期刊
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
卷 12, 期 4, 页码 243-248出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrgastro.2015.24
关键词
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资金
- National Cancer Institute Established Investigator Award in Cancer Prevention and Control [K05 CA124911]
- Cancer Research UK [12088, 15874] Funding Source: researchfish
The incidence of oesophageal adenocarcinoma has risen rapidly over the past four decades. Unfortunately, treatments have not kept pace; unless their cancer is identified at a very early stage, most patients will not survive a year after diagnosis. The beginnings of this widespread problem were first recognized over 25 years ago, yet rates have continued to rise against a backdrop of much improved understanding and management of oesophageal adenocarcinoma. We estimate that only similar to 7% of the 10,000 cases of oesophageal adenocarcinoma diagnosed annually in the USA are identified through current approaches to cancer control, and trace pathways by which the remaining 93% are 'lost'. On the basis of emerging data on aetiology and predictive factors, together with new diagnostic tools, we suggest a five-tier strategy for prevention and control that begins with a wide population base and triages individuals into progressively higher risk strata, each with risk-appropriate prevention, screening and treatment options.
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