Article
Biotechnology & Applied Microbiology
Camille Cavestri, Patricia Savard, Ismail Fliss, Jean-Guillaume Emond-Rheault, Jeremie Hamel, Irena Kukavica-Ibrulj, Brian Boyle, France Daigle, Danielle Malo, Sadjia Bekal, Linda J. Harris, Roger C. Levesque, Lawrence Goodridge, Gisele LaPointe
Summary: This study evaluated the survival capability of high and low virulence Salmonella strains in a simulated gastrointestinal environment. Results showed that high virulence strains had a significantly better survival rate, possibly due to their enhanced acid and bile resistance.
Article
Microbiology
Hyojeong Koo, Eunna Choi, Shinae Park, Eun-Jin Lee, Jung-Shin Lee
Summary: Deficiency in protein acetylation affects the pathogenicity and replication ability of Salmonella Typhimurium, possibly by regulating the binding affinity of nucleoid-associated protein H-NS to virulence genes.
JOURNAL OF MICROBIOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Wansen Guo, Jinshen Wang, Chao Shi, Jianhong Chen, Wenhui Zeng, Guoxiao He, Kunying Ding
Summary: In this study, the morphological and property changes of YSZ sintering were experimentally investigated, and a coupled analysis of the YSZ crack propagation mode under the hot spot was performed using ABAQUS. The results show that the pore fractal size D of YSZ increases by 15%, and the coating has a shear stress of 75 MPa inside the hot spot region. The hot spot causes crack initiation at the tip of the pores inside the coating and oblique propagation, resulting in the formation of an oblique crack connection through the pores.
Review
Microbiology
Jean Guard
Summary: This review revisits the biological phenomenon that contributes to the success of Salmonella enterica as a pathogen and explores the progress in epidemiology based on whole genome sequencing. By correlating genotype with phenotype, this research aims to develop a better understanding of the interactome and its potential implications in therapeutics, control measures, environmental remediations, and vaccine design.
Article
Biochemical Research Methods
Pratik Goswami, Martin Bartas, Matej Lexa, Natalia Bohalova, Adriana Volna, Jiri Cerven, Veronika Cervenova, Petr Pecinka, Vladimir Spunda, Miroslav Fojta, Vaclav Brazda
Summary: By analyzing high-frequency mutations of SARS-CoV-2 and their overlay with IR and CpG island loci, this study found that hot-spot mutations of the virus are significantly enriched within these regions. The hypothesis is that hypermethylation of CpG islands may decrease the transcription of viral ORFs and therefore limit the progression of the disease.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Biotechnology & Applied Microbiology
Youngho Koh, Yunyoung Bae, Min-Jung Lee, Yu-Si Lee, Dong-Hyun Kang, Soon Han Kim
Summary: This study characterized S. Thompson strains isolated from chocolate cakes linked to foodborne Salmonella enterica Thompson outbreaks in Korea. The strains showed similar genetic features and were related to the same batch of Salmonella Thompson. Comparative analysis also revealed the genetic similarities of domestic S. Thompson strains.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Mingzhe Yang, Qingli Dong, Hongmei Niu, Jiaming Li, Zijie Lin, Muhammad Zohaib Aslam, Xiang Wang, Zhuosi Li, Yangtai Liu, Yue Ma, Xiaojie Qin
Summary: This study aims to investigate whether continuous exposure to sublethal concentrations of benzalkonium chloride (BC) could lead to acquired resistance of Salmonella enterica serovar 1,4,[5],12:i:- (S. 1,4,[5],12:i:-) to BC and other environmental stresses. The results showed that all tested strains exhibited increased BC tolerance and antibiotic resistance after exposure to gradually increasing concentrations of BC. In addition, BC-adapted strains showed reduced zeta potential and increased resistance to heat and acid.
JOURNAL OF APPLIED MICROBIOLOGY
(2023)
Article
Microbiology
Joseph A. Villanueva, Amy L. Crooks, Toni A. Nagy, Joaquin L. J. Quintana, Zachary D. Dalebroux, Corrella S. Detweiler
Summary: Researchers have identified two small molecules that can enter bacterial cells by exploiting outer membrane damage, and use them to kill Salmonella enterica serovar Typhimurium. These compounds interact with Escherichia coli and have different mechanisms of antibacterial activity. This study highlights the ability of host innate immunity to facilitate the action of small molecules as antibiotics.
Article
Thermodynamics
Bo Ye, Jian Qu, Hongzhao Wang, Shan Gao, Huihe Qiu
Summary: In this study, the bubble nucleation and evolution characteristics of subcooled flow boiling in high aspect ratio flat microchannels were experimentally investigated. The results showed that bubble nucleation was significantly suppressed on the smooth bottom surface, even at a localized hot spot heat flux above 2.5 kW/cm2. The introduction of staggered short micro-pin fin arrays at the bottom wall lowered the threshold heat flux and onset temperature of bubble nucleation and reinforced bubble growth. The heterogeneous boiling mechanism was found to still work on both smooth and micro-structured surfaces.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2023)
Article
Infectious Diseases
Jorrit Broertjes, Rogier Jansen, Iedan Verly, Kim van der Zwaluw, Alje van Dam
Summary: We present a case of a laboratory-acquired Salmonella Typhi infection, resulting in hospitalization of a technician. The strain of S. Typhi isolated from blood and stool cultures was found to be identical to the strain the employee had recently worked with, confirmed through core-genome multilocus sequence typing. Despite working in a biosafety cabinet, the incident still occurred.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2023)
Article
Thermodynamics
Efi Zemach, Avihai Spizzichino, Yuri Feldman
Summary: The study numerically investigated the instability characteristics of a 3D highly separated natural convection flow developing within a cold cubic enclosure in the presence of a tandem of hot and cold horizontally aligned cylinders. It was found that the transition to unsteadiness of the flow sets in via the first Hopf bifurcation, which preserves two types of reflectional symmetry with respect to the central cross-section of the cubic enclosure. The impact of the closeness of the cavity boundaries to the cylinder surfaces on the quantitative and qualitative characteristics of the observed instabilities was extensively investigated.
INTERNATIONAL JOURNAL OF THERMAL SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Gizem Levent, Ashlynn Schlochtermeier, Samuel E. Ives, Ken N. Norman, Sara D. Lawhon, Guy H. Loneragan, Robin C. Anderson, Javier Vinasco, Henk C. den Bakker, H. Morgan Scott
Summary: Our study reveals that clonal expansion of Salmonella strains in cattle is mainly influenced by the randomization of block and pen, as well as the origin/source of the cattle, regardless of sampling time and sample type (i.e., feces, lymph node, or hide). Further research is needed concerning the role of the feedlot pen environment prior to cattle placement to better understand carryover contributions of existing strains of Salmonella and their bacteriophages.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Genetics & Heredity
Irani U. Rathnayake, Rikki M. A. Graham, Jo Bayliss, Megan Staples, Gino Micalizzi, Lawrence Ariotti, Leonie Cover, Brett Heron, Trudy Graham, Russell Stafford, Sally Rubenach, Andrew D'Addona, Amy V. Jennison
Summary: This study reports how routine genetic surveillance of Salmonella enterica serovar Enteritidis isolates allowed the identification of the source of an outbreak in a remote town in Australia. The findings highlight the importance of genomic surveillance in outbreak detection and management.
MICROBIAL GENOMICS
(2023)
Article
Environmental Sciences
Zhongbin Li, David P. Roy, Hankui K. Zhang
Summary: The study found that hot-spot sensing conditions on the GOES-16 ABI occurred in different geographic regions of North America during spring and autumn, with the phenomenon not being negligible. Furthermore, the analysis revealed significant differences in reflectance in ABI data under hot-spot conditions.
REMOTE SENSING OF ENVIRONMENT
(2021)
Article
Infectious Diseases
Tushabe John Vianney, Duncan J. Berger, Stephen R. Doyle, Geetha Sankaranarayanan, Joel Serubanja, Prossy Kabuubi Nakawungu, Fred Besigye, Richard E. Sanya, Nancy Holroyd, Fiona Allan, Emily L. Webb, Alison M. Elliott, Matthew Berriman, James A. Cotton
Summary: This study aims to understand the impact of praziquantel (PZQ) treatment on the genetics of schistosomes. The authors obtained whole-genome sequence data from 174 individual miracidia collected from fishing communities in Uganda and investigated the genetic variation and genomic signatures of natural selection in pre- and post-treatment parasite populations. The study found higher genetic diversity in pre-treatment parasite populations and identified genes with evidence of recent positive selection in post-treatment and intensively treated parasites that could be related to reduced susceptibility to PZQ treatment.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Ozhan Ozkaya, Roberto Balbontin, Isabel Gordo, Karina B. Xavier
Review
Biochemistry & Molecular Biology
Paulo Durao, Roberto Balbontin, Isabel Gordo
TRENDS IN MICROBIOLOGY
(2018)
Article
Genetics & Heredity
Lucia Garcia-Pastor, Maria Antonia Sanchez-Romero, Gabriel Gutierrez, Elena Puerta-Fernandez, Josep Casadesus
Article
Biochemistry & Molecular Biology
Lucia Garcia-Pastor, Maria A. Sanchez-Romero, Marcello Jakomin, Elena Puerta-Fernandez, Josep Casadesus
NUCLEIC ACIDS RESEARCH
(2019)
Article
Microbiology
Juan Farizano, Lucia Garcia-Pastor, Josep Casadesus, Monica A. Delgado
Review
Microbiology
Maria A. Sanchez-Romero, Josep Casadesus
NATURE REVIEWS MICROBIOLOGY
(2020)
Article
Multidisciplinary Sciences
David R. Olivenza, Herve Nicoloff, Maria Antonia Sanchez-Romero, Ignacio Cota, Dan I. Andersson, Josep Casadesus
SCIENTIFIC REPORTS
(2019)
Correction
Multidisciplinary Sciences
David R. Olivenza, Herve Nicoloff, Maria Antonia Sanchez-Romero, Ignacio Cota, Dan I. Andersson, Josep Casadesus
SCIENTIFIC REPORTS
(2019)
Article
Microbiology
David R. Olivenza, Josep Casadesus, Mireille Ansaldi
ENVIRONMENTAL MICROBIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Maria A. Sanchez-Romero, David R. Olivenza, Gabriel Gutierrez, Josep Casadesus
NUCLEIC ACIDS RESEARCH
(2020)
Article
Biology
Camille Henry, Laurent Loiseau, Alexandra Vergnes, Didier Vertommen, Angela Merida-Floriano, Sindhu Chitteni-Pattu, Elizabeth A. Wood, Josep Casadesus, Michael M. Cox, Frederic Barras, Benjamin Ezraty
Summary: Reactive oxygen species (ROS) oxidize RecA recombinase, altering its DNA repair and recombination activities. However, this damage can be suppressed by methionine sulfoxide reductases MsrA/B, maintaining RecA homeostasis control.ROS not only damage DNA structure directly, but also prevent repair of DNA damage by inhibiting RecA activity.
Article
Biochemistry & Molecular Biology
Roberto Balbontin, Nelson Frazao, Isabel Gordo
Summary: The study reveals that the fitness cost of antibiotic resistance mutations in Escherichia coil is strongly correlated with DNA breaks, which are generated via transcription-translation uncoupling and increased formation of RNA-DNA hybrids. Targeting RNase HI enzyme can further increase DNA breaks and the cost of resistance. This research suggests a specific strategy to eliminate resistant bacteria.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Article
Multidisciplinary Sciences
Nara Figueroa-Bossi, Maria Antonia Sanchez-Romero, Patricia Kerboriou, Delphine Naquin, Clara Mendes, Philippe Bouloc, Josep Casadesus, Lionello Bossi
Summary: This study analyzed the mechanism of up-regulation of H-NS-silenced Salmonella pathogenicity island 1 (SPI-1) in cells depleted of Rho-cofactor NusG. It was found that when Rho cannot stop the transcription from spurious antisense promoters, it elongates into a H-NS-bound regulatory region of SPI-1, displacing H-NS and leading to the activation of SPI-1 transcription.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Julia Aguilera-Herce, Concepcion Panadero-Medianero, Maria Antonia Sanchez-Romero, Roberto Balbontin, Joaquin Bernal-Bayard, Francisco Ramos-Morales
Summary: Type III secretion systems are commonly found in many Gram-negative pathogens and symbionts. Salmonella enterica possess two type III secretion systems associated with virulence, one for host cell invasion and another for intracellular niche maintenance. This study investigates the biochemical function of the SrfJ effector and its impact on mammalian host cells. The results indicate that SrfJ acts as a glucosylceramidase, altering the lipidome and transcriptome of host cells, both in epithelial cells and macrophages during Salmonella infection. Furthermore, analysis of gene expression changes suggests that SrfJ may play a role in protecting Salmonella from host immune defenses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Veronica Urdaneta, Sara B. Hernandez, Josep Casadesus
SCIENTIFIC REPORTS
(2019)
