Article
Medicine, General & Internal
Igor Kudryavtsev, Yulia Zinchenko, Anna Starshinova, Maria Serebriakova, Anna Malkova, Tatiana Akisheva, Dmitriy Kudlay, Anzhela Glushkova, Piotr Yablonskiy, Yehuda Shoenfeld
Summary: This study aimed to evaluate the distribution and disturbance of circulating Treg cell subsets in patients with sarcoidosis. The results showed a decrease in the absolute numbers of Treg cells and several alterations in Treg cell subsets in patients with sarcoidosis. These findings suggest that the balance of Treg cell populations could be used for the diagnosis and prognosis of sarcoidosis.
Article
Biotechnology & Applied Microbiology
Elisavet Kaitetzidou, Gregor D. Gilfillan, Efthimia Antonopoulou, Elena Sarropoulou
Summary: This study investigated sex-biased mRNA and small non-coding RNA (sncRNA) expression patterns in the brain, adipose tissues, and gonads of the three-spined stickleback. Tissue-specific expression comprising both mRNA and sncRNA between sexes was demonstrated, emphasizing the importance of mRNA-miRNA interactions as well as new presumed genes not yet identified to have gender-specific roles.
Article
Biochemistry & Molecular Biology
Noora Puhakka, Shalini Das Gupta, Niina Vuokila, Asla Pitkanen
Summary: Neuroinflammation is a secondary injury mechanism that evolves in the brain for months after traumatic brain injury (TBI). This study found that altered small non-coding RNA (sncRNA) signature, especially dysregulation of miRNAs, plays a key role in modulating post-TBI secondary injury and neuroinflammation. These findings contribute to the development of better strategies for treating TBI and neuroinflammation.
Article
Nutrition & Dietetics
Amanda E. Bries, Joe L. Webb, Brooke Vogel, Claudia Carrillo, Timothy A. Day, Michael J. Kimber, Rudy J. Valentine, Matthew J. Rowling, Stephanie Clark, Kevin L. Schalinske, Elizabeth M. McNeill
Summary: Consumption of whole eggs for 2 weeks alters gene expression in the prefrontal cortex, visceral adipose tissue, and liver of rats, affecting pathways related to glutathione metabolism and cholesterol biosynthesis. These findings suggest that acute consumption of a diet containing whole eggs can impact key pathways involved in disease development.
FRONTIERS IN NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Tingting Zhu, Han Liu, Li Su, Ali Dawood, Changmin Hu, Xi Chen, Huanchun Chen, Yingyu Chen, Aizhen Guo
Summary: This study used RNA sequencing to analyze the miRNA expression changes in tuberculosis and identified 18 differentially expressed miRNAs in cells infected with the virulent strain of Mycobacterium tuberculosis. These miRNAs are mainly involved in apoptotic and interferon-gamma-mediated signaling pathways. The study also constructed a regulatory network to analyze the interactions among these miRNAs, target genes, and transcription factors, and confirmed the role of the BHLHE40-miR-378d-BHLHE40 axis in immune defense and evasion in tuberculosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Qian Yao, Qiuliang Ji, Ying Zhou
Summary: Pulmonary function tests play an important role in the diagnosis and treatment of sarcoidosis. While most patients have normal test results, some may experience a decline in lung function. A decrease in DLCO and FVC percentages can indicate clinically significant pathology and the need for treatment. During follow-up, changes in FVC and DLCO can reflect disease progression, and an improvement in FVC of more than 5% is considered an effective response to treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Daniel F. Cruz, Nilay Mitash, Fangping Mu, Carlos M. Farinha, Agnieszka Swiatecka-Urban
Summary: This study reveals the regulatory network of LMTK2 and its intersection with the TGF-beta 1 signaling pathway, demonstrating the important role of LMTK2 in cellular functions and disease pathways.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Siriluck Ponsuksili, Frieder Hadlich, Henry Reyer, Michael Oster, Nares Trakooljul, Muhammad A. Iqbal, Vera Sommerfeld, Markus Rodehutscord, Klaus Wimmers
Summary: The study reveals the importance of miRNAs in intestinal functions and nutritional uptake. Comparative miRNAs profiles between LB and LSL genetic backgrounds of laying hens show differences in energy pathways for LB and immune and bone signaling pathways for LSL, with the most significant expression differences observed between 16 to 24 weeks of age.
Article
Veterinary Sciences
Zhuo-Ma Luoreng, Jian Yang, Xing-Ping Wang, Da-Wei Wei, Lin-Sen Zan
Summary: Staphylococcus aureus infection causes mastitis in dairy cows, affecting milk quality and economic benefits. The study identified differentially expressed miRNAs that may regulate inflammation processes, with specific miRNAs showing significant expression changes on days 5 and 7, potentially playing important biological roles in mastitis and guiding research into molecular therapy technologies.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Respiratory System
Praveen Weeratunga, David R. Moller, Ling-Pei Ho
Summary: This article examines the immune findings in fibrotic sarcoidosis and proposes a unified mechanism for the pathobiology of fibrosis in sarcoidosis.
EUROPEAN RESPIRATORY REVIEW
(2022)
Review
Critical Care Medicine
Rohit Gupta, Marc A. Judson, Robert P. Baughman
Summary: Advanced sarcoidosis is a form of sarcoidosis that poses a significant risk of organ function loss or death, with the lung being the most commonly affected organ. It can lead to complications such as pulmonary fibrosis and bronchiectasis. Although it affects a small proportion of patients, it is the leading cause of poor outcomes.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Medicine, General & Internal
Marc A. Judson
Summary: This manuscript provides a comprehensive review of the etiology, measurement, and treatment of common pulmonary symptoms associated with sarcoidosis. It emphasizes the importance of thorough assessment of symptoms, as they serve as useful tools in diagnosis and treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Juliana Dias Lourenco, Juliana Tiyaki Ito, Milton de Arruda Martins, Iolanda de Fatima Lopes Calvo Tiberio, Fernanda Degobbi Tenorio Quirino dos Santos Lopes
Summary: The imbalance between pro-inflammatory Th17 and anti-inflammatory Treg cells plays a crucial role in the development and progression of inflammation in COPD. Studies evaluating treatments targeting Th17/Treg cells have shown conflicting results, which vary based on lung compartments, COPD stages, or local and systemic markers. Careful examination of the data is necessary.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Jan C. Grutters
Summary: Pulmonary sarcoidosis is the most common manifestation of sarcoidosis and poses challenges for diagnosis. Clinical presentation, evidence of granuloma formation, and exclusion of other diseases are the three criteria to consider. Multiple diagnostic tools are available, but the invasiveness and risk to the patient should be evaluated. In specific situations, a working diagnosis of sarcoidosis can be made without further invasive procedures, but close follow-up is necessary.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Erik R. Abels, Lisa Nieland, Suzanne Hickman, Marike L. D. Broekman, Joseph El Khoury, Sybren L. N. Maas
Summary: The study identified a core set of genes that are conserved in microglia of both mouse and human, termed as the microglia core sensome. The changes in the expression levels of microglial sensome genes were found to be specific to different diseases or conditions. The relevance of mouse-generated data for understanding human microglia biology was highlighted, emphasizing the importance of species-specific gene sets in disease investigations involving microglia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Allergy
Yusef Eamon Badi, Ana B. Pavel, Stelios Pavlidis, John H. Riley, Stewart Bates, Nazanin Zounemat Kermani, Richard Knowles, Johan Kolmert, Craig E. Wheelock, Sally Worsley, Mohib Uddin, Kjell Alving, Per S. Bakke, Annelie Behndig, Massimo Caruso, Pascal Chanez, Louise J. Fleming, Stephen J. Fowler, Urs Frey, Peter Howarth, Ildiko Horvath, Norbert Krug, Anke H. Maitland-van der Zee, Paolo Montuschi, Graham Roberts, Marek Sanak, Dominick E. Shaw, Florian Singer, Peter J. Sterk, Ratko Djukanovic, Sven-Eric Dahlen, Yi-Ke Guo, Kian Fan Chung, Emma Guttman-Yassky, Ian M. Adcock
Summary: The disease signature identified in atopic dermatitis (AD) can also be seen in adults with severe asthma, and the transcriptomic signature of AD patients who respond to anti-IL-22 therapy is enriched in severe asthma. The AD disease signature is enriched in the blood and sputum of patients with asthma and is correlated with the severity of asthma. The FZ-response signature is enriched in the blood and sputum of asthmatic patients and is correlated with the presence of neutrophils and mixed granulocytes in the sputum.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Behavioral Sciences
Irena Smaga, Karolina Wydra, Kacper Witek, Paulina Surpwla, Agata Suder, Renata Pieniazek, Lucia Caffino, Fabio Fumagalli, Marek Sanak, Malgorzata Filip
Summary: This study demonstrated that Tat-NR2B9c attenuated cocaine seeking behavior and cue-induced reinstatement in rats, while also reducing levels of GluN2B/PSD95 complexes in the ventral hippocampus. These findings suggest that disrupting GluN2B/PSD95 complexes during cocaine abstinence and extinction training may be a helpful strategy in reducing reinstatement of cocaine-seeking behavior.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Immunology
Marcin Surmiak, Katarzyna Wawrzycka-Adamczyk, Joanna Kosalka-Wegiel, Stanisnaw Polanski, Marek Sanak
Summary: This study characterized the profile of microRNAs trafficked by extracellular vesicles (EVs) in patients with granulomatosis with polyangiitis (GPA). Four differentially expressed microRNAs were identified in EVs from GPA patients, with miR-223-3p being the best discriminator between GPA patients and healthy controls. MiR-664a-3p was able to discriminate between active and remission phases of GPA. The correct classification rate based on multivariate discriminant analysis was 92% for acute phase and 85% for all study participants. Pathway analysis revealed potential target genes of these microRNAs, involved in focal adhesion, mTOR signaling, and neutrophil extracellular traps formation. Two microRNAs positively correlated with disease activity were found to be involved in neutrophil extracellular traps formation and apoptosis inhibition.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Letter
Allergy
Lucyna Mastalerz, Radoslaw Kacorzyk, Bogdan Jakiela, Adam Cmiel, Marek Sanak
Article
Allergy
Bogdan Jakiela, Jerzy Soja, Krzysztof Sladek, Marek Przybyszowski, Hanna Plutecka, Anna Gielicz, Sabina Licholai, Alar Aab, Ana Rebane, Grazyna Bochenek
Summary: This study characterized the immunological endotypes of nonsteroidal anti-inflammatory drugs-exacerbated respiratory disease (N-ERD) based on gene expression profiles. The results showed the presence of a T2-high endotype and a proinflammatory endotype in N-ERD patients. The T2-high endotype was characterized by increased expression of mast cell and eosinophil markers, goblet cell hyperplasia, and elevated LTE4 and PGD2 concentrations in bronchoalveolar lavage fluid (BALF). The proinflammatory endotype was associated with neutrophilic inflammation, increased innate immunity mediators in BALF, and a more severe course of asthma with marked airway obstruction.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Stanislawa Bazan-Socha, Bogdan Jakiela
Article
Biochemistry & Molecular Biology
Pawel Kozlik-Siwiec, Sylwia Buregwa-Czuma, Izabela Zawlik, Sylwia Dziedzina, Aleksander Myszka, Joanna Zuk-Kuwik, Andzelika Siwiec-Kozlik, Jacek Zarychta, Krzysztof Okon, Lech Zareba, Jerzy Soja, Bogdan Jakiela, Michal Kepski, Jan G. Bazan, Stanislawa Bazan-Socha
Summary: This study compared the phenotypic features, bronchial epithelial gene expression, and functional and structural measures of airway remodeling between moderate to severe eosinophilic asthma (EA) and non-eosinophilic asthma (NEA) patients. The results showed that there was no significant difference in airway remodeling between EA and NEA patients, but EA patients had increased expression of genes involved in immune response and inflammation, and decreased expression of genes involved in epithelial integrity and histone acetylation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Urszula Radzikowska, Andrzej Eljaszewicz, Ge Tan, Nino Stocker, Anja Heider, Patrick Westermann, Silvio Steiner, Anita Dreher, Paulina Wawrzyniak, Beate Ruckert, Juan Rodriguez-Coira, Damir Zhakparov, Mengting Huang, Bogdan Jakiela, Marek Sanak, Marcin Moniuszko, Liam O'Mahony, Marek Jutel, Tatiana Kebadze, J. David Jackson, R. Michael Edwards, Volker Thiel, L. Sebastian Johnston, A. Cezmi Akdis, Milena Sokolowska
Summary: Viral infections and exposure to inhaled allergens, such as rhinovirus and house dust mite, are associated with asthma exacerbations. In this study, the authors found that rhinovirus-induced activation of the RIG-I inflammasome suppresses antiviral immunity, promotes inflammation, and aggravates subsequent infection with SARS-CoV-2, particularly after exposure to house dust mite. Understanding these mechanisms could lead to more effective treatment strategies for asthma and respiratory virus infections.
NATURE COMMUNICATIONS
(2023)
Article
Allergy
Lucyna Mastalerz, Natalia Celejewska-Wojcik, Adam Cmiel, Krzysztof Wojcik, Joanna Szaleniec, Karolina Hydzik-Sobocinska, Jerzy Tomik, Marek Sanak
Summary: This study examined the heterogeneity of non-eosinophilic asthma (NEA) with aspirin hypersensitivity in patients with nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD). Four NEA subtypes were identified based on clinical and laboratory data, with distinct inflammatory signatures and asthma severity. Sputum prostaglandin D-2 levels were found to be a distinguishing factor among these subtypes.
CLINICAL AND TRANSLATIONAL ALLERGY
(2023)
Article
Immunology
Monika Bociaga-Jasik, Martyna Lara, Aleksandra Raczynska, Barbara Wizner, Stanislaw Polanski, Ewa Mlicka-Kowalczyk, Aleksander Garlicki, Marek Sanak
Summary: This study evaluated the immune response of 121 PLWH after receiving COVID-19 vaccines. The majority of patients who received mRNA vaccines developed an immune response, while a small number of patients did not. The mRNA-1273 vaccine showed the best immune response in this population.
Article
Allergy
Jerzy Soja, Karolina Gorka, Iwona Gross-Sondej, Bogdan Jakieta, Stawomir Mikrut, Krzysztof Okon, Adam Cmiel, Piotr Sadowski, Wojciech Szczeklik, Anna Andrychiewicz, Tomasz Stachura, Grazyna Bochenek, Stanistawa Bazan-Socha, Krzysztof Stadek
Summary: The aim of this study was to validate the use of endobronchial ultrasound (EBUS) in assessing the effectiveness of bronchial thermoplasty (BT) treatment for severe asthma. BT was found to significantly decrease the thickness of bronchial wall layers and reduce the mass of airway smooth muscle. However, EBUS was not able to predict the clinical response to BT therapy.
JOURNAL OF ASTHMA AND ALLERGY
(2023)
Article
Biochemistry & Molecular Biology
Sabina Licholai, Dorota Studzinska, Hanna Plutecka, Tomasz Gubala, Marek Sanak
Summary: Non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, have been extensively studied for their ability to regulate cellular processes. However, the interactions between these molecules and the biogenesis of circular RNAs remain unclear. In this study, we analyzed the circular RNAs in endothelial cells and identified their expression across the genome. We also proposed computational strategies to identify potentially functional molecules and demonstrated the altered expression levels of circRNAs mediated by microRNAs using an in vitro model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Dorota Mizera, Radoslaw Dziedzic, Anna Drynda, Ada Gradzikiewicz, Bogdan Jakiela, Magdalena Celinska-Lowenhoff, Agnieszka Padjas, Aleksandra Matyja-Bednarczyk, Lech Zareba, Stanislawa Bazan-Socha
Summary: This study analyzed virus-specific T-cell responses in primary antibody deficiency (PAD) patients after booster vaccination against SARS-CoV-2. The results showed that vaccinated PAD patients had increased release of interferon-gamma and higher levels of anti-SARS-CoV-2 IgG. Subgroup analysis revealed similar T-cell responses in CVID and unclassified IgG deficiencies, which were significantly higher compared to XLA and isotype defects or IgG subclass deficiencies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Materials Science, Biomaterials
Aldona Mzyk, Gabriela Imbir, Yuri Noguchi, Marek Sanak, Roman Major, Justyna Wiecek, Przemyslaw Kurtyka, Hanna Plutecka, Klaudia Trembecka-Wojciga, Yasuhiko Iwasaki, Masato Ueda, Sachiro Kakinoki
Summary: The blood compatibility of self-assembled monolayers (SAMs) of oligoproline was studied and found to strongly suppress the adsorption of blood components and the adhesion of blood cells, especially the activation of platelets.
BIOMATERIALS SCIENCE
(2022)
Article
Immunology
Shane Kelly, Katherine J. L. Jackson, Timothy J. Peters, Dan Suan, Christopher C. Goodnow
Summary: This study successfully identified and characterized PR3-specific B cells from the peripheral blood of patients with PR3 autoantibodies. These cells exhibited specific immunological features, suggesting that PR3 self-reactivity may occur early in B-cell development.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Ana Merino-Vico, Jan Piet van Hamburg, Paul Tuijnenburg, Giulia Frazzei, Aram Al-Soudi, Carlo G. Bonasia, Boy Helder, Abraham Rutgers, Wayel H. Abdulahad, Coen A. Stegeman, Jan-Stephan Sanders, Laura Bergamaschi, Paul A. Lyons, Theo Bijma, Laura van Keep, Kirsten Wesenhagen, Aldo Jongejan, Henric Olsson, Niek de Vries, Taco W. Kuijpers, Peter Heeringa, Sander W. Tas
Summary: B lineage cells play a critical role in ANCA-associated vasculitis (AAV), and the transcription factor NF-kappa B may be a potential therapeutic target for AAV and other autoimmune diseases with prominent B cell involvement.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Christopher Nelke, Thomas Muentefering, Derya Cengiz, Lukas Theissen, Vera Dobelmann, Christina B. Schroeter, Helena Block, Corinna Preu, Alexander P. E. Michels, Stefanie Lichtenberg, Marc Pawlitzki, Steffen Pfeuffer, Niklas Huntemann, Alexander Zarbock, Thorben Briese, Christoph Kittl, Carsten Dittmayer, Thomas Budde, Ingrid E. Lundberg, Werner Stenzel, Sven G. Meuth, Tobias Ruck
Summary: K2P2.1 plays a regulatory role in the autoimmune response of idiopathic inflammatory myopathies (IIMs), by regulating inflammatory cell response, adhesion, and transmigration in both endothelial and skeletal muscle cells. Inhibiting K2P2.1 enhances the inflammatory response, while activating K2P2.1 improves the disease course.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Xuan Zhang, Jun Xia, Ying Jiang, David S. Pisetsky, Josef S. Smolen, Rong Mu, Shengming Dai, Michael E. Weinblatt, Tore K. Kvien, Juan Li, Thomas Doerner, Yu Zhang, Liwei Lu, Chengde Yang, Pingting Yang, Yuan Zhang, Chenchen Xu, Zhan Zhao, Peter E. Lipsky
Summary: The study suggests that TwHF may be as effective as MTX in treating active RA, and combination therapy may be more effective than monotherapy.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Maya F. Amjadi, Maxwell H. Parker, Ryan R. Adyniec, Zihao Zheng, Alex M. Robbins, S. Janna Bashar, Michael F. Denny, Sara S. Mccoy, Irene M. Ong, Miriam A. Shelef
Summary: Rheumatoid factors (RFs) are polyreactive antibodies that can bind disease-specific epitopes. Recent studies have found that RFs in COVID-19 can bind novel IgG epitopes, which provides new insights into the mechanism of RFs.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Johanne Liberatore, Yann Nguyen, Jerome Hadjadj, Pascal Cohen, Luc Mouthon, Xavier Puechal, Loic Guillevin, Benjamin Terrier
Summary: B-cell depletion induced by rituximab (RTX) in ANCA-associated vasculitis (AAV) can lead to decreased gammaglobulin levels, which is associated with an increased risk of relapse and severe infections. Older age, low gammaglobulin levels, and receiving pulses of methylprednisolone at induction therapy are risk factors for gammaglobulin decline.
JOURNAL OF AUTOIMMUNITY
(2024)