4.4 Article

Identification of ORF636 in Phage φSLT Carrying Panton-Valentine Leukocidin Genes, Acting as an Adhesion Protein for a Poly(Glycerophosphate) Chain of Lipoteichoic Acid on the Cell Surface of Staphylococcus aureus

期刊

JOURNAL OF BACTERIOLOGY
卷 191, 期 14, 页码 4674-4680

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AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.01793-08

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  1. Japan Society for the Promotion of Sciences [13460034, 15380054, 136607, 15580055, 20580069]
  2. Grants-in-Aid for Scientific Research [15380054, 20580069, 15580055, 13460034] Funding Source: KAKEN

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The temperate phage phi SLT of Staphylococcus aureus carries genes for Panton-Valentine leukocidin. Here, we identify ORF636, a constituent of the phage tail tip structure, as a recognition/adhesion protein for a poly(glycerophosphate) chain of lipoteichoic acid on the cell surface of S. aureus. ORF636 bound specifically to S. aureus; it did not bind to any other staphylococcal species or to several gram-positive bacteria.

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