☆ 4.7 Review

'ASIA' - Autoimmune/inflammatory syndrome induced by adjuvants

JOURNAL OF AUTOIMMUNITY (2011)

期刊

JOURNAL OF AUTOIMMUNITY

卷 36, 期 1, 页码 4-8

出版社

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD

DOI: 10.1016/j.jaut.2010.07.003

关键词

Autoimmunity; Adjuvant; Vaccine; Gulf war syndrome (GWS); Macrophagic myofasciitis syndrome (MMF); Silicone

类别

Immunology

向作者/读者索取更多资源

Protocol

Reagent

摘要

The role of various environmental factors in the pathogenesis of immune mediated diseases is well established. Of which, factors entailing an immune adjuvant activity such as infectious agents, silicone, aluminium salts and others were associated with defined and non-defined immune mediated diseases both in animal models and in humans. In recent years, four conditions: siliconosis, the Gulf war syndrome (GWS), the macrophagic myofasciitis syndrome (MMF) and post-vaccination phenomena were linked with previous exposure to an adjuvant. Furthermore, these four diseases share a similar complex of signs and symptoms which further support a common denominator. Thus, we review herein the current data regarding the role of adjuvants in the pathogenesis of immune mediated diseases as well as the amassed data regarding each of these four conditions. Relating to the current knowledge we would like to suggest to include these comparable conditions under a common syndrome entitled ASIA, Autoimmune (Auto-inflammatory) Syndrome Induced by Adjuvants. (C) 2010 Elsevier Ltd. All rights reserved.

作者

我是这篇论文的作者

点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7

评分不足

次要评分

新颖性

-

重要性

-

科学严谨性

-

评价这篇论文

推荐

Article Medicine, Research & Experimental

Predicting post-exertional malaise in Gulf War Illness based on acute exercise responses

Alexander E. Boruch, Jacob B. Lindheimer, Jacquelyn C. Klein-Adams, Aaron J. Stegner, Glenn R. Wylie, Jacob Ninneman, Thomas Alexander, Nicholas P. Gretzon, Bishoy Samy, Stephanie M. Van Riper, Michael J. Falvo, Dane B. Cook

Summary: The study aimed to understand how cardiorespiratory and perceptual responses to exercise in GWI patients affect PEM, finding that compared to controls, GWI patients had greater ventilatory equivalent for oxygen, peak leg muscle pain, and fatigue during exercise, but these responses did not significantly predict the severity of PEM.

LIFE SCIENCES (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Hemorheological responses to an acute bout of maximal exercise in Veterans with Gulf War Illness

Wei Qian, Jacquelyn C. Klein-Adams, Duncan S. Ndirangu, Yang Chen, Michael J. Falvo, Michael R. Condon

Summary: The study on veterans with GWI and controls showed that individuals with GWI have more deformable red blood cells compared to controls, and this deformability is not affected by maximal exercise. Further research is needed to confirm these findings and identify associated mechanisms.

LIFE SCIENCES (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Subcortical brain segment volumes in Gulf War Illness and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Florencia Martinez Addiego, Kristina Zajur, Sarah Knack, Jessie Jamieson, Rakib U. Rayhan, James N. Baraniuk

Summary: This study examined brain volumes in CFS and GWI patients, finding significant differences and the influence of gender on brain structures. Orthostatic status and posttraumatic distress syndrome were not significant covariates in the analysis.

LIFE SCIENCES (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Mitochondrial impairment but not peripheral inflammation predicts greater Gulf War illness severity

Beatrice A. A. Golomb, Roel Sanchez Baez, Jan M. M. Schilling, Mehul Dhanani, McKenzie J. J. Fannon, Brinton K. K. Berg, Bruce J. J. Miller, Pam R. R. Taub, Hemal H. H. Patel

Summary: Gulf War illness (GWI) is a chronic multisymptom illness that may accelerate aging and is triggered by environmental factors. In this study, impaired mitochondrial respiratory chain function (MRCF) was associated with a higher number of symptoms and greater severity in GWI. Peripheral inflammation, measured by hsCRP, was related to lower MRCF in VGWI but did not predict symptom severity. These findings suggest that mitochondrial dysfunction plays a significant role in GWI.

SCIENTIFIC REPORTS (2023)

添加到收藏夹

Article Neurosciences

Sex-Based Differences in Plasma Autoantibodies to Central Nervous System Proteins in Gulf War Veterans versus Healthy and Symptomatic Controls

Mohamed B. Abou-Donia, Maxine H. Krengel, Elizabeth S. Lapadula, Clara G. Zundel, Jessica LeClair, Joseph Massaro, Emily Quinn, Lisa A. Conboy, Efi Kokkotou, Daniel D. Nguyen, Maria Abreu, Nancy G. Klimas, Kimberly Sullivan

Summary: This study compared levels of biomarkers between men and women with Gulf War illness (GWI), finding significant differences in 2 out of 10 plasma autoantibodies, with men showing elevated levels. Men and women with GWI also showed significantly different levels of autoantibodies in 8 out of 10 biomarkers to neuronal and glial proteins in plasma compared to controls.

BRAIN SCIENCES (2021)

添加到收藏夹

Article Ophthalmology

Dry eye symptoms and signs in United States Gulf War era veterans with myalgic encephalomyelitis/chronic fatigue syndrome

Victor Sanchez, Colin K. Kim, Elyana V. T. Locatelli, Adam K. Cohen, Kimberly Cabrera, Kristina Aenlle, Nancy G. Klimas, Robert O'Brien, Anat Galor

Summary: Individuals with ME/CFS report increased ocular pain but similar dry eye symptoms.

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2023)

添加到收藏夹

Article Gastroenterology & Hepatology

Self-reported gastrointestinal disorders among veterans with gulf war illness with and without posttraumatic stress disorder

D. Malhotra, S. H. Boyle, E. J. Gifford, B. A. Sullivan, T. H. Nguyen Wenker, Nono-Djotsa Abs, S. T. Ahmed, J. Upchurch, J. Vahey, C. Stafford, J. T. Efird, S. C. Hunt, A. Bradford, K. J. Sims, E. R. Hauser, D. A. Helmer, C. D. Williams

Summary: This study explores the relationship between post-traumatic stress disorder (PTSD), Gulf War Illness (GWI), and self-reported gastrointestinal (GI) disorders, and finds that Gulf War veterans with GWI and PTSD have higher odds of specific GI disorders.

NEUROGASTROENTEROLOGY AND MOTILITY (2023)

添加到收藏夹

Article Immunology

Palpitation in women with silicone breast implants: association with autoantibodies against autonomic nervous system

Tal Elroy, Gilad Halpert, Avishai M. Tsur, Harald Heidecke, Howard Amital, Yehuda Shoenfeld

Summary: Our study explored the possible association between palpitation symptoms in women with silicone breast implants (SBIs) and the circulating levels of autoantibodies directed against autonomic nervous system (ANS) receptors. By measuring the titers of various autoantibodies, we found a significant reduction in the levels of certain autoantibodies in the 'Palpitations' group compared to the 'Non' and 'Control' groups. This suggests a possible link between ANS receptor autoantibodies and existing complaints of palpitations in women with SBIs.

IMMUNOLOGIC RESEARCH (2023)

添加到收藏夹

Article Immunology

IL-17 and IL-17C Signaling Protects the Intestinal Epithelium against Diisopropyl Fluorophosphate Exposure in an Acute Model of Gulf War Veterans' Illnesses

Kristen M. Patterson, Tyler G. Vajdic, Gustavo J. Martinez, Axel G. Feller, Joseph M. Reynolds

Summary: This study investigates gastrointestinal disorders in GWI Veterans and finds that DFP exposure can negatively impact mucosal epithelium, leading to the deterioration of mechanisms protecting the GI tract from diseases.

IMMUNE NETWORK (2021)

添加到收藏夹

Article Health Care Sciences & Services

The effect of disease misclassification on the ability to detect a gene-environment interaction: implications of the specificity of case definitions for research on Gulf War illness

Robert W. Haley, Jill A. Dever, Gerald Kramer, John F. Teiber

Summary: Since 1997, research on Gulf War illness has predominantly used three case definitions, but they have not been compared against an objective standard.

BMC MEDICAL RESEARCH METHODOLOGY (2023)

添加到收藏夹

Article Neurosciences

Differential Effects of Exercise on fMRI of the Midbrain Ascending Arousal Network Nuclei in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Gulf War Illness (GWI) in a Model of Postexertional Malaise (PEM)

James N. Baraniuk, Alison Amar, Haris Pepermitwala, Stuart D. Washington

Summary: This study compared the neural activation during cognitive tests before and after submaximal exercise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Gulf War Illness (GWI), and control subjects. The results showed increased activation in ME/CFS but decreased activation in GWI after exercise. Furthermore, the midbrain and isthmus nuclei were found to contribute to postexertional malaise in both ME/CFS and GWI.

BRAIN SCIENCES (2022)

添加到收藏夹

Article Medicine, Research & Experimental

The Prevalence of Hearing Impairments in Women with Silicone Breast Implants

Assaf Greenbaum, Gilad Halpert, Arad Dotan, Shaked Shivatzki, Harald Heidecke, Ricky Kaplan Neeman, Michael Ehrenfeld, Amit Wolfovitz, Howard Amital, Yael Henkin, Yehuda Shoenfeld

Summary: Many women with silicone breast implants (SBIs) experience hearing impairments, including hearing loss and tinnitus. Audiologic evaluation showed that a majority of women with SBIs exhibited hearing loss. However, removal of the silicone implants led to improvement or resolution of hearing complaints in a significant proportion of women. This suggests a strong association between SBIs and hearing impairments, which needs to be further investigated with larger study populations.

DISEASES (2023)

添加到收藏夹

Review Neurosciences

Adaptive Immune Responses Associated with the Central Nervous System Pathology of Gulf War Illness

Aurore Nkiliza, Utsav Joshi, James E. Evans, Ghania Ait-Ghezala, Megan Parks, Fiona Crawford, Michael Mullan, Laila Abdullah

Summary: Gulf War Illness is a multisymptomatic condition affecting 30% of veterans from the 1991 Gulf War, with potential involvement of central nervous system pathology. Clinical features resemble autoimmune diseases, but the etiology is linked to hazardous chemical exposures specific to the Gulf War theatre.

NEUROSCIENCE INSIGHTS (2021)

添加到收藏夹

Review Neurosciences

At the Root of 3 Long Diseases: Persistent Antigens Inflicting Chronic Damage on the Brain and Other Organs in Gulf War Illness, Long-COVID-19, and Chronic Fatigue Syndrome

Lisa M. James, Apostolos P. Georgopoulos

Summary: Foreign antigens derived from viruses and bacteria can have long-term deleterious effects on the brain and other organs, depending on the host's immune system and HLA composition. The "Persistent Antigen hypothesis" proposes that persistent antigens contribute to chronic health conditions, including certain specific diseases.

NEUROSCIENCE INSIGHTS (2022)

添加到收藏夹

暂无数据

Article Immunology

Isolation and characterisation of PR3-specific B cells and their immunoglobulin sequences

Shane Kelly, Katherine J. L. Jackson, Timothy J. Peters, Dan Suan, Christopher C. Goodnow

Summary: This study successfully identified and characterized PR3-specific B cells from the peripheral blood of patients with PR3 autoantibodies. These cells exhibited specific immunological features, suggesting that PR3 self-reactivity may occur early in B-cell development.

JOURNAL OF AUTOIMMUNITY (2024)

添加到收藏夹

Article Immunology

Targeting NF-κB signaling in B cells as a potential new treatment modality for ANCA-associated vasculitis

Ana Merino-Vico, Jan Piet van Hamburg, Paul Tuijnenburg, Giulia Frazzei, Aram Al-Soudi, Carlo G. Bonasia, Boy Helder, Abraham Rutgers, Wayel H. Abdulahad, Coen A. Stegeman, Jan-Stephan Sanders, Laura Bergamaschi, Paul A. Lyons, Theo Bijma, Laura van Keep, Kirsten Wesenhagen, Aldo Jongejan, Henric Olsson, Niek de Vries, Taco W. Kuijpers, Peter Heeringa, Sander W. Tas

Summary: B lineage cells play a critical role in ANCA-associated vasculitis (AAV), and the transcription factor NF-kappa B may be a potential therapeutic target for AAV and other autoimmune diseases with prominent B cell involvement.

JOURNAL OF AUTOIMMUNITY (2024)

添加到收藏夹

Article Immunology

K2P2.1 is a regulator of inflammatory cell responses in idiopathic inflammatory myopathies

Christopher Nelke, Thomas Muentefering, Derya Cengiz, Lukas Theissen, Vera Dobelmann, Christina B. Schroeter, Helena Block, Corinna Preu, Alexander P. E. Michels, Stefanie Lichtenberg, Marc Pawlitzki, Steffen Pfeuffer, Niklas Huntemann, Alexander Zarbock, Thorben Briese, Christoph Kittl, Carsten Dittmayer, Thomas Budde, Ingrid E. Lundberg, Werner Stenzel, Sven G. Meuth, Tobias Ruck

Summary: K2P2.1 plays a regulatory role in the autoimmune response of idiopathic inflammatory myopathies (IIMs), by regulating inflammatory cell response, adhesion, and transmigration in both endothelial and skeletal muscle cells. Inhibiting K2P2.1 enhances the inflammatory response, while activating K2P2.1 improves the disease course.

JOURNAL OF AUTOIMMUNITY (2024)

添加到收藏夹

Article Immunology

2023 International Consensus Guidance for the use of Tripterygium Wilfordii Hook F in the treatment of active rheumatoid arthritis

Xuan Zhang, Jun Xia, Ying Jiang, David S. Pisetsky, Josef S. Smolen, Rong Mu, Shengming Dai, Michael E. Weinblatt, Tore K. Kvien, Juan Li, Thomas Doerner, Yu Zhang, Liwei Lu, Chengde Yang, Pingting Yang, Yuan Zhang, Chenchen Xu, Zhan Zhao, Peter E. Lipsky

Summary: The study suggests that TwHF may be as effective as MTX in treating active RA, and combination therapy may be more effective than monotherapy.

JOURNAL OF AUTOIMMUNITY (2024)

添加到收藏夹

Article Immunology

Novel and unique rheumatoid factors cross-react with viral epitopes in COVID-19

Maya F. Amjadi, Maxwell H. Parker, Ryan R. Adyniec, Zihao Zheng, Alex M. Robbins, S. Janna Bashar, Michael F. Denny, Sara S. Mccoy, Irene M. Ong, Miriam A. Shelef

Summary: Rheumatoid factors (RFs) are polyreactive antibodies that can bind disease-specific epitopes. Recent studies have found that RFs in COVID-19 can bind novel IgG epitopes, which provides new insights into the mechanism of RFs.

JOURNAL OF AUTOIMMUNITY (2024)

添加到收藏夹

Article Immunology

Risk factors for hypogammaglobulinemia and association with relapse and severe infections in ANCA-associated vasculitis: A cohort study

Johanne Liberatore, Yann Nguyen, Jerome Hadjadj, Pascal Cohen, Luc Mouthon, Xavier Puechal, Loic Guillevin, Benjamin Terrier

Summary: B-cell depletion induced by rituximab (RTX) in ANCA-associated vasculitis (AAV) can lead to decreased gammaglobulin levels, which is associated with an increased risk of relapse and severe infections. Older age, low gammaglobulin levels, and receiving pulses of methylprednisolone at induction therapy are risk factors for gammaglobulin decline.

JOURNAL OF AUTOIMMUNITY (2024)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.