期刊
JOURNAL OF BACTERIOLOGY
卷 190, 期 14, 页码 5137-5141出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.00246-08
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- NIAID NIH HHS [U54AI057141, R01 AI048660, U54 AI057141, R01-AI48660] Funding Source: Medline
- NIGMS NIH HHS [U54 GM069338, GM069338, T32 GM07270, T32 GM007270] Funding Source: Medline
Burkholderia mallei has two acyl-homoserine lactone (acyl-HSL) signal generator-receptor pairs and two additional signal receptors, all of which contribute to virulence. We show that B. mallei produces N-3-hydroxy-octanoyl HSL (30HC(8)-HSL) but a bmaI3 mutant does not. Recombinant Escherichia coli expressing BmaI3 produces hydroxylated acyl-HSLs, with 30HC(8)-HSL being the most abundant compound. In recombinant E. coli, BmaR3 responds to 30HC(8)-HSL but not to other acyl-HSLs. These data indicate that the signal for BmaR3-BmaI3 quorum sensing is 30HC(8)-HSL.
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