期刊
JOURNAL OF AUTOIMMUNITY
卷 31, 期 3, 页码 301-305出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jaut.2008.04.001
关键词
Autoimmunity; B cells; CD8+T cell; Diabetes
类别
Type 1 diabetes mellitus is an autoimmune disease mediated by a selective immune-mediated destruction of the insulin containing beta cells within the pancreatic islets of Langerhans. T cells reactive to beta cell-derived antigens are critical for the pathogenesis of type 1 diabetes, indeed treatments that target T cells are currently in clinical trials. CD8+ T cells may play a particularly crucial role in the onset of hyperglycaemia, as they can mediate beta cell destruction late in the pathogenesis of diabetes. However, the precise steps by which beta cell-reactive CD8+ T cells are activated are poorly understood. In this review we speculate on the possibility that B cells are essential for the activation and expansion of pathogenic CD8+ T cells that cause final beta cell destruction, We also discuss the involvement of different B cell subsets in the aetiology of diabetes. (C) 2008 Elsevier Ltd. All rights reserved.
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