Article
Genetics & Heredity
Jovanka Tepavcevic, Kaiti Yarrington, Brittany Fung, Xijin Lin, Karen L. Visick
Summary: The study reveals that Hfq plays a crucial regulatory role in various phenotypes relevant to the symbiosis between V. fischeri and its squid host, including bioluminescence, motility, and biofilm formation. The deletion of Hfq not only increased luminescence production in V. fischeri but also affected motility and biofilm formation, independent of the known regulatory pathways. Hfq is thus identified as an important regulator of multiple facets of symbiosis in this system.
Article
Multidisciplinary Sciences
Carola Gregor
Summary: The study successfully increased the brightness of bacterial bioluminescence system through mutagenesis and screening, resulting in a more powerful light emission signal. The new ilux2 strain enables highly sensitive long-term imaging of bacterial propagation without the need for external luciferin, which is significant for research on bacterial propagation.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Pat M. Fidopiastis, Chaz Childs, Jeremy J. Esin, Jordan Stellern, Anna Darin, Andrea Lorenzo, Vanessa T. Mariscal, Jason Lorenz, Vinay Gopan, Sarah McAnulty, Karen L. Visick
Summary: Bacteria utilize extracellular DNA as a nutritious resource, and the nuclease activity of V. fischeri plays a crucial role in colonization and mutualistic association with Euprymna scolopes. Understanding the specific role of nuclease activity in this process expands our knowledge of beneficial microbial associations.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Chemistry, Analytical
Ana Rita Silva, Claudia Sousa, Daniela Exner, Ruth Schwaiger, Maria Madalena Alves, Dmitri Y. Petrovykh, Luciana Pereira
Summary: The characteristics of Vibrio fischeri bacteria as biological chemosensors were studied under varying environmental conditions, revealing their resistance mechanisms under long-term stress and confirming their suitability as biological chemosensors for detecting environmental pollutants, including nanomaterials and stimulus-responsive nanomaterials that can alter their physicochemical properties.
Article
Microbiology
Xiaojun Zhong, Ranran Lu, Fuwen Liu, Jinjie Ye, Junyang Zhao, Fei Wang, Menghua Yang
Summary: This study identified a novel LuxR family regulator, RobA, in Vibrio parahaemolyticus, which influences bacterial growth and biofilm formation, and integrates into the quorum sensing circuit. RobA was found to regulate the expression of exopolysaccharides synthesis cluster and interact with other regulators to construct a complex regulatory network of biofilm formation.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Hematology
Mark A. Rishavy, Kevin W. Hallgren, Lee A. Wilson, James M. Hiznay, Kurt W. Runge, Kathleen L. Berkner
Summary: This study reveals the essentiality of processivity to VKD protein function and explains the mechanism of disease caused by disrupted processivity through the study of GGCX mutants.
Article
Plant Sciences
Minjuan Zhang, Wenqiang Li, Shuaijun Li, Junru Gao, Tiantian Gan, Qinying Li, Lijun Bao, Feng Jiao, Chao Su, Yonghua Qian
Summary: This study elucidated the molecular mechanism of mulberry's response to drought stress using quantitative proteomics. The results showed that the GPX-based antioxidant enzymes play a crucial role in modulating mulberry's response to drought stress, and higher levels of GPX improve drought tolerance by enhancing the capacity of the antioxidant system for ROS scavenging.
Article
Oncology
Elizabeth Ann Roundhill, Mariona Chicon-Bosch, Lee Jeys, Michael Parry, Kenneth S. Rankin, Alastair Droop, Susan Ann Burchill
Summary: The study aimed to isolate patient-derived ES primary cell cultures and CSCs, identifying biomarkers and therapeutic targets. The results suggest neurexin-1 as a potential therapeutic target in ES, with its expression level associated with disease prognosis.
