期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 59, 期 11, 页码 7117-7120出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01723-15
关键词
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资金
- Icahn Institute for Genomics and Multiscale Biology at Mount Sinai
- NIAID [5 T32 AI 7647-13]
- Department of Scientific Computing at the Icahn School of Medicine at Mount Sinai
Whole-genome sequences for Stenotrophomonas maltophilia serial isolates from a bacteremic patient before and after development of levofloxacin resistance were assembled de novo and differed by one single-nucleotide variant in smeT, a repressor for multidrug efflux operon smeDEF. Along with sequenced isolates from five contemporaneous cases, they displayed considerable diversity compared against all published complete genomes. Whole-genome sequencing and complete assembly can conclusively identify resistance mechanisms emerging in S. maltophilia strains during clinical therapy.
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