Article
Biochemistry & Molecular Biology
Anna E. Engell, Henrik L. Jorgensen, Bent S. Lind, Anton Pottegard, Christen L. Andersen, John S. Andersen, Margit Kriegbaum, Mia K. Grand, Lise Bathum
Summary: Lipid levels in blood have decreased significantly in the general population due to the use of statins. This trend was observed in primary health care patients who were not using statins from 2001 to 2018, with substantial decreases in total cholesterol and low-density lipoprotein cholesterol levels, especially in the elderly population.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Multidisciplinary Sciences
Hyungjong Park, Yoonkyung Chang, Heajung Lee, Iksun Hong, Tae-Jin Song
Summary: The study investigates the association between total cholesterol (TC) variability and the occurrence of venous thromboembolism (VTE) using a Korean database. The results show a positive correlation between higher TC variability and the occurrence of VTE, emphasizing the importance of maintaining stable TC levels to prevent VTE.
Article
Cardiac & Cardiovascular Systems
Mie Balling, Shoaib Afzal, George Davey Smith, Anette Varbo, Anne Langsted, Pia R. Kamstrup, Borge G. Nordestgaard
Summary: Elevated LDL triglycerides are associated with an increased risk of ASCVD and its individual components, as shown in two prospective cohort studies and meta-analyses.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Biology
Carlo Maria Barbagallo, Angelo Baldassare Cefalu, Antonina Giammanco, Davide Noto, Rosalia Caldarella, Marcello Ciaccio, Maurizio Rocco Averna, Emilio Nardi
Summary: Chronic kidney disease is an important risk factor for cardiovascular disease, with dyslipidemia often present in patients with CKD. Various lipoprotein abnormalities occur due to impaired enzymes pathways and proteins involved in lipoprotein metabolism in CKD patients. Hypolipidemic treatments may alter the progression of CVD in CKD patients.
Article
Nutrition & Dietetics
Jennifer A. Fleming, Penny M. Kris-Etherton, Kristina S. Petersen, David J. Baer
Summary: Incorporating lean beef into a Mediterranean-style diet does not attenuate the reduction in lipid and lipoprotein concentrations as compared to an average American diet.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Liv Tybjaerg Nordestgaard, Mette Christoffersen, Ruth Frikke-Schmidt
Summary: Alzheimer's disease is the most common form of dementia, while vascular dementia is distinguished from Alzheimer's by previous stroke or hemorrhage evidence. Recent evidence suggests that controlling cardiovascular risk factors can reduce the risk of dementia. Factors such as body mass index, blood lipids, blood pressure, and diabetes have shared pathogenic pathways between dementia and cardiovascular disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Minghao Kou, Ning Ding, Shoshana H. Ballew, Maya J. Salameh, Seth S. Martin, Elizabeth Selvin, Gerardo Heiss, Christie M. Ballantyne, Kunihiro Matsushita, Ron C. Hoogeveen
Summary: Triglyceride-related and HDL-related lipids were independently associated with incident PAD, indicating implications for preventive strategies. Principal component analysis identified three components related to PAD risk.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Myuri Ruthirakuhan, Hugo Cogo-Moreira, Walter Swardfager, Nathan Herrmann, Krista L. Lanctot, Sandra E. Black
Summary: This study identified three groups of cardiovascular risk factors in cognitively normal elderly individuals, and only the vascular-dominant group was significantly associated with incidence of Alzheimer's disease. Selective mortality may contribute to the attenuated association between the vascular-metabolic group and incident AD.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Biochemistry & Molecular Biology
Maureen Sampson, Rami A. Ballout, Daniel Soffer, Anna Wolska, Sierra Wilson, Jeff Meeusen, Leslie J. Donato, Erica Fatica, James D. Otvos, Eliot A. Brinton, Robert S. Rosenson, Peter Wilson, Marcelo Amar, Robert Shamburek, Sotirios K. Karathanasis, Alan T. Remaley
Summary: This study developed a new algorithm for classifying lipoprotein disorders based on the standard lipid panel, categorizing patients into classical Fredrickson-like phenotypes and introducing a new hypolipidemic phenotype (Type VI) due to genetic mutations in apoB-metabolism. The validity of the new algorithm was confirmed through lipid analysis by NMR and by concordance with classification by agarose gel electrophoresis/beta-quantification, demonstrating its potential for improving the care of patients at risk for ASCVD.
LIPIDS IN HEALTH AND DISEASE
(2021)
Review
Nutrition & Dietetics
Shuaishuai Zhou, Teng Xu, Xu Zhang, Junjie Luo, Peng An, Yongting Luo
Summary: The supplementation of casein hydrolysate can effectively reduce blood pressure without affecting blood lipids or glycemic status.
Article
Cardiac & Cardiovascular Systems
Bethan L. Clifford, Kelsey E. Jarrett, Joan Cheng, Angela Cheng, Marcus Seldin, Pauline Morand, Richard Lee, Mary Chen, Angel Baldan, Thomas Q. de Aguiar Vallim, Elizabeth J. Tarling
Summary: This study reveals a novel role of RNF130 in regulating LDL-C levels by modulating the availability of LDLR.
CIRCULATION RESEARCH
(2023)
Article
Medicine, General & Internal
Ravi Retnakaran, Baiju R. Shah
Summary: Women with gestational diabetes have an increased risk of cardiovascular disease, and adverse glycemic and lipid measures contribute to this elevated risk. Monitoring and intervention targeting these risk factors may help prevent cardiovascular disease in this population.
Article
Cardiac & Cardiovascular Systems
Anette Varbo, Borge G. Nordestgaard
Summary: The study found that high directly measured remnant cholesterol is associated with increased risk of ischaemic heart disease and myocardial infarction. Directly measured remnant cholesterol is superior to calculated remnant cholesterol in identifying individuals at increased risk.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Anette Varbo, Borge G. Nordestgaard
Summary: This study found that high directly measured remnant cholesterol is associated with increased risk of cardiovascular disease, and direct measurement of remnant cholesterol is superior in identifying individuals at increased risk compared to calculated remnant cholesterol.
EUROPEAN HEART JOURNAL
(2021)
Article
Hematology
Shripad Sinari, Juraj Koska, Yueming Hu, Jeremy Furtado, Majken K. Jensen, Matthew J. Budoff, Dobrin Nedelkov, Robyn L. McClelland, Dean Billheimer, Peter Reaven
Summary: The composition of Apo CIII proteoforms is associated with cardiovascular risk and influences plasma lipids. Total apo CIII and CIII2/III1 are positively associated with cardiovascular disease risk, while CIII0b/III1 is inversely associated with cardiovascular disease risk.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Geriatrics & Gerontology
Takuma Shibuki, Miho Iida, Sei Harada, Suzuka Kato, Kazuyo Kuwabara, Aya Hirata, Mizuki Sata, Minako Matsumoto, Yusuke Osawa, Tomonori Okamura, Daisuke Sugiyama, Toru Takebayashi
Summary: This study aimed to examine the association between sleep duration and quality and sarcopenia among older community-dwellers in Japan. The results showed that long sleep duration was positively associated with sarcopenia, especially low muscle strength and low physical performance. However, insomnia was not associated with sarcopenia or its components in long sleepers.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2023)
Article
Clinical Neurology
Ayako Kunimura, Yuichiro Yano, Takashi Hisamatsu, Sayuki Torii, Keiko Kondo, Aya Kadota, Akira Fujiyoshi, Tomonori Okamura, Yoshiyuki Watanabe, Akihiko Shiino, Kazuhiko Nozaki, Hirotsugu Ueshima, Katsuyuki Miura
Summary: This study investigated the association between serum PCSK9 levels and subclinical cerebrovascular disease in a community-dwelling Japanese male population. The results showed that higher levels of circulating PCSK9 were significantly associated with an increased prevalence of intracranial artery stenosis, but not with cerebral small vessel disease. Therefore, measuring serum PCSK9 levels may help identify individuals at high risk for cerebrovascular disease in the general population.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Peripheral Vascular Disease
Dan Wu, Aya Hirata, Takumi Hirata, Yukiko Imai, Kazuyo Kuwabara, Mika Funamoto, Daisuke Sugiyama, Tomonori Okamura
Summary: This study investigated the association between fatty liver index (FLI) and hypertension development in a general Japanese population, and found that FLI is independently associated with an increased risk of incident hypertension.
HYPERTENSION RESEARCH
(2023)
Article
Geriatrics & Gerontology
Yuto Nakao, Koki Kawamura, Taku Iwase, Aiko Osawa, Shinichiro Maeshima, Hidenori Arai
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Public, Environmental & Occupational Health
Hideki Nagata, Katsuyuki Miura, Sachiko Tanaka, Aya Kadota, Takehito Hayakawa, Keiko Kondo, Akira Fujiyoshi, Naoyuki Takashima, Yoshikuni Kita, Akira Okayama, Tomonori Okamura, Hirotsugu Ueshima
Summary: This study investigated the relationship between functional capacity and mortality risk among a population-based cohort of older residents in Japan. Impaired functional capacity was associated with a higher risk of all-cause mortality, with different factors playing a role for men and women.
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Yiwei Liu, Aya Hirata, Tomonori Okamura, Daisuke Sugiyama, Takumi Hirata, Aya Kadota, Keiko Kondo, Takayoshi Ohkubo, Katsuyuki Miura, Akira Okayama, Hirotsugu Ueshima
Summary: The impact of resting heart rate on cardiovascular disease mortality varies according to serum albumin levels in the general Japanese population.
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Geriatrics & Gerontology
Tomoki Tanaka, Hirohiko Hirano, Kazunori Ikebe, Takayuki Ueda, Masanori Iwasaki, Maki Shirobe, Shunsuke Minakuchi, Masahiro Akishita, Hidenori Arai, Katsuya Iijima
Summary: To assess oral frailty in older adults, a five-item checklist called OF-5 was developed and found to have predictive validity for physical frailty, physical disability, and mortality.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Wei-Min Chu, Hsin-En Ho, Chih-Jung Yeh, James Cheng-Chung Wei, Hidenori Arai, Meng-Chih Lee
Summary: This study explores the association between multimorbidity patterns with/ without frailty and future mortality among Taiwanese middle-aged and older adults. Frailty plays an important role in mortality among middle-aged and older adults with distinct multimorbidity patterns.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Shinichiro Maeshima, Aiko Osawa, Koki Kawamura, Takako Yoshimura, Eri Otaka, Yayoi Sato, Ikue Ueda, Naoki Itoh, Izumi Kondo, Hidenori Arai
Summary: The study investigated assessment tools used by dementia specialists, reasons for their use, and related factors. Most specialists use neuropsychological tests for diagnosis and to assess behavioral and psychological symptoms. Screening tools like the Hasegawa Dementia Scale-Revised and Mini-Mental State Examination are commonly used, while direct assessments include the Mini-Mental State Examination, Clock Drawing Test, and Cube Copying Test. Quality of life and care burden assessments are less common in clinical practice.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Sayuri Sable-Morita, Saiko Sugiura, Hirokazu Suzuki, Hideki Fukuoka, Yasumoto Matsui, Hidenori Arai
Summary: This study aimed to clarify the relationship between frailty and the senses of sight, hearing, smell, and taste. Olfactory impairment had the strongest correlation with frailty. Although the sense of smell decreases with disease and aging, olfactory impairment may be correlated with frailty as a symptom of neurodegenerative diseases.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Letter
Geriatrics & Gerontology
Yasuhiro Yamaguchi, Jiro Okochi, Tomohiko Urano, Takae Ebihara, Takafumi Kadono, Hidenori Arai, Katsuya Iijima, Shinya Ishii, Masafumi Kuzuya, Hiromi Rakugi, Masahiro Akishita, Kentaro Higashi, Koichi Kozaki
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Letter
Geriatrics & Gerontology
Minoru Yamada, Hidenori Arai
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Wei-Min Chu, Yukiko Nishita, Chikako Tange, Shu Zhang, Kanae Furuya, Hiroshi Shimokata, Meng-Chih Lee, Hidenori Arai, Rei Otsuka
Summary: Smoking, especially when combined with secondhand smoke exposure, is associated with future physical frailty among older adults.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Public, Environmental & Occupational Health
Natsuko Nakagoshi, Sachimi Kubo, Yoko Nishida, Kazuyo Kuwabara, Aya Hirata, Mizuki Sata, Aya Higashiyama, Yoshimi Kubota, Takumi Hirata, Yukako Tatsumi, Kuniko Kawamura, Junji Miyazaki, Naomi Miyamatsu, Daisuke Sugiyama, Yoshihiro Miyamoto, Tomonori Okamura
Summary: This study examines the determinants of high double product (DP) by evaluating the association between resting DP and blood test results and lifestyle factors. The results show that age, hematocrit, and gamma-glutamyl transferase levels are positively associated with high DP in both men and women. Additionally, insulin resistance is positively associated with high DP in women, while exercise is negatively associated with high DP in men. The study concludes that high DP at rest is associated with insulin resistance, gamma-glutamyl transferase, and exercise in participants without underlying disease.
ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Azusa Shima, Hideo Tanaka, Tomonori Okamura, Tomofumi Nishikawa, Ayumi Morino, Kayo Godai, Yukako Tatsumi, Mizuki Kawahara, Maiko Kiyohara, Yuichiro Kawatsu, Takashi Kimura, Naomi Miyamatsu
Summary: This study evaluated the effect of offering on-site mammography in workplaces on breast cancer screening rates. The intervention group, which received a leaflet and on-site mammography, had a screening rate of 53% in 2018, compared to 7% in the control group. This environmental approach significantly increased the breast cancer screening rate.
JOURNAL OF OCCUPATIONAL HEALTH
(2023)