期刊
JOURNAL OF BACTERIOLOGY
卷 192, 期 12, 页码 3235-3239出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.00066-10
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资金
- FRFC (Fonds de la Recherche Fondamentale Collective) [2.4521.04, 2.4541.08]
- FRS-FNRS (Fonds de la Recherche Scientifique-Fonds National de la Recherche Scientifique)
- FRIA (Fonds pour la Formation a la Recherche dans l'Industrie et dans l'Agriculture)
- ARC (Actions de Recherche Concertee) [04/09-325, 08/13-015]
The bacterial pathogen Brucella abortus was recently demonstrated to recruit the essential cytoplasmic histidine kinase PdhS to its old pole. Here, we report identification of the fumarase FumC as a specific partner for the N-terminal sensing domain of PdhS, using an ORFeome-based yeast two-hybrid screen. We observed that FumC and PdhS colocalize at the old pole of B. abortus, while the other fumarase FumA is not polarly localized. FumC is not required for PdhS localization, and polar FumC localization is not FumA dependent. FumC homologs are not polarly localized in Sinorhizobium meliloti and Caulobacter crescentus, suggesting that polar recruitment of FumC by PdhS is evolutionarily recent.
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