Article
Microbiology
Felise G. Adams, Claudia Trappetti, Jack K. Waters, Maoge Zang, Erin B. Brazel, James C. Paton, Marten F. Snel, Bart A. Eijkelkamp
Summary: The study found that Acinetobacter baumannii may rely on different sources of fatty acids during infection and synthesize fatty acids in different environments. Additionally, it is the first to reveal the importance of balancing de novo synthesis and acquisition of fatty acids in a Gram-negative bacterium during infection.
Article
Multidisciplinary Sciences
Ziheng Chen, I-Lin Ho, Melinda Soeung, Er-Yen Yen, Jintan Liu, Liang Yan, Johnathon L. L. Rose, Sanjana Srinivasan, Shan Jiang, Q. Edward Chang, Ningping Feng, Jason P. P. Gay, Qi Wang, Jing Wang, Philip L. L. Lorenzi, Lucas J. J. Veillon, Bo Wei, John N. N. Weinstein, Angela K. K. Deem, Sisi Gao, Giannicola Genovese, Andrea Viale, Wantong Yao, Costas A. A. Lyssiotis, Joseph R. R. Marszalek, Giulio F. F. Draetta, Haoqiang Ying
Summary: In pancreatic ductal adenocarcinoma, the lipid composition of cancer cells and mitochondria affects sensitivity to pharmacological inhibition of electron transport chain complex I, with ether phospholipids playing a critical role in maintaining ROS homeostasis.
NATURE COMMUNICATIONS
(2023)
Article
Agriculture, Dairy & Animal Science
Olga I. Stanishevskaya, Yulia Silyukova, Elena Fedorova, Nikolai Pleshanov, Anton Kurochkin, Vera M. Tereshina, Elena Ianutsevich
Summary: Sperm cryopreservation is important for maintaining genetic diversity in chicken breeds, but many sperm lose their viability and motility during the freezing/thawing process. Cell membranes, especially the lipid composition, play a crucial role in cryoresistance. By studying the lipid composition of spermatozoa membranes in two breeds of roosters, a cryoprotective diluent with a concentration of 9.5 mM trehalose was developed. This diluent helps maintain a high level of cell lipids and the kinetic ability of frozen/thawed spermatozoa at 52.4%.
Article
Multidisciplinary Sciences
Prasanna Kandel, Fatih Semerci, Rachana Mishra, William Choi, Aleksandar Bajic, Dodge Baluya, LiHua Ma, Kevin Chen, Austin C. Cao, Tipwarin Phongmekhin, Nick Matinyan, Alba Jimenez-Panizo, Srinivas Chamakuri, Idris O. Raji, Lyra Chang, Pablo Fuentes-Prior, Kevin R. MacKenzie, Caroline L. Benn, Eva Estebanez-Perpina, Koen Venken, David D. Moore, Damian W. Young, Mirjana Maletic-Savatic
Summary: Oleic acid is identified as the endogenous ligand for the orphan nuclear receptor TLX, which converts it from a repressor to an activator, increasing neural stem cell mitotic activity and promoting hippocampal neurogenesis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Undurti N. Das
Summary: Lipids are crucial for cell membrane composition, with polyunsaturated fatty acids playing a key role. Aging cells often lack essential fatty acids and their metabolites, with changes in desaturase activity affecting cell health and disease development.
Article
Nutrition & Dietetics
Ariel Frajerman, Boris Chaumette, Dominique Farabos, Gaetan Despres, Christelle Simonard, Antonin Lamaziere, Marie-Odile Krebs, Oussama Kebir
Summary: This study explored the role of sterols, fatty acids, and phospholipids in individuals at ultra-high risk of psychosis for the first time. The study found that elevated baseline membrane linoleic acid level was associated with conversion to psychosis, and combining sterols, fatty acids, and phospholipids improved the prediction of psychosis onset.
Article
Gastroenterology & Hepatology
Ruth X. Wang, Morkos A. Henen, J. Scott Lee, Beat Vogeli, Sean P. Colgan
Summary: The gut microbiota plays a crucial role in human health by providing short-chain fatty acids (SCFAs), particularly butyrate, which contribute to gut homeostasis and disease resistance. Butyrate is shown to directly inhibit hypoxia-inducible factor (HIF) prolyl hydroxylases (PHDs) to stabilize HIF, offering potential therapeutic impact. Microbiota-derived butyrate is essential for stabilizing HIF in murine colonic tissue, suggesting a co-evolution of mammals and mutualistic microbiota in impacting critical gene regulation pathways.
Article
Psychiatry
Minghui Li, Yan Gao, Dandan Wang, Xiaowen Hu, Jie Jiang, Ying Qing, Xuhan Yang, Gaoping Cui, Pengkun Wang, Juan Zhang, Liya Sun, Chunling Wan
Summary: This study investigated the lipidome of the erythrocyte membrane in patients with schizophrenia (SCZ) and found disturbances in the metabolism of membrane phospholipids. The results showed that phosphatidylcholines and phosphatidylethanolamines were significantly decreased in the membrane of SCZ patients, as well as the total polyunsaturated fatty acids (PUFAs), leading to a decrease in membrane fluidity. Moreover, the accumulation of oxidized lipids and the increase in peripheral lipid peroxides suggested an elevated level of oxidative stress in SCZ. Further exploration revealed the imbalanced unsaturated and saturated fatty acyl remodeling in phospholipids of SCZ patients.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Neurosciences
Eriola Hoxha, Ilaria Balbo, Roberta Parolisi, Matteo Audano, Francesca Montarolo, Francesco Ravera, Michela Guglielmotto, Luisa Muratori, Stefania Raimondo, Eleonora DiGregorio, Annalisa Buffo, Alfredo Brusco, Barbara Borroni, Nico Mitro, Donatella Caruso, Filippo Tempia
Summary: The lack of Elovl5 may cause alterations in myelin structure and affect action potential conduction; Elovl5 plays an essential role in maintaining the structure of myelin, which is crucial for the proper functioning of myelinated nerves.
Article
Food Science & Technology
Emma Sherman, Farhana R. Pinu
Summary: The scientific interest in lipids and lipidomics approaches is growing due to the development of mass spectrometry-based instrumentation and data analysis pipelines. While widely used in biomedical studies, lipidomics applications in food and plant systems, such as grape and wine research, are still developing. The adoption of lipidomics in studying grape and wine research can bring innovative advances to the wine industry worldwide.
CURRENT OPINION IN FOOD SCIENCE
(2023)
Article
Clinical Neurology
Marcia R. Terluk, Julianne Tieu, Siddhee A. Sahasrabudhe, Ann Moser, Paul A. Watkins, Gerald Raymond, Reena Kartha
Summary: Adrenoleukodystrophy (ALD) is an inherited disorder characterized by accumulation of very long-chain fatty acids. We investigated nervonic acid as a potential therapy for ALD and found that it can reverse lipid accumulation and protect cells from oxidative damage. This suggests that nervonic acid could be a therapeutic option for ALD.
Review
Biotechnology & Applied Microbiology
Wade T. Johnson, Nicholas C. Dorn, Dora A. Ogbonna, Nunzio Bottini, Nisarg J. Shah
Summary: Lipids are a diverse class of molecular regulators with ubiquitous physiological roles in sustaining life. They can be used directly as structural cellular building blocks or as a substrate for generating signaling mediators to regulate cell behavior, playing a key role in immune activation and suppression.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Engineering, Environmental
Min-Jeong Suh, Marlena M. Hinkle, Stephanie S. Lau, William A. Mitch
Summary: Recent research shows that high-molecular weight disinfection byproduct (DBP) fractions contribute more to cytotoxicity than the one-to two-carbon DBPs currently of concern. Peptides and lipids are major DBP precursors in water supplies. This study focuses on the analysis of chlorine byproducts of tyrosine and oleic acid to characterize high-molecular weight DBPs. The presence of these DBPs in drinking water and their cytotoxicity levels are investigated.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2023)
Article
Nutrition & Dietetics
Hameed Ullah, Amira Sayed Khan, Babar Murtaza, Aziz Hichami, Naim Akhtar Khan
Summary: Leptin in the tongue plays an inhibitory role in the oro-sensory detection of dietary fatty acids in mice by interfering with calcium signaling and membrane potential.
Article
Plant Sciences
Maksim Tyurin, Elena Chernyak, Oksana Tomilova, Khristina Tolokonnikova, Svetlana M. Malysh, Elena Khramova, Sergey Morozov, Vadim Kryukov
Summary: This study analyzed the changes in chemical composition in potato plants during their interaction with the entomopathogenic endophytic fungus Beauveria bassiana. The results showed an increase in sterol and hydroxy fatty acid concentrations in plant leaves, as well as elevated levels of hydroxycinnamic acids in the roots after B. bassiana inoculation. These changes, possibly caused by oxidative reactions, may be responsible for the growth-promoting and protective effects of B. bassiana on the plants.
Article
Plant Sciences
Alejandro Martinez-Ceja, Antonio Romero-Estrada, Maria Crystal Columba-Palomares, Israel Hurtado-Diaz, Laura Alvarez, Rubicela Teta-Talixtacta, Mariana Sanchez-Ramos, Francisco Cruz-Sosa, Antonio Bernabe-Antonio
Summary: This study aimed to establish a cell culture of Randia aculeata, evaluate its anti-inflammatory and antibacterial potential, and determine its phytochemical profile. The results showed that the cell culture extracts of this plant exhibited potential antibacterial and antioxidant activities.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Chemistry, Analytical
Jose Gustavo Ronderos-Lara, Hugo Saldarriaga-Norena, Mario Alfonso Murillo-Tovar, Laura Alvarez, Josefina Vergara-Sanchez, Victor Barba, Jorge Antonio Guerrero-Alvarez
Summary: This study assessed the distribution and potential estrogenic risk of BPA, 4NP, NPX, IBU, E-2, and EE2 in water and sediments of the Apatlaco river micro-basin in Morelos, Mexico. The concentrations of these compounds ranged between 1 ng center dot L-1.
Article
Agriculture, Dairy & Animal Science
Angelica Maria Zuluaga Cabrera, Maria Jose Casas Soto, Jose Ramon Martinez Aranzales, Viviana Elena Castillo Vanegas, Nathalia Maria del Pilar Correa Valencia, Maria Patricia Arias Gutierrez
Summary: This study aimed to describe the physiological changes in Colombian Paso horses during increasing-intensity exercise. The findings showed evidence of sympathetic-adrenergic response activation and mobilization of energy sources.
REVISTA MEXICANA DE CIENCIAS PECUARIAS
(2022)
Article
Biochemistry & Molecular Biology
Cynthia Alias-Villegas, Francisco Fuentes-Romero, Virginia Cuellar, Pilar Navarro-Gomez, Maria J. Soto, Jose-Maria Vinardell, Sebastian Acosta-Jurado
Summary: Bacteria can spread on surfaces to colonize new environments. Flavonoids and bacterial transcriptional activator NodD have an impact on the surface motility of Sinorhizobium fredii HH103.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Jonathan Padilla-Gomez, Roberto Jhonatan Olea-Ozuna, Sandra Contreras-Martinez, Orlando Morales-Tarre, Daniela A. Garcia-Soriano, Diana X. Sahonero-Canavesi, Sebastian Poggio, Sergio Encarnacion-Guevara, Isabel M. Lopez-Lara, Otto Geiger
Summary: This study reveals that in Rhodobacteria, the structural gene for serine palmitoyltransferase (SPT) co-occurs with genes coding for a putative acyl carrier protein (ACP) and a putative acyl-CoA synthetase (ACS). It is found that the putative ACP is a specialized ACP (AcpR) required for sphingolipid biosynthesis, and the putative ACS is a specialized acyl-ACP synthetase (AasR). The study also shows that acyl-AcpR is used as a substrate for the synthesis of 3-oxo-sphinganine.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Engineering, Chemical
Mariana Sanchez-Ramos, Samantha Berman-Bahena, Laura Alvarez, Jessica Nayelli Sanchez-Carranza, Antonio Bernabe-Antonio, Angelica Roman-Guerrero, Silvia Marquina-Bahena, Francisco Cruz-Sosa
Summary: This study successfully established a callus culture to produce achillin by culturing different explants under conditions of light and total darkness. The results showed that the highest content of achillin was found in leaf calluses grown under photoperiod, using PIC and KIN as stimulants in the medium.
Article
Biochemistry & Molecular Biology
Mariana Sanchez-Ramos, Silvia Marquina-Bahena, Laura Alvarez, Antonio Bernabe-Antonio, Emmanuel Cabanas-Garcia, Angelica Roman-Guerrero, Francisco Cruz-Sosa
Summary: This study successfully established a cell culture system of A. pichinchensis and evaluated the production of anti-inflammatory compounds in a 2 L airlift bioreactor. The maximum biomass production was reached at 11 days, with a cell viability between 80% and 90%. Gas chromatography coupled with mass spectrometry analysis showed that compound 1 and compound 2 reached their maximum production at 7 and 14 days, respectively. This study stands out for its significant production of 2,3-dihydrobenzofuran and 3-epilupeol and the reduction in production time compared to previous cultures.
Article
Plant Sciences
Yazmin B. Jimenez-Nevarez, Miguel Angel Angulo-Escalante, Julio Montes-Avila, Araceli Guerrero-Alonso, Judith Gonzalez Christen, Israel Hurtado-Diaz, J. Basilio Heredia, Eber Addi Quintana-Obregon, Laura Alvarez
Summary: This study aimed to determine the phytochemical composition of bark extracts from the endemic plant J. cordata and evaluate their in vitro anti-inflammatory activity. Different solvent extracts were characterized and their bioactive groups were identified. The ethyl acetate extract showed the highest inhibition of NO production without affecting cell viability, suggesting its potential as an anti-inflammatory agent.
Article
Biochemistry & Molecular Biology
Paula Brito-Santana, Julian J. Duque-Pedraza, Lydia M. Bernabeu-Roda, Cristina Carvia-Hermoso, Virginia Cuellar, Francisco Fuentes-Romero, Sebastian Acosta-Jurado, Jose-Maria Vinardell, Maria J. Soto
Summary: Bacterial surface motility, regulated by genes such as DnaJ, plays a crucial role in host colonization and establishment of symbiosis with legumes. The lack of DnaJ results in impaired surface translocation and hindered establishment of efficient symbiosis in Sinorhizobium meliloti. This study highlights the importance of DnaJ in the free-living and symbiotic lifestyles of S. meliloti.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Isabel M. Lopez-Lara, Otto Geiger
Summary: In addition to glycerophospholipids, bacterial membranes commonly contain amino acid-containing acyloxyacyl lipids. The functional significance of these aminolipids is not well understood. However, a recent study by Stirrup et al. sheds light on their importance as major determinants for membrane properties and the relative abundance of distinct membrane proteins in bacteria.
TRENDS IN MICROBIOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Isabel M. Lopez-Lara, Elena G. Govorunova
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Multidisciplinary Sciences
Otto Geiger, Alejandro Sanchez-Flores, Jonathan Padilla-Gomez, Mauro Degli Esposti
Summary: We breathe by using oxygen consumed by mitochondria in our cells to extract energy. Mitochondria, which derive from aerobic bacteria, play crucial roles in oxidative phosphorylation and other metabolic pathways in eukaryotic cells. The exact bacterial origin of mitochondria and their relationship to the aerobic metabolism of our cells is still controversial despite the abundance of genomic data. In this study, we employ various approaches to identify the most likely bacteria that are the living relatives of the ancestral bacteria from which mitochondria originated. These bacteria inhabit marine environments and possess a high frequency of aerobic traits as well as genes for the metabolism of essential lipids found in eukaryotic membranes, such as sphingolipids and cardiolipin.
Article
Plant Sciences
Yazmin B. Jimenez-Nevarez, Julio Montes-Avila, Miguel Angel Angulo-Escalante, Ninfa Yaret Nolasco-Quintana, Judith Gonzalez Christen, Israel Hurtado-Diaz, Eber Addi Quintana-Obregon, J. Basilio Heredia, Jose Benigno Valdez-Torres, Laura Alvarez
Summary: Compounds extracted from Jatropha cordata (Ortega) Mull. Arg. show potential anti-inflammatory activity by inhibiting nitric oxide production.