
John Auchampach, Lu Han, Guo N. Huang, Bernhard Kuhn, John W. Lough, Caitlin C. O'Meara, Alexander Y. Payumo, Nadia A. Rosenthal, Henry M. Sucov, Katherine E. Yutzey, Michaela Patterson
Summary: The field of mammalian myocardial regeneration has seen significant growth in the past two decades. However, there are limitations and challenges in characterizing cardiomyocyte proliferation. Claims of cardiomyocyte proliferation often lack sufficient evidence or proper controls, and the provided data may only indicate cell-cycle activation or DNA synthesis, without proving the generation of new cardiomyocytes. Rigorous experimental strategies and standards should be used to support claims of proliferation-based remuscularization.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Anna B. Meier, Dorota Zawada, Maria Teresa De Angelis, Laura D. Martens, Gianluca Santamaria, Sophie Zengerle, Monika Nowak-Imialek, Jessica Kornherr, Fangfang Zhang, Qinghai Tian, Cordula M. Wolf, Christian Kupatt, Makoto Sahara, Peter Lipp, Fabian J. Theis, Julien Gagneur, Alexander Goedel, Karl-Ludwig Laugwitz, Tatjana Dorn, Alessandra Moretti
Summary: The lineage of human epicardium was studied through time course single-cell analysis of epicardioids. The mesothelial envelope of the vertebrate heart, known as the epicardium, serves as the source of multiple cardiac cell lineages during embryonic development and is essential for myocardial growth and repair. Using self-organizing human pluripotent stem cell-derived epicardioids, researchers were able to observe the morphological, molecular, and functional patterning of the epicardium and myocardium, similar to the left ventricular wall. This study provides insights into the specification and differentiation process of different cell lineages in epicardioids, as well as the functional cross-talk between different cardiac cell types.
NATURE BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Zhuo Wang, Zhirong Liu, Gengrui Zhao, Zichao Zhang, Xinyang Zhao, Xingyi Wan, Yalong Zhang, Zhong Lin Wang, Linlin Li
Summary: In this study, a flexible, stretchable, and highly transparent TENG is designed and fabricated based on an unsymmetrical PAM/BTO composite film. By adjusting the amount and distribution location of BTO, the output performance of the TENG can be improved. The TENG also functions as a high-sensitivity pressure sensor that can distinguish a spectrum of forces at the low frequency.
Article
Chemistry, Multidisciplinary
Sheng Zhang, Baosen Zhang, Da Zhao, Qi Gao, Zhong Lin Wang, Tinghai Cheng
Summary: A non-destructive sorting method based on bionic soft fingers, utilizing a soft robotic gripper (SRG) and Bend Recovery triboelectric sensor (TES), is proposed. The method enables grasping and size sorting of breakable objects, and a fruit sorting system based on this method achieves high sorting accuracy.
Article
Energy & Fuels
Xiang Li, Yuying Cao, Xin Yu, Yuhong Xu, Yanfei Yang, Shiming Liu, Tinghai Cheng, Zhong Lin Wang
Summary: With the utilization of lightweight rotor materials and suitable wind scoop structures, the breeze-driven triboelectric nano generator can efficiently harvest energy even at low wind speeds, making it ideal for agricultural sensor networks in farmland environments.
Article
Chemistry, Physical
Mingwei Shi, Wei Yang, Zailei Zhang, Man Zhao, Zhong Lin Wang, Xianmao Lu
Summary: This study demonstrates that the self-discharge of SSSCs can be suppressed by using PAAm hydrogels with highly concentrated LiCl electrolytes, leading to enhanced charging efficiency and significantly reduced leakage current.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Multidisciplinary Sciences
Yang Nan, Jiajia Shao, Morten Willatzen, Zhong Lin Wang
Summary: This study investigates the contact electrification mechanism and properties at a water/polymer interface using first-principle calculations. The results suggest that the gap between the highest occupied and lowest unoccupied molecular orbitals of polymers determines the extent of contact electrification. Additionally, the study proposes a new model to explain the transfer of charges at the atomic level.
Article
Chemistry, Physical
Jinyang Zhang, Shiquan Lin, Zhong Lin Wang
Summary: This study examines the interaction between a statically charged luminol droplet and the surrounding electrostatic field, and discovers that the polarity of the droplet's charge affects the reactivity of the chemical luminescence reaction. It provides a strategy for regulating chemical luminescence by charging a dielectric solid.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Nanoscience & Nanotechnology
Sanming Hu, Jing Han, Zhijun Shi, Kun Chen, Nuo Xu, Yifei Wang, Ruizhu Zheng, Yongzhen Tao, Qijun Sun, Zhong Lin Wang, Guang Yang
Summary: Researchers have developed a super-strong, biodegradable, and washable cellulose-based conductive macrofiber for fabricating wearable triboelectric nanogenerators (TENGs). The macrofibers possess high tensile strength, good electrical conductivity, and excellent stability. Fabric-based TENGs made from these macrofibers show promising potential for energy harvesting and biomechanical monitoring.
NANO-MICRO LETTERS
(2022)
Article
Nanoscience & Nanotechnology
Chaoqun Xu, Xianpeng Fu, Chengyu Li, Guoxu Liu, Yuyu Gao, Youchao Qi, Tianzhao Bu, Yuanfen Chen, Zhong Lin Wang, Chi Zhang
Summary: This research presents an autonomous system for rainfall monitoring and wireless transmission powered by raindrop energy. The system utilizes a raindrop-TENG array to both harvest raindrop energy and act as a rainfall sensor, while enabling wireless data transmission.
MICROSYSTEMS & NANOENGINEERING
(2022)
Article
Polymer Science
Wenjie Wu, Zhong Lin Wang, Liqun Zhang
Summary: Dielectric elastomers (DEs) are special materials that deform in response to an electric field. The current main mechanism suggests that the deformations in DEs are induced by Maxwell stress. However, a new molecular mechanism based on entropy-dominated elasticity has been proposed recently, highlighting its importance in the process.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Xuanli Dong, Ziming Wang, Andy Berbille, Xin Zhao, Wei Tang, Zhong Lin Wang
Summary: This study aims to investigate the optimal parameters for contact-electro-catalysis (CEC) under ultrasonic reaction condition and explore the effect of different dielectric particles on the decolorization of organic solutions. The experimental results showed that the degradation rate of methyl orange (MO) increases with the increase of ultrasonic power, and the highest degradation rate was achieved at the ultrasonic frequency of 40 kHz. Additionally, the reaction temperature and the electric polarity of the catalyst also affect the CEC reactions.
Article
Chemistry, Physical
Kai Han, Jianjun Luo, Jian Chen, Yujin Liu, Jinliang Li, Zhong Lin Wang, Wenjie Mai
Summary: Electroaerodynamics (EAD) force, a propulsion method without combustion emissions, has great potential. By combining lightweight EAD thrusters and high-voltage output triboelectric nanogenerators (TENG), successful propulsion systems can be achieved.
Article
Chemistry, Analytical
Xue Wang, Zhiping Feng, Gaoqiang Zhang, Luna Wang, Liang Chen, Jin Yang, Zhonglin Wang
Summary: Recent advances in flexible pressure sensors have made them promising technologies for human epidermal pulse wave monitoring. A 3 x 1 flexible pressure sensor array was developed using three single-electrode sensors with small area to measure pulse waves at different local positions of the radial artery. The designed single sensor has a small area of 6 x 6 mm² and demonstrates high pressure sensitivity, fast response time, wide frequency range, and stability.
Article
Computer Science, Information Systems
Jiabin Zhang, Erming Su, Chengyu Li, Shuxing Xu, Wei Tang, Leo N. Y. Cao, Ding Li, Zhong Lin Wang
Summary: This study introduces an intelligent artifact-monitoring system (SAMS) based on a porous carbon black (CB)/Ecoflex triboelectric nanogenerator (PCE-TENG) that can monitor collisions in real-time and absorb vibrations during artifact transportation. The system consists of six PCE-TENGs attached to the inner wall of the artifact transport package, allowing collision monitoring and protection in different directions. This research presents a practical strategy for artifact transportation monitoring and package engineering, which could have significant implications for the field.
Article
Chemistry, Multidisciplinary
Zihan Wang, Yuchao Jin, Chengyue Lu, Jiyu Wang, Ziwu Song, Xu Yang, Yidan Cao, Yunlong Zi, Zhong Lin Wang, Wenbo Ding
Summary: This study achieves self-powered infrared wireless communication by integrating a triboelectric nanogenerator (TENG) and an infrared transmitter. The frequency and amplitude features of the infrared signal are leveraged for conveying information through the mechanical motion or structure of the TENG devices. This research is of significant importance for the development of a new generation of sustainable self-powered communications.
ENERGY & ENVIRONMENTAL SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Liqiang Zhang, Haifang Cai, Liang Xu, Li Ji, Daoai Wang, Youbin Zheng, Yange Feng, Xudong Sui, Yufeng Guo, Wanlin Guo, Feng Zhou, Weimin Liu, Zhong Lin Wang
Summary: In this study, a new macroscale superlubric triboelectric nanogenerator (SL-TENG) was developed to achieve ultra-low friction and wear under high-contact stress. The SL-TENG showed high power density and output current, and the ultralow friction on the hydrogenated surface was identified as the key factor. The SL-TENG demonstrated the ability to light up LEDs without rectification and enable online friction monitoring and early warning.