Article
Microbiology
Jinshil Kim, Myungseo Park, Eunbyeol Ahn, Qingqing Mao, Chi Chen, Sangryeol Ryu, Byeonghwa Jeon
Summary: The ability of a foodborne pathogen to tolerate environmental stress is crucial for food safety. Campylobacter jejuni, a leading cause of foodborne illnesses, has been found to develop a thick layer of bacterial capsules to protect itself under aerobic conditions.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Ekaterina Shagieva, Katerina Demnerova, Hana Michova
Summary: Campylobacter jejuni is a leading cause of bacterial gastroenteritis worldwide. It can survive in the environment and exhibits antibiotic resistance, ability to survive at low temperature, develop aerotolerance, and interact with potential hosts. The study highlighted the potential environmental transmission route of campylobacteriosis.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Lara Vogelsang, Karl -Josef Dietz
Summary: The temporal and spatial patterns of reactive oxygen species (ROS) in cells and tissues determine the plant's response to various stresses. Recent progress in dynamic cell imaging probes and sensitive proteomics has provided important information on the cellular redox state. Thiol peroxidases play a central role in this process.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Plant Sciences
Guozhi Bi, Man Hu, Ling Fu, Xiaojuan Zhang, Jianru Zuo, Jiayang Li, Jing Yang, Jian-Min Zhou
Summary: H2O2 plays a crucial role in plant immune responses, but the mechanisms by which plants sense and regulate H2O2 signaling are poorly understood. This study identifies PRXIIB as the sensor for H2O2 and ABI2 as the target protein, revealing a redox relay mechanism that mediates reactive oxygen species signaling during plant immunity.
Article
Gastroenterology & Hepatology
Igori Balta, Adela Marcu, Mark Linton, Carmel Kelly, Ozan Gundogdu, Lavinia Stef, Ioan Pet, Patrick Ward, Myriam Deshaies, Todd Callaway, Phittawat Sopharat, Gratiela Gradisteanu-Pircalabioru, Nicolae Corcionivoschi
Summary: This study demonstrates that mixtures of natural antimicrobials can reduce virulence of pathogens and restore cellular structures, while blocking the ERK-MAPK kinase pathway responsible for inflammatory cytokine release. The antimicrobial mixture also prevents the formation of substrates used by bacterial pathogens to grow and survive in anaerobic environments.
Article
Environmental Sciences
Benjamin M. C. Swift, Malcolm Bennett, Katie Waller, Christine Dodd, Annie Murray, Rachel L. Gomes, Bethan Humphreys, Jon L. Hobman, Michael A. Jones, Sophia E. Whitlock, Lucy J. Mitchell, Rosie J. Lennon, Kathryn E. Arnold
SCIENCE OF THE TOTAL ENVIRONMENT
(2019)
Article
Multidisciplinary Sciences
Lucy K. Shewell, Christopher J. Day, Freda E-C Jen, Thomas Haselhorst, John M. Atack, Josephine F. Reijneveld, Arun Everest-Dass, David B. A. James, Kristina M. Boguslawski, Stephan Brouwer, Christine M. Gillen, Zhenyao Luo, Bostjan Kobe, Victor Nizet, Mark von Itzstein, Mark J. Walker, Adrienne W. Paton, James C. Paton, Victor J. Torres, Michael P. Jennings
Article
Microbiology
John M. Atack, Chengying Guo, Thomas Litfin, Long Yang, Patrick J. Blackall, Yaoqi Zhou, Michael P. Jennings
Article
Microbiology
Ying Tang, Michael Jones, Paul A. Barrow, Neil Foster
Article
Microbiology
Ryan Cook, Steve Hooton, Urmi Trivedi, Liz King, Christine E. R. Dodd, Jon L. Hobman, Dov J. Stekel, Michael A. Jones, Andrew D. Millard
Summary: The study revealed that the viral community in UK cattle slurry is highly diverse, dominated by lytic bacteriophages, and contains many novel genera. Despite fluctuations in slurry composition, the viral community remained stable over a 5-month period. Functional annotation identified a wide range of auxiliary metabolic genes and novel features, as well as a previously rare presence of diversity-generating retroelements in lytic viral genomes.
Article
Microbiology
Greg Tram, Freda E. -C. Jen, Zachary N. Phillips, Jamie Timms, Asma-Ul Husna, Michael P. Jennings, Patrick J. Blackall, John M. Atack
Summary: Streptococcus suis is a significant pathogen causing bacterial meningitis in humans and pigs. A Type III DNA methyltransferase called ModS in S. suis controls phasevarions through biphasic ON-OFF switching, influencing growth patterns and antibiotic resistance. Understanding ModS phase variation is crucial for developing treatments and vaccines against this important pathogen.
Article
Chemistry, Medicinal
Greg Tram, Jessica Poole, Felise G. Adams, Michael P. Jennings, Bart A. Eijkelkamp, John M. Atack
Summary: Our study demonstrates that the trimeric autotransporter adhesin Ata exhibits high-affinity binding to galactose, N-acetylglucosamine, and galactose (beta 1-3/4) N-acetylglucosamine. This lectin activity plays a key role in host adherence, particularly in the recognition of human plasma fibronectin. Understanding this mechanism will aid in developing new and effective treatments for multidrug resistant A. baumannii infections by targeting host interactions involving glycans.
ACS INFECTIOUS DISEASES
(2021)
Article
Microbiology
Freda E-C Jen, John M. Atack, Yuan Zhang, Jennifer L. Edwards, Michael P. Jennings
Summary: The complete genome of Neisseria meningitidis strain C311 is 2,311,508 bp long, contains a total of 2,274 genes, and has a GC content of 51.25%.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2021)
Article
Microbiology
Freda E-C Jen, John M. Atack, Jennifer L. Edwards, Michael P. Jennings
Summary: The study presents the fully annotated genome sequences for seven N. gonorrhoeae strains obtained through single-molecule real-time long-read genome sequencing. These bacteria have developed resistance to all commonly prescribed antibiotics and currently there is no available vaccine for prevention.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2021)
Review
Microbiology
Michael P. Jennings, Christopher J. Day, John M. Atack
Summary: This review provides an update on the advances made in understanding the role of sialic acid in bacteria-host interactions, particularly focusing on molecular mimicry and the role of sialic acid as a receptor for bacterial adhesins and toxins.
Article
Environmental Sciences
Michelle Baker, Alexander D. Williams, Steven P. T. Hooton, Richard Helliwell, Elizabeth King, Thomas Dodsworth, Rosa Maria Baena-Nogueras, Andrew Warry, Catherine A. Ortori, Henry Todman, Charlotte J. Gray-Hammerton, Alexander C. W. Pritchard, Ethan Iles, Ryan Cook, Richard D. Emes, Michael A. Jones, Theodore Kypraios, Helen West, David A. Barrett, Stephen J. Ramsden, Rachel L. Gomes, Chris Hudson, Andrew D. Millard, Sujatha Raman, Carol Morris, Christine E. R. Dodd, Jan-Ulrich Kreft, Jon L. Hobman, Dov J. Stekel
Summary: Waste from dairy production is a significant source of contamination from antimicrobial resistant bacteria and genes. Storing slurry waste for at least 60 days can significantly reduce the spread of ARB onto land. Furthermore, further reductions in AMR are unlikely on farms with low antibiotic use.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Microbiology
Greg Tram, Freda E. -C. Jen, Zachary N. Phillips, John F. Lancashire, Jamie Timms, Jessica Poole, Michael P. Jennings, John M. Atack
Summary: This study characterized the ModA phasevarion in H. influenzae biogroup aegyptius, finding ModA13 in non-BPF causing strains and ModA16 unique to BPF causing isolates. Phase variation of ModA13 and ModA16 resulted in genome-wide changes to DNA methylation, leading to altered protein expression. However, these changes did not affect serum resistance in H. influenzae biogroup aegyptius strains.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
John M. Atack, Kenneth L. Brockman, Lauren O. Bakaletz, Michael P. Jennings
Summary: This study presents high-depth coverage RNA-Seq data from prototype NTHi strains 723 and R2866, which encode two of the most common phase-variable ModA alleles found in NTHi strains, ModA2 and ModA10.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)
Article
Microbiology
Ryan Cook, Nathan Brown, Tamsin Redgwell, Branko Rihtman, Megan Barnes, Martha Clokie, Dov J. Stekel, Jon Hobman, Michael A. Jones, Andrew Millard
Summary: As of January 2021, 14,244 complete phage genomes have been sequenced. The majority of phages in the database infect a small number of bacterial genera, with a bias towards lytic phages. The study suggests isolating and sequencing more phages, especially temperate phages, from a wider variety of hosts to better understand phage diversity.
PHAGE-THERAPY APPLICATIONS AND RESEARCH
(2021)
Article
Microbiology
Luke Blakeway, Aimee Tan, Ian R. Peak, John M. Atack, Kate L. Seib
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2020)