Article
Environmental Sciences
Marnie F. Hazlehurst, Logan C. Dearborn, Allison R. Sherris, Christine T. Loftus, Margaret A. Adgent, Adam A. Szpiro, Yu Ni, Drew B. Day, Joel D. Kaufman, Neeta Thakur, Rosalind J. Wright, Sheela Sathyanarayana, Kecia N. Carroll, Paul E. Moore, Catherine J. Karr
Summary: This study aimed to investigate the impact of ozone exposure from birth to age 8 on lung function in middle childhood. The results showed that there were no adverse associations between ozone exposure and lung function in children with low ozone concentrations.
ENVIRONMENTAL RESEARCH
(2024)
Article
Cardiac & Cardiovascular Systems
Qiaoyun Zhang, Xiaoyu Zhang, Jie Zhang, Biyan Wang, Xiaoni Meng, Qiuyue Tian, Jinxia Zhang, Mengyang Jiang, Yiqiang Zhang, Deqiang Zheng, Lijuan Wu, Wei Wang, Baoguo Wang, Youxin Wang
Summary: The study found no causal relationship between lung function and risk of atrial fibrillation based on various Mendelian randomization analysis methods. Although there are some associations between lung function and AF, there is no direct causal link.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Environmental Sciences
Iana Markevych, Tianyu Zhao, Elaine Fuertes, Alessandro Marcon, Payam Dadvand, Danielle Vienneau, Judith Garcia Aymerich, Dennis Nowak, Kees de Hoogh, Deborah Jarvis, Michael J. Abramson, Simone Accordini, Andre F. S. Amaral, Hayat Bentouhami, Randi Jacobsen Bertelsen, Anne Boudier, Roberto Bono, Gayan Bowatte, Lidia Casas, Shyamali C. Dharmage, Bertil Forsberg, Thorarinn Gislason, Marco Gnesi, Mathias Holm, Benedicte Jacquemin, Christer Janson, Rain Jogi, Ane Johannessen, Dirk Keidel, Benedicte Leynaert, Jose Antonio Maldonado Perez, Pierpaolo Marchetti, Enrica Migliore, Jesus Martinez-Moratalla, Hans Orru, Isabelle Pin, James Potts, Nicole Probst-Hensch, Andrea Ranzi, Jose Luis Sanchez-Ramos, Valerie Siroux, David Soussan, Jordi Sunyer, Isabel Urrutia Landa, Simona Villani, Joachim Heinrich
Summary: This study examined the association between residential greenspace and change in lung function over 20 years in middle-aged European adults. The findings showed that living in more greenspaces was not associated with better lung function, but instead there were slight but consistent declines in lung function parameters. These findings need to be verified in future studies.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Respiratory System
Simona Piaggi, Elisabetta Marchi, Vittoria Carnicelli, Riccardo Zucchi, Matthias Griese, Andreas Hector, Claudio Sorio, Alfonso Pompella, Alessandro Corti
Summary: The study found soluble GSTO1-1 in the airways of CF patients, which was associated with inflammatory parameters and negatively correlated with lung function indicators FEV1 and FEV1/FVC ratio. Additionally, the A140D polymorphism of GSTO1-1 was linked to lower levels of anti-inflammatory mediators and decreased FEV1/FVC ratio in CF patients. Further research is needed to fully understand extracellular GSTO1-1's role in inflamed tissues.
JOURNAL OF CYSTIC FIBROSIS
(2021)
Article
Medicine, General & Internal
Ting Tian, Xueqin Jiang, Rujie Qin, Yuqing Ding, Chengxiao Yu, Xin Xu, Ci Song
Summary: China aims to reduce adult smoking prevalence from 27.7% to 20% by 2030. Understanding the ongoing impairment in lung function in smokers is crucial for promoting smoking behavior change. The study found that smoking is significantly associated with declines in lung function, and early smoking cessation can slow down the decline.
FRONTIERS IN MEDICINE
(2023)
Article
Respiratory System
Lucy Perrem, David Wilson, Sharon D. Dell, Felix Ratjen
Summary: This study develops and compares a quality grading algorithm for forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) in school-aged children. The algorithm utilizes smaller ranges of expired volumes to define repeatability, and shows a more uniform distribution of grades. It suggests that a more tailored algorithm is feasible and appropriate for pediatric pulmonary function laboratories.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Immunology
Afaq H. Beigh, Roohi Rasool, Fizalah Kawoosa, Sharika Manzoor, Rabiya Rashid, Khurshid Iqbal Andrabi, Zafar A. Shah, Taha Qureshi
Summary: The study demonstrates that AIT has a significant impact on pulmonary function and serum variables in patients with mild allergic asthma, improving symptoms and reducing medication use.
IMMUNOLOGY LETTERS
(2021)
Article
Nutrition & Dietetics
Zhimin Yu, Chengkai Xu, Chenggang Fang, Fangfang Zhang
Summary: This study used Mendelian randomization design to explore the potential causal relationships between iron status and lung function. The results showed a strong positive association between iron status and FEV1 and FVC, while no causal association was found between iron status and FEV1/FVC ratio.
FRONTIERS IN NUTRITION
(2022)
Article
Clinical Neurology
Leigh Hartog, Jing Zhao, Jerry Reynolds, Gabrielle Brokamp, Ferdinand Vilson, W. David Arnold, Samantha LoRusso
Summary: Respiratory complications are the most common cause of death among patients with Myotonic Dystrophy type 1 (DM1). Factors influencing the progression of respiratory dysfunction were studied in 110 adult patients, with FVC (% predicted) identified as a key correlate of disease severity. While factors like CTG repeat size and MIRS rating were associated with lower baseline FVC, they did not predict the annual rate of change in FVC. The wide variability in clinical phenotype posed challenges in determining disease measures directly related to respiratory functional decline.
FRONTIERS IN NEUROLOGY
(2021)
Article
Nutrition & Dietetics
Stefanie N. Sveiven, Rachel Bookman, Jihyun Ma, Elizabeth Lyden, Corrine Hanson, Tara M. Nordgren
Summary: The study found that certain milk consumption tendencies were associated with pulmonary function values among normal and asthmatic populations, while the type of milk had variable influence and significance on the outcomes.
Article
Respiratory System
Daniel J. Tan, Caroline J. Lodge, Adrian J. Lowe, Dinh S. Bui, Gayan Bowatte, David P. Johns, Garun S. Hamilton, Paul S. Thomas, Michael J. Abramson, E. Haydn Walters, Jennifer L. Perret, Shyamali C. Dharmage
Summary: Bronchodilator reversibility (BDR) was evaluated for its diagnostic accuracy in adult asthma and asthma-COPD overlap. The study found that a threshold of >= 12% and >= 200 mL from baseline provided the best balance between sensitivity and specificity for asthma (9% and 97%) and ACO (47% and 97%). A positive BDR test significantly altered the post-test probability of disease, especially in those with ACO.
Article
Immunology
Indranil Ganai, Ishita Saha, Priyajit Banerjee, Arghya Laha, Saheen Sultana, Nasima Sultana, Himani Biswas, Saibal Moitra, Sanjoy Podder
Summary: This study aimed to assess the potential association of TBXA2R rs34377097 polymorphism with pollen-induced asthma in an Indian population. The results showed a significant difference in genotype frequencies between asthma patients and control subjects, as well as a significant correlation between the polymorphism and clinical parameters such as FEV1, FEV1/FVC, and PEFR. The in-silico analysis also revealed the structural alteration of the mutated TBXA2R protein and its potential role in asthma response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Klara Komici, Fabio D'Amico, Sofia Verderosa, Iacopo Piomboni, Carmine D'Addona, Vito Picerno, Antonio Bianco, Andrea Caiazzo, Leonardo Bencivenga, Giuseppe Rengo, Germano Guerra
Summary: This study found that fat-free mass and muscle mass are positively associated with pulmonary function in athletes, while waist-to-height ratio is negatively associated. These findings suggest that body composition in athletes may be helpful in monitoring respiratory function.
Article
Respiratory System
Pakvirin Nanakorn Chanachon, Wanlapa Jotikasthira, Potjanee Kiewngam, Adithep Sawatchai, Watcharoot Kanchongkittiphon, Wiparat Manuyakorn
Summary: This study found an association between dyslipidemia and pulmonary function parameters in asthmatic children, especially with HDL-C and LDL-C concentrations and respiratory resistance.
Article
Biochemistry & Molecular Biology
Man She, Tao Li, Wenqing Shi, Bing Li, Xiaodong Zhou
Summary: This study found that tear concentrations of amphiregulin (AREG) are associated with the development of myopia, and AREG may play a role in scleral remodeling through the ERK1/2-MMP-2 pathway. Therefore, AREG could be a potential target for myopia control.
Article
Immunology
Liane J. Kang, Petya T. Koleva, Catherine J. Field, Gerald F. Giesbrecht, Eytan Wine, Allan B. Becker, Piushkumar J. Mandhane, Stuart E. Turvey, Padmaja Subbarao, Malcolm R. Sears, James A. Scott, Anita L. Kozyrskyj
BRAIN BEHAVIOR AND IMMUNITY
(2018)
Article
Biochemistry & Molecular Biology
Andreanne Morin, Anne-Marie Madore, Tony Kwan, Maria Ban, Jukka Partanen, Lars Ronnblom, Ann-Christine Syvanen, Stephen Sawcer, Hendrik Stunnenberg, Mark Lathrop, Tomi Pastinen, Catherine Laprise
EUROPEAN JOURNAL OF HUMAN GENETICS
(2019)
Review
Medical Laboratory Technology
Mathieu Simard, Catherine Laprise, Simon L. Girard
CLINICAL CHEMISTRY
(2019)
Article
Otorhinolaryngology
Claudie Laprise, Sreenath Arekunnath Madathil, Nicolas F. Schlecht, Genevieve Castonguay, Denis Soulieres, Phuc Felix Nguyen-Tan, Paul Allison, Francois Coutlee, Michael Hier, Marie-Claude Rousseau, Eduardo L. Franco, Belinda Nicolau
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2019)
Article
Allergy
Sarah E. Reese, Cheng-Jian Xu, Herman T. den Dekker, Mi Kyeong Lee, Sinjini Sikdar, Carlos Ruiz-Arenas, Simon K. Merid, Faisal Rezwan, Christian M. Page, Vilhelmina Ullemar, Phillip E. Melton, Sam S. Oh, Ivana Yang, Kimberley Burrows, Cilla Soderhall, Dereje D. Jima, Lu Gao, Ryan Arathimos, Leanne K. Kupers, Matthias Wielscher, Peter Rzehak, Jari Lahti, Catherine Laprise, Anne-Marie Madore, James Ward, Brian D. Bennett, Tianyuan Wang, Douglas A. Bell, Judith M. Vonk, Siri E. Haberg, Shanshan Zhao, Robert Karlsson, Elysia Hollams, Donglei Hu, Adam J. Richards, Anna Bergstrom, Gemma C. Sharp, Janine F. Felix, Mariona Bustamante, Olena Gruzieva, Rachel L. Maguire, Frank Gilliland, Nour Baiz, Ellen A. Nohr, Eva Corpeleijn, Sylvain Sebert, Wilfried Karmaus, Veit Grote, Eero Kajantie, Maria C. Magnus, Anne K. Ortqvist, Celeste Eng, Andrew H. Liu, Inger Kull, Vincent W. V. Jaddoe, Jordi Sunyer, Juha Kere, Cathrine Hoyo, Isabella Annesi-Maesano, Syed Hasan Arshad, Berthold Koletzko, Bert Brunekreef, Elisabeth B. Binder, Katri Raikkonen, Eva Reischl, John W. Holloway, Marjo-Riitta Jarvelin, Harold Snieder, Nabila Kazmi, Carrie Breton, Susan K. Murphy, Goran Pershagen, Josep Maria Anto, Caroline L. Relton, David A. Schwartz, Esteban G. Burchard, Rae-Chi Huang, WeRae-Che Nystad, Catarina Almqvist, A. John Henderson, Erik Melen, Liesbeth Duijts, Gerard H. Koppelman, Stephanie J. London
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2019)
Article
Respiratory System
Marie-Helene Dizier, Patricia Margaritte-Jeannin, Lucile Pain, Chloe Sarnowski, Myriam Brossard, Hamida Mohamdi, Nolwenn Lavielle, Marie-Claude C. Babron, Jocelyne Just, Mark Lathrop, Catherine Laprise, Emmanuelle Bouzigon, Florence Demenais, Rachel Nadif
Article
Clinical Neurology
Brittany A. Matenchuk, Sukhpreet K. Tamana, Wendy Y. W. Lou, Diana L. Lefebvre, Malcolm R. Sears, Allan B. Becker, Meghan B. Azad, Theo J. Moraes, Stuart E. Turvey, Padmaja Subbarao, Anita L. Kozyrskyj, Piush J. Mandhane, P. Subbarao, S. E. Turvey, S. S. Anand, M. B. Azad, A. B. Becker, A. D. Befus, M. Brauer, J. R. Brook, E. Chen, M. M. Cyr, D. Daley, S. D. Dell, J. A. Denburg, Q. L. Duan, T. Eiwegger, H. Grasemann, K. HayGlass, R. G. Hegele, D. L. Holness, P. Hystad, M. Kobor, T. R. Kollmann, A. L. Kozyrskyj, C. Laprise, W. Y. W. Lou, J. Macri, P. J. Mandhane, G. Miller, T. J. Moraes, P. Pare, C. Ramsey, F. Ratjen, A. Sandford, J. A. Scott, J. Scott, M. R. Sears, F. Silverman, E. Simons, T. Takaro, S. J. Tebbutt, T. To
Article
Cell Biology
Yvette Mukaneza, Aaron Cohen, Marie-Eve Rivard, Jessica Tardif, Sonia Deschenes, Matthieu Ruiz, Catherine Laprise, Christine Des Rosiers, Lise Coderre, Bruce G. Allen, Claudine Beauchamp, Chantal Bemeur, Yan Burelle, Guy Charron, Francois Labarthe, Jeannine Landry, Genevieve Lavallee, Pierre Lavoie, Sylvie Lesage, Bruno Maranda, Charles Morin, John D. Rioux, Eric A. Shoubridge, Julie Thompson Legault, Nancy Tremblay, Vanessa Tremblay-Vaillancourt, Luc Vachon, Josee Villeneuve
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2019)
Article
Multidisciplinary Sciences
Sukhpreet Tamana, Victor Ezeugwu, Joyce Chikuma, Diana Lefebvre, Meghan Azad, Theo Moraes, Padmaja Subbarao, Allan Becker, Stuart Turvey, Malcolm Sears, Bruce Dick, Valerie Carson, Carmen Rasmussen, Jacqueline Pei, Piush Mandhane
Article
Allergy
Pierre-Emmanuel Sugier, Chloe Sarnowski, Raquel Granell, Catherine Laprise, Markus J. Ege, Patricia Margaritte-Jeannin, Marie-Helene Dizier, Cosetta Minelli, Miriam F. Moffatt, Mark Lathrop, William O. C. M. Cookson, A. John Henderson, Erika von Mutius, Manolis Kogevinas, Florence Demenais, Emmanuelle Bouzigon
CLINICAL AND EXPERIMENTAL ALLERGY
(2019)
Article
Biochemistry & Molecular Biology
Emile Belanger, Anne-Marie Madore, Anne-Marie Boucher-Lafleur, Marie-Michelle Simon, Tony Kwan, Tomi Pastinen, Catherine Laprise
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Emile Belanger, Catherine Laprise
Summary: Epigenetics is a study of changes in gene expression influenced by environment or social factors, involving mechanisms such as DNA methylation, histone modification, and noncoding RNA. Understanding epigenetic mechanisms in human diseases provides valuable insights into disease severity and development. Research on the regulation of allergies and asthma through epigenetic mechanisms, particularly using eosinophil samples, is limited, but can enhance understanding of eosinophil recruitment in allergic and asthmatic symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
William Bourumeau, Karine Tremblay, Guillaume Jourdan, Catherine Girard, Catherine Laprise
Summary: This study finds that COVID-19 infection leads to dysbiosis in the upper respiratory tract, and identifies different biomarkers for positive and negative-tested individuals. These findings suggest that individuals with prior dysbiosis may have a higher risk of opportunistic pathogen infections.
Article
Public, Environmental & Occupational Health
John E. Krzeczkowski, Amanda Lau, Jennifer Fitzpatrick, Sukhpreet Tamana, Lisa Smithson, Russell de Souza, Anita L. Kozyrskyj, Diana Lefebvre, Allan B. Becker, Padmaja Subbarao, Stuart E. Turvey, Jacqueline Pei, Louis A. Schmidt, Malcolm R. Sears, Ryan J. Van Lieshout, Piush J. Mandhane, P. Subbarao, S. E. Turvey, S. S. Anand, M. Azad, A. B. Becker, A. D. Befus, M. Brauer, J. R. Brook, E. Chen, M. Cyr, D. Daley, S. Dell, J. A. Denburg, Q. Duan, T. Eiwegger, H. Grasemann, K. HayGlass, R. Hegele, D. L. Holness, Perry Hystad, M. S. Kobor, T. R. Kollman, A. L. Kozyrskyj, C. Laprise, W. Y. W. Lou, J. Macri, P. M. Mandhane, G. Miller, T. Moraes, P. D. Pare, C. Ramsey, F. Ratjen, A. Sandford, J. A. Scott, J. Scott, M. R. Sears, F. Silverman, E. Simons, T. Takaro, S. Tebbutt, T. To
MATERNAL AND CHILD HEALTH JOURNAL
(2019)
Article
Allergy
C. Dharma, D. L. Lefebvre, M. M. Tran, W. Y. W. Lou, P. Subbarao, A. B. Becker, P. J. Mandhane, S. E. Turvey, M. R. Sears
CLINICAL AND EXPERIMENTAL ALLERGY
(2018)