Review
Biochemistry & Molecular Biology
Ali Youness, Charles-Henry Miquel, Jean-Charles Guery
Summary: Women are more susceptible to autoimmune diseases, not only due to sex hormones, but also because of X-linked genetic factors. X chromosome inactivation in female mammals results in cellular mosaicism and escape of some X-linked genes from inactivation, impacting the functional plasticity of female immune cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Yanwen Lu, Yiqi Zhu, Wenliang Ma, Ning Liu, Xiang Dong, Qiancheng Shi, Fei Yu, Hongqian Guo, Dongmei Li, Weidong Gan
Summary: Based on the epidemiological characteristics, estrogen may be responsible for the susceptibility and age selectivity of women in Xp11.2 translocation renal cell carcinoma (Xp11.2 tRCC). Rad54l2, a key effector protein of estrogen-mediated DNA damage, is downregulated in multiple cancers, but its role in the epidemiological characteristics of Xp11.2 tRCC needs further investigation.
SCIENTIFIC REPORTS
(2023)
Review
Pathology
Nicholas Baniak, Justine A. Barletta, Michelle S. Hirsch
Summary: This article provides an overview of renal neoplasms more commonly diagnosed in females, such as metanephric adenoma and mixed epithelial and stromal tumor. It discusses the clinical, gross, microscopic, immunohistochemical, genetic, and molecular alterations in these tumors, as well as differential diagnoses.
ADVANCES IN ANATOMIC PATHOLOGY
(2021)
Article
Multidisciplinary Sciences
Hongmei Yang, Chang-ki Oh, Haitham Amal, John S. Wishnok, Sarah Lewis, Emily Schahrer, Dorit Trudler, Tomohiro Nakamura, Steven R. Tannenbaum, Stuart A. Lipton
Summary: Protein S-nitrosylation plays a crucial role in various processes in health and disease, and it is implicated in synaptic damage in Alzheimer's disease. By studying SNO proteins in AD brains, we found that the formation of SNO-C3 is sex-dependent and may contribute to cognitive decline through increased synaptic phagocytosis.
Article
Biochemistry & Molecular Biology
I-Heng Chiu, Tsen-Fang Tsai
Summary: Ixekizumab (Taltz(®)) is a humanized anti-IL-17A monoclonal antibody used to treat inflammatory diseases. Overweight or obesity may be protective against ixekizumab-induced injection site reactions, while a positive family history of psoriasis may be a potential risk factor. Additionally, patients experiencing diarrhea after ixekizumab injection are at higher risk for developing injection site reactions.
Article
Sport Sciences
Philip L. Edwards, Aine MacNamara, Chris Saward
Summary: This study examined the psychological characteristics of female field hockey players in a national talent development program in North America. The results showed that age, selection status, and their interaction played a role in the players' psychological profiles. The findings suggest that the PCDEQ-2 is an important tool to support athletes' development at both group and individual levels.
JOURNAL OF SPORTS SCIENCES
(2023)
Article
Immunology
Georg Christian Lodde, Frederik Krefting, Jan-Malte Placke, Lea Schneider, Melanie Fiedler, Ulf Dittmer, Juergen Christian Becker, Stefanie Hoelsken, Dirk Schadendorf, Selma Ugurel, Wiebke Sondermann
Summary: This prospective single-center cohort study aimed to determine the rate of seroconversion after COVID-19 vaccination in patients under active systemic treatment for moderate to severe psoriasis. The results showed that 96.1% of patients undergoing systemic treatment for psoriasis achieved anti-SARS-CoV-2-S IgG seroconversion after COVID-19 vaccination, but impaired immune response was observed in patients receiving MTX and/or TNF-alpha inhibitors.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Oncology
Jennifer J. Gao, Richard Pazdur
Summary: The Oncology Center of Excellence of the US Food and Drug Administration has taken initiatives to address COVID-19-related challenges faced by patients with cancer and the healthcare professionals who provide cancer treatment.
Article
Dermatology
Giacomo Caldarola, Gennaro Marco Falco, Laura Calabrese, Alessandra D'Amore, Andrea Chiricozzi, Marco Mariani, Gerardo Palmisano, Clara De Simone, Ketty Peris
Summary: Treatment of palmoplantar psoriasis is challenging, and biologic drugs provide longer persistence in treatment compared to non-biologics.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Surgery
Hope N. Moore, Alexis R. Chirco, Trevor Plescia, Shushmita Ahmed, Barbara Jachniewicz, Ganesh Rajasekar, Mohamed R. Ali, Victoria Lyo
Summary: Gastrointestinal symptoms are common after bariatric surgery and exocrine pancreatic insufficiency (EPI) is recognized as a contributor to these symptoms. This study found that EPI is more common in older patients with lower BMI, and it is more prevalent in patients who underwent RYGB and BPD-DS procedures.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Plant Sciences
Yagut Allahverdiyeva, Eva-Mari Aro, Bert van Bavel, Carlos Escudero, Christiane Funk, Jarna Heinonen, Lars Herfindal, Peter Lindblad, Sari Makinen, Merja Penttila, Kaarina Sivonen, Matilde Skogen Chauton, Hanne Skomedal, Jorunn Skjermo
Summary: NordAqua is a Nordic Center of Excellence focused on promoting Blue Bioeconomy and reforming the use of natural resources sustainably. Their key research includes improving photosynthesis, developing novel photosynthetic cell factories, promoting diversity of Nordic cyanobacteria and algae, and improving bio-based wastewater purification technologies.
PHYSIOLOGIA PLANTARUM
(2021)
Article
Biochemistry & Molecular Biology
Paolo Solidoro, Stefania Nicola, Irene Ridolfi, Giorgio Walter Canonica, Francesco Blasi, Pierluigi Paggiaro, Enrico Heffler, Diego Bagnasco, Filippo Patrucco, Fulvia Ribolla, Caterina Bucca, Giovanni Rolla, Carlo Albera, Luisa Brussino
Summary: Biologic drugs have shown significant long-term efficacy in most patients with severe eosinophilic asthma (SEA), and switching to another biological drug may lead to significant improvement in patients with poor asthma control.
Article
Medicine, General & Internal
Yi-Wei Huang, Tsen-Fang Tsai
Summary: Flare-ups of psoriasis have been reported following COVID-19 vaccination, possibly due to the induction of Th17 cells. Psoriasis patients should be aware of potential fluctuations in disease activity after vaccination, but the benefits of vaccination in preventing severe COVID-19 infection and mortality outweigh the risks for those with psoriasis.
FRONTIERS IN MEDICINE
(2021)
Article
Computer Science, Information Systems
Eija Hartikainen, Virpi Hotti, Markku Tukiainen
Summary: The research found that commercial monitoring tools for RPA maintenance in large-scale environments do not meet the functional requirements, and organizations need to develop their own tools. Meanwhile, either in-house or outsourced Centers of Excellence (CoE) seem to be one of the success factors in RPA maintenance in large-scale environments.
Article
Education, Scientific Disciplines
Andrew A. Marano, Melissa Noyes, Lauren Eisenbeis, Helene F. Hedian, Kara Segna, Paula M. Neira, Kate Thomas, W. P. Andrew Lee, Richard J. Redett, Devin Coon
Summary: Gender-affirming care for TGD individuals requires coordinated efforts of specialized practitioners. The Johns Hopkins Center for Transgender Health used a service line model to provide a patient-centered experience with seamless integration of disciplines. The center's growth was facilitated by partnerships among various medical fields, aiming to expand healthcare quality and access for TGD individuals.
Letter
Rheumatology
Maria De Santis, Antonio Voza, Victor Savevski, Salvatore Badalamenti, Maurizio Cecconi, Alberto Mantovani, Carlo Selmi
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Allergy
Maria Elena Laino, Angela Ammirabile, Francesca Motta, Maria De Santis, Victor Savevski, Marco Francone, Arturo Chiti, Lorenzo Mannelli, Carlo Selmi, Lorenzo Monti
Summary: The cardiovascular system is frequently affected by COVID-19, particularly in hospitalized cases, leading to complications such as myocarditis and pulmonary embolism. Early detection through imaging techniques such as CT scan and MRI is important for prompt disease recognition and evaluation. The immune system's abnormal response is responsible for severe COVID-19 and organ-specific injury, with molecular mimicry possibly being the immunological mechanism for myocarditis in COVID-19.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2023)
Article
Allergy
Rossana Scrivo, Salvatore D'Angelo, Antonio Carriero, Chiara Castellani, Fabio Massimo Perrotta, Fabrizio Conti, Matteo Vecellio, Carlo Selmi, Ennio Lubrano
Summary: Psoriatic arthritis is a chronic inflammatory disease characterized by various symptoms and comorbidities. Its pathogenesis involves both autoinflammatory and autoimmune aspects.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2023)
Article
Allergy
Augusto Bleve, Francesca Motta, Barbara Durante, Chiara Pandolfo, Carlo Selmi, Antonio Sica
Summary: The immune system plays a crucial role in maintaining tissue homeostasis and defending against pathogens and cancer cells. However, the aging process leads to a decline in immune function, resulting in compromised immune responses and unresolved inflammation. This contributes to a subclinical syndrome of homeostatic frailty in the elderly, making them more susceptible to immune debilitation and chronic low-grade inflammation, which in turn increase the risk of chronic and degenerative diseases. This review focuses on the age-dependent changes in myeloid populations and their impact on frailty and diseases in the elderly.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2023)
Review
Immunology
Carlo Ticconi, Annalisa Inversetti, Eleonora Logruosso, Matilda Ghio, Luisa Casadei, Carlo Selmi, Nicoletta Di Simone
Summary: This systematic review and meta-analysis aimed to investigate the correlation between isolated serum antinuclear antibody (ANA) and infertility in IVF, idiopathic recurrent pregnancy losses (RPL), and pregnancy complications in the second/third trimester. The study found that ANA-positive women undergoing IVF had a lower pregnancy rate and a higher miscarriage rate compared to ANA-negative women. In terms of RPL, there was a higher prevalence of ANA-positivity. However, the effect of serum ANA on late pregnancy complications was inconclusive.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Editorial Material
Rheumatology
Nicoletta Luciano, Carlo Selmi
Article
Medicine, General & Internal
Karolina Akinosoglou, Antigone Kotsaki, Ioanna-Maria Gounaridi, Eirini Christaki, Simeon Metallidis, Georgios Adamis, Archontoula Fragkou, Massimo Fantoni, Aggeliki Rapti, Ioannis Kalomenidis, Georgios Chrysos, Gloria Boni, Ilias Kainis, Zoi Alexiou, Francesco Castelli, Francesco Saverio Serino, Petros Bakakos, Emanuele Nicastri, Vassiliki Tzavara, Asimina Safarika, Sofia Ioannou, Lorenzo Dagna, Katerina Dimakou, Glykeria Tzatzagou, Maria Chini, Matteo Bassetti, Vasileios Kotsis, Andrea Angheben, George Tsoukalas, Carlo Selmi, Olga-Maria Spiropoulou, Michael Samarkos, Michael Doumas, Georgia Damoraki, Aikaterini Masgala, Ilias Papanikolaou, Aikaterini Argyraki, Marcantonio Negri, Konstantinos Leventogiannis, Styliani Sympardi, Nikolaos K. Gatselis, Vasileios Petrakis, Mihai G. Netea, Periklis Panagopoulos, Vissaria Sakka, George N. Dalekos, Evangelos J. Giamarellos-Bourboulis
Summary: The SAVE-MORE trial found that anakinra treatment in COVID-19 pneumonia patients with suPAR levels of 6 ng/mL or more was associated with worse outcomes compared to placebo at day 28. Subgroup analyses showed that anakinra treatment had lower odds of worse outcomes in all studied subgroups. Long-term outcomes at days 60 and 90 also favored anakinra treatment.
Article
Immunology
Elena Azzolini, Maximiliano Mollura, Chiara Pozzi, Leonardo Ubaldi, Alberto Mantovani, Carlo Selmi, Riccardo Barbieri, Maria Rescigno
Summary: An important issue often ignored is the discrepancy in medical treatment response between male and female genders. COVID-19 vaccine administration has revealed that females tend to experience more adverse events compared to males despite following identical protocols. Through logistic regression analysis of adverse events in 2385 healthcare workers receiving the Comirnaty vaccine, we found that age, sex, COVID-19 history, and BMI may contribute to the development of adverse events, particularly in young subjects, females, and individuals with a BMI below 25 kg/m(2). Furthermore, partial dependence plots indicate a 50% probability of mild adverse events lasting for a long period (>= 7 days) or any duration of severe adverse events in women below 40 years old with a BMI < 20 kg/m(2). Given that this effect is more prominent after the second vaccine dose, we propose adjusting the vaccine dosage for additional booster doses based on age, sex, and BMI to reduce adverse events without compromising vaccine efficacy.
Review
Medicine, General & Internal
Anna Stainer, Antonio Tonutti, Maria De Santis, Francesco Amati, Angela Ceribelli, Gabriele Bongiovanni, Chiara Torrisi, Antonio Iacopino, Giuseppe Mangiameli, Stefano Aliberti, Carlo Selmi
Summary: Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovitis, and interstitial lung disease (RA-ILD) is a common extra-articular feature. The mechanisms and predictors of RA-ILD are limited, and early identification is crucial for timely treatment. New biomarkers, imaging techniques, and diagnostic pathways are needed for better management of RA-ILD.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Angela Ceribelli, Antonio Tonutti, Natasa Isailovic, Maria De Santis, Carlo Selmi
Summary: Progressive pulmonary fibrosis is diagnosed when interstitial lung disease progresses without any other causes, and some myositis patients with associated interstitial lung disease may develop this condition. Autoantibodies increase the risk of pulmonary fibrosis in myositis, and serum biomarkers can predict pulmonary involvement and the early identification of progressive pulmonary fibrosis. The association between anti-Ro52 and pulmonary fibrosis in patients with inflammatory myositis has been supported by previous evidence.
FRONTIERS IN MEDICINE
(2023)
Article
Health Care Sciences & Services
Margherita Zen, Mariele Gatto, Roberto Depascale, Francesca Regola, Micaela Fredi, Laura Andreoli, Franco Franceschini, Maria Letizia Urban, Giacomo Emmi, Fulvia Ceccarelli, Fabrizio Conti, Alessandra Bortoluzzi, Marcello Govoni, Chiara Tani, Marta Mosca, Tania Ubiali, Maria Gerosa, Enrica P. Bozzolo, Valentina Canti, Paolo Cardinaletti, Armando Gabrielli, Giacomo Tanti, Elisa Gremese, Ginevra De Marchi, Salvatore De Vita, Serena Fasano, Francesco Ciccia, Giulia Pazzola, Carlo Salvarani, Simone Negrini, Andrea Di Matteo, Rossella De Angelis, Giovanni Orsolini, Maurizio Rossini, Paola Faggioli, Antonella Laria, Matteo Piga, Alberto Cauli, Salvatore Scarpato, Francesca Wanda Rossi, Amato De Paulis, Enrico Brunetta, Angela Ceribelli, Carlo Selmi, Marcella Prete, Vito Racanelli, Angelo Vacca, Elena Bartoloni, Roberto Gerli, Elisabetta Zanatta, Maddalena Larosa, Francesca Saccon, Andrea Doria, Luca Iaccarino
Summary: This study assessed the efficacy of belimumab in treating joint and skin manifestations in a nationwide cohort of SLE patients. The results showed that belimumab significantly improved joint and skin symptoms and reduced the use of glucocorticoids. A significant proportion of patients who did not achieve complete remission initially achieved remission during follow-up.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Medicine, General & Internal
Antonio Tonutti, Iside Scarfo, Giovanni La Canna, Carlo Selmi, Maria De Santis
Summary: Nonbacterial thrombotic endocarditis (NBTE) is a type of endocarditis that occurs in patients with predisposing conditions, commonly referred to as marantic or Libman-Sacks endocarditis. The clinical presentation involves embolic events, with fewer valvular complications compared to infective forms of endocarditis. The diagnosis is primarily based on echocardiography, with comprehensive microbiological and serological tests to exclude infective endocarditis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Meeting Abstract
Rheumatology
Angela Ceribelli, Francesca Motta, Nicoletta Luciano, Giacomo Maria Guidelli, Marta Caprioli, Natasa Isailovic, Matteo Vecellio, Sofia Manara, Lorenzo Monti, Marco Francone, Carlo Selmi, Maria De Santis
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Article
Rheumatology
Antonio Tonutti, Edoardo Simonetta, Anna Stainer, Giulia Suigo, Maria De Santis, Carlo Selmi, Chiara Masetti, Ana Lleo, Luigi Maria Terracciano, Stefano Aliberti, Francesco Amati
Summary: We report the first case of ANCA-associated vasculitis following Pfizer-BioNTech vaccine, with prominent liver involvement and alveolar haemorrhage. The patient developed inflammatory arthralgias and hypertransaminasaemia two weeks after vaccination. Fever and haemoptysis appeared two months later, and the patient tested positive for anti-proteinase 3 autoantibodies.
MODERN RHEUMATOLOGY CASE REPORTS
(2023)
Article
Allergy
Francesca Motta, Elisa Barone, Antonio Sica, Carlo Selmi
Summary: Osteoarthritis is a prevalent disease in the elderly population, and the role of inflammaging in its development has been explored. Inflammaging affects immune response and cartilage degradation, and may serve as a potential therapeutic target.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2023)
Article
Immunology
Shane Kelly, Katherine J. L. Jackson, Timothy J. Peters, Dan Suan, Christopher C. Goodnow
Summary: This study successfully identified and characterized PR3-specific B cells from the peripheral blood of patients with PR3 autoantibodies. These cells exhibited specific immunological features, suggesting that PR3 self-reactivity may occur early in B-cell development.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Ana Merino-Vico, Jan Piet van Hamburg, Paul Tuijnenburg, Giulia Frazzei, Aram Al-Soudi, Carlo G. Bonasia, Boy Helder, Abraham Rutgers, Wayel H. Abdulahad, Coen A. Stegeman, Jan-Stephan Sanders, Laura Bergamaschi, Paul A. Lyons, Theo Bijma, Laura van Keep, Kirsten Wesenhagen, Aldo Jongejan, Henric Olsson, Niek de Vries, Taco W. Kuijpers, Peter Heeringa, Sander W. Tas
Summary: B lineage cells play a critical role in ANCA-associated vasculitis (AAV), and the transcription factor NF-kappa B may be a potential therapeutic target for AAV and other autoimmune diseases with prominent B cell involvement.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Christopher Nelke, Thomas Muentefering, Derya Cengiz, Lukas Theissen, Vera Dobelmann, Christina B. Schroeter, Helena Block, Corinna Preu, Alexander P. E. Michels, Stefanie Lichtenberg, Marc Pawlitzki, Steffen Pfeuffer, Niklas Huntemann, Alexander Zarbock, Thorben Briese, Christoph Kittl, Carsten Dittmayer, Thomas Budde, Ingrid E. Lundberg, Werner Stenzel, Sven G. Meuth, Tobias Ruck
Summary: K2P2.1 plays a regulatory role in the autoimmune response of idiopathic inflammatory myopathies (IIMs), by regulating inflammatory cell response, adhesion, and transmigration in both endothelial and skeletal muscle cells. Inhibiting K2P2.1 enhances the inflammatory response, while activating K2P2.1 improves the disease course.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Xuan Zhang, Jun Xia, Ying Jiang, David S. Pisetsky, Josef S. Smolen, Rong Mu, Shengming Dai, Michael E. Weinblatt, Tore K. Kvien, Juan Li, Thomas Doerner, Yu Zhang, Liwei Lu, Chengde Yang, Pingting Yang, Yuan Zhang, Chenchen Xu, Zhan Zhao, Peter E. Lipsky
Summary: The study suggests that TwHF may be as effective as MTX in treating active RA, and combination therapy may be more effective than monotherapy.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Maya F. Amjadi, Maxwell H. Parker, Ryan R. Adyniec, Zihao Zheng, Alex M. Robbins, S. Janna Bashar, Michael F. Denny, Sara S. Mccoy, Irene M. Ong, Miriam A. Shelef
Summary: Rheumatoid factors (RFs) are polyreactive antibodies that can bind disease-specific epitopes. Recent studies have found that RFs in COVID-19 can bind novel IgG epitopes, which provides new insights into the mechanism of RFs.
JOURNAL OF AUTOIMMUNITY
(2024)
Article
Immunology
Johanne Liberatore, Yann Nguyen, Jerome Hadjadj, Pascal Cohen, Luc Mouthon, Xavier Puechal, Loic Guillevin, Benjamin Terrier
Summary: B-cell depletion induced by rituximab (RTX) in ANCA-associated vasculitis (AAV) can lead to decreased gammaglobulin levels, which is associated with an increased risk of relapse and severe infections. Older age, low gammaglobulin levels, and receiving pulses of methylprednisolone at induction therapy are risk factors for gammaglobulin decline.
JOURNAL OF AUTOIMMUNITY
(2024)
