Article
Gastroenterology & Hepatology
Joan A. Culpepper-Morgan, Alexandra Guillaume, Jeremy Louissaint, Renee Williams
Summary: The viewpoint discusses the members' routes into gastroenterology and hepatology, the promotion of inclusivity and equity in academia and medicine, and advice to Black students interested in a career in science or medicine.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Alireza Lorzadeh, Maile Romero-Wolf, Ajay Goel, Unmesh Jadhav
Summary: Mutational defects and epigenetic regulation play crucial roles in diseases like colorectal cancer and inflammatory bowel diseases. The interplay of epigenetic features, such as polycomb repressive complex 2-mediated trimethylation of lysine 27 on histone 3 and DNA methylation, are important in these diseases, but molecular details are still lacking. This review also discusses other epigenetic mechanisms relevant to gastrointestinal cancers and the current understanding of chromatin control in the pathogenesis of inflammatory bowel diseases.
Review
Gastroenterology & Hepatology
Dingzhi Wang, Carlos S. Cabalag, Nicholas J. Clemons, Raymond N. DuBois
Summary: The cyclooxygenase-2-prostaglandin E2 pathway plays an important role in the development of gastrointestinal cancer, promoting tumor growth and affecting host defenses. Overcoming tumor immune evasion is a major challenge in cancer immunotherapy.
Editorial Material
Gastroenterology & Hepatology
Naima Amrani
Summary: As the first woman to serve as the president of the World Gastroenterology Organisation, I have the chance to reflect on the place of women in gastroenterology and assess the progress we have made and the challenges still ahead of us.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Editorial Material
Gastroenterology & Hepatology
Patrizia Burra, Alberto Zanetto, Giacomo Germani
Summary: Biological sex bias is a common issue in clinical trials, including fields such as gastroenterology and hepatology. Lack of sex parity and attention to sex-specific analyses hinder the translation of trial results into real-world clinical practice, leading to unpredictable consequences for patient care.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Ji-Qiao Liu, Jia-Yu Ren, Xiao-Lan Xu, Li-Yan Xiong, Yue-Xiang Peng, Xiao-Fang Pan, Christoph F. Dietrich, Xin-Wu Cui
Summary: Artificial intelligence (AI), especially deep learning, has gained attention for its performance in medical image analysis. It can help doctors make more accurate diagnoses by automatically assessing complex medical images. AI based on ultrasound has shown promising results in analyzing liver diseases and gastrointestinal conditions, such as predicting the severity of fatty liver and identifying benign and malignant liver lesions. It has also been applied in detecting pancreatic cancer and predicting tumor deposits in rectal cancer using endoscopic ultrasonography. This review focuses on the technical knowledge and clinical applications of AI in ultrasound of liver and gastroenterology diseases, as well as discusses the challenges and future perspectives of AI.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Kristel K. Leung, Noor Jawaid, Natasha Bollegala
Summary: This study examined the gender distribution of first and senior authors as well as editorial board members in high impact factor journals in gastroenterology and hepatology. The findings revealed that there is still a male dominance in positions such as editor-in-chief, editorial board membership, and senior authorship. Positive correlations were found between male-dominated editorial boards and male first and senior authorship, while negative correlations were observed between male-dominated editorial boards and female first and senior authorship. Additionally, there were positive correlations between the publication of first and senior authors of the same gender.
GASTROINTESTINAL ENDOSCOPY
(2021)
Review
Gastroenterology & Hepatology
Markus F. Neurath
Summary: The COVID-19 pandemic has posed global health crisis, particularly affecting clinical care for patients with gastrointestinal diseases. Immune cell dysregulation and cytokine storm syndrome may lead to severe complications for some patients.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Jia-Sheng Cao, Zi-Yi Lu, Ming-Yu Chen, Bin Zhang, Sarun Juengpanich, Jia-Hao Hu, Shi-Jie Li, Win Topatana, Xue-Yin Zhou, Xu Feng, Ji-Liang Shen, Yu Liu, Xiu-Jun Cai
Summary: Artificial intelligence has made significant breakthroughs in clinical medicine, especially in medical image analysis, playing a crucial role in diagnosing and treating diseases. Despite facing challenges in application, cooperation between doctors and researchers can overcome these challenges to develop more accurate AI tools for improved clinical applications.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Editorial Material
Gastroenterology & Hepatology
Nurulamin M. Noor
Summary: Clinicians lack formal training in clinical trial methodology, and with the increasing complexity of randomized controlled trials, there is a need for focused training to develop the next generation of clinician trialists.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Harman K. Rahal, James H. Tabibian, Rachel B. Issaka, Sandra Quezada, Darrell M. Gray, Sophie Balzora, Liu Yang, Jayraan Badiee, Folasade P. May
Summary: This survey assessed the perspectives of GI and hepatology professionals in the US on racial and ethnic workforce diversity and healthcare disparities. The findings revealed insufficient representation of underrepresented racial and ethnic minority groups and suggested interventions to increase career mentorship and medical student opportunities, as well as provide leadership roles for underrepresented groups.
Article
Gastroenterology & Hepatology
Harman K. Rahal, James H. Tabibian, Rachel Issaka, Sandra Quezada, Darrell M. Gray, Sophie Balzora, Liu Yang, Jayraan Badiee, Folasade P. May
Summary: This study assessed the perspectives of gastroenterology and hepatology professionals in the United States on racial and ethnic workforce diversity and healthcare disparities. The survey found that a lack of representation in the education and training pipeline was a major barrier to increasing diversity, and suggested interventions included increasing career mentorship and medical student opportunities.
Review
Gastroenterology & Hepatology
Maria D. Giraldez, David Carneros, Christoph Garbers, Stefan Rose-John, Matilde Bustos
Summary: IL-6 family cytokines play crucial roles in metabolism, liver disease, and gastrointestinal disease, with potential as therapeutic targets. Therapies modulating gp130 signaling have shown promise in various clinical settings, including obesity, cancer, and inflammatory bowel disease.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Hao Chen, Joseph J. Y. Sung
Summary: With the advancement of AI technology, AI-image analysis applications in gastroenterology and hepatology show great potential in improving the quality and consistency of patient care. Future research should focus on the promises and challenges of AI in medical image analysis.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Harman K. Rahal, James H. Tabibian, Rachel Issaka, Sandra Quezada, Darrell Gray, Sophie Balzora, Liu Yang, Jayraan Badiee, Folasade May
Summary: This study aimed to assess the perspectives of GI and hepatology professionals in the US on racial and ethnic workforce diversity and healthcare disparities, providing valuable insights for future interventions and improvements in health equity.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)