Article
Immunology
Haohang Ruan, Qing Huang, Benting Wan, Ming Yang
Summary: Curcumin can alleviate inflammatory damage in vascular smooth muscle cells induced by LPS by inhibiting the release of inflammatory cytokines, increasing cell viability, and reducing apoptosis. Additionally, curcumin increases the expression of TLR4 and acts through blocking NF-κB and JNK signaling pathways.
INFLAMMOPHARMACOLOGY
(2022)
Article
Peripheral Vascular Disease
Jaime Ibarrola, Qing Lu, Maria-Christina Zennaro, Iris Z. Jaffe
Summary: This study investigated the regulatory mechanisms of MR gene transcription in aging human smooth muscle cells. The results revealed the involvement of the inflammatory transcription factor NF kappa B and the hypoxia-inducible factor HIF1 alpha in the regulation of SMC MR transcription, which contributes to aging-related vascular stiffness and cardiovascular disease.
Article
Food Science & Technology
Hong Zhang, Mengyi Chi, Yaxian Wang, Linlin Chen, Xipeng Sun, Lili Wan, Quanjun Yang, Cheng Guo
Summary: The study demonstrated that naringenin can alleviate cisplatin-induced skeletal muscle atrophy and cachexia by regulating multiple pathways to lower inflammatory cytokine levels, enhancing anti-tumor effects, and inhibiting protein degradation, suggesting that naringenin may be a candidate drug for treating chemotherapy-related side effects.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Chemistry, Medicinal
Xinxin Zhang, Yating Qin, Weibin Ruan, Xiaoning Wan, Chao Lv, Lin He, Li Lu, Xiaomei Guo
Summary: Baicalein, a flavonoid phytochemical, demonstrates anti-inflammatory properties in macrophages, endothelial cells, and vascular smooth muscle cells by activating the AMPK/Mfn-2 axis and inhibiting MAPKs/NF-kappa B signaling transduction pathway. Baicalein effectively reduces proinflammatory cytokine levels, suggesting its potential role in atherosclerosis treatment. Further studies may be needed to fully understand the mechanisms of baicalein's anti-inflammatory effects.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yang Bai, Long Zhang, Bin Zheng, Xinhua Zhang, Hong Zhang, Anning Zhao, Jing Yu, Zhan Yang, Jinkun Wen
Summary: circACTA2 derived from the smooth muscle alpha-actin gene regulates vascular smooth muscle cell (VSMC) phenotype and inflammation through the inhibition of NLRP3 inflammasome activation. Overexpression of circACTA2 reduces neointimal hyperplasia and inflammation induced by vascular injury by suppressing NF-kappa B-mediated transcription of NLRP3 gene and inhibiting inflammasome activation. Furthermore, circACTA2 inhibits VSMC pyroptosis and can be targeted to attenuate the expression of NLRP3, ASC, and caspase-1, providing a potential therapeutic strategy for vascular remodeling.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Guanxin Zhang, Qing Qin, Chen Zhang, Xiaobo Sun, Kyosuke Kazama, Bing Yi, Fang Cheng, Zhi-Fu Guo, Jianxin Sun
Summary: The study finds that NDRG1 plays an essential role in cell differentiation, proliferation, and stress responses. The expression of NDRG1 significantly increases in cytokine-stimulated endothelial cells and atherosclerotic lesions. Inhibition of NDRG1 not only suppresses the expression of procoagulant molecules but also exerts antithrombotic effects in endothelial cells, highlighting its potential as a therapeutic target for vascular diseases.
CIRCULATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yuan-ru Zheng, Chun-lin Fan, Ye Chen, Jing-yu Quan, Ling-zhu Shi, Chun-yang Tian, Xiao Shang, Ni-shan Xu, Wen-cai Ye, Lin-zhong Yu, Jun-shan Liu
Summary: This study discovered that dammarane-type triterpenoid saponins from Panax notoginseng have anti-inflammatory, anti-angiogenetic, and anti-dengue virus effects. They may be developed as potential functional foods for treating inflammation, angiogenesis, and dengue-related diseases.
Article
Pharmacology & Pharmacy
Ji Hu, Ru Chen, Jie An, Yilong Wang, Minglu Liang, Kai Huang
Summary: The study demonstrates that dauricine can alleviate endothelial inflammation by suppressing the NF-κB pathway, leading to a decrease in adhesion of THP-1 cells to HUVECs and protection against acute lung injury in mice.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Arshiya Parveen, Kyle R. Bohnert, Meiricris Tomaz da Silva, Yefei Wen, Raksha Bhat, Anirban Roy, Ashok Kumar
Summary: The study demonstrates the important role of the MyD88 signaling pathway in denervation-induced muscle wasting, potentially through influencing NF-kappa B, AMPK, and UPR pathways.
Article
Chemistry, Multidisciplinary
Chih-Wei Chiu, Chih-Hao Yang, Jie-Heng Tsai, Cheng-Ying Hsieh, Shih-Yi Huang
Summary: The study found that platonin has inhibitory effects on inflammatory VSMCs, reducing the expression of inducible nitric oxide synthetase and interleukin-1 beta, suppressing NF-kappa B activation, decreasing MCP-1 production, preventing lipid accumulation, and demonstrating potent anti-inflammatory and vascular protective properties.
APPLIED SCIENCES-BASEL
(2021)
Article
Oncology
Paula Gonzalez-Lopez, Marta Alvarez-Villarreal, Ruben Ruiz-Simon, Andrea R. Lopez-Pastor, Melina Vega de Ceniga, Leticia Esparza, Jose L. Martin-Ventura, Oscar Escribano, Almudena Gomez-Hernandez
Summary: MicroRNAs miR-15a-5p and miR-199a-3p are significantly decreased in aortic and carotid samples from atherosclerosis patients and mice. Overexpression of these miRNAs can reduce inflammation and progression of atherosclerosis. MiR-15a-5p may serve as a novel diagnostic biomarker for advanced atherosclerosis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Donald Ho, Tyler O. Lynd, Claire Jun, Juhee Shin, Reid C. Millican, Benjamin K. Estep, Jun Chen, Xixi Zhang, Brigitta C. Brott, Dong Woon Kim, Jennifer A. Sherwood, Patrick T. J. Hwang
Summary: Vascular insults can lead to vascular diseases such as atherosclerosis through an inflammatory cascade involving endothelial cell, smooth muscle cell, and macrophage activation. This study introduces miR-146a encapsulated liposomes to reduce inflammatory responses in vascular cells and macrophages. The results showed that miR-146a encapsulated liposomes effectively reduced vascular inflammation by inhibiting ICAM-1 expression, decreasing monocyte adhesion, and reducing proinflammatory cytokine production and foam cell formation.
Article
Cell Biology
Jin Ha Park, Jiae Lee, Gong-Rak Lee, Minjeong Kwon, Hye In Lee, Narae Kim, Hee Jin Kim, Mi-Ock Lee, Woojin Jeong
Summary: Cholesterol sulfate (CS) activates retinoic acid-related orphan receptor a (ROR alpha). CS and ROR alpha inhibit osteoclast differentiation. The mechanism involves the AMPK-Sirt1 axis, leading to NF-kappa B inhibition. CS also induces apoptosis and protects against bone loss in mouse models.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Cell Biology
Jia-Ni Yuan, Yu Hong, Zhuo-Lin Ma, Rui-Ping Pang, Qing-Qing Lei, Xiao-Fei Lv, Jia-Guo Zhou, Hui Huang, Ting-Ting Zhang
Summary: miR-302a acts as an effective suppressor of vascular inflammation by inhibiting the NF-kappa B pathway in endothelial cells, indicating its potential as a novel target for relieving vascular inflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tao Li, Yu Chen, Yuan Li, Gang Chen, Yuqing Zhao, Guangyue Su
Summary: In this study, it was found that 20(R)-25-methoxyl-dammarane-3 beta,12 beta,20-triol (AD-1) can alleviate pulmonary fibrosis (PF) both in vitro and in vivo. The underlying mechanism may involve decreasing extracellular matrix (ECM) deposition and inflammation, enhancing antioxidant capacity, and regulating lung cell apoptosis and the TGF-beta 1/TIMP-1/alpha-SMA signaling pathway.