Article
Nutrition & Dietetics
Mengying Qu, Siyuan Wan, Huaiyong Wu, Bingxuan Ren, Yao Chen, Lixiang Liu, Hongmei Shen
Summary: The present study aimed to explore the DNA methylation patterns in AIT patients and different iodine levels areas. The findings showed that DNA methylation levels of the DAPK1 gene were higher in AIT cases, and there were differences in methylation between cases and controls in different iodine levels areas. The results suggest that environmental iodine may affect DNA methylation to some extent.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Armando Flores-Rebollar, Ivan Perez-Diaz, Olynka Vega-Vega, Raul Rivera-Moscoso, Reynerio Fagundo-Sierra, Sergio L. Carbajal-Morelos, Hillary K. Osorio-Landa, Maria G. Lopez-Carrasco, Ana R. Lira-Reyes, Ricardo Correa-Rotter
Summary: The study aimed to evaluate thyroid dysfunction prevalence in a cohort of healthy individuals in Mexico City and investigate the potential associations with their iodine intake. Results showed a high prevalence of thyroid dysfunction, with most individuals having adequate iodine intake but discrepancies in urinary iodine markers. Further studies are needed to define the prevalence of thyroid dysfunction and iodine nutritional status in Mexico.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Yiwen Li, Hao Liu, Chengyan He, Yawen Lin, Lei Ma, Haibo Xue
Summary: Excessive iodine intake can cause and worsen autoimmune thyroiditis (AIT), which is a typical autoimmune disease mediated by CD4(+) T cells. This study found that the proportion of Th9 cells, a novel subpopulation of CD4(+) T cells, increased in murine models of AIT induced by excess iodine intake. The increase in Th9 cells may be an important factor in the occurrence and development of AIT.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Immunology
Wei Wang, Qi-Lan Jiang, Qin Xu, Yang Zeng, Rui Jiang, Jun Jiang
Summary: Selenium supplementation has the potential to improve the prognosis of autoimmune thyroiditis (AIT) by altering the subset differentiation and/or function of CD4+ T cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Yuhang Zhao, Lili Xu, Qing Wang, Chengqian Li, Tao Zhang, Shichao Xing, Xiaolong Yu
Summary: This study reveals the important role of LINC01061 in the development of autoimmune thyroid disease (AITD) by upregulating the expression of BRD4. The findings provide insights into the pathogenesis of AITD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Environmental Sciences
Hongmei Shen, Jinjin Liu, Yun Chen, Bingxuan Ren, Zheng Zhou, Meihui Jin, Lingbo Wang, Yanhong He, Fan Li, Baoxiang Li, Mengxue Du
Summary: This study aimed to identify and verify G protein-related methylated genes in AIT patients, and investigate their expression in AIT patients exposed to different water iodine levels. The results showed hypomethylation and high expression of RAB8A and RAP1A in all AIT cases. In different water iodine areas, RAB8A was mainly hypomethylated in IFA and IEA, while RAP1A was primarily hypomethylated in IEA.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2023)
Article
Medicine, General & Internal
Xiajing Zhu, Chao Liu
Summary: Iodinated thyroglobulin reflects the iodine content in thyroid hormone in the human body and is closely related to thyroid function. However, the relationship between iodinated TG and autoimmune thyroiditis is still controversial and requires further research for confirmation.
ACTA MEDICA MEDITERRANEA
(2021)
Article
Endocrinology & Metabolism
Siyuan Wan, Lixiang Liu, Bingxuan Ren, Mengying Qu, Huaiyong Wu, Wen Jiang, Xiaoming Wang, Hongmei Shen
Summary: This study confirmed the differential methylation status in genomic DNA of patients with autoimmune thyroiditis, and some gene methylation levels were negatively correlated with relative mRNA expression levels. HLA-DPB1 and PDCD1LG2 genes related to the cell adhesion molecule pathway may play a role in the development of AIT, with potential differences based on different water iodine levels.
Review
Pharmacology & Pharmacy
Silvia Martina Ferrari, Francesca Ragusa, Giusy Elia, Sabrina Rosaria Paparo, Valeria Mazzi, Enke Baldini, Salvatore Benvenga, Alessandro Antonelli, Poupak Fallahi
Summary: Autoimmune thyroid diseases, such as Hashimoto's thyroiditis and Graves' disease, are treated with daily synthetic L-thyroxine. Treatment with myoinositol and selenium can significantly reduce TSH and antithyroid autoantibodies levels. In rare cases, thyroidectomy may be recommended in patients with autoimmune thyroiditis. Further research is needed to investigate the impact of these new treatments on quality of life in a larger population.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Tiantian Cai, Peng Du, Lixia Suo, Xiaozhen Jiang, Qiu Qin, Ronghua Song, Xiaorong Yang, Yanfei Jiang, Jin-an Zhang
Summary: This study found that hyperpolarization of M1-type macrophages is closely related to the pathogenesis of autoimmune thyroid disease (AITD). High iodine can affect macrophage polarization and mediate it through the metabolic gene HK3.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Xihua Yang, Lixia Chen, Lili Zhao, Yongming Yang, Jing Wang, Lei Yan, Gang Tai, Hong Zhang
Summary: The study aimed to investigate the therapeutic effect of Isaria felina on experimental autoimmune thyroiditis (EAT). The results showed that high-dose Isaria felina treatment significantly reduced circulating TSH, thyroid antibody, and cytokine levels in EAT mice. In addition, high-dose Isaria felina alleviated histopathological abnormalities and attenuated cell apoptosis in the thyroid tissue samples.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Zvi Laron, Lester Shulman, Christiane Hampe, Orit Blumenfeld
Summary: Children and adolescents with early onset autoimmune diseases are born in different months compared to the general population. This suggests that infections during pregnancy or shortly after birth may play a role in triggering these diseases. Data supports the use of Rotavirus vaccinations in reducing the incidence of childhood T1D, and further research is needed on the potential benefits of other anti-virus vaccines for other autoimmune diseases such as multiple sclerosis, atopic dermatitis, psoriasis, rheumatoid arthritis subtypes, and Hashimoto thyroiditis.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Nutrition & Dietetics
Zheng Zhou, Meihui Jin, Baoxiang Li, Yanhong He, Lixiang Liu, Bingxuan Ren, Jianshuang Li, Fan Li, Jinjin Liu, Yun Chen, Siyuan Wan, Hongmei Shen
Summary: Iodine is a necessary nutrient that can impact the occurrence of autoimmune thyroiditis (AIT). This study examined the methylation and mRNA expression of genes involved in apoptosis and DNA methylation in relation to iodine levels in AIT patients. It was found that certain genes were hypermethylated or hypomethylated in AIT patients, and there was a negative correlation between methylation levels and mRNA expression. The combination of iodine fortification and specific gene methylation was associated with an increased risk of AIT.
BRITISH JOURNAL OF NUTRITION
(2023)
Review
Immunology
Qian Zhu, Qian-Han Xu, Ting Xie, Li-Ling Wang, Hong Liu, Kahindo P. Muyayalo, Xiao-Bo Huang, Si-Jia Zhao, Ai-Hua Liao
Summary: Autoimmune thyroiditis (AIT) is associated with adverse reproductive outcomes, potentially due to abnormal changes in the maternal immune system and maternal-fetal interface. Dysfunctions in both humoral and cellular immunity may contribute to infertility, miscarriage, and preterm birth in women with AIT.
CLINICAL IMMUNOLOGY
(2021)
Review
Clinical Neurology
Chunxiao Wei, Yanxin Shen, Weijie Zhai, Tianling Shang, Zicheng Wang, Yongchun Wang, Mingxi Li, Yang Zhao, Li Sun
Summary: Hashimoto's encephalopathy (HE) is characterized by a variety of clinical manifestations and neuropsychiatric features, with non-specific encephalopathy and cerebellar ataxia as main symptoms being rare. We reported a case of HE with cerebellar ataxia as the main manifestation, which showed improvement after steroid treatment. Based on our findings and literature review, prompt diagnosis and effective treatment should be initiated for encephalopathy without an obvious cause.
FRONTIERS IN NEUROLOGY
(2022)
Article
Immunology
Shane Kelly, Katherine J. L. Jackson, Timothy J. Peters, Dan Suan, Christopher C. Goodnow
Summary: This study successfully identified and characterized PR3-specific B cells from the peripheral blood of patients with PR3 autoantibodies. These cells exhibited specific immunological features, suggesting that PR3 self-reactivity may occur early in B-cell development.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Ana Merino-Vico, Jan Piet van Hamburg, Paul Tuijnenburg, Giulia Frazzei, Aram Al-Soudi, Carlo G. Bonasia, Boy Helder, Abraham Rutgers, Wayel H. Abdulahad, Coen A. Stegeman, Jan-Stephan Sanders, Laura Bergamaschi, Paul A. Lyons, Theo Bijma, Laura van Keep, Kirsten Wesenhagen, Aldo Jongejan, Henric Olsson, Niek de Vries, Taco W. Kuijpers, Peter Heeringa, Sander W. Tas
Summary: B lineage cells play a critical role in ANCA-associated vasculitis (AAV), and the transcription factor NF-kappa B may be a potential therapeutic target for AAV and other autoimmune diseases with prominent B cell involvement.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Christopher Nelke, Thomas Muentefering, Derya Cengiz, Lukas Theissen, Vera Dobelmann, Christina B. Schroeter, Helena Block, Corinna Preu, Alexander P. E. Michels, Stefanie Lichtenberg, Marc Pawlitzki, Steffen Pfeuffer, Niklas Huntemann, Alexander Zarbock, Thorben Briese, Christoph Kittl, Carsten Dittmayer, Thomas Budde, Ingrid E. Lundberg, Werner Stenzel, Sven G. Meuth, Tobias Ruck
Summary: K2P2.1 plays a regulatory role in the autoimmune response of idiopathic inflammatory myopathies (IIMs), by regulating inflammatory cell response, adhesion, and transmigration in both endothelial and skeletal muscle cells. Inhibiting K2P2.1 enhances the inflammatory response, while activating K2P2.1 improves the disease course.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Xuan Zhang, Jun Xia, Ying Jiang, David S. Pisetsky, Josef S. Smolen, Rong Mu, Shengming Dai, Michael E. Weinblatt, Tore K. Kvien, Juan Li, Thomas Doerner, Yu Zhang, Liwei Lu, Chengde Yang, Pingting Yang, Yuan Zhang, Chenchen Xu, Zhan Zhao, Peter E. Lipsky
Summary: The study suggests that TwHF may be as effective as MTX in treating active RA, and combination therapy may be more effective than monotherapy.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Maya F. Amjadi, Maxwell H. Parker, Ryan R. Adyniec, Zihao Zheng, Alex M. Robbins, S. Janna Bashar, Michael F. Denny, Sara S. Mccoy, Irene M. Ong, Miriam A. Shelef
Summary: Rheumatoid factors (RFs) are polyreactive antibodies that can bind disease-specific epitopes. Recent studies have found that RFs in COVID-19 can bind novel IgG epitopes, which provides new insights into the mechanism of RFs.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Johanne Liberatore, Yann Nguyen, Jerome Hadjadj, Pascal Cohen, Luc Mouthon, Xavier Puechal, Loic Guillevin, Benjamin Terrier
Summary: B-cell depletion induced by rituximab (RTX) in ANCA-associated vasculitis (AAV) can lead to decreased gammaglobulin levels, which is associated with an increased risk of relapse and severe infections. Older age, low gammaglobulin levels, and receiving pulses of methylprednisolone at induction therapy are risk factors for gammaglobulin decline.
JOURNAL OF AUTOIMMUNITY
(2024)