期刊
JOURNAL OF BACTERIOLOGY
卷 191, 期 17, 页码 5549-5552出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.00381-09
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- National Institutes of Health (National Institute of Diabetes, Digestive, and Kidney Diseases)
A strain of Escherichia coli was constructed in which all of the genes involved in polyamine biosynthesis speA (arginine decarboxylase), speB (agmatine ureohydrolase), speC (ornithine decarboxylase), spe D (adeno-sylmethionine decarboxylase), speE (spermidine synthase), speF (inducible ornithine decarboxylase), cadA (lysine decarboxylase), and ldcC (lysine decarboxylase)-had been deleted. Despite the complete absence of all of the polyamines, the strain grew indefinitely in air in amine-free medium, albeit at a slightly (ca. 40 to 50%) reduced growth rate. Even though this strain grew well in the absence of the amines in air, it was still sensitive to oxygen stress in the absence of added spermidine. In contrast to the ability to grow in air in the absence of polyamines, this strain, surprisingly, showed a requirement for polyamines for growth under strictly anaerobic conditions.
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