Article
Multidisciplinary Sciences
R. Sainte-Rose, C. Petit, L. Dijols, C. Frapsauce, F. Guerif
Summary: The study found that blastocyst development rate is significantly reduced in advanced maternal age patients, with blastocysts showing growth retardation on day 5. While cell organization is unaffected by age, blastocysts with 'good' morphology in AMA patients have decreased implantation probability compared to 'average' morphology blastocysts in younger women. Although extended embryo culture is not harmful for AMA patients, it cannot compensate for the reduced implantation and live birth rates associated with maternal age.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Emmanouella E. Chatzidaki, Sean Powell, Bart J. H. Dequeker, Johanna Gassler, Mariana C. C. Silva, Kikue Tachibana
Summary: The study shows that reducing ovulation can delay oocyte aging and decrease chromosomal abnormalities in eggs. Protecting Rec8 from loss can maintain chromosome cohesion and preserve 3D chromatin structure, leading to the production of euploid eggs.
Article
Obstetrics & Gynecology
P. Verdyck, G. Altarescu, S. Santos-Ribeiro, C. Vrettou, U. Koehler, G. Griesinger, V Goossens, C. Magli, C. Albanese, M. Parriego, L. Coll, R. Ron-El, K. Sermon, J. Traeger-Synodinos
Summary: The study found that known chromosome segregation errors accounted for 90.4% of abnormal chromosome copy numbers in polar bodies of oocytes from women of advanced maternal age. These errors were associated with impaired embryo development.
HUMAN REPRODUCTION
(2023)
Article
Medicine, General & Internal
Jae Kyun Park, So-Yeon Ahn, Su Hee Seok, Eun Mi Chang, Ji Won Kim, In Pyung Kwak, Woo Sik Lee
Summary: This study investigated the association between post-warming extended culture duration and pregnancy outcomes in patients of advanced maternal age (AMA) undergoing vitrified-warmed blastocyst transfer (SVBT). The results showed that there were no significant differences in the live birth rates (LBR) between AMA patients and younger patients based on blastocyst morphology and post-warming extended culture duration. This finding suggests that post-warming extended culture of blastocysts is not harmful to AMA patients and could be useful in clinical counseling for fertility treatments.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Emilie Derisoud, Luc Jouneau, Cedric Dubois, Catherine Archilla, Yan Jaszczyszyn, Rachel Legendre, Nathalie Daniel, Nathalie Peynot, Michele Dahirel, Juliette Auclair-Ronzaud, Laurence Wimel, Veronique Duranthon, Pascale Chavatte-Palmer
Summary: This study found that maternal age affects gene expression in equine blastocysts. As mares age, gene expression related to mitochondria and protein metabolism is disrupted, leading to impaired embryo development and decreased fertility.
Article
Genetics & Heredity
Fang Wang, David H. H. McCulloh, Kasey Chan, Ashley Wiltshire, Caroline McCaffrey, James A. A. Grifo, David L. Keefe
Summary: This study investigated the telomere length, telomerase gene expression, and telomerase activity in aneuploid blastocysts compared to euploid blastocysts. The results showed that aneuploid blastocysts had longer telomeres, higher TERT mRNA expression, and lower telomerase activity. The presence of telomerase and maintenance of telomeres in aneuploid blastocysts explain why extended in vitro culture alone is insufficient to eliminate aneuploid embryos during in vitro fertilization.
Article
Reproductive Biology
Yilun Sui, Min Xiao, Jing Fu, Lu Li, Yining Xu, Caixia Lei, Xiaoxi Sun
Summary: Supplementation with growth hormone (GH) during ovarian stimulation in elderly women can significantly increase the chance of obtaining euploid blastocysts, especially in patients aged 38-40 years.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Obstetrics & Gynecology
Peng Yuan, Qianying Guo, Honshan Guo, Ying Lian, Fan Zhai, Zhigianq Yan, Chuan Long, Ping Zhu, Fuchou Tang, Jie Qiao, Liying Yan
Summary: The methylome of first polar bodies (PB1) closely reflects that of sibling MII oocytes, with hypermethylated LINE and LTRs indicating poor embryo development. Higher DNA methylation in PB1 was associated with embryos that could not reach the blastocyst stage, with methylation levels in PB1 promoters negatively correlating with gene expression in MII oocytes.
HUMAN REPRODUCTION
(2021)
Article
Multidisciplinary Sciences
Hiroaki Tanaka, Junichi Hasegawa, Shinji Katsuragi, Kayo Tanaka, Tatsuya Arakaki, Masamitsu Nakamura, Eijiro Hayata, Masahiko Nakata, Takeshi Murakoshi, Akihiko Sekizawa, Isamu Ishiwata, Tomoaki Ikeda
Summary: This study investigates the relationship between maternal mortality and advanced maternal age in Japan, revealing significantly higher mortality rates in women over 40 years. The most common cause of death in this age group was hemorrhagic stroke, with more than half of these cases being associated with preeclampsia. These findings highlight the importance of considering these risks for older pregnant women and healthcare providers involved in their care.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Maryam Daneshvar, Mansoureh Movahedin, Mohammad Salehi, Mehrdad Noruzinia
Summary: The study evaluated the impact of re-vitrification on the expression of miR-16, miR-let7a, and target genes in human blastocysts. The results showed that re-vitrification did not affect the ability of blastocysts to re-expand in culture, but led to a significant decrease in the expression of miR-16 and miR-let7a, along with a significant upregulation of the target genes ITG beta 3 and BCL-2 in re-vitrified and vitrified embryos.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Kenji Ezoe, Tetsuya Miki, Hikari Akaike, Kiyoe Shimazaki, Tsubasa Takahashi, Yuko Tanimura, Ayumi Amagai, Ayano Sawado, Mai Mogi, Shigeru Kaneko, Satoshi Ueno, Giovanni Coticchio, Danilo Cimadomo, Andrea Borini, Laura Rienzi, Keiichi Kato
Summary: Maternal ageing significantly affects pronuclear size and intra-and extra-nuclear dynamics during fertilization, dysregulates cell polarity during compaction, and reduces blastocoel expansion.
HUMAN REPRODUCTION
(2023)
Article
Genetics & Heredity
Yongle Yang, Wei Tan, Changsheng Chen, Lei Jin, Bo Huang
Summary: Polar bodies have been widely used for preimplantation genetic diagnosis, but their relationship with embryonic ploidy remains unclear. This study found that the state of polar bodies is not directly related to the ploidy of blastocysts, suggesting that it should not be used as a sole predictor for embryo selection.
FRONTIERS IN GENETICS
(2022)
Article
Obstetrics & Gynecology
Elpiniki Chronopoulou, Claudia Raperport, Paul Serhal, Wael Saab, Srividya Seshadri
Summary: Older pregnant women face higher risks, preconception tests can identify health issues and risk factors, contributing to preventing complications and improving maternal health.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Review
Cell Biology
Jan J. Brosens, Phillip R. Bennett, Vikki M. Abrahams, Rosanna Ramhorst, Arri Coomarasamy, Siobhan Quenby, Emma S. Lucas, Rajiv C. McCoy
Summary: Compared to other mammals, human pregnancy is unique in its involvement of chromosomally diverse embryos and the cyclical breakdown and regeneration of the uterine mucosa. Understanding the mechanisms behind miscarriage can provide insights into the maternal selection of embryos during early gestation.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Editorial Material
Cell & Tissue Engineering
Jere Weltner, Fredrik Lanner
Summary: Using time-lapse embryo staging and single-cell sequencing, Meistermann et al. (2021) provide new insights into the precise timing of lineage specification during human preimplantation development and raise questions about the concept of a human inner cell mass.
