Article
Engineering, Environmental
Huiqiang Yang, Na Chen, Zhiqiang Wang, Jinbo Liu, Jianjun Qin, Kecheng Zhu, Hanzhong Jia
Summary: This study found that the free radicals in biochar have toxic effects on soil bacteria, reducing bacterial alpha diversity and causing phosphorus limitation in the soil.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Soziema E. E. Dauda, Jessica A. A. Collins, Jo Ann W. Byl, Yanran Lu, Jack C. C. Yalowich, Mark J. J. Mitton-Fry, Neil Osheroff
Summary: Novel bacterial topoisomerase inhibitors (NBTIs) are a new class of antibiotics that target gyrase and topoisomerase IV. NBTIs can induce gyrase/topoisomerase IV-mediated single-stranded DNA breaks and suppress the generation of double-stranded breaks. However, some dioxane-linked amide NBTIs have been found to induce double-stranded DNA breaks mediated by Staphylococcus aureus gyrase. The compound OSUAB-185 induces single-stranded and suppressed double-stranded DNA breaks mediated by Neisseria gonorrhoeae gyrase, while stabilizing both single- and double-stranded DNA breaks mediated by topoisomerase IV.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Environmental
Alexander John, Irene Carra, Bruce Jefferson, Monika Jodkowska, Adam Brookes, Peter Jarvis
Summary: The application of microbubbles in water treatment has shown to enhance gas-liquid contacting processes and compound removal compared to conventional bubbling techniques. However, this study found that there was no significant difference in hydroxyl radical generation between microbubble and conventional bubble ozonation systems.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Inorganic & Nuclear
Pedro Levin, Lucia M. Balsa, Carlos P. Silva, Austin E. Herzog, Andres Vega, Jorge Pavez, Ignacio E. Leon, Luis Lemus
Summary: Copper complexes show promising potential as anticancer agents due to their ability to generate reactive oxygen species in cellular environments. Two novel copper(I) complexes were synthesized and characterized, with the binuclear helicate showing higher activity and cytotoxicity against cancer cell lines compared to the mononuclear complex and cisplatin. The DNA cleavage mechanism involves the generation of hydroxyl radical in a Fenton-like reaction.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Kexin Wang, Yunjian Xu, Zhenjiang Chen, Huixian Li, Rui Hu, Junle Qu, Yuan Lu, Liwei Liu
Summary: Researchers utilized squaric acid nanoparticles for photodynamic therapy of deep hypoxic tumors, achieving significant therapeutic effects and improving the survival rate of mice.
Article
Chemistry, Multidisciplinary
Haiyang Wang, Tian Qin, Wen Wang, Xie Zhou, Faxu Lin, Guodong Liang, Zhiyong Yang, Zhenguo Chi, Ben Zhong Tang
Summary: In this study, new selenium-containing type-I photosensitizers Se6 and Se5 with benzoselenadiazole acceptor were designed and showed aggregation-induced emission characteristic. Se6 exhibited a smaller energy gap (Delta E-ST) of 0.03 eV and improved ROS efficiency, generating both long-lived superoxide anion (O-2(center dot-)) and short-lived hydroxyl ((OH)-O-center dot) upon irradiation. Simultaneous processes to produce (OH)-O-center dot were revealed, including disproportionation of O-2(center dot-) and reaction between excited PS and water. Se6 demonstrated superior in-vitro PDT performance to commercial chlorin e6 (Ce6) under normoxia or hypoxia, and a significantly higher tumor growth inhibition rate of 99% was observed in the in-vivo PDT performance of Se6. These findings provide new insights for both molecular design and mechanism study of type-I photosensitizers.
Article
Materials Science, Multidisciplinary
Wen Wang, Tian Qin, Haiyang Wang, Zhiyong Yang, Zhenguo Chi, Xie Zhou
Summary: A new type-I photosensitizer that can simultaneously generate multiple type-I reactive oxygen species (ROS) under hypoxia condition of tumors is reported. In vitro and in vivo experiments demonstrate its excellent photodynamic therapy effects on tumor cells. The mechanism of ROS generation is revealed through experiments in aqueous and in vitro conditions.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Runfeng Lin, Junkai Liu, Weilin Xu, Zicheng Liu, Xiang He, Canze Zheng, Miaomiao Kang, Xue Li, Zhijun Zhang, Hai-Tao Feng, Jacky W. Y. Lam, Dong Wang, Ming Chen, Ben Zhong Tang
Summary: In this work, a pyrazine-based near-infrared type I photosensitizer (PS) with remarkable donor-acceptor effect and efficient intramolecular motions was developed. The PS exhibited high photothermal conversion efficiency and strong hydroxyl radical generation due to its vigorous intramolecular motions. It also demonstrated excellent imaging-guided cancer synergistic therapy, stimulating the development of advanced PS and solid-state intramolecular motions for biomedical applications.
ADVANCED MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Eva Dvorak Tomastikova, Klara Prochazkova, Fen Yang, Jitka Jemelkova, Andreas Finke, Annika Dorn, Mahmoud Said, Holger Puchta, Ales Pecinka
Summary: DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block DNA replication and transcription. Arabidopsis has three pathways to repair DPCs: endonucleolytic cleavage, proteolytic degradation, and cleavage of phosphodiester bonds. The SMC5/6 complex is identified as an important factor in plant DPC repair through a genetic screen.
Article
Chemistry, Physical
Zahra Khajavi, Arman Ghasedi, Behnam Mahdavi, Ehsan Koushki
Summary: Carbon quantum dots (CQDs) have potential applications in various industries and have attracted much attention. This study synthesized CQDs using a thermal decomposition method and post-treated the sample with ethylenediaminetetraacetic acid (EDTA) as the surface modifier to prepare EDx-CQDs. Cephalexin (Cp) with different concentrations was loaded onto the EDx-CQDs to investigate Cp adsorption. UV light source was used to trigger the Cp desorption process, and a series of spectroscopic analyses were conducted to assess structural changes of the drug-loaded sample before and after UV exposure.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Chemistry, Physical
Chenglin Zhang, Qiuchen He, Su Zhan, Feng Zhou
Summary: This study established a ballast water treatment system that can efficiently inactivate marine microorganisms without the need for additional sacrificial agents. The introduction of AgQDs improved the photocatalytic sterilization efficiency, and it was found that AgQDs play multiple roles in facilitating charge transportation and generating robust oxygen species for bacterial inactivation.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Eric M. Smith, Alfonso Mondragon
Summary: DNA gyrase is a type II topoisomerase responsible for maintaining the topological state of bacterial and some archaeal genomes. Recent research suggests that three conserved basic residues in the C-gate of DNA gyrase play a crucial role in DNA supercoiling activity, facilitating T-segment passage through a positively charged region into the cavity between the DNA gate and C-gate.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Microbiology
Dennis J. Doorduijn, Dani A. C. Heesterbeek, Maartje Ruyken, Carla J. C. de Haas, Daphne A. C. Stapels, Piet C. Aerts, Suzan H. M. Rooijakkers, Bart W. Bardoel
Summary: This study demonstrates that polymerization of C9 enhances bacterial damage and accelerates killing, requiring an excess of C9 per C5b-8, and complement-resistant E. coli can specifically block C9 polymerization. Additionally, all tested complement-resistant E. coli strains express LPS O-antigen (O-Ag), while only a minority of sensitive strains do.
Article
Chemistry, Multidisciplinary
Qing An, Yang-Yang Xing, Ruihua Pu, Menghui Jia, Yuegang Chen, Anhua Hu, Shuo-Qing Zhang, Na Yu, Jianbo Du, Yanxia Zhang, Jinquan Chen, Weimin Liu, Xin Hong, Zhiwei Zuo
Summary: The importance of alkoxy radicals in cerium-catalyzed C-H functionalization reactions has been confirmed and the involvement of chlorine radicals has been ruled out. The study also emphasizes the influence of the relative ratio of alcohol to cerium on the reaction selectivity. Furthermore, the selectivity of alkoxy radical generation and the regulatory role of back-electron transfer have been analyzed.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Eman M. Ahmed, Nadia A. Khalil, Ashraf F. Zaher, Shimaa M. Alhamaky, Mona S. El-Zoghbi
Summary: A series of newly synthesized compounds showed potent cytotoxic effects against tumor cell lines, with compounds 3a, 3d, 3e, and 3f exhibiting strong inhibition across various cancer cell lines and 4d and 4e demonstrating selective cytotoxic activity against melanoma cancer cells.
BIOORGANIC CHEMISTRY
(2021)
Article
Genetics & Heredity
Carmen de Sena-Tomas, Jeanette H. Sutherland, Mira Milisavljevic, Dragana B. Nikolic, Jose Perez-Martin, Milorad Kojic, William K. Holloman
Article
Genetics & Heredity
Milorad Kojic, Jeanette H. Sutherland, Jose Perez-Martin, William K. Holloman
Article
Infectious Diseases
I-Fen Liu, Jeanette H. Sutherland, Bokun Cheng, Yuk-Ching Tse-Dinh
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2011)
Article
Microbiology
Jeanette H. Sutherland, Bokun Cheng, I-Fen Liu, Yuk-Ching Tse-Dinh
JOURNAL OF BACTERIOLOGY
(2008)
Article
Microbiology
Jeanette H. Sutherland, Yuk-Ching Tse-Dinh
JOURNAL OF BACTERIOLOGY
(2010)
Article
Genetics & Heredity
Jeanette H. Sutherland, William K. Holloman
Article
Biology
Eun Young Yu, Syed S. Zahid, Swapna Ganduri, Jeanette H. Sutherland, Min Hsu, William K. Holloman, Neal F. Lue
COMMUNICATIONS BIOLOGY
(2020)
Article
Genetics & Heredity
Syed Zahid, Sarah Aloe, Jeanette H. Sutherland, William K. Holloman, Neal F. Lue
Summary: Pot1 plays multifaceted roles in telomere maintenance and protection. It interacts with DNA repair factors, such as Rad51 and Brh2, in a context-dependent manner. Pot1 negatively regulates the recombination activities of Rad51 and Brh2 to protect telomeres when they become dysfunctional.
Article
Genetics & Heredity
Jeanette H. Sutherland, William K. Holloman
