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Biology
Chien-Liang Chao, Chao-Jih Wang, Hsin-Wen Huang, Han-Peng Kuo, Muh-Hwan Su, Hang-Ching Lin, Chia-Wen Teng, Leticia B. Sy, Wen-Mein Wu
Summary: This study demonstrates that Poria cocos extract (Lipucan(R)) has anti-allergic and anti-asthmatic effects by reducing inflammation, eosinophil infiltration, and Th2 cytokines while increasing Th1 immune response. Moreover, P. cocos extract also enhances NK cell activity and potentially prevents or alleviates allergy-induced asthma.
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Plant Sciences
Ibrahim Sulaiman, Emmanuel Oshiogwe Okwuofu, Norhafizah Mohtarrudin, Jonathan Chee Woei Lim, Johnson Stanslas
Summary: The standardized Andrographis paniculata 50% ethanol extract (APEE50) showed anti-inflammatory effects in a mouse asthma model by down-regulating Th2 cytokine gene expression and oxidative stress levels.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Qiang Li, Chunmiao Zhai, Guodong Wang, Jia Zhou, Weiguang Li, Liquan Xie, Zhanli Shi
Summary: The study showed that Rh1 significantly alleviated asthma symptoms in mice, including lung resistance, airway resistance, and inflammation cell count. Furthermore, Rh1 reversed the imbalance of Th1/Th2 cytokines in the mice model.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2021)
Article
Plant Sciences
Jing Han, Siwang Zhang, Baoping Jiang, Jingwen Wang, Xiaojing Ge, Bingrong Wu, Sen Zhang, Dongsheng Wang
Summary: The sesquiterpene lactones, including five major constituents, may be the main active constituent of X. sibiricum for its anti-asthma activity. SL-XS exerted its anti-asthma effect by modulating the Th1/Th2 balance via the JAK/STAT signaling pathway.
Review
Immunology
Weihang Luo, Jindong Hu, Weifang Xu, Jingcheng Dong
Summary: The immune response in the asthmatic respiratory tract is driven by CD4(+) T helper cells, especially Th2 cells. Asthma is a heterogeneous and progressive disease, with different stages of the disease course showing different immune responses. The complex immune networks in the inflammatory airway make it challenging to find a universal treatment for all asthmatics.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yumei Zhou, Linhan Hu, Honglei Zhang, Haiyun Zhang, Juntong Liu, Xiaoshan Zhao, Ji Wang, Qi Wang
Summary: The study found that GMK achieves a similar effect as dexamethasone in controlling symptoms of allergic asthma and inhibiting inflammation, reconstructs the immune balance of Th1/Th2 and Treg/Th17 cells, and impacts asthma treatment by altering gut microbiota. Metabolome results reveal specific substances associated with Th1/Th2 and Treg/Th17 cell balance.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Yuan Zhang, Jiuli Zhang, Jun Bao, Chaohua Tang, Ziwei Zhang
Summary: The study found that selenium deficiency can lead to necroptosis, inflammatory responses, and abnormal expression of cytokines in swine intestine tissues, potentially causing damage to the digestive system.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Liping Qin, Yu Song, Fan Zhang, Ru Wang, Li Zhou, Shiqi Jin, Chaojia Chen, Chunyang Li, Molin Wang, Baichun Jiang, Gongping Sun, Chunhong Ma, Yaoqin Gong, Peishan Li
Summary: CUL4B plays a critical role in Th cell differentiation through regulating histone modifications.
CELL DEATH AND DIFFERENTIATION
(2023)
Review
Biochemistry & Molecular Biology
Yang Wang, Chengping Hu
Summary: Leptin, as an adipokine, plays a role in the proinflammatory obese-associated phenotype and is implicated in the pathology of asthma. Studies have shown that leptin affects adipogenesis, chronic inflammation, immune cell pathways, and has both positive and negative effects on asthma development. However, the conclusive effects of leptin on asthma are not well elucidated and require further research.
Article
Immunology
Wenjing Gu, Suyu Guo, Jiahui Zhang, Xinxing Zhang, Zhichao Sun, Zhengrong Chen, Li Huang
Summary: Asthma is an inflammatory disease in which Th2 differentiation and dendritic cells (DCs) play important roles. Highly expressed March1 can promote Th2 differentiation induced by DCs through facilitating OX40L expression and contribute to the development of asthma. These findings might provide new insights into the treatment of asthma.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Beibei Zhang, Mengnan Zeng, Qinqin Zhang, Ru Wang, Jufang Jia, Bing Cao, Meng Liu, Pengli Guo, Yuhan Zhang, Xiaoke Zheng, Weisheng Feng
Summary: The study demonstrated that Ephedrae Herba polysaccharides could effectively improve symptoms, ameliorate lung pathology, inhibit inflammation, apoptosis, and oxidative stress, and regulate immune cell levels in rats with asthma.
MOLECULAR IMMUNOLOGY
(2022)
Article
Virology
Karolina Akinosoglou, Anne-Lise Delastic, Vasilina Dimakopoulou, Markos Marangos, Charalambos Gogos
Summary: A study found no difference in Th1/Th2 responses between severe and mild COVID-19 patients, except for varying levels of IL-6 and IL-10. Future studies should investigate lung-specific versus systemic inflammatory responses and diverse immunotypes influencing poor clinical outcomes.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Thi Van Nguyen, Chun Hua Piao, Yan Jing Fan, Zhen Nan Yu, So-Young Lee, Chang Ho Song, Hee Soon Shin, Ok Hee Chai
Summary: This study investigated the effects of Artemisia gmelinii extracts (AGE) on an ovalbumin-induced CARAS mouse model. The results demonstrated that AGE could alleviate symptoms, regulate immune response, and inhibit mast cell degranulation, suggesting its potential as a therapeutic agent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Mohamed Hamed Abdelaziz, Xiaoyun Ji, Jie Wan, Fatma A. Abouelnazar, Sayed F. Abdelwahab, Huaxi Xu
Summary: This article discusses the correlation between allergic asthma and natural infections, exploring effective methods for preventing allergic asthma through natural infections. The authors mentioned the impact of Mycobacterium tuberculosis and helminth infections on the development of allergic asthma, as well as possible pathways for preventing allergic asthma through vaccine design.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Veterinary Sciences
Marcella Massimini, Elena Dalle Vedove, Benedetta Bachetti, Francesco Di Pierro, Cataldo Ribecco, Claudio D'Addario, Mariangela Pucci
Summary: By using a novel in vitro model of AD, researchers attempted to reverse the altered transcriptional regulation of key genes associated with canine atopic dermatitis using a nutraceutical mixture. The results showed a significant downregulation of gene expression in inflamed cells and an increase in DNA methylation at specific CpG sites, laying the groundwork for potential use in veterinary medicine and deeper understanding of the mechanisms of action.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Editorial Material
Critical Care Medicine
Yonatan Y. Greenstein, Bennyson Young G. So, Jonathan Gong, Jose Cardenas-Garcia, Rubin I. Cohen, Seth Koenig
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Medicine, General & Internal
Lewis J. Smith, Ravi Kalhan, Robert A. Wise, Elizabeth A. Sugar, John J. Lima, Charles G. Irvin, Allen J. Dozor, Janet T. Holbrook
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2015)
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Allergy
Anne E. Dixon, Anne E. Dixon, Mario Castro, Rubin I. Cohen, Lynn B. Gerald, Janet T. Holbrook, Charles G. Irvin, Shyam Mohapatra, Stephen P. Peters, Sobharani Rayapudi, Elizabeth A. Sugar, Robert A. Wise
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2015)
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Critical Care Medicine
Rubin I. Cohen, Ann Eichorn, Caroline Motschwiller, Viera Laktikova, Grace La Torre, Nicole Ginsberg, Harry Steinberg
JOURNAL OF CRITICAL CARE
(2015)
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Critical Care Medicine
Rubin I. Cohen, Heather Kennedy, Bernadette Amitrano, Maryanne Dillon, Sarah Guigui, Andrew Kanner
JOURNAL OF CRITICAL CARE
(2015)
Editorial Material
Critical Care Medicine
Patricia W. Finn, Rubin Cohen
LANCET RESPIRATORY MEDICINE
(2015)
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Respiratory System
Jessica Goggin, Rubin I. Cohen
JOURNAL OF CYSTIC FIBROSIS
(2016)
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Respiratory System
Elisabeth P. Dellon, Elaine Chen, Jessica Goggin, Karen Homa, Bruce C. Marshall, Kathryn A. Sabadosa, Rubin I. Cohen
JOURNAL OF CYSTIC FIBROSIS
(2016)
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Critical Care Medicine
Rubin I. Cohen, Fatima Jaffrey, Joyce Bruno Reitzner, Michael H. Baumann
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Critical Care Medicine
Margarita Oks, Krystal L. Cleven, Jose Cardenas-Garcia, Jennifer Ann Schaub, Seth Koenig, Rubin I. Cohen, Paul H. Mayo, Mangala Narasimhan
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Respiratory System
Harly Greenberg, Rubin I. Cohen
CURRENT OPINION IN PULMONARY MEDICINE
(2012)
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Respiratory System
Rubin I. Cohen, Nicole Ginsberg, Donna Tsang, Li Chen Wann, Xiaobing Ye, Shu Fang Liu
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Respiratory System
Subani Chandra, Pralay K. Sarkar, Divay Chandra, Nicole E. Ginsberg, Rubin I. Cohen
BMC PULMONARY MEDICINE
(2013)
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Respiratory System
S. Guigui, J. Wang, R. I. Cohen
RESPIRATORY MEDICINE CASE REPORTS
(2016)
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Critical Care Medicine
Michael Blaivas, Konstantinos Stefanidis, Serafim Nanas, John Poularas, Mitchell Wachtel, Rubin Cohen, Dimitrios Karakitsos
CRITICAL CARE RESEARCH AND PRACTICE
(2012)