Article
Microbiology
Rimi Chowdhury, Paulina D. Pavinski Bitar, Ivan Keresztes, Anthony M. Condo, Craig Altier
Summary: The survival of pathogens in the complex intestinal environment relies on their ability to sense and utilize specific environmental signals. Salmonella optimizes its invasion by using specific spatial cues in the host intestine. A long chain unsaturated fatty acid acts as a potent repressor of Salmonella invasion in the murine large intestine.
Article
Gastroenterology & Hepatology
Mudasir Ali Rather, Rimi Chowdhury, Paulina D. Pavinski D. Bitar, Craig Altier
Summary: By recombinantly producing diffusible signal factors (DSF) in the gut, the invasion ability and the virulence of Salmonella can be significantly reduced, thus reducing its colonization and spread in animals.
Article
Cell Biology
Xin-Xing Lei, Shu-Lan Wang, Ying Xia, Min Yan, Bin He, Bo Wang, Zi-Jie Long, Quentin Liu
Summary: SOX1, a well-known tumor suppressor, can delay malignant progression in most cancers, but high expression of SOX1 in late-stage head and neck squamous cell carcinoma leads to poor prognosis. This study reveals that SOX1 induces quiescence in nasopharyngeal carcinoma (NPC) cells and a subpopulation of these cells become refractory to the chemotherapy drug paclitaxel. However, decreased expression of SOX1 can reverse the quiescent state and make the cells sensitive to paclitaxel again.
CELL DEATH DISCOVERY
(2023)
Article
Cardiac & Cardiovascular Systems
Shiju Ye, He Huang, Xue Han, Wu Luo, Lili Wu, Yang Ye, Yingchao Gong, Xia Zhao, Weijian Huang, Yi Wang, Xiaohong Long, Guosheng Fu, Guang Liang
Summary: In this study, the researchers discovered that dectin-1, a pattern recognition receptor, plays a crucial role in cardiac remodeling. They found that Ang II can directly bind to dectin-1, activating downstream signaling pathways and inducing inflammatory responses, leading to heart damage and dysfunction. These findings suggest that dectin-1 may be a potential target for treating hypertension-related heart failure.
CIRCULATION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Shuyu Li, Hengxi Sun, Jianghan Li, Yujiao Zhao, Ruiying Wang, Lei Xu, Chongyi Duan, Jialin Li, Zhuo Wang, Qinmeng Liu, Yao Wang, Songying Ouyang, Xihui Shen, Lei Zhang
Summary: Cyclic di-GMP transduces extracellular stimuli into intracellular responses to modulate important biological processes. Here, the authors show that AI-2 and bile salts induce cyclic di-GMP synthesis via YeaJ and YedQ, respectively, to repress the T3SS via a cyclic-di-GMP-responsive T3SS chaperone.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Yuxin Chen, Hai Li, Weiwei Liang, Yan Guo, Miaoguan Peng, Wen Ke, Haipeng Xiao, Hongyu Guan, Yanbing Li
Summary: SLC6A15 is downregulated in papillary thyroid cancer (PTC) and its overexpression impairs the migratory and invasive abilities of PTC cells in vitro. The involvement of intercellular adhesion molecule-1 in the effects of SLC6A15 on PTC cells suggests SLC6A15 acts as a tumor suppressor and a potential therapeutic target for PTC treatment.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Jei-Ming Peng, Sheng-Hsuan Lin, Ming-Chin Yu, Sen-Yung Hsieh
Summary: CLIC1 regulates the formation of cell-matrix adhesions and membrane protrusions through the recruitment of PIP5Ks to the plasma membrane. Upregulated expression of CLIC1 in hepatocellular carcinoma is associated with tumor invasiveness, metastasis, and poor prognosis.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cell Biology
Shu Hu, Jiancheng Liu, Shuying Feng, Yue Wang, Hongchao Liu
Summary: The study revealed that SUMO1P3 plays a crucial role in HCC progression, with its enhanced expression correlating with malignant features of liver cancer. Depletion of SUMO1P3 induces HCC cell apoptosis, suppresses cell migration and invasion, and ultimately delays tumor growth and metastasis.
Article
Oncology
Varsha D. Shiragannavar, Nirmala G. Sannappa Gowda, Divya P. Kumar, Faridoddin Mirshahi, Prasanna K. Santhekadur
Summary: Withaferin A exhibits anti-proliferative, anti-migratory, anti-invasive, and anti-anchorage-independent growth effects on HCC cells by activating LXR-α to inhibit NF-κB transcriptional activity. This suggests that Withaferin A may be a useful anticancer compound for the treatment of HCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Shouyun Li, Xue Yang, Shuang Liu, Yirui Chen, Haiyan Xing, Kejing Tang, Zheng Tian, Yingxi Xu, Qing Rao, Min Wang, Jianxiang Wang
Summary: The study found that expression of TR in mouse hematopoietic progenitors induces blockade of differentiation with enhanced proliferative capacity in vitro and established a new mouse leukemia model that more accurately recapitulates human APL. Despite sensitivity to ATRA-induced cell differentiation, neither ATRA monotherapy nor combination with As2O3 confers survival benefit to TR mice, consistent with poor clinical outcomes of APL patients with the TR fusion gene. Based on histone deacetylation phenotypes implied by bioinformatic analysis, HDAC inhibitors demonstrated significant survival superiority in the survival of TR mice, providing insights into clinical efficacy against rare types of APL.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Xiao Yu, Pengfei Zhao, Qingyu Luo, Xiaowei Wu, Yating Wang, Yabing Nan, Shi Liu, Wenyan Gao, Bin Li, Zhihua Liu, Zhumei Cui
Summary: This study reveals that lncRNA RUNX1-IT1 plays a critical role in the progression of ovarian cancer. Its overexpression is associated with shorter survival and worse prognosis in patients. Knockdown of RUNX1-IT1 suppresses the proliferation, migration, and invasion of ovarian cancer cells and reduces metastasis formation. Mechanistically, RUNX1-IT1 regulates intracellular reactive oxygen homeostasis by altering histone modification status and activates NF-κB signaling. Targeting RUNX1-IT1 may be a promising therapeutic strategy for ovarian cancer treatment.
Article
Cell Biology
Guiying Zhang, Haolin Luo, Xinyi Li, Zhangli Hu, Quan Wang
Summary: In eukaryotes, the polyadenylate tail of mRNA is now known to play a vital role in a sophisticated signaling system that regulates mRNA metabolism. It acts as a platform that is constantly regulated by polyadenylation and deadenylation machinery, and it can recruit RNA-binding proteins and interact with diverse factors to send signals. This paper outlines the main complexes involved, explains the polyadenylation/deadenylation process, and summarizes the diverse signals emitted by this hub.
Article
Multidisciplinary Sciences
Bing Chen, Shiya Zheng, Feng Jiang
Summary: The study revealed that miR-1293 promotes the proliferation, migration, and invasion of LUAD cells via targeting PGM5. Higher miR-1293 expression was associated with advanced pathologic stage and poor overall survival in LUAD patients.
Article
Multidisciplinary Sciences
Hualiang Pi, Andy Weiss, Clare L. Laut, Caroline M. Grunenwald, Hannah K. Lin, Xinjie Yi, Devin L. Stauff, Eric P. Skaar
Summary: HitRS is a two-component system that responds to cell envelope damage in the human pathogen Bacillus anthracis. KrrA, an RNA-binding protein, regulates HitRS function by modulating the stability of the hitRS mRNA. KrrA also binds to over 70 RNAs and affects the expression of over 150 genes involved in multiple processes.
NATURE COMMUNICATIONS
(2022)
Article
Biotechnology & Applied Microbiology
Wei Zhong, Lei Bao, Yangyi Yuan, Yanzhi Meng
Summary: Our study revealed that circRASSF2 regulates BC progression through the miR-1205/HOXA1 pathway. High expression of circRASSF2 is associated with distant metastasis, lymph node metastasis, TNM stage, differentiation, and tumor size in BC patients, leading to inferior overall survival (OS) and progression-free survival (PFS). This indicates the potential of circRASSF2 as a therapeutic target for treating BC patients.