Review
Immunology
Chunjiao Zheng, Yuling Shi, Ying Zou
Summary: The use of immune checkpoint inhibitors (ICIs) in cancer treatment may lead to progressive atopic dermatitis (AD) by affecting T cell reactivation. T cell co-signaling pathways play a critical role in the pathogenesis of AD, determining the magnitude of the T cell response to antigens. Understanding these pathways is important for investigating the mechanism and treatment of AD.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Stinne R. Greisen, Maithri Aspari, Bent Deleuran
Summary: Immune checkpoint receptors play a crucial role in regulating immune responses, including generating a strong immune response, balancing the response, and protecting against tissue damage and autoimmune events. Inhibitory immune checkpoints, such as PD-1 and CTLA-4, have been shown to have a significant impact on cancer treatments. Blocking these pathways enhances immune activity, but can also lead to immune-related adverse events and the development of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Bernardo L. Rapoport, Helen C. Steel, Nomsa Hlatshwayo, Annette J. Theron, Pieter W. A. Meyer, Simon Nayler, Carol-Ann Benn, Teresa Smit, Luyanda L. I. Kwofie, Liezl Heyman, Ronald Anderson
Summary: Breast cancer cells exploit immune checkpoint proteins to evade immune responses, and newly diagnosed breast cancer patients have low levels of soluble immune checkpoint molecules, which is seemingly associated with systemic immune dysregulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Aleksander Gryciuk, Marta Rogalska, Joanna Baran, Lukasz Kuryk, Monika Staniszewska
Summary: In clinical trials, adenovirus vectors are commonly used for gene delivery therapy. Recent developments in molecular techniques have influenced the development of genetically engineered adenovirus vectors with therapeutic potential. This review provides a broad overview of oncolytic therapy and ongoing clinical trials based on oncolytic adenoviruses. HAdV-based strategies in immune oncology show promise in targeting tumors and can change the landscape of cancer treatment.
Review
Medicine, Research & Experimental
Bingyu Wang, Zaibo Zhang, Wenbo Liu, Bibo Tan
Summary: Gastric cancer is a common malignancy worldwide, and regulatory T cells (Tregs) play a crucial role in its pathogenesis and prognosis. This review discusses the role of Tregs in gastric cancer, and strategies for targeting Tregs through various mechanisms. It also highlights the importance of Tregs metabolism and the emerging role of microbiome and combined therapy in modulating Tregs in gastric cancer treatment. Additionally, a novel regulator, magnesium, is mentioned as being involved in mediating Tregs in gastric cancer. These research advances provide new insights and challenges for gastric cancer progression, treatment, and prognosis, and stimulate further discovery and implication of mediators and pathways targeting Tregs.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Immunology
Christian Schuetz, Xenofon Baraliakos
Summary: Ankylosing spondylitis is an inflammatory disease affecting musculoskeletal and extra-musculoskeletal sites. The immune system plays a crucial role in its pathogenesis, but the exact mechanism is still unclear. This review summarizes the available experimental and genetic data on immune checkpoint signals in ankylosing spondylitis, focusing on markers such as PD-1 and CTLA-4. The findings suggest an impaired negative immune regulation in this disease, providing potential targets for further research and treatment strategies.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Article
Immunology
Beatriz F. F. Corte-Real, Rebeca Arroyo Hornero, Aleksandra Dyczko, Ibrahim Hamad, Markus Kleinewietfeld
Summary: CSF2RB (CD131) may serve as a potential biomarker for autoimmune diseases in Tregs, with its overexpression potentially being linked to disease development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Norma A. Tellez-Navarrete, Lucero A. Ramon-Luing, Marcela Munoz-Torrico, Mario Preciado-Garcia, Karen Medina-Quero, Rogelio Hernandez-Pando, Leslie Chavez-Galan
Summary: The study found that after 6 months of anti-TB therapy, both drug-susceptible and drug-resistant tuberculosis patients showed changes in the expression levels of certain T cell subpopulations and related proteins. Additionally, drug-resistant tuberculosis patients exhibited a systemic inflammatory status after therapy.
MOLECULAR MEDICINE
(2021)
Review
Oncology
Dafne Mueller
Summary: The clinical approval of immune checkpoint inhibitors has advanced cancer immunotherapy, but their limited efficacy has led to the investigation of combination therapies. This review summarizes and discusses the development of agonists targeting co-stimulatory receptors of the TNF-SF as promising options to enhance immunomodulation. It provides an overview of current formats, trends, and clinical studies of recombinant antibody and ligand-based agonists of 4-1BB, OX40, and GITR in relation to the challenges posed by the TNFR-SF's structural and mechanistic features.
Review
Biochemistry & Molecular Biology
Muhammad Adnan Sabir Mughal, Muhammad Kasib Khan, Zaheer Abbas, Rao Zahid Abbas, Hammad Ur Rehman Bajwa, Abdullah Khalid Chatha, Muhammad Imran, Zia Ud Din Sindhu, Asghar Abbas, Arsalan Zafar, Muhammad Nadeem
Summary: Helminths, as long-term companions of humans, can live undetected in the tissues and provide protection against certain inflammatory diseases. Their immunomodulatory abilities are being explored for potential use in preventing diabetes and other autoimmune disorders.
MOLECULAR BIOLOGY REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Mackenzie M. Honikel, Scott H. Olejniczak
Summary: T cell engineering strategies, particularly CAR-T cell therapy, have shown great success in treating human cancer. The inclusion of a co-stimulatory domain in CARs plays a crucial role in CAR-T cell activation, proliferation, and anti-tumor efficacy. Currently, CAR-T therapy is FDA approved for hematological malignancies, and ongoing research explores the potential of multiple co-stimulatory molecules or domains to enhance CAR-T cell function.
Article
Environmental Sciences
Yang Cao, Ying-Lei Liu, Xiao-Yan Lu, Hai-Li Kai, Yun Han, Yan-Li Zheng
Summary: Ovarian cancer (OC) is associated with poor prognosis and regulatory T cells (Tregs) in the immune microenvironment. The correlation between Tregs-related genes (TRGs) and OC prognosis is not fully understood. This study identified potential TRGs and molecular subtypes using computational analysis and demonstrated their clinical relevance. The findings provide insights into the role of Tregs in OC and propose potential therapeutic targets and prognostic models for personalized treatment.
ENVIRONMENTAL TOXICOLOGY
(2023)
Review
Nutrition & Dietetics
Luis Fernando Mendez-Lopez, Deisy Sosa de Leon, Manuel Lopez-Cabanillas Lomeli, Blanca Edelia Gonzalez-Martinez, Jesus Alberto Vazquez-Rodriguez
Summary: This article reviews the potential role of phytocompounds in broad beans in the management of autoimmune diseases. The findings suggest that the compounds in broad beans may protect against autoimmune disease pathogenesis by modulating the AhR pathway.
FRONTIERS IN NUTRITION
(2022)
Review
Immunology
Osman Dadas, Ayse Ertay, Mark S. Cragg
Summary: The tumor necrosis factor superfamily and their receptors play important roles in regulating the immune system. Targeting these receptors for immunotherapy shows promise, but challenges remain in translating successful pre-clinical studies into clinical applications. This review discusses the importance of co-stimulatory members of the receptor family, the rationale for targeting them in immunotherapy, and the development of next generation agents to overcome limitations and provide effective and safe drugs for patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Carmen Reitinger, Andrea Ipsen-Escobedo, Chiara Hornung, Lukas Heger, Diana Dudziak, Anja Lux, Falk Nimmerjahn
Summary: Checkpoint control and immunomodulatory antibodies are important tools for modulating tumor or self-reactive immune responses. However, severe side effects limit their full potential. Choosing IgG subclasses with low Fc-γR interaction and glycoengineering can reduce these side effects and improve therapeutic window.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Prabhakaran Kumar, Ganesan Subramaniyam
Review
Biochemistry & Molecular Biology
Palash Bhattacharya, Muthusamy Thiruppathi, Hatem A. Elshabrawy, Khaled Alharshawi, Prabhakaran Kumar, Bellur S. Prabhakar
Article
Immunology
Christine S. Haddad, Palash Bhattacharya, Khaled Alharshawi, Alejandra Marinelarena, Prabhakaran Kumar, Osama El-Sayed, Hatem A. Elshabrawy, Alan L. Epstein, Bellur S. Prabhakar
Article
Multidisciplinary Sciences
Khaled Alharshawi, Alejandra Marinelarena, Prabhakaran Kumar, Osama El-Sayed, Palash Bhattacharya, Zuoming Sun, Alan L. Epstein, Ajay V. Maker, Bellur S. Prabhakar
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Prabhakaran Kumar, Khaled Alharshawi, Palash Bhattacharya, Alejandra Marinelarena, Christine Haddad, Zuoming Sun, Shigeru Chiba, Alan L. Epstein, Bellur S. Prabhakar
SCIENTIFIC REPORTS
(2017)
Article
Immunology
Prabhakaran Kumar, Alejandra Marinelarena, Divya Raghunathan, Vandhana K. Ragothaman, Shikha Saini, Palash Bhattacharya, Jilao Fan, Alan L. Epstein, Ajay V. Maker, Bellur S. Prabhakar
CELLULAR & MOLECULAR IMMUNOLOGY
(2019)
Article
Cell Biology
Prabhakaran Kumar, Shikha Saini, Saad Khan, Swarali Surendra Lele, Bellur S. Prabhakar
CELLULAR IMMUNOLOGY
(2019)
Article
Cell Biology
Prabhakaran Kumar, Kartiga Natarajan, Narkunaraja Shanmugam
CELLULAR SIGNALLING
(2014)
Article
Multidisciplinary Sciences
Alejandra Marinelarena, Palash Bhattacharya, Prabhakaran Kumar, Ajay V. Maker, Bellur S. Prabhakar
SCIENTIFIC REPORTS
(2018)
Review
Oncology
Prabhakaran Kumar, Shikha Saini, Bellur S. Prabhakar
SEMINARS IN CANCER BIOLOGY
(2020)
Article
Cell Biology
Shikha Saini, Lakshmi Sripada, Kiara Tulla, Prabhakaran Kumar, Fei Yue, Nicholas Kunda, Ajay V. Maker, Bellur S. Prabhakar
CELL DEATH & DISEASE
(2019)
Article
Immunology
Prabhakaran Kumar, Swarali Surendra Lele, Vandhana K. Ragothaman, Divya Raghunathan, Alan L. Epstein, Shigeru Chiba, Bellur S. Prabhakar
JOURNAL OF IMMUNOLOGY
(2019)
Article
Immunology
Prabhakaran Kumar, Sivasangari Balakrishnan, Swarali Surendra Lele, Suman Setty, Shaurya Dhingra, Alan L. Epstein, Bellur S. Prabhakar
Summary: T follicular regulatory (TFR) cells, which are specialized in suppressing germinal center (GC) B cell response, play an important role in lupus nephritis (LN). In this study, the researchers found a reduction in TFR cells and decreased TFR/TFH ratio in NZBWF1/j mice, which correlated with increased GC-B cells and proteinuria onset in LN. Treatment with soluble OX40L and Jagged-1 (JAG1) proteins increased TFR cells and TFR/TFH ratio, and reduced TFH cells, GC B cells, and anti-dsDNA IgG antibody levels, leading to suppression of LN onset. Mechanistic studies showed inhibited TFH functions and diminished GC events in treated mice. RNA sequencing studies revealed inhibition of HIF-1 alpha and STAT3 signaling in T cells from treated mice. Overall, the increased TFR/TFH ratio and restoration of homeostatic balance suppressed LN pathogenesis.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Physiology
Kelly N. Z. Fuller, Rudy J. Valentine, Edwin R. Miranda, Prabhakaran Kumar, Bellur S. Prabhakar, Jacob M. Haus
PHYSIOLOGICAL REPORTS
(2018)
Article
Immunology
Shane Kelly, Katherine J. L. Jackson, Timothy J. Peters, Dan Suan, Christopher C. Goodnow
Summary: This study successfully identified and characterized PR3-specific B cells from the peripheral blood of patients with PR3 autoantibodies. These cells exhibited specific immunological features, suggesting that PR3 self-reactivity may occur early in B-cell development.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Ana Merino-Vico, Jan Piet van Hamburg, Paul Tuijnenburg, Giulia Frazzei, Aram Al-Soudi, Carlo G. Bonasia, Boy Helder, Abraham Rutgers, Wayel H. Abdulahad, Coen A. Stegeman, Jan-Stephan Sanders, Laura Bergamaschi, Paul A. Lyons, Theo Bijma, Laura van Keep, Kirsten Wesenhagen, Aldo Jongejan, Henric Olsson, Niek de Vries, Taco W. Kuijpers, Peter Heeringa, Sander W. Tas
Summary: B lineage cells play a critical role in ANCA-associated vasculitis (AAV), and the transcription factor NF-kappa B may be a potential therapeutic target for AAV and other autoimmune diseases with prominent B cell involvement.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Christopher Nelke, Thomas Muentefering, Derya Cengiz, Lukas Theissen, Vera Dobelmann, Christina B. Schroeter, Helena Block, Corinna Preu, Alexander P. E. Michels, Stefanie Lichtenberg, Marc Pawlitzki, Steffen Pfeuffer, Niklas Huntemann, Alexander Zarbock, Thorben Briese, Christoph Kittl, Carsten Dittmayer, Thomas Budde, Ingrid E. Lundberg, Werner Stenzel, Sven G. Meuth, Tobias Ruck
Summary: K2P2.1 plays a regulatory role in the autoimmune response of idiopathic inflammatory myopathies (IIMs), by regulating inflammatory cell response, adhesion, and transmigration in both endothelial and skeletal muscle cells. Inhibiting K2P2.1 enhances the inflammatory response, while activating K2P2.1 improves the disease course.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Xuan Zhang, Jun Xia, Ying Jiang, David S. Pisetsky, Josef S. Smolen, Rong Mu, Shengming Dai, Michael E. Weinblatt, Tore K. Kvien, Juan Li, Thomas Doerner, Yu Zhang, Liwei Lu, Chengde Yang, Pingting Yang, Yuan Zhang, Chenchen Xu, Zhan Zhao, Peter E. Lipsky
Summary: The study suggests that TwHF may be as effective as MTX in treating active RA, and combination therapy may be more effective than monotherapy.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Maya F. Amjadi, Maxwell H. Parker, Ryan R. Adyniec, Zihao Zheng, Alex M. Robbins, S. Janna Bashar, Michael F. Denny, Sara S. Mccoy, Irene M. Ong, Miriam A. Shelef
Summary: Rheumatoid factors (RFs) are polyreactive antibodies that can bind disease-specific epitopes. Recent studies have found that RFs in COVID-19 can bind novel IgG epitopes, which provides new insights into the mechanism of RFs.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Johanne Liberatore, Yann Nguyen, Jerome Hadjadj, Pascal Cohen, Luc Mouthon, Xavier Puechal, Loic Guillevin, Benjamin Terrier
Summary: B-cell depletion induced by rituximab (RTX) in ANCA-associated vasculitis (AAV) can lead to decreased gammaglobulin levels, which is associated with an increased risk of relapse and severe infections. Older age, low gammaglobulin levels, and receiving pulses of methylprednisolone at induction therapy are risk factors for gammaglobulin decline.
JOURNAL OF AUTOIMMUNITY
(2024)