Article
Biotechnology & Applied Microbiology
Nehemie Nzoyikorera, Idrissa Diawara, Pablo Fresia, Fakhreddine Maaloum, Khalid Katfy, Kaotar Nayme, Mossaab Maaloum, Jennifer Cornick, Chrispin Chaguza, Mohammed Timinouni, Houria Belabess, Khalid Zerouali, Naima Elmdaghri
Summary: Whole genome sequencing provides detailed analysis of the virulent serotype 1 in Casablanca, Morocco. Results show that the phylogeography of S. pneumoniae serotype 1 is structured by country. Despite the small sample size from Morocco, the genetic cohesion of the Moroccan invasive isolates is evident.
Article
Biochemistry & Molecular Biology
Prasanna Mutusamy, Kirnpal Kaur Banga Singh, Lee Su Yin, Bent Petersen, Thomas Sicheritz-Ponten, Martha R. J. Clokie, Stella Loke, Andrew Millard, Sivachandran Parimannan, Heera Rajandas
Summary: Salmonella infections are becoming harder to control due to the emergence of multidrug-resistant strains. Researchers have found new Salmonella-specific phages from a rainforest, which have potential as an alternative treatment for these infections. The phages show differences in their lytic spectrum and pH stability, possibly due to nucleotide sequence variations in certain proteins. This study highlights the diversity of novel Salmonella phages in rainforest regions and their potential as antimicrobial agents against multidrug-resistant strains.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Eugene E. Kulikov, Alla K. Golomidova, Alexandr D. Efimov, Ilya S. Belalov, Maria A. Letarova, Evelina L. Zdorovenko, Yuriy A. Knirel, Andrei S. Dmitrenok, Andrey Letarov
Summary: Tailed bacteriophages are predominant in the intestinal viromes of vertebrate animals, but the distinction between lytic and lysogenic lifestyles can vary between species or individuals. The human viromes are mostly dominated by temperate phages, while in horse feces, virulent phages are more common. The Hf4s temperate coliphage isolated from horse feces has unique characteristics, such as recognizing the host O antigen as its primary receptor and possessing a seroconversion cluster that protects lysogens from superinfection by some virulent coliphages.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Microbiology
Tracy L. Nicholson, Ursula Waack, Tavis K. Anderson, Darrell O. Bayles, Sam R. Zaia, Isaiah Goertz, Mark Eppinger, Samantha J. Hau, Susan L. Brockmeier, Sarah M. Shore
Summary: This study explores the virulence mechanisms of Streptococcus suis isolates in swine, finding no clear correlation between disease-causing capacity and genomic attributes. However, specific protein coding sequences unique to highly virulent isolates were identified, providing potential targets for future studies on virulence factors.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Muhammad Imran Nisar, Fyezah Jehan, Shahira Shahid, Sheraz Ahmed, Sadia Shakoor, Furqan Kabir, Aneeta Hotwani, Sahrish Muneer, Farah Khalid, Sajid Muhammad, Benjamin M. Althouse, Hao Hu, Cynthia G. Whitney, Asad Ali, Anita K. M. Zaidi, Saad B. Omer, Najeeha Iqbal
Summary: Pakistan introduced the PCV10 vaccine in 2013 and conducted a study on infants from 2014-2018. The study showed a significant decrease in carriage of vaccine-related serotypes and an increase in non-vaccine related serotypes. This highlights the need for continuous monitoring and evaluation of existing vaccine formulations.
Article
Genetics & Heredity
David W. Cleary, Stephanie W. Lo, Narender Kumar, Stephen D. Bentley, Saul N. Faust, Stuart C. Clarke
Summary: Despite its inclusion in PCV13, serotype 3 pneumococci remains a significant cause of disease. Recent studies have identified three clades within the population structure, with Clade II being more antibiotic-resistant. A genomic analysis of serotype 3 isolates in Southampton, UK showed that Clade I alpha CC180 GPSC12 is the dominant cause of both carriage and invasive disease.
MICROBIAL GENOMICS
(2023)
Article
Immunology
Wang Li, Hengzhao Guo, Yi Gao, Xiaofan Yang, Ruirui Li, Shuangyu Li, Chunlong Sun, Wen Du, Shaopeng Chen, Pengpeng Xu, Wenwen Huang, Jia Shi, Xinfeng Yi, Xiaobin Li
Summary: This study systematically analyzed the characteristics of 191 plasmids carrying bla(OXA-48)-like genes in K. pneumoniae. Multiple variants of bla(OXA-48)-like genes were identified, and their high prevalence, geographic distribution, and plasmid types were determined.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Kennedy T. L. Gifford, Brett E. Pickett
Summary: In this study, a meta-analysis was performed to compare the transcriptional responses in host cells during Streptococcus pneumoniae infection and carriage in humans and mice. The findings revealed no overlapping significant signaling pathways between the two species, highlighting the need for additional controlled datasets to understand the underlying mechanisms of invasion and pathogenesis.
MICROBIAL PATHOGENESIS
(2022)
Article
Infectious Diseases
Ed Clarke, Adedapo Bashorun, Ikechukwu Adigweme, Mariama Badjie Hydara, Ama Umesi, Ahmed Futa, Magnus Ochoge, Dolapo Obayemi, Bassey Edem, Ebrima Saidy-Jah, Chukwuemeka Onwuchekwa, Rajeev Dhere, Vistasp Sethna, Beate Kampmann, David Goldblatt, Douglas Taylor, Indah Andi-Lolo, Nancy Hosken, Kalpana Antony, Bruce L. Innis, Mark R. Alderson, Steve Lamola
Summary: This study examined the immunogenicity and safety of a novel ten-valent pneumococcal conjugate vaccine, demonstrating its non-inferiority in terms of immunogenicity and its compatibility with routine vaccines. The safety of the vaccine meets standard requirements.
LANCET INFECTIOUS DISEASES
(2021)
Article
Biotechnology & Applied Microbiology
Zhien He, Yongqiang Yang, Wei Li, Xiaoling Ma, Changfeng Zhang, Jingxiang Zhang, Baolin Sun, Tao Ding, Guo-Bao Tian
Summary: This study provides important information on Enterobacteriaceae bacteria carrying mcr-like genes and serves as a reference for the study of mcr-1 transmission in China and globally.
Article
Microbiology
Wanzhen Li, Xiaofen Liu, Waitang Tsui, An Xu, Dan Li, Xuefei Zhang, Pei Li, Xingchen Bian, Jing Zhang
Summary: This study provides new insights into the characteristics of T6SS in Klebsiella pneumoniae through in-depth comparative genomic analysis, revealing the prevalence and genetic features of T6SS in this bacterium. This contributes to future research on the mechanism and effectors of T6SS, potentially identifying proteins with novel antimicrobial properties.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Antonio J. Martin-Galiano, Ernesto Garcia
Summary: Bacteriophages are viruses that infect bacteria and can integrate into the host chromosome. Prophages have been found in abundance in sequenced bacterial genomes and can modulate the virulence of their host through different mechanisms. A study on Streptococcus pneumoniae genomes revealed the presence of various prophages, coding for virulence factors and potential integrases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Cristian A. Suarez, Soledad T. Carrasco, Facundo N. A. Brandolisio, Virginia Abatangelo, Carina A. Boncompain, Natalia Peresutti-Bacci, Hector R. Morbidoni
Summary: Epidemiology and virulence studies have revealed that temperate bacteriophages play a crucial role in the evolution of Staphylococcus aureus due to their abundance and genomic diversity. This study focuses on the isolation, genome sequencing, and analysis of 14 bacteriophages from lysogenic S. aureus strains of human and veterinary origin. The findings provide insights into the genetic composition and distinctive features of these bacteriophages, revealing their potential impact on host evolution.
MICROBIOLOGY SPECTRUM
(2022)
Article
Virology
Marta Gomes, Rita Domingues, Dann Turner, Hugo Oliveira
Summary: In this study, two novel bacteriophages, nACB1 and nACB2, were isolated from sewage samples. They infect Acinetobacter beijerinckii and Acinetobacter halotolerans, respectively. Genetic analysis revealed that nACB1 and nACB2 are novel members of the Schitoviridae and the Ackermannviridae families. This study provides valuable information on phage-Acinetobacter interactions and the genetic evolution of phages.
Article
Microbiology
Yuwei Zhang, Fenfen Lv, Yan Su, Huan Zhang, Baojiang Zhang
Summary: Genetic exchange across Streptococcus equi strains influences the development of donkey S. equi genome and offers important insights for future epidemiological studies of S. equi infection.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Ecology
Maria J. Ferrandiz, Maria I. Cercenado, Miriam Domenech, Jose M. Tirado-Velez, Maria S. Escolano-Martinez, Jose Yuste, Ernesto Garcia, Adela G. de la Campa, Antonio J. Martin-Galiano
Article
Biochemistry & Molecular Biology
Emma Roig-Molina, Mirian Domenech, Maria de Gracia Retamosa, Montserrat Nacher-Vazquez, Luis Rivas, Beatriz Maestro, Pedro Garcia, Ernesto Garcia, Jesus M. Sanz
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2019)
Article
Multidisciplinary Sciences
Fen Z. Hu, Jaroslaw E. Krol, Chen Hsuan Sherry Tsai, Rory A. Eutsey, Luisa N. Hiller, Bhaswati Sen, Azad Ahmed, Todd Hillman, Farrel J. Buchinsky, Laura Nistico, Bethany Dice, Mark Longwell, Edward Horsey, Garth D. Ehrlich
Article
Multidisciplinary Sciences
Maria Ercibengoa, Marta Alonso, Diego Vicente, Maria Morales, Ernesto Garcia, Jose Maria Marimon
Article
Immunology
Anfal Shakir Motib, Firas A. Y. Al-Bayati, Irfan Manzoor, Sulman Shafeeq, Anagha Kadam, Oscar P. Kuipers, N. Luisa Hiller, Peter W. Andrew, Hasan Yesilkaya
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2019)
Review
Infectious Diseases
Nestor D. Tomycz, Christopher Payne, Boyle C. Cheng, Luisa Hiller, Rory Eutsey, Donald M. Whiting, Saadyah Averick
SURGICAL INFECTIONS
(2020)
Article
Multidisciplinary Sciences
Surya D. Aggarwal, Adrian J. Lloyd, Saigopalakrishna S. Yerneni, Ana Rita Narciso, Jennifer Shepherd, David Roper, Christopher G. Dowson, Sergio R. Filipe, N. Luisa Hiller
Summary: In response to unfavorable conditions, the Gram-positive pathogen Streptococcus pneumoniae relies on cell wall biosynthesis proteins MurM and MurN. MurM modulates stress response by decreasing the pool of mischarged tRNAs, while enhanced lysis in the absence of MurM may be caused by LytA.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Microbiology
Saigopalakrishna S. Yerneni, Sarah Werner, Juliana H. Azambuja, Nils Ludwig, Rory Eutsey, Surya D. Aggarwal, Peter C. Lucas, Nathanael Bailey, Theresa L. Whiteside, Phil G. Campbell, N. Luisa Hiller
Summary: pEVs produced by Streptococcus pneumoniae affect macrophages in different ways and may serve as a reservoir for the bacteria, leading to inflammatory responses and tissue damage in mammalian hosts.
Article
Genetics & Heredity
Salini Konikkat, Michelle R. Scribner, Rory Eutsey, N. Luisa Hiller, Vaughn S. Cooper, Joel McManus
Summary: The antibiotic azithromycin alters the gene expression and intragenic 3' end formation in Pseudomonas aeruginosa, contributing to impaired biofilm growth and quorum sensing while upregulating genes associated with persistence. This study provides insights into the molecular mechanisms underlying the response of P. aeruginosa to antibiotics and potential new therapeutic strategies.
Article
Microbiology
Surya D. Aggarwal, Jessica M. Gullett, Tara Fedder, J. Pedro F. Safi, Charles O. Rock, N. Luisa Hiller
Summary: The balance of unsaturated and saturated fatty acids affects membrane homeostasis in Streptococcus pneumoniae, with the cell-cell communication peptide BriC playing a role in this regulation. The control of fatty acid biosynthesis pathways and factors influencing this balance are important for bacterial host adaptation.
Article
Biochemistry & Molecular Biology
Iman Tajer Abdullah, Andrew T. Ulijasz, Umakhanth Venkatraman Girija, Sien Tam, Peter Andrew, Natalia Luisa Hiller, Russell Wallis, Hasan Yesilkaya
Summary: The importance of each residue within the active short hydrophobic peptide (SHP) in the Streptococcus pneumoniae Rgg144/SHP144 regulator-peptide quorum sensing system was characterized by this study. The study identified key interactions and mechanisms of activation in this critical pneumococcal QS system, providing a theoretical basis for the development of inhibitors.
MOLECULAR MICROBIOLOGY
(2022)
Article
Microbiology
Andrea J. French, Nicole C. Rockey, Valerie Le Sage, Karina Mueller Brown, Meredith J. Shephard, Sheila Frizzell, Mike M. Myerburg, N. Luisa Hiller, Seema S. Lakdawala
Summary: The impact of microbial communities on transmission fitness and environmental persistence is not well studied. It is important to understand the stability of microbes in the environment to identify transmission risks and mitigation strategies. Co-infection with S. pneumoniae during influenza virus infection may affect the stability of both pathogens. In this study, we found that co-infected hosts can expel both influenza virus and S. pneumoniae, but S. pneumoniae has a trend towards increased stability in the presence of influenza viruses.
Review
Microbiology
Surya D. Aggarwal, Hasan Yesilkaya, Suzanne Dawid, N. Luisa Hiller
Article
Dentistry, Oral Surgery & Medicine
Alexandre R. Vieira, N. Luisa Hiller, Evan Powell, Leon Hak-Jin Kim, Tracy Spirk, Adriana Modesto, Rachael Kreft
CLINICAL AND EXPERIMENTAL DENTAL RESEARCH
(2019)
Article
Allergy
Hamid Kazemian, Davoud Afshar, Ernesto Garcia, Mohammad Reza Pourmand, Mahmood Jeddi-Tehrani, Farzaneh Aminharati, Fazel Shokri, Mohammad Hossein Yazdi
IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY
(2018)