Article
Cardiac & Cardiovascular Systems
Xiangyu Zhang, Trent D. Evans, Sunny Chen, Ismail Sergin, Jeremiah Stitham, Se-Jin Jeong, Astrid Rodriguez-Velez, Yu-Sheng Yeh, Arick Park, In-Hyuk Jung, Abhinav Diwan, Joel D. Schilling, Oren Rom, Arif Yurdagul, Slava Epelman, Jaehyung Cho, Irfan J. Lodhi, Bettina Mittendorfer, Babak Razani
Summary: The mTOR pathway plays a significant role in atherosclerosis, with mTORC1 promoting lesion formation and mTORC2 inhibiting inflammatory response and regulating plaque complexity. The balanced and opposing roles of these two arms of mTOR signaling have important implications for plaque size and complexity.
CIRCULATION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Panagiotis Theofilis, Evangelos Oikonomou, Konstantinos Tsioufis, Dimitris Tousoulis
Summary: Atherosclerotic diseases are a major global health issue, and understanding the role of macrophages in the development and regression of atherosclerosis is crucial for improving patient care. Tissue-resident and monocyte-derived macrophages have distinct functions in the atherosclerotic cascade, and targeting pathways such as M2 polarization and macrophage autophagy shows promise in preventing or treating atherosclerosis. Recent experimental studies have also identified macrophage receptors as potential drug targets, and macrophage-membrane-coated carriers have shown promising results as well.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Laura A. Bosmans, Claudia M. van Tiel, Suzanne A. B. M. Aarts, Lisa Willemsen, Jeroen Baardman, Bram W. van Os, Myrthe den Toom, Linda Beckers, David J. Ahern, Johannes H. M. Levels, Aldo Jongejan, Perry D. Moerland, Sanne G. S. Verberk, Jan van den Bossche, Menno M. P. J. de Winther, Christian Weber, Dorothee Atzler, Claudia Monaco, Norbert Gerdes, Annelie Shami, Esther Lutgens
Summary: This study investigates the role of CD40 in atherosclerosis and shows that inhibiting CD40 signaling can reduce atherosclerosis. The researchers used myeloid-specific CD40-deficient mice and found that the absence of CD40 in myeloid cells reduces atherosclerosis and systemic inflammation by preventing pro-inflammatory macrophage polarization.
CARDIOVASCULAR RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Bin Wen, Yuan-ye Dang, Su-hua Wu, Yi-min Huang, Kong-yang Ma, Yi-ming Xu, Xi-Long Zheng, Xiao-yan Dai
Summary: DHC ameliorates atherosclerosis in ApoE(-/-) mice by inhibiting inflammation, likely by targeting macrophage p65- and ERK1/2-mediated pathways.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Cell Biology
Xiaorong Hu, Ruisong Ma, Jianlei Cao, Xianjin Du, Xinyong Cai, Yongzhen Fan
Summary: This study revealed the negative role of PTPN2 in atherosclerosis and provided a new potential target for its treatment.
Article
Cell Biology
Ning Huangfu, Yong Wang, Zhenyu Xu, Wenyuan Zheng, Chunlan Tao, Zhenwei Li, Yewen Hu, Xiaomin Chen
Summary: The study found that TDP43 promotes NF-κB activation, leading to increased expression of inflammatory factors in macrophages by triggering mitochondrial DNA release to activate the cGAS-STING signaling pathway. Additionally, TDP43 enhances lipid uptake in macrophages by regulating the beta-catenin and PPAR-γ complex, thereby promoting CD36 transcription and exacerbating atherosclerosis progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Phuong Tran Pham, Daiju Fukuda, Sachiko Nishimoto, Joo-Ri Kim-Kaneyama, Xiao-Feng Lei, Yutaka Takahashi, Tomohito Sato, Kimie Tanaka, Kumiko Suto, Yutaka Kawabata, Koji Yamaguchi, Shusuke Yagi, Kenya Kusunose, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Kenji Shimada, Yasuhisa Kanematsu, Yasushi Takagi, Michio Shimabukuro, Mitsutoshi Setou, Glen N. Barber, Masataka Sata
Summary: The study indicates that the stimulator of interferon genes (STING) plays a role in atherosclerosis, and its signaling may serve as a potential therapeutic target for the disease by inhibiting STING activation to improve atherosclerosis progression.
EUROPEAN HEART JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Anastasia Poznyak, Nikita G. Nikiforov, Antonina Starodubova, Tatyana Popkova, Alexander N. Orekhov
Summary: Atherosclerosis remains a major cause of death globally, primarily due to the lack of effective preventive and therapeutic measures. Lifestyle and genetic factors play significant roles in the development of the disease.
Article
Immunology
Sirui Shen, Zhuqi Huang, Liming Lin, Zimin Fang, Weixin Li, Wu Luo, Gaojun Wu, Zhouqing Huang, Guang Liang
Summary: This study suggests that TUS, a natural product with anti-inflammatory activities, can alleviate inflammation and reduce atherosclerotic plaque areas. The mechanism involves the inhibition of MAPK pathway phosphorylation. TUS may be a potential therapeutic candidate for atherosclerosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Jiayong Wu, Shengping He, Zhengkun Song, Sikai Chen, Xuefeng Lin, Huimei Sun, Pengyu Zhou, Qinbao Peng, Songlin Du, Shaoyi Zheng, Xiu Liu
Summary: Atherosclerosis is a chronic inflammatory disease affecting large and medium arteries, with macrophages playing a crucial role in the inflammatory response. Modulating macrophage polarization has shown potential in controlling the progression of atherosclerosis. This review explores the role of macrophage polarization in atherosclerosis and summarizes emerging therapies for its regulation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mathias Jensen, Nicoline W. Thorsen, Line A. E. Hallberg, Per Hagglund, Clare L. Hawkins
Summary: Neutrophil extracellular trap (NET) release plays a key role in chronic diseases like atherosclerosis, but the release of macrophage extracellular traps (METs) and their composition are less understood. This study investigated MET release from human THP-1 macrophages exposed to different stimuli and discovered that METs were composed of histones, various proteins involved in different cellular processes, and the absence of proteases. These findings provide new insights into the implications of MET formation in immune defense and pathology.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Immunology
Hongxia Li, Zhiqiang Cao, Lili Wang, Chang Liu, Hongkun Lin, Yuhan Tang, Ping Yao
Summary: Cardiovascular diseases are mainly caused by atherosclerosis, and macrophages play a crucial role in its progression. The polarization phenotypes and death pathways of macrophages have an impact on plaque formation and cardiovascular vulnerability.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Christina Kassiteridi, Jennifer E. Cole, Thibault Griseri, Mika Falck-Hansen, Michael E. Goddard, Anusha N. Seneviratne, Patricia A. Green, Inhye Park, Annelie G. Shami, Tanyaporn Pattarabanjird, Aditi Upadhye, Angela M. Taylor, Ashok Handa, Keith M. Channon, Esther Lutgens, Coleen A. McNamara, Richard O. Williams, Claudia Monaco
Summary: The study demonstrates the significant role of CD200 in atherosclerosis, where CD200 deficiency increases atherosclerotic lesion formation. The CD200/CD200R pathway restrains macrophage activation and monocyte recruitment, limiting the progression of atherosclerosis.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Liangwei Duan, Yucong Zhao, Jing Jia, Tianzhu Chao, Hao Wang, Yinming Liang, Yunwei Lou, Qianqian Zheng, Hui Wang
Summary: In atherosclerosis, macrophages play an important role in inflammation. CD68, a specific receptor in macrophages, regulates the occurrence and development of atherosclerosis. CD68 deficiency can reduce atherosclerosis, decrease inflammation and necrotic content, and increase smooth muscle cell content in atherosclerotic plaques.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Medicine, Research & Experimental
Zhuqi Huang, Sirui Shen, Xue Han, Weixin Li, Wu Luo, Liming Lin, Mingjiang Xu, Yi Wang, Weijian Huang, Gaojun Wu, Guang Liang
Summary: In this study, upregulated DCLK1 in macrophages in atherosclerotic lesions of ApoE(-/-) mice fed an HFD was identified, and it was determined that macrophage-specific DCLK1 deletion attenuates atherosclerosis by reducing inflammation in mice. RNA sequencing analysis indicated that DCLK1 mediates oxLDL-induced inflammation via NF-kappa B signaling pathway, and DCLK1 directly interacts with IKK beta and phosphorylates IKK beta at S177/181, thereby activating NF-kappa B and promoting inflammatory gene expression in macrophages.
EMBO MOLECULAR MEDICINE
(2023)
