4.1 Article

A polyurethane-gelatin hybrid construct for manufacturing implantable bioartificial livers

期刊

出版社

SAGE PUBLICATIONS LTD
DOI: 10.1177/0883911508095517

关键词

rapid prototyping (RP); hybrid construct; vascular systems; cell assembling; liver manufacturing

资金

  1. National Natural Science Foundation of China
  2. Research Grants Council of Hong Kong (NSFC/RGC) [50731160625]
  3. Foundation of Key Laboratory for Advanced Materials Processing Technology
  4. Ministry of Education of China [2006009]
  5. National Natural Science Foundation of China [30540060, 30440043]
  6. Beijing Municipal Science & Technology Commission [H060920050530]

向作者/读者索取更多资源

A novel 3D hybrid construct was developed for liver manufacturing by depositing biodegradable polyurethane (PU) and a naturally derived polymer gelatin simultaneously via a double nozzle rapid prototyping (RP) technique. A grid object was produced by precisely and simultaneously dispersing the PU and gelatin to form 3D constructs with interconnected macro-channels at a low temperature (-28 degrees C). Micro-pores were formed by freeze-drying the constructs. The PU polymer provided mechanical support while gelatin provided accommodation for implant cells. The hydrophilicity of the hybrid constructs was between the pure PU and pure gelatin structures. The interconnected channels allow nutrients and oxygen to be supplied throughout the construct as well as provide space for the attachment of cells. The design and fabrication strategies, used to create complex physical objects directly from computer aided design (CAD) models, represent a promising technique for implantable bioartificial livers. It is anticipated that these PU-gelatin hybrid constructs will serve as a useful model for bioartificial liver manufacturing.

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