Article
Biochemistry & Molecular Biology
Nele Wagener, Wolfgang Lehmann, Lukas Weiser, Katharina Jaeckle, Pietro Di Fazio, Arndt F. Schilling, Kai O. Boeker
Summary: Attention deficit hyperactivity disorder (ADHD) is a common mental disorder in children, young people and adults. The abuse of ADHD-related drugs is increasing, and this study found that three cognitive enhancers negatively influence the differentiation and migration of bone-forming cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Yves Dauvilliers, Isabelle Arnulf, Nancy Foldvary-Schaefer, Anne Marie Morse, Karel Sonka, Michael J. Thorpy, Emmanuel Mignot, Patricia Chandler, Rupa Parvataneni, Jed Black, Amanda Sterkel, Dan Chen, Franck Skobieranda, Richard K. Bogan
Summary: Lower-sodium oxybate has been proven to be a safe and effective treatment for idiopathic hypersomnia.
Review
Biochemistry & Molecular Biology
Melinda Hersey, Mattingly K. Bartole, Claire S. Jones, Amy Hauck Newman, Gianluigi Tanda
Summary: Psychostimulant use disorders (PSUD) have significant public health and economic burdens, with sex differences observed in dependence onset, relapse rates, and treatment success. These differences may be related to neurochemical differences in the dopaminergic system, with females showing greater effects during the high estradiol phase. Women are more likely to start drug use at younger ages and exhibit higher desire for cocaine compared to men. Modafinil, a DAT inhibitor used for narcolepsy and sleep disorders, shows promise in treating PSUD, and its therapeutic potential is discussed in this review.
Article
Psychiatry
Yael Richter, Carlos Gordon, Gabriel Vainstein, Carmel Bublil-Mor, Dario Geisinger, Noya Meital-Kfir, Zohar Elyoseph
Summary: The study confirmed the significant benefits of peripheral visual stimulation intervention for adult ADHD patients, improving symptoms and executive functions. Neuro-glasses showed positive effects on response inhibition, with no major adverse events reported.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Behavioral Sciences
Sarah Kittel-Schneider, Boris B. Quednow, Anna Linda Leutritz, Rhiannon McNeill, Andreas Reif
Summary: This review focuses on analyzing the association of maternal ADHD with pregnancy, birth outcomes, early parent-child interaction, and child development in the first 3 years, as well as the impact of parental ADHD on early parent-child interaction and child development. Additionally, it also reviews the risks of stimulant and non-stimulant treatment for ADHD in pregnancy and lactation.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Valeska Cid-Jofre, Macarena Moreno, Ramon Sotomayor-Zarate, Gonzalo Cruz, Georgina M. Renard
Summary: This study aimed to evaluate the effects of chronic MOD treatment on neurochemicals, dopamine receptor 2 expression, and behavior in the mesocorticolimbic system of young healthy rats. The results showed that chronic use of MOD during adolescence induces behavioral and neurochemical changes associated with the mesocorticolimbic system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychiatry
Kanako Ishizuka, Tomomi Ishiguro, Norio Nomura, Toshiya Inada
Summary: The study found a significant correlation between depressive states and subjective ADHD symptoms. The higher the rate of improvement in depressive symptoms, the lower the frequency of positive ADHD screening by ASRS. Caution should be exercised when using self-report scales for diagnostic evaluation of comorbid ADHD in a primary care setting.
PSYCHIATRY RESEARCH
(2021)
Article
Psychology, Clinical
Andrew J. Cutler, Ann C. Childress, Antonio Pardo, Stephanie Duhoux, Roberto Gomeni, Eman Rafla, Thomas R. King, Judith C. Kando
Summary: This study evaluated the efficacy and safety of amphetamine extended-release tablets for the treatment of ADHD in adults. The results showed that the PERMP score was significantly higher in the AMPH ER TAB group compared to the placebo group at all time points. Common adverse events included decreased appetite, insomnia, and dry mouth. Most treatment-emergent adverse events were mild to moderate in severity, and no serious adverse events were reported.
JOURNAL OF CLINICAL PSYCHIATRY
(2022)
Article
Education, Special
Tomer Schmidt-Barad, Shlomit Asheri, Malka Margalit
Summary: This study aims to examine the relationships between memories of adults with ADHD and their social support and self-efficacy. The results indicated that positive and negative memories, family support, and peer support mediated the relations between ADHD symptoms and self-efficacy.
EUROPEAN JOURNAL OF SPECIAL NEEDS EDUCATION
(2023)
Article
Mathematics
Sonia Jarque Fernandez, Laura Amado Luz, Marta Oporto Alonso, Marina Fernandez-Andujar
Summary: The active participation of teachers in the diagnosis and intervention of ADHD is crucial for helping children with ADHD, and long-term psycho-education training programmes have been shown to significantly increase teachers' knowledge and perceived self-efficacy in managing ADHD.
Article
Psychiatry
Carlos Lopez-Pinar, Benjamin Selaskowski, Niclas Braun, Victoria Fornnes-Ferrer, Rebekka Euscher, Swantje Matthies, Thomas Jans, Ludger Tebartz van Elst, Christian Jacob, Michael Huss, Esther Sobanski, Wolfgang Retz, Michael Roesler, Petra Retz-Junginger, Barbara Alm, Bernhard Kis, Mona Abdel-Hamid, Michael Colla, Mathias Berger, Silke Lux, Alexandra Philipsen
Summary: This study compared the efficacy of dialectical behaviour group therapy (GPT) vs. individual clinical management (CM) and methylphenidate (MPH) vs. placebo (PLB) on emotional symptoms in adults with ADHD. The results showed that the reduction of anxiety symptoms was smaller in the GPT+MPH group at week 13, but the differences disappeared at subsequent assessments. The improvement in emotional symptoms was significantly predicted by reductions in core ADHD symptoms in all groups except the GPT+MPH group.
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Stephen V. Faraone, Roberto Gomeni, Joseph T. Hull, Soumya A. Chaturvedi, Gregory D. Busse, Zare Melyan, Welton O'Neal, Jonathan Rubin, Azmi Nasser
Summary: Early response to viloxazine ER treatment predicts efficacy outcome in ADHD patients, and the predictive model is consistent across different age groups.
PSYCHIATRY RESEARCH
(2022)
Article
Neurosciences
Samantha R. Linton, Michael Murphy, Hans S. Schroder, Micah Breiger, Ann M. Iturra-Mena, Brian D. Kangas, Jack Bergman, William A. Carlezon, Victoria B. Risbrough, Samuel A. Barnes, Andre Der-Avakian, Diego A. Pizzagalli
Summary: This study found that Modafinil increased the proportion and occurrence of microstate C, while decreasing the proportion and occurrence of microstate A and B. However, these Modafinil-related changes in microstate parameters were not associated with similar changes in flanker ERPs or behavior. Thus, Modafinil may deactivate large-scale sensory networks in favor of a higher order functional network during resting-state in healthy adults.
PSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Dara E. Babinski, Erika F. H. Saunders, Fan He, Duanping Liao, Amanda M. Pearl, Daniel A. Waschbusch
Summary: This study examined the diagnostic indicators, clinical characteristics, and functional impairment associated with adult ADHD using electronic medical records and self-report measures. The results showed a significant difference in prevalence of ADHD between self-report screening and medical records. ADHD was found to contribute to functional impairment even when controlling for other psychiatric comorbidities.
PSYCHIATRY RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Martin Seifrid, Riley J. Hickman, Andres Aguilar-Granda, Cyrille Lavigne, Jenya Vestfrid, Tony C. Wu, Theophile Gaudin, Emily J. Hopkins, Alan Aspuru-Guzik
Summary: Self-driving laboratories, in the form of automated experimentation platforms guided by machine learning algorithms, have emerged as a potential solution to the need for accelerated science. While automated synthesis remains a bottleneck, combining automated and manual synthesis efforts significantly expands the explorable chemical space. Quantifying the cost and considering the capabilities of both automated and manual synthesis can help determine the most efficient synthetic route.
ACS CENTRAL SCIENCE
(2022)
Article
Psychology, Developmental
Lenard A. Adler, Mary Solanto, Rodrigo Escobar, Sarah Lipsius, Himanshu Upadhyaya
JOURNAL OF ATTENTION DISORDERS
(2020)
Article
Pediatrics
Lenard A. Adler, Brigitte Robertson, Jie Chen, Elias Sarkis
JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
(2020)
Review
Psychiatry
Deepti Anbarasan, Michael Kitchin, Lenard A. Adler
CURRENT PSYCHIATRY REPORTS
(2020)
Article
Neurosciences
Moshe Isserles, Aron Tendler, Yiftach Roth, Alexander Bystritsky, Daniel M. Blumberger, Herbert Ward, David Feifel, Laura Viner, Walter Duffy, Joseph Zohar, Corey J. Keller, Mahendra T. Bhati, Amit Etkin, Mark S. George, Igor Filipcic, Kyle Lapidus, Leah Casuto, Sandeep Vaishnavi, Ahava Stein, Lisa Deutsch, Frederic Deutsch, Oscar Morales, Zafiris J. Daskalakis, Abraham Zangen, Kerry J. Ressler
Summary: This study examined the efficacy and safety of mPFC dTMS combined with exposure therapy in treating PTSD patients. Results showed significant improvement in PTSD symptoms in both groups at 5 and 9 weeks, though the dTMS group had smaller improvements. The study suggests that repeated ultrabrief exposure therapy alone may be an effective treatment for PTSD.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Pharmacology & Pharmacy
Lenard A. Adler, Robert Goldman, Seth C. Hopkins, Kenneth S. Koblan, Justine Kent, Jay Hsu, Antony Loebel
Summary: The study aimed to evaluate the efficacy and safety of dasotraline at doses of 4 and 6 mg/day in adults with ADHD. While the 6 mg/day dose showed significant effects on ADHD Rating Scale and Clinical Global Impression scores, the 4 mg/day dose did not show significant differences compared to placebo. Treatment with dasotraline was generally well tolerated and provided additional evidence supporting its potential efficacy at the 6 mg/day dose in adults with ADHD.
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2021)
Article
Neurosciences
Jillian M. Rung, Marilyn Horta, Erin M. Tammi, Eliany Perez, Marite C. Ojeda, Tian Lin, Griffin Harris, Jessie Somerville, Dinia Salmeron, Susan E. Beltz, Bhanuprasad Sandesara, David Feifel, Natalie C. Ebner
Summary: This study investigated the safety and tolerability of chronic intranasal oxytocin in generally healthy older men, finding it to be safe and well-tolerated. These findings support further research on the potential benefits of chronic oxytocin in older adult populations.
PSYCHOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Joseph J. Taylor, Noam G. Newberger, Adam P. Stern, Angela Phillips, David Feifel, Rebecca A. Betensky, Daniel Z. Press
Summary: Seizures during rTMS treatment are rare, with a low absolute risk but a higher relative risk associated with Brainsway H-coil compared to figure-8 coil devices. Well-designed prospective studies are needed to further investigate this risk.
Article
Psychiatry
Abraham Zangen, Hagar Moshe, Diana Martinez, Noam Barnea-Ygael, Tanya Vapnik, Alexander Bystritsky, Walter Duffy, Doron Toder, Leah Casuto, Moran Lipkinsky Grosz, Edward Nunes, Herbert Ward, Aron Tendler, David Feifel, Oscar Morales, Yiftach Roth, Dan Iosifescu, Jaron Winston, Theodore Wirecki, Ahava Stein, Frederic Deutsch, Xingbao Li, Mark S. George
Summary: rTMS is a non-invasive brain stimulation method increasingly used to treat psychiatric disorders, primarily depression. Initial studies suggest that rTMS may help to treat addictions, but evaluation in multicenter randomized controlled trials (RCTs) is needed. This study establishes a safe treatment protocol that promotes smoking cessation by stimulating relevant brain circuits.
Article
Neurosciences
Peiwei Liu, Tian Lin, David Feifel, Natalie C. Ebner
Summary: Growing evidence suggests that the neuropeptide oxytocin plays a role in promoting social cognition and prosocial behavior by modulating the salience of social information. This study found that self-administered intranasal oxytocin reduced resting-state functional connectivity within the salience network, with a stronger effect observed in older participants.
Article
Psychology, Multidisciplinary
Tian Lin, Didem Pehlivanoglu, Maryam Ziaei, Peiwei Liu, Adam J. Woods, David Feifel, Hakan Fischer, Natalie C. Ebner
Summary: The study found that older adults show dampened response to faces with lower trustworthiness compared to young adults, supporting the idea of reduced sensitivity to cues of untrustworthiness in aging. Additionally, the results extend evidence of an age-related positivity effect to the evaluation of face trustworthiness.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Medicine, General & Internal
Guy M. Goodwin, Scott T. Aaronson, Oscar Alvarez, Peter C. Arden, Annie Baker, James C. Bennett, Catherine Bird, Renske E. Blom, Christine Brennan, Donna Brusch, Lisa Burke, Kete Campbell-Coker, Robin Carhart-Harris, Joseph Cattell, Aster Daniel, Charles DeBattista, Boadie W. Dunlop, Katherine Eisen, David Feifel, MacKenzie Forbes, Hannah M. Haumann, David J. Hellerstein, Astrid I. Hoppe, Muhammad I. Husain, Luke A. Jelen, Jeanine Kamphuis, Julie Kawasaki, John R. Kelly, Richard E. Key, Ronit Kishon, Stephanie Knatz Peck, Gemma Knight, Martijn H. B. Koolen, Melanie Lean, Rasmus W. Licht, Jessica L. Maples-Keller, Jan Mars, Lindsey Marwood, Martin C. McElhiney, Tammy L. Miller, Arvin Mirow, Sunil Mistry, Tanja Mletzko-Crowe, Liam N. Modlin, Rene E. Nielsen, Elizabeth M. Nielson, Sjoerd R. Offerhaus, Veronica O'Keane, Tomas Palenicek, David Printz, Marleen C. Rademaker, Aumer van Reemst, Frederick Reinholdt, Dimitris Repantis, James Rucker, Samuel Rudow, Simon Ruffell, A. John Rush, Robert A. Schoevers, Mathieu Seynaeve, Samantha Shao, Jair C. Soares, Metten Somers, Susan C. Stansfield, Diane Sterling, Aaron Strockis, Joyce Tsai, Lucy Visser, Mourad Wahba, Samuel Williams, Allan H. Young, Paula Ywema, Sidney Zisook, Ekaterina Malievskaia
Summary: Psilocybin may be effective in treating treatment-resistant depression, but dosage and adverse effects need further investigation.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Clinical Neurology
Guy M. Goodwin, Scott T. Aaronson, Oscar Alvarez, Merve Atli, James C. Bennett, Megan Croal, Charles DeBattista, Boadie W. Dunlop, David Feifel, David J. Hellerstein, Muhammad Ishrat Husain, John R. Kelly, Molly R. Lennard-Jones, Rasmus W. Licht, Lindsey Marwood, Sunil Mistry, Tomas Palenicek, Ozlem Redjep, Dimitris Repantis, Robert A. Schoevers, Batya Septimus, Hollie J. Simmons, Jair C. Soares, Metten Somers, Susan C. Stansfield, Jessica R. Stuart, Hannah H. Tadley, Nisha K. Thiara, Joyce Tsai, Mourad Wahba, Sam Williams, Rachel I. Winzer, Allan H. Young, Matthew B. Young, Sid Zisook, Ekaterina Malievskaia
Summary: This study explores the efficacy of COMP360, a synthetic formulation of psilocybin, in treating treatment-resistant depression (TRD). Results show that a single dose of psilocybin at 25 mg and 10 mg can significantly improve symptoms of depression. This study expands on previous research on the use of psilocybin in treating TRD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Medicine, Research & Experimental
Abraham Zangen, Samuel Zibman, Aron Tendler, Noam Barnea-Ygael, Uri Alyagon, Daniel M. Blumberger, Geoffrey Grammer, Hadar Shalev, Tatiana Gulevski, Tanya Vapnik, Alexander Bystritsky, Igor Filipcic, David Feifel, Ahava Stein, Frederic Deutsch, Yiftach Roth, Mark S. George
Summary: This study investigates whether targeting the medial prefrontal cortex (MPFC) using the H7 coil in deep transcranial magnetic stimulation (Deep TMS) is noninferior to targeting the lateral prefrontal cortex (LPFC) using the H1 coil. The results show that both techniques have similar clinical efficacy and safety profiles, and electrical brain activity measured by EEG correlates with clinical outcomes.
Article
Medicine, General & Internal
Terry Schwartz, Mary Ellen Trunko, David Feifel, Emily Lopez, Danika Peterson, Guido K. W. Frank, Walter Kaye
Summary: Ketamine treatment shows promise in improving depression in patients with treatment-resistant depression and enduring eating disorders.
CLINICAL CASE REPORTS
(2021)
Article
Gerontology
Ian Frazier, Tian Lin, Peiwei Liu, Sondre Skarsten, David Feifel, Natalie C. Ebner
Summary: This study found that older adults show reduced responsiveness to cues of untrustworthiness, and that oxytocin has modulatory effects on activity in the left superior temporal gyrus in older participants. Younger participants are more influenced by breach-of-trust feedback in the trust game, while older participants show more stable behavior in response to such feedback.
PSYCHOLOGY AND AGING
(2021)
