期刊
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
卷 36, 期 1, 页码 165-172出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10815-018-1322-2
关键词
Embryo transfer; Mosaic embryo; Live birth; Obstetric outcome; Mosaicism
资金
- National Key Research and Development Program of China [2016YFC1000202]
- National Natural Science Foundation of China [81671522]
- Innovative Foundation of Reproductive Hospital Affiliated to Shandong University [20171114]
PurposeMosaicism is a prevalent characteristic of human preimplantation embryos. This retrospective cohort study aimed to investigate pregnancy outcomes after transfer ofmosaic or euploid embryos.MethodsThe embryos, which had been transferred as euploidy, were processed using array-based comparative genomic hybridization (aCGH). The original aCGH charts of the transferred embryos were reanalyzed. Mosaic and control euploid embryos were defined according to log2 ratio calls.ResultsOverall, 102 embryos were determined to be mosaic, of which 101 were estimated to harbor no more than 50% aneuploid mosaicism. Additionally, 268 euploid embryos were matched as controls. The rates of live birth (46.6% vs. 59.1%, odds ratio (OR) 0.60, 95% confidence interval (CI) 0.38-0.95), and biochemical pregnancy (65.7% vs. 76.1%, OR 0.60, 95% CI 0.37-0.99) per transfer cycle were significantly lower after mosaic embryo transfer than after euploid embryo transfer. The rates of clinical pregnancy and pregnancy loss and the risks of obstetric outcomes did not differ significantly between the two groups.ConclusionsCompared with euploid embryo transfer, mosaic embryo transfer is associated with a lower rate of live birth, which is mainly attributed to a decreased rate of conception. However, as mosaic embryo transfer yielded a live birth rate of 46.6%, patients without euploid embryos could be counseled regarding this alternative option.
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