Article
Biochemistry & Molecular Biology
Markus J. Frojd, Klas Flardh
MOLECULAR MICROBIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Beer Chakra Sen, Sebastian Wasserstrom, Kim Findlay, Niklas Soderholm, Linda Sandblad, Claes von Wachenfeldt, Klas Flardh
MOLECULAR MICROBIOLOGY
(2019)
Article
Microbiology
Markus J. Frojd, Klas Flardh
Article
Microbiology
Tomasz Lebkowski, Marcin Wolanski, Stanislaw Oldziej, Klas Flardh, Jolanta Zakrzewska-Czerwinska
JOURNAL OF BACTERIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Miroslav Jurasek, Klas Flardh, Robert Vacha
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2020)
Article
Biochemistry & Molecular Biology
Manuela Mengozzi, Andrew Hesketh, Giselda Bucca, Pietro Ghezzi, Colin P. Smith
MOLECULAR MEDICINE
(2020)
Article
Microbiology
Paul G. Becher, Vasiliki Verschut, Maureen J. Bibb, Matthew J. Bush, Bela P. Molnar, Elisabeth Barane, Mahmoud M. Al-Bassam, Govind Chandra, Lijiang Songs, Gregory L. Challis, Mark J. Buttner, Klas Flardh
NATURE MICROBIOLOGY
(2020)
Article
Microbiology
Stuart Cantlay, Beer Chakra Sen, Klas Flardh, Joseph R. McCormick
Summary: This study investigated the relationship between cell division and sporulation in the soil bacterium Streptomyces venezuelae by isolating mutants with deletions in different core divisome components. The results suggest that division is partially functional even without multiple core divisome proteins, indicating the presence of redundant functions. The study also showed that the stability of Z rings, essential for cell division, depends on specific divisome membrane components.
Article
Microbiology
Andy Hesketh, Giselda Bucca, Colin P. Smith, Hee-Jeon Hong
Summary: Dalbavancin, vancomycin, and chlorobiphenyl-vancomycin are glycopeptide antibiotics with similar structures and modes of action, but they induce different gene expression patterns and have diverse impacts on bacterial cell wall biosynthesis and other physiological processes.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fanny M. Passot, Stuart Cantlay, Klas Flardh
Summary: Members of the Actinobacteria, such as mycobacteria and streptomycetes, display a unique mode of polar growth with cell wall synthesis directed by DivIVA. The protein phosphatase SppA plays a significant role in regulating polar growth and cell shape determination, reversing the phosphorylation of DivIVA mediated by AfsK. The phenotypic effects of SppA deletion are independent of DivIVA phosphorylation and involve other substrates, while AfsK and SppA partially share target proteins involved in hyphal branching and tip extension.
MOLECULAR MICROBIOLOGY
(2022)
Article
Immunology
Louise R. Durrant, Giselda Bucca, Andrew Hesketh, Carla Moller-Levet, Laura Tripkovic, Huihai Wu, Kathryn H. Hart, John C. Mathers, Ruan M. Elliott, Susan A. Lanham-New, Colin P. Smith
Summary: Vitamin D plays a crucial role in maintaining bone health and calcium balance, and also has broad effects on cellular physiology and the immune system. This study examines the differences in gene expression following supplementation with vitamin D-2 and D-3, and suggests the existence of ethnic variations in the response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Thomas A. Burley, Andrew Hesketh, Giselda Bucca, Emma Kennedy, Eleni E. Ladikou, Benjamin P. Towler, Simon Mitchell, Colin P. Smith, Christopher Fegan, Rosalynd Johnston, Andrea Pepper, Chris Pepper
Summary: The study revealed the role of the FAK signaling pathway in CLL cell migration and tissue invasion by investigating the mechanisms underlying CLL cell migration. Inhibition of FAK effectively reduced CLL cell migration and invasion, suggesting the potential for combining FAK inhibition with current targeted therapies to enhance CLL treatment efficacy.
Article
Materials Science, Multidisciplinary
Grace Cooksley, Marcus K. Dymond, Nicolas A. Stewart, Giselda Bucca, Andrew Hesketh, Joseph Lacey, Yury Gogotsi, Susan Sandeman
Summary: This study investigates the impact of two-dimensional titanium carbide MXene on pathways related to inflammation and epithelial-mesenchymal transition (EMT) using an in vitro LECs model. The results demonstrate that Ti3C2T(x) can decrease the expression of inflammatory cytokines and does not promote EMT, promoting a positive wound healing response.
Editorial Material
Engineering, Biomedical
Shirin Saberianpour, Gianluca Melotto, Rachel Forss, Lucy Redhead, Jacqueline Elsom, Nadia Terrazzini, Susan Sandeman, Dipak Sarker, Giselda Bucca, Andrew Hesketh, Cyril Crua, Matteo Santin
EXPERT REVIEW OF MEDICAL DEVICES
(2023)
Article
Biology
Ala Javadi, Niklas Soderholm, Annelie Olofsson, Klas Flardh, Linda Sandblad
LIFE SCIENCE ALLIANCE
(2019)