Article
Hematology
Julia Stomper, Paulina Richter-Pechanska, Dietmar Pfeifer, Immacolata Andolfo, Achille Iolascon, Martina U. Muckenthaler, Michael Luebbert
Summary: This study describes sustained and dose-dependent erythroid improvement in a patient with constitutional variants in the TRIB2 and ABCB6 genes after treatment with DFX.
Article
Biochemistry & Molecular Biology
Sam A. Jamieson, Michael Pudjihartono, Christopher R. Horne, Juan Salamanca Viloria, Jessica L. Dunlop, Hamish D. McMillan, Robert C. Day, Karen Keeshan, James M. Murphy, Peter D. Mace
Summary: This study reports the identification of nanobodies that bind the TRIB2 pseudokinase domain and stabilize a TRIB2 pseudokinase domain dimer. The nanobodies specifically recognize TRIB2 in an activated conformation. These findings provide insights for the development of TRIB2 inhibitors and nanobody tools for future research.
Review
Cell Biology
Yu Fang, Angelina Olegovna Zekiy, Farhoodeh Ghaedrahmati, Anton Timoshin, Maryam Farzaneh, Amir Anbiyaiee, Seyed Esmaeil Khoshnam
Summary: Trib2 is a pseudo serine/threonine kinase that plays important roles in regulating key signaling pathways and cell fate determination.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Cell Biology
Yuan-Rong Liu, Dan-Dan Song, Dong-Min Liang, You-Jie Li, Yun-Fei Yan, Hong-Fang Sun, Mei-Ling Zhang, Jin-Xia Hu, Yu-Long Zhao, Yan Liang, Yan-Mei Li, Zhen Yang, Ran-Ran Wang, Hou-Feng Zheng, Pingyu Wang, Shu-Yang Xie
Summary: This study demonstrates that TRIB2 can directly phosphorylate PKM2 in cancer cells and promote its nuclear translocation, leading to increased expression of aerobic glycolysis-related genes. This enhances cancer cell proliferation and migration while reducing cellular ATP content.
CELL DEATH DISCOVERY
(2022)
Article
Oncology
Nianxue Wang, Jing Wen, Wei Ren, Yuting Wu, Chaonan Deng
Summary: The study revealed that upregulation of TRIB2 through Wnt/beta-catenin activation leads to resistance to vemurafenib in PTC with BRAF(V600) mutation. TRIB2 could potentially be a therapeutic target for resistant PTC.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2021)
Review
Immunology
Roland S. Liblau, Daniela Latorre, Birgitte R. Kornum, Yves Dauvilliers, Emmanuel J. Mignot
Summary: Narcolepsy type 1 (NT1) is a chronic sleep disorder caused by the loss of certain hypothalamic neurons. It is suspected to have an immune-mediated basis, supported by genetic evidence and increased incidence after vaccination. The search for antigens recognized by pathogenic T cell response in NT1 is ongoing, and animal models provide insights into the roles of autoreactive T cells.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Zain Ul Abadeen, Muhammad Tariq Javed, Tariq Jamil, Azam Ali Nasir
Summary: This study evaluated the ameliorative effects of antibody in necrotic enteritis (NE) in poultry. Passive immunization showed improvements in behavior and lesions, suggesting a potential treatment method. However, further studies regarding safe production and reliable application are still needed.
Article
Biotechnology & Applied Microbiology
Marshall S. Goodwin, Olga Sinyavskaya, Franklin Burg, Veronica O'Neal, Carolina Ceballos-Diaz, Pedro E. Cruz, Jada Lewis, Benoit Giasson, Peter Davies, Todd E. Golde, Yona Levites
Summary: The efficacy of disease modification does not necessarily require antibody effector functions; intracellular targeting of tau with phosphorylated tau-specific iBs is more effective than extracellular targeting with scFvs; robust effects on tau pathology before neurodegeneration only resulted in modest disease modification as assessed by delay of severe motor phenotype.
Article
Hematology
Maddalena Casale, Maria Grazia Di Girolamo, Nicoletta Di Maio, Rita Tomeo, Martina Iengo, Saverio Scianguetta, Teresa Palma, Federica Porcelli, Saverio Misso, Silverio Perrotta
Summary: This study demonstrates that deplasmated and leukodepleted red blood cells (RBCs) do not contain significant amounts of immune globulin, and transfusions with these RBCs do not require delayed vaccinations. The removal of IgG content from the RBC units ensures the absence of anti-COVID-19 antibodies, even from donors with high serum titre.
ANNALS OF HEMATOLOGY
(2023)
Article
Medicine, Research & Experimental
T. V. Davydova, M. A. Gruden, V. S. Kudrin, V. B. Narkevich, L. A. Vetrile, I. A. Zakharova, R. D. E. Sewell
Summary: The study showed that delayed administration of anti-glutamate antibodies in aging mice can significantly improve memory function, with persistent changes in neurotransmitter levels after treatment cessation. This research reveals the potential long-term effects of anti-glutamate antibodies on brain function.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Medicine, Research & Experimental
Shaukat Ali, Elisha Shalim, Farah Farhan, Fatima Anjum, Ayesha Ali, Syed Muneeb Uddin, Faisal Shahab, Mustafa Haider, Iqra Ahmed, Mir Rashid Ali, Sadaf Khan, Sadia Rao, Kabeer Guriro, Saud Elahi, Muhammad Ali, Tehreem Mushtaq, Muneeba Ahsan Sayeed, Sheikh Muhammad Muhaymin, Shoba Luxmi, Saifullah, Saeed Qureshi
Summary: This study aims to evaluate the safety and efficacy of hyperimmune anti-COVID-19 intravenous immunoglobulin (C-IVIG) in severe COVID-19 patients, providing clinical evidence for the use of C-IVIG as a first-line therapeutic option for severe COVID-19 patients.
Article
Engineering, Biomedical
Gabriel Rojas-Jimenez, Daniela Solano, Alvaro Segura, Andres Sanchez, Stephanie Chaves-Araya, Maria Herrera, Mariangela Vargas, Maykel Cerdas, Gerardo Calvo, Jonathan Alfaro, Sebastian Molina, Kimberly Bolanos, Andres Moreira-Soto, Mauren Villalta, Adriana Sanchez, Daniel Cordero, Gina Duran, Gabriela Solano, Aaron Gomez, Andres Hernandez, Laura Sanchez, Marco Vargas, Jean Felix Drexler, Alberto Alape-Giron, Cecilia Diaz, Guillermo Leon
Summary: A study found that intravenous immunoglobulins (IVIg) prepared using caprylic acid precipitation have higher immunological efficacy and neutralizing antibody concentrations against SARS-CoV-2 compared to IVIg prepared from convalescent plasma. Caprylic acid precipitation could be a simple, feasible, and affordable alternative for producing IVIg formulations to combat the COVID-19 pandemic in middle and low-income countries.
FRONTIERS IN MEDICAL TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zehavit Goldberg, Ifat Sher, Lamis Qassim, Joab Chapman, Ygal Rotenstreich, Efrat Shavit-Stein
Summary: This study characterized the distribution of thrombin receptor PAR1 in the neuroretina and suggested a potential role of the thrombin pathway in retinal function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Jeremy Manry, Paul Bastard, Adrian Gervais, Tom Le Voyer, Jeremie Rosain, Quentin Philippot, Eleftherios Michailidis, Hans-Heinrich Hoffmann, Shohei Eto, Marina Garcia-Prat, Lucy Bizien, Alba Parra-Martinez, Rui Yang, Liis Haljasmagi, Melanie Migaud, Karita Sarekannu, Julia Maslovskaja, Nicolas de Prost, Yacine Tandjaoui-Lambiotte, Charles-Edouard Luyt, Blanca Amador-Borrero, Alexandre Gaudet, Julien Poissy, Pascal Morel, Pascale Richard, Fabrice Cognasse, Jesus Troya, Sophie Trouillet-Assant, Alexandre Belot, Kahina Saker, Pierre Garcon, Jacques G. Riviere, Jean-Christophe Lagier, Stephanie Gentile, Lindsey B. Rosen, Elana Shaw, Tomohiro Morio, Junko Tanaka, David Dalmau, Pierre-Louis Tharaux, Damien Sene, Alain Stepanian, Bruno Megarbane, Vasiliki Triantafyllia, Arnaud Fekkar, James R. Heath, Jose Luis Franco, Juan-Manuel Anaya, Jordi Sole-Violan, Luisa Imberti, Andrea Biondi, Paolo Bonfanti, Riccardo Castagnoli, Ottavia M. Delmonte, Yu Zhang, Andrew L. Snow, Steven M. Holland, Catherine M. Biggs, Marcela Moncada-Velez, Andres Augusto Arias, Lazaro Lorenzo, Soraya Boucherit, Dany Anglicheau, Anna M. Planas, Filomeen Haerynck, Sotirija Duvlis, Tayfun Ozcelik, Sevgi Keles, Ahmed A. Bousfiha, Jalila El Bakkouri, Carolina Ramirez-Santana, Stephane Paul, Qiang Pan-Hammarstrom, Lennart Hammarstrom, Annabelle Dupont, Alina Kurolap, Christine N. Metz, Alessandro Aiuti, Giorgio Casari, Vito Lampasona, Fabio Ciceri, Lucila A. Barreiros, Elena Dominguez-Garrido, Mateus Vidigal, Mayana Zatz, Diederik van de Beek, Sabina Sahanic, Ivan Tancevski, Yurii Stepanovskyy, Oksana Boyarchuk, Yoko Nukui, Miyuki Tsumura, Loreto Vidaur, Stuart G. Tangye, Sonia Burrel, Darragh Duffy, Lluis Quintana-Murci, Adam Klocperk, Nelli Y. Kann, Anna Shcherbina, Yu-Lung Lau, Daniel Leung, Matthieu Coulongeat, Julien Marlet, Rutger Koning, Luis Felipe Reyes, Angelique Chauvineau-Grenier, Fabienne Venet, Guillaume Monneret, Michel C. Nussenzweig, Romain Arrestier, Idris Boudhabhay, Hagit Baris-Feldman, David Hagin, Joost Wauters, Isabelle Meyts, Adam H. Dyer, Sean Kennelly, Nollaig M. Bourkeh, Rabih Halwan, Fatemeh Saheb Sharif-Askar, Karim Dorgham, Jerome Sallette, Souad Mehlal Sedkaoui, Suzan AlKhater, Raul Rigo-Bonnin, Francisco Morandeira, Lucie Roussel, Donald C. Vinh, Christian Erikstrup, Antonio Condino-Neto, Carolina Prando, Anastasiia Bondarenko, Andras N. Spaan, Laurent Gilardin, Jacques Fellay, Stanislas Lyonnet, Kaya Bilguvar, Richard P. Lifton, Shrikant Mane, Mark S. Anderson, Bertrand Boisson, Vivien Beziat, Shen-Ying Zhang, Evangelos Andreakos, Olivier Hermine, Aurora Pujol, Part Peterson, Trine H. Mogensen, Lee Rowen, James Mond, Stephanie Debette, Xavier de Lamballerie, Charles Burdet, Lila Bouadma, Marie Zins, Pere Soler-Palacin, Roger Colobran, Guy Gorochov, Xavier Solanich, Sophie Susen, Javier Martinez-Picado, Didier Raoult, Marc Vasse, Peter K. Gregersen, Lorenzo Piemonti, Carlos Rodriguez-Gallego, Luigi D Notarangelo, Helen C. Su, Kai Kisand, Satoshi Okada, Anne Puel, Emmanuelle Jouanguy, Charles M. Rice, Pierre Tiberghien, Qian Zhang, Jean-Laurent Casanova, Laurent Abel, Aurelie Cobat
Summary: This study investigates the impact of autoimmunity on COVID-19-related deaths and finds that individuals carrying autoantibodies neutralizing type I interferons are at higher risk of death, with the risk decreasing with age.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Infectious Diseases
Manuel Rojas, Yhojan Rodriguez, Juan Carlos Hernandez, Juan C. Diaz-Coronado, Jose Alejandro Daza Vergara, Veronica Posada Velez, Jessica Porras Mancilla, Ivan Araujo, Jairo Torres Yepes, Oscar Briceno Ricaurte, Juan Mauricio Pardo-Oviedo, Diana M. Monsalve, Yeny Acosta-Ampudia, Carolina Ramirez-Santana, Paula Gaviria Garcia, Lina Acevedo Landinez, Luisa Duarte Correales, Jeser Santiago Grass, Cristian Ricaurte Perez, Gustavo Salguero Lopez, Nataly Mateus, Laura Mancera, Ronald Rengifo Devia, Juan Esteban Orjuela, Christian R. Parra-Moreno, Andres Alfonso Buitrago, Ines Elvira Ordonez, Claudia Fabra Osorio, Nathalia Ballesteros, Luz H. Patino, Sergio Castaneda, Marina Munoz, Juan David Ramirez, Paul Bastard, Adrian Gervais, Lucy Bizien, Jean-Laurent Casanova, Bernardo Camacho, Juan Esteban Gallo, Oscar Gomez, Adriana Rojas-Villarraga, Carlos E. Perez, Ruben Manrique, Ruben D. Mantilla, Juan-Manuel Anaya
Summary: The use of convalescent plasma (CP) in the early stages of COVID-19 did not lead to a reduction in viral load, but it was found to be safe and may reduce hospital stay.
BMC INFECTIOUS DISEASES
(2022)
Article
Immunology
Juan-Manuel Anaya, Maria Herran, Santiago Beltran, Manuel Rojas
Summary: This article introduces the post-COVID syndrome (PCS) and its mechanisms related to autoimmunity. The author emphasizes the importance of defining and classifying PCS, and suggests the need for longitudinal and controlled studies to better understand PCS. It is also noted that with the increasing prevalence of COVID-19 cases, there may be an increase in autoimmune diseases.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Bhuwan Khatri, Kandice L. Tessneer, Astrid Rasmussen, Farhang Aghakhanian, Tove Ragna Reksten, Adam Adler, Ilias Alevizos, Juan-Manuel Anaya, Lara A. Aqrawi, Eva Baecklund, Johan G. Brun, Sara Magnusson Bucher, Maija-Leena Eloranta, Fiona Engelke, Helena Forsblad-d'Elia, Stuart B. Glenn, Daniel Hammenfors, Juliana Imgenberg-Kreuz, Janicke Liaaen Jensen, Svein Joar Auglaend Johnsen, Malin Jonsson, Marika Kvarnstrom, Jennifer A. Kelly, He Li, Thomas Mandl, Javier Martin, Gaetane Nocturne, Katrine Braekke Norheim, Oyvind Palm, Kathrine Skarstein, Anna M. Stolarczyk, Kimberly E. Taylor, Maria Teruel, Elke Theander, Swamy Venuturupalli, Daniel J. Wallace, Kiely M. Grundahl, Kimberly S. Hefner, Lida Radfar, David M. Lewis, Donald U. Stone, C. Erick Kaufman, Michael T. Brennan, Joel M. Guthridge, Judith A. James, R. Hal Scofield, Patrick M. Gaffney, Lindsey A. Criswell, Roland Jonsson, Per Eriksson, Simon J. Bowman, Roald Omdal, Lars Ronnblom, Blake Warner, Maureen Rischmueller, Torsten Witte, A. Darise Farris, Xavier Mariette, Marta E. Alarcon-Riquelme, Caroline H. Shiboski, Marie Wahren-Herlenius, Wan-Fai Ng, Kathy L. Sivils, Indra Adrianto, Gunnel Nordmark, Christopher J. Lessard
Summary: This study identifies ten novel genetic risk regions associated with Sjogren's disease, implicating genes involved in immune and salivary gland function.
NATURE COMMUNICATIONS
(2022)
Review
Immunology
Yhojan Rodriguez, Manuel Rojas, Santiago Beltran, Fernando Polo, Laura Camacho-Dominguez, Samuel David Morales, M. Eric Gershwin, Juan-Manuel Anaya
Summary: This study suggests a potential association between COVID-19 vaccination and autoimmune and inflammatory diseases. New-onset conditions were more common, with immune thrombocytopenia, myocarditis, and Guillain-Barre syndrome being the most common diseases associated with new-onset events. Some diseases may relapse after vaccination. Further large-scale studies are needed to validate this relationship.
JOURNAL OF AUTOIMMUNITY
(2022)
Correction
Multidisciplinary Sciences
Bhuwan Khatri, Kandice L. Tessneer, Astrid Rasmussen, Farhang Aghakhanian, Tove Ragna Reksten, Adam Adler, Ilias Alevizos, Juan-Manuel Anaya, Lara A. Aqrawi, Eva Baecklund, Johan G. Brun, Sara Magnusson Bucher, Maija-Leena Eloranta, Fiona Engelke, Helena Forsblad-d'Elia, Stuart B. Glenn, Daniel Hammenfors, Juliana Imgenberg-Kreuz, Janicke Liaaen Jensen, Svein Joar Auglaend Johnsen, Malin V. Jonsson, Marika Kvarnstrom, Jennifer A. Kelly, He Li, Thomas Mandl, Javier Martin, Gaetane Nocturne, Katrine Braekke Norheim, Oyvind Palm, Kathrine Skarstein, Anna M. Stolarczyk, Kimberly E. Taylor, Maria Teruel, Elke Theander, Swamy Venuturupalli, Daniel J. Wallace, Kiely M. Grundahl, Kimberly S. Hefner, Lida Radfar, David M. Lewis, Donald U. Stone, C. Erick Kaufman, Michael T. Brennan, Joel M. Guthridge, Judith A. James, R. Hal Scofield, Patrick M. Gaffney, Lindsey A. Criswell, Roland Jonsson, Per Eriksson, Simon J. Bowman, Roald Omdal, Lars Ronnblom, Blake Warner, Maureen Rischmueller, Torsten Witte, A. Darise Farris, Xavier Mariette, Marta E. Alarcon-Riquelme, Caroline H. Shiboski, Marie Wahren-Herlenius, Wan-Fai Ng, Kathy L. Sivils, Indra Adrianto, Gunnel Nordmark, Christopher J. Lessard
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Shinichi Hayashi, Souichi Oe, Taro Koike, Ryohei Seki-Omura, Yosuke Nakano, Yukie Hirahara, Susumu Tanaka, Takeshi Ito, Yoshiki Yasukochi, Koichiro Higasa, Masaaki Kitada
Summary: Cells possess inheritable features that maintain a unique gene expression pattern and contribute to cellular memory. Some transcription factors, including OLIG2, can be retained in mitotic chromosomes and participate in cellular memory. In the neural tube of mouse embryos, OLIG2 binds to chromatin through every cell cycle, indicating its role as an in vivo bookmarking transcription factor.
JOURNAL OF NEUROCHEMISTRY
(2023)
Correction
Multidisciplinary Sciences
Bhuwan Khatri, Kandice Tessneer, Astrid Rasmussen, Farhang Aghakhanian, Tove Ragna Reksten, Adam A. Adler, Ilias Alevizos, Juan-Manuel G. Anaya, Lara Aqrawi, Eva Baecklund, Johan Brun, Sara Magnusson Bucher, Maija-Leena B. Eloranta, Fiona Engelke, Helena Forsblad-d'Elia, Stuart Glenn, Daniel Hammenfors, Juliana V. Imgenberg-Kreuz, Janicke Liaaen Jensen, Svein Joar Auglaend A. Johnsen, Malin Jonsson, Marika Kvarnstroem, Jennifer Kelly, He Li, Thomas Mandl, Javier Martin, Gaetane Nocturne, Katrine Braekke M. Norheim, Oyvind E. Palm, Kathrine Skarstein, Anna Stolarczyk, Kimberly Taylor, Maria J. Teruel, Elke M. Theander, Swamy S. Venuturupalli, Daniel Wallace, Kiely M. Grundahl, Kimberly U. Hefner, Lida Radfar, David T. Lewis, Donald M. Stone, C. Erick A. Kaufman, Michael Brennan, Joel M. Guthridge, Judith A. James, R. Hal Scofield, Patrick Gaffney, Lindsey J. Criswell, Roland Jonsson, Per Eriksson, Simon Bowman, Roald Omdal, Lars Roennblom, Blake Warner, Maureen Rischmueller, Torsten E. Witte, A. Darise H. Farris, Xavier Mariette, Marta Alarcon-Riquelme, Caroline L. Shiboski, Marie Wahren-Herlenius, Wan-Fai Ng, Kathy J. Sivils, Indra Adrianto, Gunnel Nordmark, Christopher Lessard
NATURE COMMUNICATIONS
(2023)
Article
Clinical Neurology
Alexander J. Davies, Cinta Lleixa, Ana M. Siles, Dawn S. Gourlay, Georgina Berridge, Wanwisa Dejnirattisai, Carolina Ramirez-Santana, Juan-Manuel Anaya, Andrew K. Falconar, Claudia M. Romero-Vivas, Lyda Osorio, Beatriz Parra, Gavin R. Screaton, Juthathip Mongkolsapaya, Roman Fischer, Carlos A. Pardo, Susan K. Halstead, Hugh J. Willison, Luis Querol, Simon Rinaldi
Summary: By screening the sera of patients with Zika virus (ZIKV) with and without Guillain-Barre syndrome (GBS), researchers discovered the presence of autoantibodies targeting peripheral nerves. This suggests that Zika virus infection may lead to immune-mediated neurologic symptoms.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2023)
Review
Virology
Ruediger E. Scharf, Juan-Manuel Anaya
Summary: This article provides an overview of various aspects related to post-COVID syndrome, including its prevalence, symptoms and sequelae, risk determinants, and psychosocial implications. It also discusses the pathogenesis of post-COVID condition, focusing on thrombo-inflammation, neutrophil extracellular traps, and venous thromboembolism. Additionally, it reviews COVID-19 and post-COVID syndrome in immunocompromising conditions, and the impact of vaccination on the prevention and treatment of post-COVID symptoms. The article highlights autoimmunity as a hallmark of post-COVID syndrome and the potential increase of autoimmune disorders globally.
Meeting Abstract
Critical Care Medicine
L. Acevedo, B. E. Pineres, L. F. Nino, L. Mazzillo, I. J. Ardila, S. Chacon, J. C. Jaramillo, H. Mulett, O. Gonzalez, E. Zemanate, L. Izquierdo, J. Rojas, J. Piracoca, J. L. Junco, B. Giraldo, C. Bonilla, H. Preciado, R. Orozco, M. Alvarez, C. Giraldo, J. C. Salazar, J. M. Anaya
PEDIATRIC CRITICAL CARE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Shani Berkowitz, Shany Guly Gofrit, Shay Anat Aharoni, Valery Golderman, Lamis Qassim, Zehavit Goldberg, Amir Dori, Nicola Maggio, Joab Chapman, Efrat Shavit-Stein
Summary: The study found that there is an interaction between neuroinflammation and coagulation, and enoxaparin can protect against inflammation induced by LPS, reducing neuronal damage. The findings may provide a new pharmacological mechanism for intervening in neuroinflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Laura Camacho-Dominguez, Yhojan Rodriguez, Fernando Polo, Juan Carlos Restrepo Gutierrez, Elizabeth Zapata, Manuel Rojas, Juan-Manuel Anaya
Summary: This report presents a case of a 79-year-old man who developed autoimmune hepatitis type 1 after receiving the ChAdOx1 nCoV-19 vaccine. Clinical symptoms improved rapidly after immunomodulatory treatment was initiated. This case, along with a comprehensive literature review, highlights the association between COVID-19 vaccines and the development of autoimmune conditions.
JOURNAL OF TRANSLATIONAL AUTOIMMUNITY
(2022)
Review
Biochemistry & Molecular Biology
Nae Takizawa, Susumu Tanaka, Koshiro Nishimoto, Yuki Sugiura, Makoto Suematsu, Chisato Ohe, Haruyuki Ohsugi, Yosuke Mizuno, Kuniaki Mukai, Tsugio Seki, Kenji Oki, Celso E. Gomez-Sanchez, Tadashi Matsuda
Summary: This study presents an unusual case of familial hyperaldosteronism type 3 (FH3) in a young woman who was first diagnosed with primary aldosteronism at the age of 6 years. Despite undergoing unilateral adrenalectomy to alleviate hyperaldosteronism, the hyperaldosteronism persisted. At the age of 26 years, additional adrenal tumors were discovered and removed. Histological, immunohistochemical, and molecular evaluation of the tumors and adrenal gland showed the presence of aldosterone synthase (CYP11B2) immunoreactivity, as well as a somatic beta-catenin activating mutation in the larger tumor. In situ visualization of aldosterone also revealed its presence only in the subcapsular regions of the adrenal gland and not in the tumors.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Immunology
Shane Kelly, Katherine J. L. Jackson, Timothy J. Peters, Dan Suan, Christopher C. Goodnow
Summary: This study successfully identified and characterized PR3-specific B cells from the peripheral blood of patients with PR3 autoantibodies. These cells exhibited specific immunological features, suggesting that PR3 self-reactivity may occur early in B-cell development.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Ana Merino-Vico, Jan Piet van Hamburg, Paul Tuijnenburg, Giulia Frazzei, Aram Al-Soudi, Carlo G. Bonasia, Boy Helder, Abraham Rutgers, Wayel H. Abdulahad, Coen A. Stegeman, Jan-Stephan Sanders, Laura Bergamaschi, Paul A. Lyons, Theo Bijma, Laura van Keep, Kirsten Wesenhagen, Aldo Jongejan, Henric Olsson, Niek de Vries, Taco W. Kuijpers, Peter Heeringa, Sander W. Tas
Summary: B lineage cells play a critical role in ANCA-associated vasculitis (AAV), and the transcription factor NF-kappa B may be a potential therapeutic target for AAV and other autoimmune diseases with prominent B cell involvement.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Christopher Nelke, Thomas Muentefering, Derya Cengiz, Lukas Theissen, Vera Dobelmann, Christina B. Schroeter, Helena Block, Corinna Preu, Alexander P. E. Michels, Stefanie Lichtenberg, Marc Pawlitzki, Steffen Pfeuffer, Niklas Huntemann, Alexander Zarbock, Thorben Briese, Christoph Kittl, Carsten Dittmayer, Thomas Budde, Ingrid E. Lundberg, Werner Stenzel, Sven G. Meuth, Tobias Ruck
Summary: K2P2.1 plays a regulatory role in the autoimmune response of idiopathic inflammatory myopathies (IIMs), by regulating inflammatory cell response, adhesion, and transmigration in both endothelial and skeletal muscle cells. Inhibiting K2P2.1 enhances the inflammatory response, while activating K2P2.1 improves the disease course.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Xuan Zhang, Jun Xia, Ying Jiang, David S. Pisetsky, Josef S. Smolen, Rong Mu, Shengming Dai, Michael E. Weinblatt, Tore K. Kvien, Juan Li, Thomas Doerner, Yu Zhang, Liwei Lu, Chengde Yang, Pingting Yang, Yuan Zhang, Chenchen Xu, Zhan Zhao, Peter E. Lipsky
Summary: The study suggests that TwHF may be as effective as MTX in treating active RA, and combination therapy may be more effective than monotherapy.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Maya F. Amjadi, Maxwell H. Parker, Ryan R. Adyniec, Zihao Zheng, Alex M. Robbins, S. Janna Bashar, Michael F. Denny, Sara S. Mccoy, Irene M. Ong, Miriam A. Shelef
Summary: Rheumatoid factors (RFs) are polyreactive antibodies that can bind disease-specific epitopes. Recent studies have found that RFs in COVID-19 can bind novel IgG epitopes, which provides new insights into the mechanism of RFs.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Johanne Liberatore, Yann Nguyen, Jerome Hadjadj, Pascal Cohen, Luc Mouthon, Xavier Puechal, Loic Guillevin, Benjamin Terrier
Summary: B-cell depletion induced by rituximab (RTX) in ANCA-associated vasculitis (AAV) can lead to decreased gammaglobulin levels, which is associated with an increased risk of relapse and severe infections. Older age, low gammaglobulin levels, and receiving pulses of methylprednisolone at induction therapy are risk factors for gammaglobulin decline.
JOURNAL OF AUTOIMMUNITY
(2024)