Review
Medicine, General & Internal
Alexander Carvajal-Gonzalez, Suma Sri Chennapragada, Ekin Ozluk, Phani Morisetti
Summary: The evaluation of bilateral lung nodules on imaging is challenging due to the wide range of possible causes. This case study presents a woman with multiple lung nodules, which were ultimately found to be related to an underlying autoimmune condition (Sjogren's syndrome). Management with intravenous steroids resulted in significant improvement.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Article
Immunology
Yung-Hsiang Chao, Chin-Hsiu Liu, Yu-An Pan, Fu-Shun Yen, Jeng-Yuan Chiou, James Cheng-Chung Wei
Summary: This population-based cohort study found that patients with a history of endometriosis have an increased risk of developing Sjogren's syndrome, especially within the first five years after diagnosis, and in the age group of 20-39.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Yu Cao, Hao Lu, Wangzi Xu, Ming Zhong
Summary: The study reveals a causal relationship between gut microbiota composition and Sjogren's Syndrome risk, with some microbial species positively correlated and others negatively correlated. Additionally, four genes related to gut microbiota were found to have a causal effect on Sjogren's Syndrome.
FRONTIERS IN IMMUNOLOGY
(2023)
Letter
Ophthalmology
Carlos Cifuentes-Gonzalez, William Rojas-Carabali, Maria Camila Sierra-Cote, Alejandra de-la-Torre
Summary: This case report presents a patient with sclerouveitis and alkaptonuria who developed multiple autoimmune syndrome (MAS) including Hashimoto's thyroiditis and Sjogren's syndrome. The patient had ocular symptoms such as decreased visual acuity, red eye, foreign body sensation, and ocular pain. Ophthalmological examination revealed conjunctival hyperemia, ochronosis, scleral nodule, keratic precipitates, anterior chamber cells, vitreous cells, and vitreous haze. In addition to immunomodulatory medications, biological treatment was suggested due to refractory response.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Review
Biochemistry & Molecular Biology
Yuko Okawa, Kenji Ihara
Summary: Sjogren's syndrome is a chronic autoimmune disease that affects the salivary and lachrymal glands. It can be classified into primary and secondary forms, with varying degrees of severity. Sensorineural hearing loss can occur in some cases. This review article provides a comprehensive overview of the pathology, clinical manifestations, inner ear diseases, immunological characteristics, pathophysiology, treatment options, and future directions of Sjogren's syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Min Song, Jide Tian, Blake Middleton, Cuong Q. Nguyen, Daniel L. Kaufman
Summary: Oral administration of GABA may have potential for ameliorating Sjogren's syndrome (SS) by increasing salivary and tear production and reducing symptoms. This treatment does not significantly affect lymphocytic infiltration and could provide a new approach for improving SS symptoms.
Article
Immunology
Manuel Rojas, Carolina Ramirez-Santana, Yeny Acosta-Ampudia, Diana M. Monsalve, Monica Rodriguez-Jimenez, Elizabeth Zapata, Angie Naranjo-Pulido, Ana Suarez-Avellaneda, Lady J. Rios-Serna, Carolina Prieto, William Zambrano-Romero, Maria Alejandra Valero, Yhojan Rodriguez, Ruben D. Mantilla, Chengsong Zhu, Quan-Zhen Li, Carlos Enrique Toro-Gutierrez, Gabriel J. Tobon, Juan-Manuel Anaya
Summary: This study explored a new taxonomy of ADs based on PolyA, finding that latent PolyA is more common than overt PolyA. The combination of autoantibodies allows high accuracy in the classification of ADs, and three distinct clusters based on PolyA were observed with unique clinical and immunological phenotypes.
JOURNAL OF AUTOIMMUNITY
(2022)
Review
Endocrinology & Metabolism
C. Betterle, J. Furmaniak, C. Sabbadin, C. Scaroni, F. Presotto
Summary: The number of autoimmune diseases (AIDs) has increased and they often co-occur in a single patient, with autoimmune thyroid diseases (AITD) being the most prevalent. AITD can be viewed as the center of autoimmunity, with other AIDs gravitating around it like satellites.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Rheumatology
Valentina Pucino, Jason D. Turner, Saba Nayar, Florian Kollert, Saaeha Rauz, Andrea Richards, Jon Higham, Ana Poveda-Gallego, Simon J. Bowman, Francesca Barone, Benjamin A. Fisher
Summary: This study aimed to compare clinical and proteomic predictors of primary Sjogren's syndrome (SjS) and non-SjS sicca syndrome (sicca), and identify the key predictors of symptoms. The results showed that obesity-related metabolic factors may regulate symptoms in sicca, while further research is needed to explore the non-inflammatory drivers of high symptom burden in SjS.
Review
Multidisciplinary Sciences
Shan Liu, MiaoShui Bai, Yinlong Zhao
Summary: Although CVT is commonly caused by autoimmune diseases, such as lupus and antiphospholipid syndrome, CVT caused by Sjögren's syndrome is rarely reported. We present a case report of a 41-year-old woman with SS-induced CVT and review six additional cases, discussing the pathogenesis, clinical symptoms, treatment, and prognosis. This study aims to enhance clinicians' understanding of SS-induced CVT and minimize missed diagnoses.
Article
Immunology
Tian-Ping Zhang, Li-Jun Wang, Shan Wang, Ping Wang, Xiao-Hui Zhou, Li Wang, Chun-Mei Yang, Xiao-Mei Li
Summary: The study revealed a significant association between gaseous pollutants and SS hospitalizations, with exposure to NO2 and CO linked to an increased risk of hospitalizations, while exposure to SO2 and O-3 may lower the risk. Patients of different genders and age groups showed varying sensitivities to gaseous pollutants, and exposure to O-3 and CO in the cold season were more likely to impact SS hospitalizations.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Katelyn A. Bruno, Andrea Carolina Morales-Lara, Edsel B. Bittencourt, Habeeba Siddiqui, Gabriella Bommarito, Jenil Patel, John M. Sousou, Gary R. Salomon, Rinald Paloka, Shelby T. Watford, David O. Hodge, Scott M. Lieberman, Todd D. Rozen, Paldeep S. Atwal, Peter T. Dorsher, Lynsey A. Seim, DeLisa Fairweather
Summary: The most common comorbidities in Sjogren's disease patients are fibromyalgia, depression, and pain. Women with Sjogren's disease have a higher risk of developing conditions like hypermobile syndromes and migraines, while men with Sjogren's disease are more likely to develop cardiovascular diseases.
FRONTIERS IN MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Yoko Ogawa, Tsutomu Takeuchi, Kazuo Tsubota
Summary: Autoimmune epithelitis and chronic inflammation are characteristic features of the immune pathogenesis of Sjogren's syndrome (SS)-related dry eye disease, affecting the secretion of tear fluid and mucin. Dysfunction of ocular surface epithelium can lead to dry eye disease, with potential targets for treatment including various molecules in tear film, cornea, conjunctiva, lacrimal glands, and meibomian glands.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Mihnea Casian, Ciprian Jurcut, Alina Dima, Ancuta Mihai, Silviu Stanciu, Ruxandra Jurcut
Summary: In the ever evolving landscape of systemic immune mediated diseases, there has been increased awareness regarding the associated cardiovascular system impairment. The cardiovascular profile of primary Sjogren's Syndrome (pSS), one of the most frequent autoimmune diseases affecting middle-aged individuals, has been less studied compared to other autoimmune diseases. The multifaceted cardiovascular risk profile in pSS is sometimes difficult to assess due to the intertwined traditional cardiovascular risk factors and disease specific risk factors. Recent data suggests a higher prevalence of subclinical myocardial and vascular damage in pSS compared to the general population. However, clinicians often face difficulty translating literature data into everyday practice when dealing with cardiovascular diseases in patients with pSS. This review aims to synthesize the existing evidence on pSS associated cardiovascular changes in a clinically relevant manner.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Rheumatology
Emiko Desvaux, Jacques-Olivier Pers
Summary: Primary Sjogren's syndrome (pSS) is an autoimmune disorder characterized by epithelitis and chronic inflammation of the exocrine glands. Lymphocytes infiltrate the affected organs, damaging the epithelial structures. Epithelial cells express major histocompatibility complexes and costimulatory molecules, activating T and B lymphocytes through cellular crosstalk pathways. Glandular epithelial cells are believed to be central regulators of the local autoimmune response.
Article
Immunology
Manuel Rojas, Carolina Ramirez-Santana, Yeny Acosta-Ampudia, Diana M. Monsalve, Monica Rodriguez-Jimenez, Elizabeth Zapata, Angie Naranjo-Pulido, Ana Suarez-Avellaneda, Lady J. Rios-Serna, Carolina Prieto, William Zambrano-Romero, Maria Alejandra Valero, Yhojan Rodriguez, Ruben D. Mantilla, Chengsong Zhu, Quan-Zhen Li, Carlos Enrique Toro-Gutierrez, Gabriel J. Tobon, Juan-Manuel Anaya
Summary: This study explored a new taxonomy of ADs based on PolyA, finding that latent PolyA is more common than overt PolyA. The combination of autoantibodies allows high accuracy in the classification of ADs, and three distinct clusters based on PolyA were observed with unique clinical and immunological phenotypes.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Immunology
Yeny Acosta-Ampudia, Diana M. Monsalve, Manuel Rojas, Yhojan Rodriguez, Elizabeth Zapata, Carolina Ramirez-Santana, Juan-Manuel Anaya
Summary: Post-COVID syndrome is characterized by the persistence of latent autoimmunity up to 11 months after recovery, accompanied by a persistent proinflammatory state and altered effector phenotype. The need to evaluate the role of immunomodulation in the treatment of PCS is suggested.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Medicine, General & Internal
Claudia Mendoza-Pinto, Pamela Munguia-Realpzo, Mario Garcia-Carrasco, Karla Godinez-Bolanos, Adriana Rojas-Villarraga, Ivet Morales-Etchegaray, Jorge Ayon-Aguilar, Socorro Mendez-Martinez, Ricard Cervera
Summary: This systematic review and meta-analysis examined the relationship between coronary artery disease (CAD) assessed by coronary computed tomography (CT) and systemic lupus erythematosus (SLE). The results show that SLE patients have a higher prevalence of asymptomatic CAD and higher rates of multivessel disease compared to controls. However, there was no significant increase in the extent of coronary artery calcification (CAC) in SLE patients compared to controls.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Letter
Immunology
Yeny Acosta-Ampudia, Juan-Manuel Anaya
JOURNAL OF INFECTIOUS DISEASES
(2022)
Editorial Material
Medicine, Research & Experimental
Manuel Rojas, Yhojan Rodriguez, Yeny Acosta-Ampudia, Diana M. Monsalve, Chengsong Zhu, Quan-Zhen Li, Carolina Ramirez-Santana, Juan-Manuel Anaya
Summary: Autoimmunity is a characteristic of post-COVID syndrome (PCS), and it is correlated with the humoral response to SARS-CoV-2.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Jeremy Manry, Paul Bastard, Adrian Gervais, Tom Le Voyer, Jeremie Rosain, Quentin Philippot, Eleftherios Michailidis, Hans-Heinrich Hoffmann, Shohei Eto, Marina Garcia-Prat, Lucy Bizien, Alba Parra-Martinez, Rui Yang, Liis Haljasmagi, Melanie Migaud, Karita Sarekannu, Julia Maslovskaja, Nicolas de Prost, Yacine Tandjaoui-Lambiotte, Charles-Edouard Luyt, Blanca Amador-Borrero, Alexandre Gaudet, Julien Poissy, Pascal Morel, Pascale Richard, Fabrice Cognasse, Jesus Troya, Sophie Trouillet-Assant, Alexandre Belot, Kahina Saker, Pierre Garcon, Jacques G. Riviere, Jean-Christophe Lagier, Stephanie Gentile, Lindsey B. Rosen, Elana Shaw, Tomohiro Morio, Junko Tanaka, David Dalmau, Pierre-Louis Tharaux, Damien Sene, Alain Stepanian, Bruno Megarbane, Vasiliki Triantafyllia, Arnaud Fekkar, James R. Heath, Jose Luis Franco, Juan-Manuel Anaya, Jordi Sole-Violan, Luisa Imberti, Andrea Biondi, Paolo Bonfanti, Riccardo Castagnoli, Ottavia M. Delmonte, Yu Zhang, Andrew L. Snow, Steven M. Holland, Catherine M. Biggs, Marcela Moncada-Velez, Andres Augusto Arias, Lazaro Lorenzo, Soraya Boucherit, Dany Anglicheau, Anna M. Planas, Filomeen Haerynck, Sotirija Duvlis, Tayfun Ozcelik, Sevgi Keles, Ahmed A. Bousfiha, Jalila El Bakkouri, Carolina Ramirez-Santana, Stephane Paul, Qiang Pan-Hammarstrom, Lennart Hammarstrom, Annabelle Dupont, Alina Kurolap, Christine N. Metz, Alessandro Aiuti, Giorgio Casari, Vito Lampasona, Fabio Ciceri, Lucila A. Barreiros, Elena Dominguez-Garrido, Mateus Vidigal, Mayana Zatz, Diederik van de Beek, Sabina Sahanic, Ivan Tancevski, Yurii Stepanovskyy, Oksana Boyarchuk, Yoko Nukui, Miyuki Tsumura, Loreto Vidaur, Stuart G. Tangye, Sonia Burrel, Darragh Duffy, Lluis Quintana-Murci, Adam Klocperk, Nelli Y. Kann, Anna Shcherbina, Yu-Lung Lau, Daniel Leung, Matthieu Coulongeat, Julien Marlet, Rutger Koning, Luis Felipe Reyes, Angelique Chauvineau-Grenier, Fabienne Venet, Guillaume Monneret, Michel C. Nussenzweig, Romain Arrestier, Idris Boudhabhay, Hagit Baris-Feldman, David Hagin, Joost Wauters, Isabelle Meyts, Adam H. Dyer, Sean Kennelly, Nollaig M. Bourkeh, Rabih Halwan, Fatemeh Saheb Sharif-Askar, Karim Dorgham, Jerome Sallette, Souad Mehlal Sedkaoui, Suzan AlKhater, Raul Rigo-Bonnin, Francisco Morandeira, Lucie Roussel, Donald C. Vinh, Christian Erikstrup, Antonio Condino-Neto, Carolina Prando, Anastasiia Bondarenko, Andras N. Spaan, Laurent Gilardin, Jacques Fellay, Stanislas Lyonnet, Kaya Bilguvar, Richard P. Lifton, Shrikant Mane, Mark S. Anderson, Bertrand Boisson, Vivien Beziat, Shen-Ying Zhang, Evangelos Andreakos, Olivier Hermine, Aurora Pujol, Part Peterson, Trine H. Mogensen, Lee Rowen, James Mond, Stephanie Debette, Xavier de Lamballerie, Charles Burdet, Lila Bouadma, Marie Zins, Pere Soler-Palacin, Roger Colobran, Guy Gorochov, Xavier Solanich, Sophie Susen, Javier Martinez-Picado, Didier Raoult, Marc Vasse, Peter K. Gregersen, Lorenzo Piemonti, Carlos Rodriguez-Gallego, Luigi D Notarangelo, Helen C. Su, Kai Kisand, Satoshi Okada, Anne Puel, Emmanuelle Jouanguy, Charles M. Rice, Pierre Tiberghien, Qian Zhang, Jean-Laurent Casanova, Laurent Abel, Aurelie Cobat
Summary: This study investigates the impact of autoimmunity on COVID-19-related deaths and finds that individuals carrying autoantibodies neutralizing type I interferons are at higher risk of death, with the risk decreasing with age.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Infectious Diseases
Manuel Rojas, Yhojan Rodriguez, Juan Carlos Hernandez, Juan C. Diaz-Coronado, Jose Alejandro Daza Vergara, Veronica Posada Velez, Jessica Porras Mancilla, Ivan Araujo, Jairo Torres Yepes, Oscar Briceno Ricaurte, Juan Mauricio Pardo-Oviedo, Diana M. Monsalve, Yeny Acosta-Ampudia, Carolina Ramirez-Santana, Paula Gaviria Garcia, Lina Acevedo Landinez, Luisa Duarte Correales, Jeser Santiago Grass, Cristian Ricaurte Perez, Gustavo Salguero Lopez, Nataly Mateus, Laura Mancera, Ronald Rengifo Devia, Juan Esteban Orjuela, Christian R. Parra-Moreno, Andres Alfonso Buitrago, Ines Elvira Ordonez, Claudia Fabra Osorio, Nathalia Ballesteros, Luz H. Patino, Sergio Castaneda, Marina Munoz, Juan David Ramirez, Paul Bastard, Adrian Gervais, Lucy Bizien, Jean-Laurent Casanova, Bernardo Camacho, Juan Esteban Gallo, Oscar Gomez, Adriana Rojas-Villarraga, Carlos E. Perez, Ruben Manrique, Ruben D. Mantilla, Juan-Manuel Anaya
Summary: The use of convalescent plasma (CP) in the early stages of COVID-19 did not lead to a reduction in viral load, but it was found to be safe and may reduce hospital stay.
BMC INFECTIOUS DISEASES
(2022)
Article
Immunology
Juan-Manuel Anaya, Maria Herran, Santiago Beltran, Manuel Rojas
Summary: This article introduces the post-COVID syndrome (PCS) and its mechanisms related to autoimmunity. The author emphasizes the importance of defining and classifying PCS, and suggests the need for longitudinal and controlled studies to better understand PCS. It is also noted that with the increasing prevalence of COVID-19 cases, there may be an increase in autoimmune diseases.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2022)
Correction
Multidisciplinary Sciences
Bhuwan Khatri, Kandice Tessneer, Astrid Rasmussen, Farhang Aghakhanian, Tove Ragna Reksten, Adam A. Adler, Ilias Alevizos, Juan-Manuel G. Anaya, Lara Aqrawi, Eva Baecklund, Johan Brun, Sara Magnusson Bucher, Maija-Leena B. Eloranta, Fiona Engelke, Helena Forsblad-d'Elia, Stuart Glenn, Daniel Hammenfors, Juliana V. Imgenberg-Kreuz, Janicke Liaaen Jensen, Svein Joar Auglaend A. Johnsen, Malin Jonsson, Marika Kvarnstroem, Jennifer Kelly, He Li, Thomas Mandl, Javier Martin, Gaetane Nocturne, Katrine Braekke M. Norheim, Oyvind E. Palm, Kathrine Skarstein, Anna Stolarczyk, Kimberly Taylor, Maria J. Teruel, Elke M. Theander, Swamy S. Venuturupalli, Daniel Wallace, Kiely M. Grundahl, Kimberly U. Hefner, Lida Radfar, David T. Lewis, Donald M. Stone, C. Erick A. Kaufman, Michael Brennan, Joel M. Guthridge, Judith A. James, R. Hal Scofield, Patrick Gaffney, Lindsey J. Criswell, Roland Jonsson, Per Eriksson, Simon Bowman, Roald Omdal, Lars Roennblom, Blake Warner, Maureen Rischmueller, Torsten E. Witte, A. Darise H. Farris, Xavier Mariette, Marta Alarcon-Riquelme, Caroline L. Shiboski, Marie Wahren-Herlenius, Wan-Fai Ng, Kathy J. Sivils, Indra Adrianto, Gunnel Nordmark, Christopher Lessard
NATURE COMMUNICATIONS
(2023)
Article
Clinical Neurology
Alexander J. Davies, Cinta Lleixa, Ana M. Siles, Dawn S. Gourlay, Georgina Berridge, Wanwisa Dejnirattisai, Carolina Ramirez-Santana, Juan-Manuel Anaya, Andrew K. Falconar, Claudia M. Romero-Vivas, Lyda Osorio, Beatriz Parra, Gavin R. Screaton, Juthathip Mongkolsapaya, Roman Fischer, Carlos A. Pardo, Susan K. Halstead, Hugh J. Willison, Luis Querol, Simon Rinaldi
Summary: By screening the sera of patients with Zika virus (ZIKV) with and without Guillain-Barre syndrome (GBS), researchers discovered the presence of autoantibodies targeting peripheral nerves. This suggests that Zika virus infection may lead to immune-mediated neurologic symptoms.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2023)
Article
Immunology
Pedro Santos-Moreno, Julian Arias-Aponte, Gabriel-Santiago Rodriguez-Vargas, Paula Daniela Nieto-Zambrano, Laura Villarreal, Linda Ibata, Susan Martinez, Jaime-Andres Rubio-Rubio, Pedro Rodriguez, Adriana Rojas-Villarraga
Summary: This study aimed to assess the frequency and associated factors of polyautoimmunity (PolyA) in Colombian patients with systemic lupus erythematosus (SLE). The results identified age, xerophthalmia, central nervous system occlusion, and deep vein thrombosis as factors associated with PolyA. Renal impairment was significantly less frequent in PolyA patients.
JOURNAL OF TRANSLATIONAL AUTOIMMUNITY
(2023)
Review
Virology
Ruediger E. Scharf, Juan-Manuel Anaya
Summary: This article provides an overview of various aspects related to post-COVID syndrome, including its prevalence, symptoms and sequelae, risk determinants, and psychosocial implications. It also discusses the pathogenesis of post-COVID condition, focusing on thrombo-inflammation, neutrophil extracellular traps, and venous thromboembolism. Additionally, it reviews COVID-19 and post-COVID syndrome in immunocompromising conditions, and the impact of vaccination on the prevention and treatment of post-COVID symptoms. The article highlights autoimmunity as a hallmark of post-COVID syndrome and the potential increase of autoimmune disorders globally.
Article
Ophthalmology
Jad F. Assaf, Dan Z. Reinstein, Cyril Zakka, Juan G. Arbelaez, Peter Boufadel, Mathieu Choufani, Timothy Archer, Perla Ibrahim, Shady T. Awwad
Summary: In this study, a deep learning neural network was developed and validated to automatically measure the vault of implantable collamer lens (ICL) using anterior segment optical coherence tomography (AS-OCT). By using transfer learning, the model achieved high accuracy in estimating the ICL vault from AS-OCT scans with a MAPE of 3.42%, an MAE of 15.82µm, and a Pearson correlation coefficient r of +0.98.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Meeting Abstract
Critical Care Medicine
L. Acevedo, B. E. Pineres, L. F. Nino, L. Mazzillo, I. J. Ardila, S. Chacon, J. C. Jaramillo, H. Mulett, O. Gonzalez, E. Zemanate, L. Izquierdo, J. Rojas, J. Piracoca, J. L. Junco, B. Giraldo, C. Bonilla, H. Preciado, R. Orozco, M. Alvarez, C. Giraldo, J. C. Salazar, J. M. Anaya
PEDIATRIC CRITICAL CARE MEDICINE
(2022)
Review
Immunology
Laura Camacho-Dominguez, Yhojan Rodriguez, Fernando Polo, Juan Carlos Restrepo Gutierrez, Elizabeth Zapata, Manuel Rojas, Juan-Manuel Anaya
Summary: This report presents a case of a 79-year-old man who developed autoimmune hepatitis type 1 after receiving the ChAdOx1 nCoV-19 vaccine. Clinical symptoms improved rapidly after immunomodulatory treatment was initiated. This case, along with a comprehensive literature review, highlights the association between COVID-19 vaccines and the development of autoimmune conditions.
JOURNAL OF TRANSLATIONAL AUTOIMMUNITY
(2022)
Article
Immunology
Shane Kelly, Katherine J. L. Jackson, Timothy J. Peters, Dan Suan, Christopher C. Goodnow
Summary: This study successfully identified and characterized PR3-specific B cells from the peripheral blood of patients with PR3 autoantibodies. These cells exhibited specific immunological features, suggesting that PR3 self-reactivity may occur early in B-cell development.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Ana Merino-Vico, Jan Piet van Hamburg, Paul Tuijnenburg, Giulia Frazzei, Aram Al-Soudi, Carlo G. Bonasia, Boy Helder, Abraham Rutgers, Wayel H. Abdulahad, Coen A. Stegeman, Jan-Stephan Sanders, Laura Bergamaschi, Paul A. Lyons, Theo Bijma, Laura van Keep, Kirsten Wesenhagen, Aldo Jongejan, Henric Olsson, Niek de Vries, Taco W. Kuijpers, Peter Heeringa, Sander W. Tas
Summary: B lineage cells play a critical role in ANCA-associated vasculitis (AAV), and the transcription factor NF-kappa B may be a potential therapeutic target for AAV and other autoimmune diseases with prominent B cell involvement.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Christopher Nelke, Thomas Muentefering, Derya Cengiz, Lukas Theissen, Vera Dobelmann, Christina B. Schroeter, Helena Block, Corinna Preu, Alexander P. E. Michels, Stefanie Lichtenberg, Marc Pawlitzki, Steffen Pfeuffer, Niklas Huntemann, Alexander Zarbock, Thorben Briese, Christoph Kittl, Carsten Dittmayer, Thomas Budde, Ingrid E. Lundberg, Werner Stenzel, Sven G. Meuth, Tobias Ruck
Summary: K2P2.1 plays a regulatory role in the autoimmune response of idiopathic inflammatory myopathies (IIMs), by regulating inflammatory cell response, adhesion, and transmigration in both endothelial and skeletal muscle cells. Inhibiting K2P2.1 enhances the inflammatory response, while activating K2P2.1 improves the disease course.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Xuan Zhang, Jun Xia, Ying Jiang, David S. Pisetsky, Josef S. Smolen, Rong Mu, Shengming Dai, Michael E. Weinblatt, Tore K. Kvien, Juan Li, Thomas Doerner, Yu Zhang, Liwei Lu, Chengde Yang, Pingting Yang, Yuan Zhang, Chenchen Xu, Zhan Zhao, Peter E. Lipsky
Summary: The study suggests that TwHF may be as effective as MTX in treating active RA, and combination therapy may be more effective than monotherapy.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Maya F. Amjadi, Maxwell H. Parker, Ryan R. Adyniec, Zihao Zheng, Alex M. Robbins, S. Janna Bashar, Michael F. Denny, Sara S. Mccoy, Irene M. Ong, Miriam A. Shelef
Summary: Rheumatoid factors (RFs) are polyreactive antibodies that can bind disease-specific epitopes. Recent studies have found that RFs in COVID-19 can bind novel IgG epitopes, which provides new insights into the mechanism of RFs.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Johanne Liberatore, Yann Nguyen, Jerome Hadjadj, Pascal Cohen, Luc Mouthon, Xavier Puechal, Loic Guillevin, Benjamin Terrier
Summary: B-cell depletion induced by rituximab (RTX) in ANCA-associated vasculitis (AAV) can lead to decreased gammaglobulin levels, which is associated with an increased risk of relapse and severe infections. Older age, low gammaglobulin levels, and receiving pulses of methylprednisolone at induction therapy are risk factors for gammaglobulin decline.
JOURNAL OF AUTOIMMUNITY
(2024)
