Pervasive robustness in biological systems

Low Affinity Binding Site Clusters Confer Hox Specificity and Regulatory Robustness

(2015) Justin Crocker et al.   CELL

MicroRNAs and their roles in developmental canalization

(2014) Diana M Posadas et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Escape from homeostasis

(2014) H. Frederik Nijhout et al.   MATHEMATICAL BIOSCIENCES

Cryptic genetic variation: evolution's hidden substrate

(2014) Annalise B. Paaby et al.   NATURE REVIEWS GENETICS

Noise in biology

(2014) Lev S Tsimring   REPORTS ON PROGRESS IN PHYSICS

A BMP-FGF Morphogen Toggle Switch Drives the Ultrasensitive Expression of Multiple Genes in the Developing Forebrain

(2014) Shyam Srinivasan et al.   PLoS Computational Biology

Coordination of Wing and Whole-Body Development at Developmental Milestones Ensures Robustness against Environmental and Physiological Perturbations

(2014) Marisa M. Oliveira et al.   PLoS Genetics

Regulation of Noise in Gene Expression

(2013) Alvaro Sanchez et al.   Annual Review of Biophysics

Feedback Control of Gene Expression Variability in the Caenorhabditis elegans Wnt Pathway

(2013) Ni Ji et al.   CELL

miR-9a Minimizes the Phenotypic Impact of Genomic Diversity by Buffering a Transcription Factor

(2013) Justin J. Cassidy et al.   CELL

Specified Neural Progenitors Sort to Form Sharp Domains after Noisy Shh Signaling

(2013) Fengzhu Xiong et al.   CELL

Precise Developmental Gene Expression Arises from Globally Stochastic Transcriptional Activity

(2013) Shawn C. Little et al.   CELL

A Genetic Network Conferring Canalization to a Bistable Patterning System in Drosophila

(2013) Jackie Gavin-Smyth et al.   CURRENT BIOLOGY

Live Imaging of Bicoid-Dependent Transcription in Drosophila Embryos

(2013) Tanguy Lucas et al.   CURRENT BIOLOGY

The details in the distributions: why and how to study phenotypic variability

(2013) KA Geiler-Samerotte et al.   CURRENT OPINION IN BIOTECHNOLOGY

Lack of tailless leads to an increase in expression variability in Drosophila embryos

(2013) Hilde Janssens et al.   DEVELOPMENTAL BIOLOGY

Quantitative dynamics and increased variability of segmentation gene expression in the Drosophila Krüppel and knirps mutants

(2013) Svetlana Surkova et al.   DEVELOPMENTAL BIOLOGY

Robustness and Epistasis in the C. elegans Vulval Signaling Network Revealed by Pathway Dosage Modulation

(2013) Michalis Barkoulas et al.   DEVELOPMENTAL CELL

STRONG ASSORTATIVE MATING BY DIET, COLOR, SIZE, AND MORPHOLOGY BUT LIMITED PROGRESS TOWARD SYMPATRIC SPECIATION IN A CLASSIC EXAMPLE: CAMEROON CRATER LAKE CICHLIDS

(2013) Christopher H. Martin   EVOLUTION

Two DNA-encoded strategies for increasing expression with opposing effects on promoter dynamics and transcriptional noise

(2013) M. Dadiani et al.   GENOME RESEARCH

Genetic and Nongenetic Determinants of Cell Growth Variation Assessed by High-Throughput Microscopy

(2013) Naomi Ziv et al.   MOLECULAR BIOLOGY AND EVOLUTION

The Utility of Paradoxical Components in Biological Circuits

(2013) Yuval Hart et al.   MOLECULAR CELL

Natural sequence variants of yeast environmental sensors confer cell-to-cell expression variability

(2013) S. Fehrmann et al.   Molecular Systems Biology

Genotype to phenotype: lessons from model organisms for human genetics

(2013) Ben Lehner   NATURE REVIEWS GENETICS

Dynamic interpretation of maternal inputs by the Drosophila segmentation gene network

(2013) F. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryptic Variation in Morphological Evolution: HSP90 as a Capacitor for Loss of Eyes in Cavefish

(2013) N. Rohner et al.   SCIENCE

Molecular Basis of Age-Dependent Vernalization in Cardamine flexuosa

(2013) C.-M. Zhou et al.   SCIENCE

How Cells Know Where They Are

(2013) A. D. Lander   SCIENCE

Mechanisms of Age-Dependent Response to Winter Temperature in Perennial Flowering of Arabis alpina

(2013) S. Bergonzi et al.   SCIENCE

‘Particle genetics’: treating every cell as unique

(2013) Gaël Yvert   TRENDS IN GENETICS

miRNAs confer phenotypic robustness to gene networks by suppressing biological noise

(2013) Velia Siciliano et al.   Nature Communications

Histone Variant HTZ1 Shows Extensive Epistasis with, but Does Not Increase Robustness to, New Mutations

(2013) Joshua B. Richardson et al.   PLoS Genetics

Hsp90 is important for fecundity, longevity, and buffering of cryptic deleterious variation in wild fly populations

(2012) Bing Chen et al.   BMC EVOLUTIONARY BIOLOGY

Recent developments in statistical methods for detecting genetic loci affecting phenotypic variability

(2012) Lars Rönnegård et al.   BMC GENETICS

Hsp90 Globally Targets Paused RNA Polymerase to Regulate Gene Expression in Response to Environmental Stimuli

(2012) Ritwick Sawarkar et al.   CELL

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

Roles for MicroRNAs in Conferring Robustness to Biological Processes

(2012) Margaret S. Ebert et al.   CELL

DEFICIENCY SCREENING FOR GENOMIC REGIONS WITH EFFECTS ON ENVIRONMENTAL SENSITIVITY OF THE SENSORY BRISTLES OF DROSOPHILA MELANOGASTER

(2012) Kazuo H. Takahashi et al.   EVOLUTION

Multiple capacitors for natural genetic variation inDrosophila melanogaster

(2012) Kazuo H. Takahashi   MOLECULAR ECOLOGY

PTEN Negatively Regulates MAPK Signaling during Caenorhabditis elegans Vulval Development

(2012) Itay Nakdimon et al.   PLoS Genetics

Inheritance Beyond Plain Heritability: Variance-Controlling Genes in Arabidopsis thaliana

(2012) Xia Shen et al.   PLoS Genetics

Quantitative Variation in Autocrine Signaling and Pathway Crosstalk in the Caenorhabditis Vulval Network

(2011) Erika Hoyos et al.   CURRENT BIOLOGY

Molecular spandrels: tests of adaptation at the genetic level

(2011) Rowan D. H. Barrett et al.   NATURE REVIEWS GENETICS

Environmental Stress-Dependent Effects of Deletions Encompassing Hsp70Ba on Canalization and Quantitative Trait Asymmetry in Drosophila melanogaster

(2011) Kazuo H. Takahashi et al.   PLoS One

Exploring transcription regulation through cell-to-cell variability

(2011) R. Rinott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple enhancers ensure precision of gap gene-expression patterns in the Drosophila embryo

(2011) M. W. Perry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developmental Stability: A Major Role for Cyclin G in Drosophila melanogaster

(2011) Vincent Debat et al.   PLoS Genetics

Shadow Enhancers Foster Robustness of Drosophila Gastrulation

(2010) Michael W. Perry et al.   CURRENT BIOLOGY

Violations of robustness trade-offs

(2010) Hiroaki Kitano   Molecular Systems Biology

Hsp90 prevents phenotypic variation by suppressing the mutagenic activity of transposons

(2010) Valeria Specchia et al.   NATURE

Phenotypic robustness conferred by apparently redundant transcriptional enhancers

(2010) Nicolás Frankel et al.   NATURE

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Quantitative Genetics of Phenotypic Robustness

(2010) Hunter B. Fraser et al.   PLoS One

Genes Confer Similar Robustness to Environmental, Stochastic, and Genetic Perturbations in Yeast

(2010) Ben Lehner   PLoS One

Robustness and Evolvability

(2010) Joanna Masel et al.   TRENDS IN GENETICS

Dynamic Assignment and Maintenance of Positional Identity in the Ventral Neural Tube by the Morphogen Sonic Hedgehog

(2010) Eric Dessaud et al.   PLOS BIOLOGY

On the Use of Variance per Genotype as a Tool to Identify Quantitative Trait Interaction Effects: A Report from the Women's Genome Health Study

(2010) Guillaume Paré et al.   PLoS Genetics

Bias and Evolution of the Mutationally Accessible Phenotypic Space in a Developmental System

(2010) Christian Braendle et al.   PLoS Genetics

The evolutionary context of robust and redundant cell biological mechanisms

(2009) Marie Delattre et al.   BIOESSAYS

A MicroRNA Imparts Robustness against Environmental Fluctuation during Development

(2009) Xin Li et al.   CELL

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

PLASTICITY, CANALIZATION, AND DEVELOPMENTAL STABILITY OF THEDROSOPHILAWING: JOINT EFFECTS OF MUTATIONS AND DEVELOPMENTAL TEMPERATURE

(2009) Vincent Debat et al.   EVOLUTION

Evolution under canalization and the dual roles of microRNAs--A hypothesis

(2009) C.-I Wu et al.   GENOME RESEARCH

The Endo-siRNA Pathway Is Essential for Robust Development of the Drosophila Embryo

(2009) Elena M. Lucchetta et al.   PLoS One

Robustness: mechanisms and consequences

(2009) Joanna Masel et al.   TRENDS IN GENETICS

Effects of Ploidy and Recombination on Evolution of Robustness in a Model of the Segment Polarity Network

(2009) Kerry J. Kim et al.   PLoS Computational Biology

Quantifying the Decanalizing Effects of Spontaneous Mutations in Rhabditid Nematodes

(2008) Charles F. Baer   AMERICAN NATURALIST

Plasticity and Errors of a Robust Developmental System in Different Environments

(2008) Christian Braendle et al.   DEVELOPMENTAL CELL

Intraspecific evolution of the intercellular signaling network underlying a robust developmental system

(2008) J. Milloz et al.   GENES & DEVELOPMENT

The Chemical Genomic Portrait of Yeast: Uncovering a Phenotype for All Genes

(2008) M. E. Hillenmeyer et al.   SCIENCE

Network Hubs Buffer Environmental Variation in Saccharomyces cerevisiae

(2008) Sasha F Levy et al.   PLOS BIOLOGY