Article
Cardiac & Cardiovascular Systems
Julia Hinterdobler, Simin Schott, Hong Jin, Almut Meesmann, Anna-Lena Steinsiek, Anna-Sophia Zimmermann, Jana Wobst, Philipp Mueller, Carina Mauersberger, Baiba Vilne, Alexandra Baecklund, Chien-Sin Chen, Aldo Moggio, Quinte Braster, Michael Molitor, Markus Krane, Wolfgang E. Kempf, Karl-Heinz Ladwig, Michael Hristov, Maarten Hulsmans, Ingo Hilgendorf, Christian Weber, Philip Wenzel, Christoph Scheiermann, Lars Maegdefessel, Oliver Soehnlein, Peter Libby, Matthias Nahrendorf, Heribert Schunkert, Thorsten Kessler, Hendrik B. Sager
Summary: This study reveals how acute mental stress exacerbates vascular inflammation and promotes plaque rupture. Acute stress increases the influx of inflammatory leucocytes into mouse atherosclerotic plaques by modulating endothelial cells. Chemical or surgical disruption of norepinephrine signaling reduces stress-induced leucocyte migration into mouse atherosclerotic plaques.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Weiyu Chen, Sergey Tumanov, Christopher P. Stanley, Stephanie M. Y. Kong, James Nadel, Niv Vigder, Darren L. Newington, Xiao Suo Wang, Louise L. Dunn, Roland Stocker
Summary: This study shows that deficiency of bilirubin is associated with increased risk of atherosclerosis and cardiovascular disease. In the experiments, mice deficient in bilirubin showed higher burden of atherosclerotic plaques, increased systemic oxidative stress, endothelial dysfunction, and hyperlipidemia. Furthermore, the study found that bilirubin deficiency selectively enhanced neutrophil-mediated inflammation and destabilization of unstable plaques.
CIRCULATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Tom Adriaenssens, Marc P. Allard-Ratick, Vikas Thondapu, Tomoyo Sugiyama, O. Christopher Raffel, Peter Barlis, Eric K. W. Poon, Makoto Araki, Akihiro Nakajima, Yoshiyasu Minami, Masamichi Takano, Osamu Kurihara, Valentin Fuster, Tsunekazu Kakuta, Ik-Kyung Jang
Summary: The development of optical coherence tomography (OCT) technology has significantly impacted our understanding of coronary artery disease by revealing unique mechanisms of plaque growth and stability through the study of different hemodynamic factors. Recent research has introduced a new concept of plaque healing, changing the way we perceive coronary artery disease.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ravichandran Ramasamy, Alexander Shekhtman, Ann Marie Schmidt
Summary: Increasing evidence suggests that the RAGE/DIAPH1 signaling axis is involved in the pathogenesis of diabetic complications, potentially impacting interferon signaling pathways and inflammatory responses in vulnerable tissues. Recent research indicates that targeting RAGE intracellular signaling may be a promising therapeutic approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Marko Kumric, Josip A. Borovac, Dinko Martinovic, Tina Ticinovic Kurir, Josko Bozic
Summary: Despite advancements in mitigating ACS complications, it remains a global health burden. Most vulnerable plaques leading to ACS are due to sudden disruption rather than gradual narrowing of vessel lumen. Current imaging modalities for vulnerable plaque detection are invasive, leading to the search for biomarkers from lipid and inflammation processes.
Article
Biochemistry & Molecular Biology
Dongxia Wang, Jiaying Li, Gang Luo, Juan Zhou, Ning Wang, Shanshan Wang, Rui Zhao, Xin Cao, Yuxia Ma, Gang Liu, Liping Hao
Summary: This review provides an overview of the role and regulatory mechanisms of Nox4 in diabetic microangiopathy, with a special emphasis on its upregulation in diabetic nephropathy. It also presents novel perspectives, such as epigenetics, on how Nox4 regulates diabetic microangiopathy. Additionally, the review discusses Nox4 as a therapeutic target and highlights drugs, inhibitors, and dietary components that target Nox4 for the prevention and treatment of diabetic microangiopathy.
Article
Cardiac & Cardiovascular Systems
Francesca Fasolo, Hong Jin, Greg Winski, Ekaterina Chernogubova, Jessica Pauli, Hanna Winter, Daniel Y. Li, Nadiya Glukha, Sabine Bauer, Susanne Metschl, Zhiyuan Wu, Marlys L. Koschinsky, Muredach Reilly, Jaroslav Pelisek, Wolfgang Kempf, Hans-Henning Eckstein, Oliver Soehnlein, Ljubica Matic, Ulf Hedin, Alexandra Baecklund, Claes Bergmark, Valentina Paloschi, Lars Maegdefessel
Summary: The study identified lncRNA MIAT as a key regulator in advanced atherosclerosis, controlling the proliferation, apoptosis, and phenotypic transition of SMCs, as well as the proinflammatory properties of macrophages. Experimental knockdown of MIAT significantly impacted cell behaviors, revealing a potential therapeutic target for atherosclerotic diseases.
Review
Pharmacology & Pharmacy
Kensei Taguchi, Kei Fukami
Summary: Diabetes, a leading cause of death worldwide, is expected to affect 642 million people by 2040. The concept of diabetic kidney disease (DKD) is widely accepted due to the increasing number of diabetes patients with multiple underlying diseases. Receptor for advanced glycation endproducts (RAGE), a multiligand receptor, is upregulated in patients with diabetes, hypertension, obesity, and chronic inflammation, and can be a therapeutic target for inhibiting the progression of DKD and its complications.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Endocrinology & Metabolism
Vinay Singh Tanwar, Marpadga A. Reddy, Rama Natarajan
Summary: Chronic metabolic disorders like obesity and diabetes are associated with accelerated vascular complications, and long non-coding RNAs play a crucial role in regulating gene expression in these diseases. Understanding the characteristics and mechanisms of lncRNAs can provide insights for the development of new therapeutic approaches to manage these disorders effectively.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Anqi Chen, Hailing Wang, Ying Su, Chunlin Zhang, Yanmei Qiu, Yifan Zhou, Yan Wan, Bo Hu, Yanan Li
Summary: Exosomes play an important role in diabetic systemic vasculopathy, showing potential therapeutic effects, but there are still some limitations in current research.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Tae-Yeon Kim, Yong-Yeon Song, Il-Jung, Yong-Jin Na, Young-Hoon Lee, Jung-Yeul Kim, Min-Woo Lee
Summary: The study aimed to investigate the effects of prolonged type 2 diabetes (T2DM) on the retinal microvasculature of patients without clinical diabetic retinopathy (DR). The results showed that T2DM patients without DR had decreased vessel densities in both the superficial and deep capillary plexus. The impairment in the deep capillary plexus was more severe in patients with T2DM for more than 10 years. Best corrected visual acuity, hypertension, and duration of diabetes were significant factors associated with the deep vascular density.
Review
Biochemistry & Molecular Biology
Xia-Qing Wu, Dan-Dan Zhang, Yan-Ni Wang, Yue-Qi Tan, Xiao-Yong Yu, Ying-Yong Zhao
Summary: Diabetic kidney disease is a major cause of chronic kidney disease, and controlling blood glucose is effective in preventing it. However, the formation of AGEs related to high glucose plays a central role in the pathogenesis of DKD, causing oxidative stress and inflammation.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Clinical Neurology
Lena Lavie, Erez Si-On, Aaron Hoffman
Summary: Patients with sleep-disordered breathing (SDB) exhibited significantly higher levels of 3-nitrotyrosine and intracellular lipid content in carotid plaques, along with lower SMC-actin levels. These markers are associated with increased plaque vulnerability and instability, indicating a higher susceptibility to plaque rupture in SDB patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Dermatology
Jordan M. Johnson, Yared Takebe, Geping Zhang, Rebecca Ober, Alicia McLuckie, George W. Niedt, Lynne L. Johnson
Summary: The study found that administering an antibody that blocks RAGE can accelerate the healing of dorsal wounds in diabetic pigs, while patches were not effective in promoting wound healing.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Alok D. Singh, Yogesh A. Kulkarni
Summary: VAP-1 is a multifunctional protein that plays an important role in diabetes and its complications. Studies have shown a correlation between increased insulin levels and elevated VAP-1 levels. Inhibitors of VAP-1 have been found to reduce the severity of diabetic animal models.
PHARMACOLOGICAL REPORTS
(2022)