Article
Microbiology
Yun Jeong Lee, Jooyun Kim, Ji Hoon Jeon, Hyeri Seok, Won Sun Choi, Eun-Ah Chang, Hyung Joon Yim, Dae Won Park
Summary: This case report discusses a 30-year-old male with acute hepatitis and Yersinia pseudotuberculosis bacteremia, who recovered after 10 days of hospitalization. It highlights the importance of considering Y. pseudotuberculosis as a potential causative organism in patients with acute colitis and hepatitis.
Article
Chemistry, Analytical
Bin Feng, Liyuan Shi, Haipeng Zhang, Haimei Shi, Chuanfan Ding, Peng Wang, Shaoning Yu
Summary: This study established a complete MALDI-TOF MS data pipeline and identified a Y. pestis-specific biomarker, achieving nearly perfect separation between Y. pseudotuberculosis and Y. pestis with a separation accuracy of 0.999 using an LDA model. The new computing method paves the way for automatic differentiation between the two highly similar bacterial species.
Article
Biochemistry & Molecular Biology
Evgeniya Bystritskaya, Nadezhda Chernysheva, Anna Stenkova, Konstantin Guzev, Alexander Rakin, Marina Isaeva
Summary: The study revealed that Yersinia pseudotuberculosis exhibited temporal regulation of porin genes in response to sublethal concentrations of antibiotics. While the major porin gene expression initially decreased and later recovered, the alternative porin genes showed increased expression, indicating phenotypic heterogeneity within the bacterial population.
Article
Microbiology
Aleksandra Platt-Samoraj, Klaudia Konczyk-Kmiecik, Tadeusz Bakula
Summary: The study found a high prevalence of Y. enterocolitica among commensal rodents, with all isolates classified as biotype 1A and sporadic isolation of Y. pseudotuberculosis, indicating no high epidemiological risk.
Review
Biochemistry & Molecular Biology
Yuriy A. Knirel, Andrey P. Anisimov, Angelina A. Kislichkina, Anna N. Kondakova, Olga V. Bystrova, Anastasia S. Vagaiskaya, Konstantin Y. Shatalin, Alexander S. Shashkov, Svetlana V. Dentovskaya
Summary: This review summarizes studies on the biosynthesis of Yersinia pseudotuberculosis complex LPSs and the roles of their structural components in the molecular mechanisms of yersiniae pathogenesis and immunogenesis.
Article
Multidisciplinary Sciences
Maya Weinberg, Omer Mazar, Adi Rachum, Xing Chen, Sophia Goutink, Nora Lifshitz, Rona Winter-Livneh, Gabor a. Czirjak, Yossi Yovel
Summary: The study reveals that free-ranging Rousettus aegyptiacus face challenges at the northern edge of their distribution, with significant increase in morbidity during winter and peak in abandoned pups during spring and summer. GPS tracking showed that harsh weather mainly drives winter morbidity, suggesting potential limitations on further northward spread for this tropical species.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Cyril Savin, Anne-Sophie Le Guern, Fanny Chereau, Julien Guglielmini, Guillaume Heuze, Christian Demeure, Javier Pizarro-Cerda
Summary: We report the first Y. pseudotuberculosis clonal outbreak in France that occurred in 2020 and used a new cgMLST scheme for epidemiological investigation and molecular typing. This method displays excellent discriminatory power and is available to the scientific community.
MICROBIOLOGY SPECTRUM
(2022)
Article
Biochemistry & Molecular Biology
Mirian Becerril Ramirez, Lucia Soto Urzua, Maria de los angeles Martinez Martinez, Luis Javier Martinez Morales
Summary: The function of chaperones is to correct or degrade misfolded proteins inside the cell. Classic molecular chaperones such as GroEL and DnaK have not been found in the periplasm of Yersinia pseudotuberculosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Anja Wiechmann, Vanina Garcia, Linzy Elton, Paul Williams, Steve Atkinson
Summary: Biofilm formation in Y. pseudotuberculosis is regulated by NagC and quorum sensing (QS), and NagC negatively regulates the ytbI and ypsI QS genes. The nagC mutant shows impaired biofilm production, but can be partially restored by exogenous GlcNAc. These findings reveal a reciprocal regulatory relationship between NagC and QS in modulating biofilm formation.
Article
Microbiology
Marta Odyniec, Agata Bancerz-Kisiel
Summary: This study aimed to determine the prevalence of potentially human-pathogenic Y. enterocolitica and Y. pseudotuberculosis strains in free-living and farmed fallow deer, and evaluate their sensitivity to chemotherapeutics. The results indicated that multiple drug-resistant Y. enterocolitica strains can be carried by fallow deer, which raises serious concerns regarding the consumption of fallow deer meat.
Article
Gastroenterology & Hepatology
Alyssa C. Fasciano, Gaya S. Dasanayake, Mary K. Estes, Nicholas C. Zachos, David T. Breault, Ralph R. Isberg, Shumin Tan, Joan Mecsas
Summary: Researchers studied the interaction between the enteric pathogen Yersinia pseudotuberculosis (Yptb) and M cells using human ileal enteroid-derived monolayers. They found that the transcytosis of Yptb through M cells was influenced by its expression levels of T3SS, and that Yops impede the function of M cells, allowing early infectious stage Yptb to more effectively penetrate M cells.
Article
Microbiology
Chuanjiang Dong, Wei Chen, Lili Zou, Binbin Liu, Kaihong Deng, Dingrui Guo, Peng Wang, Hao Chen, Helen Wang, Jun Wang
Summary: The study found that Ebselen exhibited synergistic antibacterial activity with silver nitrate against Yersinia pseudotuberculosis, and it also showed antibacterial and immune-modulatory properties in a mouse gastroenteritis model.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Mariela Serrano-Gutierrez, Enrique Merino
Summary: Riboswitches are RNA elements involved in gene regulation. Most riboswitches are located at the 5' end of their target genes, but rare cases of riboswitches at the 3' end and transcribing in the antisense direction have been described. A computational analysis identified 292 potential examples of antisense-acting riboswitches, shedding new light on this novel type of gene regulation.
Article
Biochemical Research Methods
Shunsuke Ikeuchi, Hien Thi Bui, Yukiko Sassa-O'brien, Takeshi Niwa, Minato Okumura, Yukiko Hara-Kudo, Takahide Taniguchi, Hideki Hayashidani
Summary: This study aimed to develop multiplex real-time PCR methods for rapid and sensitive diagnosis of three pathogenic Yersinia groups. Specific primer and probe combinations were designed for differentiation using three chromosomally encoded genes. The developed methods successfully detected and differentiated the pathogenic Yersinia groups, with a detection limit of approximately 101 CFU/reaction of genomic DNA. The methods also detected the pathogen from biological samples, demonstrating their usefulness for epidemiological monitoring and diagnosis of Yersinia infections.
JOURNAL OF MICROBIOLOGICAL METHODS
(2023)
Article
Multidisciplinary Sciences
Qing Zhong, Yanyu Zhao, Fangfei Ye, Zaiyu Xiao, Gaoxingyu Huang, Meng Xu, Yuanyuan Zhang, Xiechao Zhan, Ke Sun, Zhizhi Wang, Shanshan Cheng, Shan Feng, Xiuxiu Zhao, Jizhong Zhang, Peilong Lu, Wenqing Xu, Qiang Zhou, Dan Ma
Summary: The study presents the cryo-EM structure of human WLS in complex with Wnt3a at 2.2 angstrom resolution, offering insights into the palmitoleoylation mechanism required for WLS-mediated Wnt secretion.
NATURE COMMUNICATIONS
(2021)